Daily Archives: February 3, 2022
[Preprint] Results from the first Covid-19 human challenge study (deliberately infecting individuals in a controlled environment).
3 Feb, 2022 | 09:48h | UTCSafety, tolerability and viral kinetics during SARS-CoV-2 human challenge – Research Square
Commentaries:
Scientists deliberately gave people COVID — here’s what they learnt – Nature
First COVID-19 human challenge study yields infection clues – CIDRAP
Exposure to one nasal droplet enough for Covid infection – study – The Guardian
Related:
World’s first coronavirus “Human Challenge” study receives ethics approval in the UK (several texts on the subject) Are SARS-CoV-2 Human Challenge Trials Ethical? – “A clinical trial is underway in the UK in which young, healthy participants are exposed deliberately to SARS-CoV-2 to assess the viral inoculum needed to produce an infection and to test vaccine efficacy”.
Perspective: Challenges in inferring intrinsic severity of the SARS-CoV-2 Omicron variant.
3 Feb, 2022 | 09:58h | UTCChallenges in Inferring Intrinsic Severity of the SARS-CoV-2 Omicron Variant – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Omicron’s spread in South Africa has led to fewer hospitalizations and deaths than were seen during previous waves. But caution is warranted when it comes to making inferences about omicron’s intrinsic severity using population-level observations. #COVID19 https://t.co/xVb3tm8juc pic.twitter.com/HwNVvb5zpC
— NEJM (@NEJM) February 2, 2022
[Preprint] SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters.
3 Feb, 2022 | 09:50h | UTCSARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters – Nature
See also: [Preprint] Attenuated replication and pathogenicity of SARS-CoV-2 B.1.1.529 Omicron – Nature
Commentary: Omicron causes less severe illness in animal models than previous variants – University of Wisconsin–Madison
Commentary on Twitter
Two reports @nature today for decreased pathogenicity of Omicron in experimental models cf prior variants, now 8 studies all concordant, summarized herehttps://t.co/1dVXE1eRkNhttps://t.co/E8PJylfwp0 pic.twitter.com/c3gqi9MhID
— Eric Topol (@EricTopol) January 21, 2022
Consensus Statement: Preoperative management of medications for psychiatric diseases.
3 Feb, 2022 | 09:59h | UTC
Cohort Study: In high-transmission settings, the use of malaria-preventing mosquito nets in early childhood was associated with increased survival decades later.
3 Feb, 2022 | 08:56h | UTCCommentaries:
Malaria-preventing bed nets save children’s lives—with impacts that can last for decades – Science
Mosquito nets in young children save lives into adulthood – University of Basel
RCT: In patients with advanced esophageal squamous-cell carcinoma, both nivolumab plus chemotherapy and nivolumab plus ipilimumab resulted in longer overall survival than chemotherapy alone.
3 Feb, 2022 | 09:46h | UTCNivolumab Combination Therapy in Advanced Esophageal Squamous-Cell Carcinoma – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary (2021 ASCO Annual Meeting): Nivolumab Plus Chemotherapy and Nivolumab Plus Ipilimumab as First-Line Treatment for Patients With Advanced Esophageal Cancer – The ASCO Post
Commentary on Twitter
First-line treatment of advanced esophageal squamous-cell carcinoma with either nivolumab plus chemo or nivolumab plus ipilimumab resulted in a significant overall survival benefit and durable responses as compared with chemo alone. https://t.co/a000bDsh1N pic.twitter.com/NuY2eX58gp
— NEJM (@NEJM) February 2, 2022
Omicron’s sister variant spreads faster. So why did the one we call Omicron hit first?
3 Feb, 2022 | 08:54h | UTCOmicron’s sister variant spreads faster. So why did the one we call Omicron hit first? – STAT
Related:
BA.2 is like Omicron’s sister. Here’s what we know about it so far – The Conversation
Perspective: The origins, development, and context of the Lancet Commission on the Value of Death – “Death has turned from being a family, social, and cultural event to primarily a medical event”.
3 Feb, 2022 | 08:51h | UTCThe origins, development, and context of the Lancet Commission on the Value of Death – The BMJ
Cluster randomized controlled trial: An innovative telemedical network to improve infectious disease management in critically ill patients and outpatients.
3 Feb, 2022 | 08:53h | UTCRelated:
The “Choosing Wisely” initiative in infectious diseases – German Society of Infectious Diseases (link to abstract – $ for full-text)
Infectious Diseases Society of America: Five Things Physicians and Patients Should Question
Guideline: atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS).
3 Feb, 2022 | 08:48h | UTC
A nationwide study in Sweden showed the risk of death doubled in patients with chronic disease and co-occurring psychiatric disorders.
3 Feb, 2022 | 08:49h | UTC
M-A: Timing of tracheostomy in acute traumatic spinal cord injury.
3 Feb, 2022 | 08:44h | UTC
Evaluation and management of traumatic pneumothorax: A Western Trauma Association critical decisions algorithm.
3 Feb, 2022 | 08:46h | UTC
Optimal Background Pharmacological Therapy for Heart Failure Patients in Clinical Trials: JACC Review Topic of the Week.
3 Feb, 2022 | 08:42h | UTC
Cross-sectional analysis: increased visceral adipose tissue in adults linked to reduced cognitive scores.
3 Feb, 2022 | 08:41h | UTCEvaluation of Adiposity and Cognitive Function in Adults – JAMA Network Open
Commentaries:
Excess Body Fat Tied to Lower Cognitive Scores in Adults – HealthDay
Commentary on Twitter
In this study, excess body fat was associated with lower cognitive test performance, independent of other cardiovascular risk factors and MRI-detected vascular brain injury cognitive scores. #adiposity https://t.co/xNJbOa8rbK
— JAMA Network Open (@JAMANetworkOpen) February 1, 2022
Perspective: Trade-offs and policy options — using insights from economics to inform public health policy.
3 Feb, 2022 | 08:39h | UTC
Review: Diagnosis and treatment of acromegaly.
3 Feb, 2022 | 08:34h | UTCDiagnosis and Treatment of Acromegaly: An Update – Mayo Clinic Proceedings
Review: Evaluation and management of vaginitis.
3 Feb, 2022 | 08:37h | UTCEvaluation and Management of Vaginitis – Mayo Clinic Proceedings
Review: Behçet syndrome.
3 Feb, 2022 | 08:29h | UTCBehçet syndrome – Nature Reviews Disease Primers (if the link is paywalled, try this one)
Infographic: Behçet syndrome (if the link is paywalled, try this one)
Related: EULAR recommendations for the management of Behçet’s syndrome
M-A: Adverse events of immune checkpoint inhibitors therapy for urologic cancer patients in clinical trials.
3 Feb, 2022 | 08:31h | UTC
Commentary on Twitter
Adverse Events of Immune Checkpoint Inhibitors Therapy for Urologic Cancer Patients in Clinical Trials: A Collaborative Systematic Review and Meta-analysishttps://t.co/cnLe3oxATE@ricautor @spsutkaMD @MRoupret @AndreaNecchi @pcvblack pic.twitter.com/EmeapD8O54
— European Urology (@EUplatinum) January 30, 2022
Development and validation of BLOOMY prediction scores for 14-day and 6-month mortality in hospitalized adults with bloodstream infections: a multicenter, prospective, cohort study.
3 Feb, 2022 | 08:28h | UTCDevelopment and validation of BLOOMY prediction scores for 14-day and 6-month mortality in hospitalised adults with bloodstream infections: a multicentre, prospective, cohort study – The Lancet Infectious Diseases (link to abstract – $ for full-text)
M-A: Timing of carotid intervention in symptomatic carotid artery stenosis.
3 Feb, 2022 | 08:33h | UTC
Increasing financial payments from industry to medical oncologists in the U.S., 2014-2017.
3 Feb, 2022 | 08:26h | UTCInvited Commentary: Physician Interactions With Industry: Striking the Right Balance – Journal of the National Comprehensive Cancer Network
M-A: Laparoscopic versus open distal gastrectomy for gastric cancer.
3 Feb, 2022 | 08:30h | UTC
Study finds there is probably a high rate of underdiagnosed Fragile X Syndrome in the general population.
3 Feb, 2022 | 08:23h | UTCPrevalence of Underdiagnosed Fragile X Syndrome in 2 Health Systems – JAMA Network Open