Daily Archives: January 19, 2022 | LinksMedicus Free Medical News & Perspectives

Systematic Review: School closures during social lockdown and mental health, health behaviors, and well-being among children and adolescents during the first Covid-19 wave.

19 Jan, 2022 | 09:00h | UTC

School Closures During Social Lockdown and Mental Health, Health Behaviors, and Well-being Among Children and Adolescents During the First COVID-19 Wave: A Systematic Review – JAMA Pediatrics

Editorial: Pandemic Recovery for Children—Beyond Reopening Schools – JAMA Pediatrics

Commentary: More Behavioral Issues Reported in Children When School Is Virtual – Psychiatric News Alert

M-A: Child and youth mental health problems have doubled during COVID-19.

Adolescents’ recreational screen time doubled during pandemic, affecting mental health.

More data on the harmful effects of the COVID-19 pandemic on the mental health of adolescents.

COVID has caused ‘mass trauma,’ worsening mental health globally.

COVID’s mental-health toll: how scientists are tracking a surge in depression

CDC Report: Mental health-related emergency department visits among children aged under 18 years raised during the COVID-19 Pandemic

WHO: COVID-19 disrupting mental health services in most countries

Commentary on Twitter (thread – click for more)

https://twitter.com/benryanwriter/status/1483482171000111111

COVID-19 testing infographics.

19 Jan, 2022 | 08:59h | UTC

COVID-19 testing infographics – British Society for Immunology

Commentary on Twitter

It’s important to understand #COVID19 testing so everyone can make informed decisions about their health ℹ🦠

Our infographics & blog have been updated with the latest information & guidance so you can find out what different tests mean for you 👉https://t.co/7a5Ul6tEZn pic.twitter.com/mUzdZc13aa

— British Society for Immunology (@britsocimm) January 17, 2022

Placebo effect accounts for more than two-thirds of COVID-19 vaccine adverse events, researchers find.

19 Jan, 2022 | 08:53h | UTC

News Release: Placebo effect accounts for more than two-thirds of COVID-19 vaccine adverse events, researchers find – Beth Israel Deaconess Medical Center

Original Study: Frequency of Adverse Events in the Placebo Arms of COVID-19 Vaccine Trials: A Systematic Review and Meta-analysis – JAMA Network Open

Commentary: ‘Nocebo effect’: two-thirds of Covid jab reactions not caused by vaccine, study suggests – The Guardian

The pandemic’s true death toll: millions more than official counts.

19 Jan, 2022 | 08:57h | UTC

The pandemic’s true death toll: millions more than official counts – Nature

We can be confident there have been far more than 5 million global Covid deaths – “Estimating ‘excess’ fatalities, a more robust analysis method, puts the pandemic’s grim toll between 10m and 19m people”.

Global Covid-19 deaths surpass five million.

Effects of the Covid-19 pandemic on life expectancy and premature mortality in 2020 – this time series analysis showed there were more than 28 million excess years of life lost in 2020 in 31 countries.

Under-reporting of deaths limits our understanding of true burden of covid-19.

Study shows COVID-19 has caused the biggest decrease in life expectancy since World War II.

Just how do deaths due to COVID-19 stack up?

Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset.

Exploring the gap between excess mortality and COVID-19 deaths in 67 countries.

Report: Three new estimates of India’s all-cause excess mortality during the COVID-19 Pandemic – pandemic death toll estimated to be between 3.4 million and 4.9 million excess deaths.

COVID-19 has caused 6.9 million deaths globally, more than double what official reports show

Commentary on Twitter

The official global death toll for the COVID-19 pandemic has reached 5.5 million, but that figure is a significant underestimate. @Nature reports how researchers are striving to narrow the uncertainties for a global estimate of pandemic deaths. https://t.co/061s4SJrRD

— Nature Portfolio (@NaturePortfolio) January 18, 2022

RCT: In non–critically ill hospitalized patients with COVID-19, the use of a P2Y12 Inhibitor (ticagrelor in 63% of patients and clopidogrel in 37%) in addition to a therapeutic dose of heparin did not improve survival free of organ support compared to therapeutic heparin alone.

19 Jan, 2022 | 08:56h | UTC

Effect of P2Y12 Inhibitors on Survival Free of Organ Support Among Non–Critically Ill Hospitalized Patients With COVID-19: A Randomized Clinical Trial – JAMA

Editorial: Antiplatelet Therapy in Patients With COVID-19—More Is Less? – JAMA

Commentary: Adding a P2Y12 Inhibitor Does Not Improve Outcomes in COVID-19 – HealthDay

Opinion: The COVID-Risk social contract is under negotiation.

19 Jan, 2022 | 08:48h | UTC

The COVID-Risk Social Contract Is Under Negotiation – The Atlantic (a few articles per month are free)

Disruptions in maternal health service use during the COVID-19 pandemic in 2020: experiences from 37 health facilities in low-income and middle-income countries.

19 Jan, 2022 | 08:50h | UTC

Disruptions in maternal health service use during the COVID-19 pandemic in 2020: experiences from 37 health facilities in low-income and middle-income countries – BMJ Global Health

Commentary from one of the authors on Twitter (thread – click for more)

Just out: **Effect of COVID-19 pandemic on maternal health services at 37 facilities in six countries** 1/

Have learned and been inspired by this collaboration including: @PIH @GHResearchCore @HMSghsm @jcmugunga @isabelfulcher @megan_b_murray https://t.co/nKIRhJS2Jm pic.twitter.com/uOkyuNRA1w

— Bethany Hedt-Gauthier, PhD (@BHedtGauthier) January 10, 2022

WHO says there’s no evidence healthy children and adolescents need Covid boosters.

19 Jan, 2022 | 08:46h | UTC

WHO says there’s no evidence healthy children and adolescents need Covid boosters – CNBC

Opinion: The world won’t be able to boost its way out of the coronavirus pandemic.

19 Jan, 2022 | 08:47h | UTC

The world won’t be able to boost its way out of the coronavirus pandemic – Politico

RCT: In critically ill adults, using a balanced multielectrolyte solution did not lower the risk of death or acute kidney injury compared to standard saline.

19 Jan, 2022 | 08:41h | UTC

Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Australian study set to guide the treatment of critically ill patients worldwide – George Institute for Global Health

BaSICS RCT: Among critically ill patients requiring fluid therapy, treatment with a balanced solution did not lead to reduced mortality compared to a 0.9% saline solution.

BaSICS RCT: Among critically ill patients requiring fluid therapy, there was no difference in mortality with slower (333 mL/h) vs. faster (999 mL/h) intravenous fluid bolus rates.

Cochrane Review: Buffered Solutions Do Not Improve Mortality in Critically Ill Adults and Children Compared to 0,9% Saline

Commentary on Twitter

https://twitter.com/NEJM/status/1483540959518281730

NICE Guideline: Rehabilitation after traumatic injury.

19 Jan, 2022 | 08:43h | UTC

Rehabilitation after traumatic injury – National Institute for Health and Care Excellence

Fact check: The theory that SARS-CoV-2 is becoming milder.

19 Jan, 2022 | 08:44h | UTC

Fact check: The theory that SARS-CoV-2 is becoming milder – NPR

ASTRO issues clinical guideline on external-beam radiation therapy for primary liver cancers.

19 Jan, 2022 | 08:36h | UTC

ASTRO Issues Clinical Guideline on External-Beam Radiation Therapy for Primary Liver Cancers – The ASCO Post

Original Article: External Beam Radiation Therapy for Primary Liver Cancers: An ASTRO Clinical Practice Guideline – Practical Radiation Oncology

RCT: Prolonging prophylactic intravenous antibiotic regimens not beneficial after endoprosthetic reconstruction for lower extremity bone tumors.

19 Jan, 2022 | 08:37h | UTC

Comparison of Prophylactic Intravenous Antibiotic Regimens After Endoprosthetic Reconstruction for Lower Extremity Bone Tumors: A Randomized Clinical Trial – JAMA Oncology

Commentary: No Benefit Seen With Longer Antibiotic Course After Surgery for Bone Tumors – Cancer Therapy Advisor

RCT: In children with community-acquired pneumonia, outpatient antibiotic therapy for 5 days resulted in similar clinical response rates compared to a standard 10-day strategy.

19 Jan, 2022 | 08:39h | UTC

Short- vs Standard-Course Outpatient Antibiotic Therapy for Community-Acquired Pneumonia in Children: The SCOUT-CAP Randomized Clinical Trial – JAMA Pediatrics (free for a limited period)

Commentaries:

Trial finds 5 days of antibiotics superior to 10 for kids with pneumonia – CIDRAP

Shorter antibiotics treatment is better for young children with outpatient pneumonia – Vanderbilt University Medical Center

ACP Guidance: Appropriate Use of Short-Course Antibiotics in Common Infections

RCT: 5 days of high-dose amoxicillin therapy noninferior to 10 days for the treatment of pediatric community-acquired pneumonia

RCT: Among children with community-acquired pneumonia discharged within 48 hours from the ED or hospital, lower-dose outpatient oral amoxicillin was noninferior to a higher dose, and a 3-day duration course was noninferior to 7 days.

Treatment of urinary tract infections in infants <2 Months: A Living Systematic Review – short and long duration of parenteral antibiotics were associated with a similar risk of UTI recurrence.

RCT: 7 days of antibiotic therapy as good as 14 days for afebrile men with urinary tract infection.

Randomized Trial: Seven vs. Fourteen Days of Antibiotic Therapy for Uncomplicated Gram-negative Bacteremia

Meta-Analysis: Efficacy of Short-Course Antibiotic Treatments for Community-Acquired Pneumonia

Clinical practice guidelines for therapeutic drug monitoring of teicoplanin.

19 Jan, 2022 | 08:27h | UTC

Clinical practice guidelines for therapeutic drug monitoring of teicoplanin: a consensus review by the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring – Journal of Antimicrobial Chemotherapy

M-A: Beta-blockers and renin–angiotensin system inhibitors may provide a modest benefit for the preservation of left ventricular function in patients with breast cancer treated with anthracyclines or trastuzumab.

19 Jan, 2022 | 08:34h | UTC

A systematic review and meta-analysis of beta-blockers and renin–angiotensin system inhibitors for preventing left ventricular dysfunction due to anthracyclines or trastuzumab in patients with breast cancer – European Journal of Cardiology (link to abstract – $ for full-text)

Commentary: BBs, ACEI/ARBs to Prevent LV Dysfunction Due to Breast Cancer Drugs – American College of Cardiology

Systematic Review: Exercise training for adults undergoing maintenance dialysis.

19 Jan, 2022 | 08:32h | UTC

Exercise training for adults undergoing maintenance dialysis – Cochrane Library

Summary: Exercise training for adults receiving dialysis treatments – Cochrane Library

Commentary on Twitter

New Review Update: Exercise training for adults undergoing maintenance dialysis. discover the latest #CochraneEvidence https://t.co/DmtG0dA6lQ #kidney failure #exercise pic.twitter.com/STYIMpPwAN

— Cochrane Kidney + Tx (@CochraneKidney) January 13, 2022