Daily Archives: January 19, 2022 | LinksMedicus Free Medical News & Perspectives

Systematic Review: School closures during social lockdown and mental health, health behaviors, and well-being among children and adolescents during the first Covid-19 wave.

19 Jan, 2022 | 09:00h | UTC

School Closures During Social Lockdown and Mental Health, Health Behaviors, and Well-being Among Children and Adolescents During the First COVID-19 Wave: A Systematic Review – JAMA Pediatrics

Editorial: Pandemic Recovery for Children—Beyond Reopening Schools – JAMA Pediatrics

Commentary: More Behavioral Issues Reported in Children When School Is Virtual – Psychiatric News Alert

M-A: Child and youth mental health problems have doubled during COVID-19.

Adolescents’ recreational screen time doubled during pandemic, affecting mental health.

More data on the harmful effects of the COVID-19 pandemic on the mental health of adolescents.

COVID has caused ‘mass trauma,’ worsening mental health globally.

COVID’s mental-health toll: how scientists are tracking a surge in depression

CDC Report: Mental health-related emergency department visits among children aged under 18 years raised during the COVID-19 Pandemic

WHO: COVID-19 disrupting mental health services in most countries

Commentary on Twitter (thread – click for more)

A systematic review in @JAMANetwork of 36 studies from 11 nations about school closures during the first Covid wave found that such closures were tied to adverse mental health symptoms (such as distress and anxiety) and health behaviors in kids. 1/3 https://t.co/invmjD73tQ pic.twitter.com/ReqriQl3g4

— Benjamin Ryan (@benryanwriter) January 18, 2022

COVID-19 testing infographics.

19 Jan, 2022 | 08:59h | UTC

COVID-19 testing infographics – British Society for Immunology

Commentary on Twitter

It’s important to understand #COVID19 testing so everyone can make informed decisions about their health ℹ?

Our infographics & blog have been updated with the latest information & guidance so you can find out what different tests mean for you ?https://t.co/7a5Ul6tEZn pic.twitter.com/mUzdZc13aa

— British Society for Immunology (@britsocimm) January 17, 2022

Placebo effect accounts for more than two-thirds of COVID-19 vaccine adverse events, researchers find.

19 Jan, 2022 | 08:53h | UTC

News Release: Placebo effect accounts for more than two-thirds of COVID-19 vaccine adverse events, researchers find – Beth Israel Deaconess Medical Center

Original Study: Frequency of Adverse Events in the Placebo Arms of COVID-19 Vaccine Trials: A Systematic Review and Meta-analysis – JAMA Network Open

Commentary: ‘Nocebo effect’: two-thirds of Covid jab reactions not caused by vaccine, study suggests – The Guardian

The pandemic’s true death toll: millions more than official counts.

19 Jan, 2022 | 08:57h | UTC

The pandemic’s true death toll: millions more than official counts – Nature

We can be confident there have been far more than 5 million global Covid deaths – “Estimating ‘excess’ fatalities, a more robust analysis method, puts the pandemic’s grim toll between 10m and 19m people”.

Global Covid-19 deaths surpass five million.

Effects of the Covid-19 pandemic on life expectancy and premature mortality in 2020 – this time series analysis showed there were more than 28 million excess years of life lost in 2020 in 31 countries.

Under-reporting of deaths limits our understanding of true burden of covid-19.

Study shows COVID-19 has caused the biggest decrease in life expectancy since World War II.

Just how do deaths due to COVID-19 stack up?

Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset.

Exploring the gap between excess mortality and COVID-19 deaths in 67 countries.

Report: Three new estimates of India’s all-cause excess mortality during the COVID-19 Pandemic – pandemic death toll estimated to be between 3.4 million and 4.9 million excess deaths.

COVID-19 has caused 6.9 million deaths globally, more than double what official reports show

Commentary on Twitter

The official global death toll for the COVID-19 pandemic has reached 5.5 million, but that figure is a significant underestimate. @Nature reports how researchers are striving to narrow the uncertainties for a global estimate of pandemic deaths. https://t.co/061s4SJrRD

— Nature Portfolio (@NaturePortfolio) January 18, 2022

RCT: In non–critically ill hospitalized patients with COVID-19, the use of a P2Y12 Inhibitor (ticagrelor in 63% of patients and clopidogrel in 37%) in addition to a therapeutic dose of heparin did not improve survival free of organ support compared to therapeutic heparin alone.

19 Jan, 2022 | 08:56h | UTC

Effect of P2Y12 Inhibitors on Survival Free of Organ Support Among Non–Critically Ill Hospitalized Patients With COVID-19: A Randomized Clinical Trial – JAMA

Editorial: Antiplatelet Therapy in Patients With COVID-19—More Is Less? – JAMA

Commentary: Adding a P2Y12 Inhibitor Does Not Improve Outcomes in COVID-19 – HealthDay

Opinion: The COVID-Risk social contract is under negotiation.

19 Jan, 2022 | 08:48h | UTC

The COVID-Risk Social Contract Is Under Negotiation – The Atlantic (a few articles per month are free)

Disruptions in maternal health service use during the COVID-19 pandemic in 2020: experiences from 37 health facilities in low-income and middle-income countries.

19 Jan, 2022 | 08:50h | UTC

Disruptions in maternal health service use during the COVID-19 pandemic in 2020: experiences from 37 health facilities in low-income and middle-income countries – BMJ Global Health

Commentary from one of the authors on Twitter (thread – click for more)

Just out: **Effect of COVID-19 pandemic on maternal health services at 37 facilities in six countries** 1/

Have learned and been inspired by this collaboration including: @PIH @GHResearchCore @HMSghsm @jcmugunga @isabelfulcher @megan_b_murray https://t.co/nKIRhJS2Jm pic.twitter.com/uOkyuNRA1w

— Bethany Hedt-Gauthier, PhD (@BHedtGauthier) January 10, 2022

WHO says there’s no evidence healthy children and adolescents need Covid boosters.

19 Jan, 2022 | 08:46h | UTC

WHO says there’s no evidence healthy children and adolescents need Covid boosters – CNBC

Opinion: The world won’t be able to boost its way out of the coronavirus pandemic.

19 Jan, 2022 | 08:47h | UTC

The world won’t be able to boost its way out of the coronavirus pandemic – Politico

RCT: In critically ill adults, using a balanced multielectrolyte solution did not lower the risk of death or acute kidney injury compared to standard saline.

19 Jan, 2022 | 08:41h | UTC

Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Australian study set to guide the treatment of critically ill patients worldwide – George Institute for Global Health

BaSICS RCT: Among critically ill patients requiring fluid therapy, treatment with a balanced solution did not lead to reduced mortality compared to a 0.9% saline solution.

BaSICS RCT: Among critically ill patients requiring fluid therapy, there was no difference in mortality with slower (333 mL/h) vs. faster (999 mL/h) intravenous fluid bolus rates.

Cochrane Review: Buffered Solutions Do Not Improve Mortality in Critically Ill Adults and Children Compared to 0,9% Saline

Commentary on Twitter

Trial of critically ill patients compared balanced multielectrolyte solution (BMES) with saline as fluid therapy in the ICU. There was no evidence that the risk of death or acute kidney injury was lower with the use of BMES than with saline. https://t.co/bmlg4BYaw8 pic.twitter.com/OlKGOM0Dmm

— NEJM (@NEJM) January 18, 2022

NICE Guideline: Rehabilitation after traumatic injury.

19 Jan, 2022 | 08:43h | UTC

Rehabilitation after traumatic injury – National Institute for Health and Care Excellence

Fact check: The theory that SARS-CoV-2 is becoming milder.

19 Jan, 2022 | 08:44h | UTC

Fact check: The theory that SARS-CoV-2 is becoming milder – NPR

ASTRO issues clinical guideline on external-beam radiation therapy for primary liver cancers.

19 Jan, 2022 | 08:36h | UTC

ASTRO Issues Clinical Guideline on External-Beam Radiation Therapy for Primary Liver Cancers – The ASCO Post

Original Article: External Beam Radiation Therapy for Primary Liver Cancers: An ASTRO Clinical Practice Guideline – Practical Radiation Oncology

RCT: Prolonging prophylactic intravenous antibiotic regimens not beneficial after endoprosthetic reconstruction for lower extremity bone tumors.

19 Jan, 2022 | 08:37h | UTC

Comparison of Prophylactic Intravenous Antibiotic Regimens After Endoprosthetic Reconstruction for Lower Extremity Bone Tumors: A Randomized Clinical Trial – JAMA Oncology

Commentary: No Benefit Seen With Longer Antibiotic Course After Surgery for Bone Tumors – Cancer Therapy Advisor

RCT: In children with community-acquired pneumonia, outpatient antibiotic therapy for 5 days resulted in similar clinical response rates compared to a standard 10-day strategy.

19 Jan, 2022 | 08:39h | UTC

Short- vs Standard-Course Outpatient Antibiotic Therapy for Community-Acquired Pneumonia in Children: The SCOUT-CAP Randomized Clinical Trial – JAMA Pediatrics (free for a limited period)

Commentaries:

Trial finds 5 days of antibiotics superior to 10 for kids with pneumonia – CIDRAP

Shorter antibiotics treatment is better for young children with outpatient pneumonia – Vanderbilt University Medical Center

ACP Guidance: Appropriate Use of Short-Course Antibiotics in Common Infections

RCT: 5 days of high-dose amoxicillin therapy noninferior to 10 days for the treatment of pediatric community-acquired pneumonia

RCT: Among children with community-acquired pneumonia discharged within 48 hours from the ED or hospital, lower-dose outpatient oral amoxicillin was noninferior to a higher dose, and a 3-day duration course was noninferior to 7 days.

Treatment of urinary tract infections in infants <2 Months: A Living Systematic Review – short and long duration of parenteral antibiotics were associated with a similar risk of UTI recurrence.

RCT: 7 days of antibiotic therapy as good as 14 days for afebrile men with urinary tract infection.

Randomized Trial: Seven vs. Fourteen Days of Antibiotic Therapy for Uncomplicated Gram-negative Bacteremia

Meta-Analysis: Efficacy of Short-Course Antibiotic Treatments for Community-Acquired Pneumonia

Clinical practice guidelines for therapeutic drug monitoring of teicoplanin.

19 Jan, 2022 | 08:27h | UTC

Clinical practice guidelines for therapeutic drug monitoring of teicoplanin: a consensus review by the Japanese Society of Chemotherapy and the Japanese Society of Therapeutic Drug Monitoring – Journal of Antimicrobial Chemotherapy

M-A: Beta-blockers and renin–angiotensin system inhibitors may provide a modest benefit for the preservation of left ventricular function in patients with breast cancer treated with anthracyclines or trastuzumab.

19 Jan, 2022 | 08:34h | UTC

A systematic review and meta-analysis of beta-blockers and renin–angiotensin system inhibitors for preventing left ventricular dysfunction due to anthracyclines or trastuzumab in patients with breast cancer – European Journal of Cardiology (link to abstract – $ for full-text)

Commentary: BBs, ACEI/ARBs to Prevent LV Dysfunction Due to Breast Cancer Drugs – American College of Cardiology

Systematic Review: Exercise training for adults undergoing maintenance dialysis.

19 Jan, 2022 | 08:32h | UTC

Exercise training for adults undergoing maintenance dialysis – Cochrane Library

Summary: Exercise training for adults receiving dialysis treatments – Cochrane Library

Commentary on Twitter

New Review Update: Exercise training for adults undergoing maintenance dialysis. discover the latest #CochraneEvidence https://t.co/DmtG0dA6lQ #kidney failure #exercise pic.twitter.com/STYIMpPwAN

— Cochrane Kidney + Tx (@CochraneKidney) January 13, 2022