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Daily Archives: November 28, 2021

WHO Update on Omicron + Several Articles on the Subject.

28 Nov, 2021 | 21:38h | UTC

Update on Omicron – World Health Organization

Classification of Omicron (B.1.1.529): SARS-CoV-2 Variant of Concern – World Health Organization

See also:

Omicron COVID-19 variant: Africa CDC statement

Expert reaction to B.1.1.529 variant situation in South Africa; and UK travel restrictions in response – Science Media Centre

Threat Assessment Brief: Implications of the emergence and spread of the SARS-CoV-2 B.1.1. 529 variant of concern (Omicron) for the EU/EEA – European Centre for Disease Prevention and Control

‘Patience is crucial’: Why we won’t know for weeks how dangerous Omicron is – Science

Scientists rapidly identified the Omicron variant. But firm answers about its impact could take weeks – STAT

New Covid variant: Will new measures against Omicron work? – BBC

Vaccine inequity and hesitancy made the Omicron variant more likely, scientists say – CNN

Travel bans aren’t the answer to stopping new COVID variant Omicron – The Conversation

Scientists sharing Omicron data were heroic. Let’s ensure they don’t regret it – The Guardian

The Omicron variant reveals the true global danger of ‘vaccine apartheid’ – The Guardian

We Know Almost Nothing About the Omicron Variant – The Atlantic

Covid: New Omicron variant not a disaster, says Sage scientist – BBC

New Covid variant: Will new measures against Omicron work? – BBC

World is put on high alert over the Omicron coronavirus variant – CNN

Moderna Announces Strategy to Address Omicron (B.1.1.529) SARS-CoV-2 Variant – Moderna

Omicron is the new COVID kid on the block: five steps to avoid, ten to take immediately – The Conversation

What’s known and unknown about Omicron, the coronavirus variant identified in South Africa – STAT

The new variant is worrying – but it doesn’t change how we tackle Covid – The Guardian

Omicron: everything you need to know about new Covid variant – The Guardian

Omicron variant unlikely to reboot Covid in UK, expert says – The Guardian

UK detects Omicron cases, as more countries eye new COVID-19 variant – CIDRAP

New COVID variant alarms researchers, triggers travel bans – CIDRAP

The omicron variant spreads across Europe as new travel bans take effect – NPR

What to know about omicron, the new COVID variant – NPR

What we know about the Omicron variant – CNN

The new Omicron variant is a pandemic gut check – CNN

Newly discovered Covid-19 variant B.1.1.529 is ‘red flag’ but US needs to learn more, Fauci says – CNN

Omicron, a new Covid-19 variant with high number of mutations, sparks travel bans and worries scientists – CNN

What to know about the omicron variant of the coronavirus – The Washington Post

 

Commentary on Twitter (thread – click for more)

 


Omicron Variant: Videos with opinions on the subject.

28 Nov, 2021 | 21:33h | UTC

 


Milestone Moment for Pandemic Treaty in Geneva – Calls for Tough Decisions by Countries.

28 Nov, 2021 | 21:28h | UTC

Milestone Moment for Pandemic Treaty in Geneva – Calls for Tough Decisions by Countries – Health Policy Watch

See also:

Countries prepare for pandemic treaty decision – The Lancet

WHO nears consensus on future international pact to prevent pandemics – diplomats – Reuters

The WHO is seeking a new treaty on handling future pandemics. It could be a hard sell – NPR

 

Commentary on Twitter

 


Too early to tell, but preliminary information from doctors in South Africa suggests the new Covid variant Omicron may be associated with less severe disease.

28 Nov, 2021 | 21:35h | UTC

 


[Press release – not published yet] Merck’s new Covid-19 pill Molnupiravir updated data shows reduced efficacy (30%) for preventing hospitalization and death compared to initial results (50%). Absolute risk reduction of hospitalization and death fell from 7% to 3%.

28 Nov, 2021 | 21:30h | UTC

News Release: Merck and Ridgeback Biotherapeutics Provide Update on Results from MOVe-OUT Study of Molnupiravir, an Investigational Oral Antiviral Medicine, in At Risk Adults With Mild-to-Moderate COVID-19

Commentary: New data, analyses take some of the shine off Merck’s Covid pill – STAT

Related:

8 lingering questions about the new Covid pills from Merck and Pfizer.

COVID antiviral pills: what scientists still want to know – “Drugs like Molnupiravir and Paxlovid could change the course of the pandemic if clinical trial results hold up in the real world”.

[Press release – not published yet] RCT: Pfizer’s novel Covid-19 oral antiviral treatment candidate reduced risk of hospitalization or death by 89% in interim analysis of phase 2/3 EPIC-HR study.

A prominent virologist warns new COVID-19 pill could unleash dangerous mutants. Others see little cause for alarm.

The U.K. approves Merck’s COVID-19 antiviral pill, calling it a world first.

Merck to allow other nations to produce new COVID-19 antiviral.

Video: Merck’s Covid pill could transform treatment. Here’s how it works.

How antiviral pill Molnupiravir shot ahead in the COVID drug hunt.

What we know — and don’t know — about Merck’s new Covid-19 pill.

[Press release – not published yet] Merck announces oral antiviral Molnupiravir reduced the risk of hospitalization or death by approximately 50 Percent compared to placebo for patients with mild or moderate COVID-19.

Merck’s Covid-19 pill is great news but may not be a game-changer.

Video | A Pill For COVID? A Doctor Explains Molnupiravir.

 

Commentaries on Twitter

 


Screening for Lung Cancer: CHEST Guideline and Expert Panel Report.

28 Nov, 2021 | 21:22h | UTC

Executive Summary: Screening for Lung Cancer: Chest Guideline and Expert Panel Report

Full Guideline: Screening for Lung Cancer: CHEST Guideline and Expert Panel Report

News Release: CHEST releases expert guidelines for lung cancer screening – Elsevier

Related:

USPSTF Statement: begin screening for lung cancer at age 50 years instead of 55 years for patients at risk

Meta-analysis: Lung cancer screening using low-dose computed tomography reduces lung cancer–specific mortality, albeit with a tradeoff of likely overdiagnosis

 

Commentary on Twitter

 


European countries mandate medical-grade masks over homemade cloth face coverings.

28 Nov, 2021 | 21:26h | UTC

European countries mandate medical-grade masks over homemade cloth face coverings – CNN

 


Randomized Trial: Conventional in vitro fertilization resulted in a cumulative live-birth rate that was noninferior to live-birth rates with the addition of preimplantation genetic testing for aneuploidy.

28 Nov, 2021 | 21:14h | UTC

Live Birth with or without Preimplantation Genetic Testing for Aneuploidy – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: New research casts fresh doubt on a common procedure that promises to increase the odds of IVF – STAT

 


ATS Guideline: Use of fractional exhaled nitric oxide to guide the treatment of asthma.

28 Nov, 2021 | 21:20h | UTC

Use of Fractional Exhaled Nitric Oxide to Guide the Treatment of Asthma: An Official American Thoracic Society Clinical Practice Guideline – American Journal of Respiratory and Critical Care Medicine

News Release: New Clinical Practice Guideline on Fractional Exhaled Nitric Oxide (FeNO) to Help Guide Asthma Treatment – American Thoracic Society

 


International Consensus Statement on the diagnosis, multidisciplinary management, and lifelong care of individuals with achondroplasia.

28 Nov, 2021 | 21:16h | UTC

International Consensus Statement on the diagnosis, multidisciplinary management and lifelong care of individuals with achondroplasia – Nature Reviews Endocrinology (if the link is paywalled, try this one)

 

Commentary on Twitter

 


ESSM Position Statement on Surgical Treatment of Peyronie’s Disease.

28 Nov, 2021 | 21:19h | UTC

ESSM Position Statement on Surgical Treatment of Peyronie’s Disease – Sexual Medicine

 

Commentary on Twitter

 


M-A: Association of Glucagon-like Peptide 1 Analogs and agonists administered for obesity with weight loss and adverse events.

28 Nov, 2021 | 21:09h | UTC

Association of Glucagon-like Peptide 1 Analogs and Agonists Administered for Obesity with Weight Loss and Adverse Events: A Systematic Review and Network Meta-analysis – EClinicalMedicine

 


M-A: Psychiatric disorders in individuals born very preterm / very low-birth weight.

28 Nov, 2021 | 21:11h | UTC

Psychiatric disorders in individuals born very preterm / very low-birth weight: An individual participant data (IPD) meta-analysis – EClinicalMedicine

 


Brief review: The clinician’s guide to p values, confidence intervals, and magnitude of effects.

28 Nov, 2021 | 21:06h | UTC

The clinician’s guide to p values, confidence intervals, and magnitude of effects – Eye (if the link is paywalled, try this one)

Related:

Bayesian interpretation of p values in clinical trials.

Scientists Rise Up Against Statistical Significance

.050 shades of grey in p-value cutoffs

Statistical tests, P values, confidence intervals, and power: a guide to misinterpretations – European Journal of Epidemiology

What a nerdy debate about p-values shows about science — and how to fix it – VOX

Big names in statistics want to shake up much-maligned P value – Nature News

‘One-size-fits-all’ threshold for P values under fire – Nature News

Statisticians issue warning over misuse of P values – Nature News

Understanding common misconceptions about p-values – The 20% Statistician

 


Fatigue as the chief complaint: epidemiology, causes, diagnosis, and treatment.

28 Nov, 2021 | 21:05h | UTC

Fatigue as the Chief Complaint: Epidemiology, Causes, Diagnosis, and Treatment – Deutsches Ärzteblatt International

Related: NICE Guideline | Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and management.

 


Review: Studies for the evaluation of diagnostic tests.

28 Nov, 2021 | 20:59h | UTC

Studies for the Evaluation of Diagnostic Tests – Deutsches Ärzteblatt International

 


Extravasation injuries of the limbs in neonates and children: development of a treatment algorithm.

28 Nov, 2021 | 21:03h | UTC

Extravasation Injuries of the Limbs in Neonates and Children: Development of a Treatment Algorithm – Deutsches Ärzteblatt International

 


The musculoskeletal manifestations of Marfan Syndrome: diagnosis, impact, and management.

28 Nov, 2021 | 20:58h | UTC

The Musculoskeletal Manifestations of Marfan Syndrome: Diagnosis, Impact, and Management – Current Rheumatology Reports

 


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