Daily Archives: November 23, 2021
[Preprint] Systematic Review: Duration of Effectiveness of Vaccines Against SARS-CoV-2 Infection and COVID-19 Disease – “effectiveness against COVID-19 severe disease remained high (>70%) in most studies in the six months after full vaccination, although it did decrease some (on average, 8-10 percentage points) between one and six months after full vaccination”.
23 Nov, 2021 | 08:57h | UTCRelated:
Correlation of SARS-CoV-2-breakthrough infections to time-from-vaccine.
China’s COVID vaccines have been crucial — now immunity is waning.
Editorial | Covid-19 vaccination: evidence of waning immunity is overstated.
COVID vaccine effects wane over time but still prevent death and severe illness.
Perspective | What we actually know about waning immunity.
Another study shows Pfizer mRNA vaccine immunity is reduced over time.
Studies: COVID vaccine protection waning against infection but not hospitalization.
Populational study in France did not show an increased incidence of acute myocardial infarction, stroke, and pulmonary embolism following the Pfizer vaccine.
23 Nov, 2021 | 08:51h | UTC
Scientists mystified, wary, as Africa avoids COVID disaster.
23 Nov, 2021 | 08:47h | UTCScientists mystified, wary, as Africa avoids COVID disaster – Associated Press
M-A: Colchicine doesn’t lessen COVID-19 severity or stave off risk of death.
23 Nov, 2021 | 08:55h | UTCNews release: Gout drug colchicine doesn’t lessen COVID-19 severity or stave off risk of death – BMJ
Original Study: Efficacy and safety of colchicine in COVID-19: a meta-analysis of randomised controlled trials – RMD Open
Related:
The COVID-19 Patient in the Surgical Intensive Care Unit.
23 Nov, 2021 | 08:46h | UTCThe COVID-19 Patient in the Surgical Intensive Care Unit – Surgical Clinics of North America
ACG Clinical Guideline for the Diagnosis and Management of Gastroesophageal Reflux Disease.
23 Nov, 2021 | 08:40h | UTC
Commentary on Twitter (thread – click for more)
⭐️NEW @AmCollegeGastro guidelines on #GERD!⭐️
🔥 🤭 🌶 💊 ✂️
"A lot has changed, much remains the same." 🧵 ⬇️#MedTwitter #GITwitter #GI #motility #MedEd https://t.co/HS26GDk8Jd
— John Damianos, M.D. (@john_damianosMD) November 22, 2021
GRADE Guidance 24. Optimizing the integration of randomized and non-randomized studies of interventions in evidence syntheses and health guidelines.
23 Nov, 2021 | 08:38h | UTC
Commentary on Twitter
🆕#gradeguidance how & when to appropriately integrate non-randomized |observational studies in your #evidencesynthesis of intervention effects & some of the implications for @GRADE_WG approach @CharlieNeck @schunemann_mac @RMorganPhD @Elie__Akl +@JClinEpi https://t.co/2pAdQShX9q
— GRADE Working Group (@GRADE_WG) November 19, 2021
In a survey of about 27,600 U.S. individuals, 18.5% of adults with hypertension used medications that may raise blood pressure; the most commonly reported classes were antidepressants, nonsteroidal anti-inflammatory drugs, steroids, and estrogens.
23 Nov, 2021 | 08:33h | UTCPrevalence of Medications That May Raise Blood Pressure Among Adults With Hypertension in the United States – JAMA Internal Medicine (free for a limited period)
Commentary from the author on Twitter (thread – click for more)
🚨New work from our team in @JAMAInternalMed 🚨
18% of adults with #hypertension report using medications (💊) that may raise blood pressure.
Use of these 💊 associated with:
⬇️ odds of achieving BP control
⬆️ # of antihypertensives usedhttps://t.co/DlV5rlHLu3Thread
/1 pic.twitter.com/q7b7FQ4jHH— Tim Anderson (@TimAndersonMD) November 22, 2021
RCT: Educating outpatients for bowel preparation before colonoscopy using virtual reality videos improved bowel preparation, polyp and adenoma detection rates, and improved compliance and satisfaction.
23 Nov, 2021 | 08:28h | UTC
Commentary on Twitter
RCT finds patients who received virtual reality video education before a colonoscopy had better bowel preparation, higher polyp and adenoma detection rates, and improved compliance and satisfaction. https://t.co/dAUtFf2m4B pic.twitter.com/RKAVZcVGuy
— JAMA Network Open (@JAMANetworkOpen) November 22, 2021
M-A: Antiemetics for adults for prevention of nausea and vomiting caused by moderately or highly emetogenic chemotherapy.
23 Nov, 2021 | 08:21h | UTC
IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections.
23 Nov, 2021 | 08:45h | UTC
Commentary on Twitter
IDSA has released NEW guidance on treating infections caused by three of the most common drug-resistant pathogens:
• AmpC-E
• CRAB
• S. maltophiliaGuidelines: https://t.co/gjxEZcxtmy
Press release: https://t.co/ulorKCmvQ4#IDSAGuidelines #WAAW21 pic.twitter.com/Wy7uBaq2DN— IDSA (@IDSAInfo) November 22, 2021
Antibiotic Awareness: a round-up of Cochrane evidence.
23 Nov, 2021 | 08:23h | UTCAntibiotic Awareness: a round-up of Cochrane evidence – Cochrane Library
Commentary on Twitter
@CochraneUK – excellent resources and collection of antibiotic evidence review. #tldr
Azithro doesn’t work for COVID; procalcitonin reduces antibiotic use effectively; short course durations have similar outcomes to long; & so much more— Susan Hopkins (@SMHopkins) November 21, 2021
M-A: Current evidence does not support intensive blood pressure reduction as a preventive strategy for cognitive decline and dementia.
23 Nov, 2021 | 08:26h | UTC
Commentary on Twitter
Meta-analysis found no associated reduction in the risk of cognitive decline with intensive as compared to standard blood pressure (BP) interventions. There is insufficient evidence to support intensive BP management to prevent cognitive impairment. https://t.co/2BEV1ywrCO
— JAMA Network Open (@JAMANetworkOpen) November 22, 2021
Review: Prevention of emerging infections in children.
23 Nov, 2021 | 08:17h | UTCPrevention of Emerging Infections in Children – Pediatric Clinics of North America
Bowel Perforation: ED presentations, evaluation, and management.
23 Nov, 2021 | 08:19h | UTCBowel Perforation: ED presentations, evaluation, and management – emDocs
Recent updates in antimicrobial stewardship in outpatient parenteral antimicrobial therapy.
23 Nov, 2021 | 08:15h | UTC