Daily Archives: November 19, 2021
Revisiting COVID-19 policies: 10 evidence-based recommendations for where to go from here.
19 Nov, 2021 | 10:59h | UTC
RECOVERY Trial: Aspirin as an add-on therapy did not reduce mortality in patients hospitalized with COVID-19.
19 Nov, 2021 | 11:01h | UTCInvited Commentary: Studying the coagulopathy of COVID-19 – The Lancet
Commentary from the author on Twitter (thread – click for more)
RECOVERY Publication: ASPIRIN
(a widely used anti-platelet treatment in other settings)14 892 patients hospitalised with COVID-19.
No impact on mortality.
Small improvement in hospital stay.
No impact on need for mechanical ventilation
6 more bleeds. 6 fewer thromboses (clots) pic.twitter.com/LxDzudss9F— Martin Landray (@MartinLandray) November 18, 2021
Global tuberculosis progress reversed by COVID-19 pandemic.
19 Nov, 2021 | 10:51h | UTCGlobal tuberculosis progress reversed by COVID-19 pandemic – The Lancet Respiratory Diseases
Related:
How COVID is derailing the fight against HIV, TB and malaria.
How COVID hurt the fight against other dangerous diseases
World TB Day | Report: COVID-19 Eliminates Twelve Years of Progress Against Tuberculosis
Tuberculosis and Covid-19: Fighting a deadly syndemic
Commentary on Twitter
NEWS—Global #tuberculosis progress reversed by #COVID19 pandemic
"Due to the delayed effects from #COVID19, #tuberculosis deaths are projected to rise again in 2022 while the world readjusts to a new normality and services resume."
Read more here: https://t.co/tWVXswZsvs
— The Lancet Respiratory Medicine (@LancetRespirMed) November 3, 2021
Editorial: COVID-19 vaccines for children – “Although it is true that most children experience asymptomatic or mild disease, some will get quite sick, and a small number will die. It’s why children are vaccinated against influenza, meningitis, chickenpox, and hepatitis”.
19 Nov, 2021 | 10:57h | UTCCOVID-19 vaccines for children – Science
Related: Review: Should children under 12 years of age be vaccinated against COVID-19?
Commentary on Twitter
"Although it is true that most children experience asymptomatic or mild COVID disease, some will get quite sick, and a small number will die.
It’s why children are vaccinated against influenza, meningitis, chickenpox, and hepatitis" @DrPaulOffit et al.https://t.co/mvXHXdiYha
— Madhu Pai, MD, PhD (@paimadhu) November 18, 2021
Correlation of SARS-CoV-2-breakthrough infections to time-from-vaccine.
19 Nov, 2021 | 10:47h | UTCCorrelation of SARS-CoV-2-breakthrough infections to time-from-vaccine – Nature Communications
Commentary: Long-term effectiveness of Pfizer/BioNTech two-dose regimen mRNA vaccine – News Medical
China’s COVID vaccines have been crucial — now immunity is waning.
Editorial | Covid-19 vaccination: evidence of waning immunity is overstated.
COVID vaccine effects wane over time but still prevent death and severe illness.
Perspective | What we actually know about waning immunity.
Another study shows Pfizer mRNA vaccine immunity is reduced over time.
Studies: COVID vaccine protection waning against infection but not hospitalization.
Commentary on Twitter
A paper in @NatureComms presents preliminary evidence of Pfizer-BioNTech COVID-19 vaccine waning, with a higher incidence of breakthrough infection in people who received their second dose early in 2021 compared to later in the year. https://t.co/QJ7sPZIDuC pic.twitter.com/Gwkj0ugz57
— Nature Portfolio (@NaturePortfolio) November 18, 2021
Opinion: With 128 Covid vaccines in clinical development, we don’t know if the approved/authorized ones are the best ones.
19 Nov, 2021 | 10:45h | UTC
Review: Counting the neurological cost of COVID-19.
19 Nov, 2021 | 10:52h | UTCCounting the neurological cost of COVID-19 – Nature Reviews Neurology
Commentary on Twitter
In our latest News & Views, Abdul Mannan Baig discusses how the neurological manifestations of COVID-19 are expected to increase the burden of morbidity and mortality. #NewfromNRNeurology https://t.co/DNc6B1OBpM
— Nat Rev Neurology (@NatRevNeurol) November 18, 2021
Global, regional, and national causes of under-5 mortality in 2000–19: an updated systematic analysis with implications for the Sustainable Development Goals.
19 Nov, 2021 | 10:40h | UTC
Commentary on Twitter
Progress is still needed to improve child health and end preventable deaths among children <5 years
New cause-specific estimates of infant mortality for 2000-19 are explored in this Article by Jamie Perin and colleagues @JohnsHopkinsSPH, @LSHTM & @WHO https://t.co/QJEDAd5jYT pic.twitter.com/Wis0v8YSav
— The Lancet Child & Adolescent Health (@LancetChildAdol) November 18, 2021
Pneumonia remains #1 postneonatal killer for children <5. Most deaths occur in children who live in poverty or humanitarian settings, have poor access to quality care, are malnourished & unimmunised. Many health centres don’t have antibiotics or O2. It’s 2021 not the Middle Ages. https://t.co/P7EhDN9KJ2
— Fiona Russell (@Fiona_M_Russell) November 18, 2021
Perspective | The Future of SARS-CoV-2 Vaccination — Lessons from Influenza.
19 Nov, 2021 | 10:49h | UTCThe Future of SARS-CoV-2 Vaccination — Lessons from Influenza – New England Journal of Medicine
Consensus and expert recommendations: basic ultrasound head-to-toe skills for intensivists in the general and neuro intensive care unit population.
19 Nov, 2021 | 10:37h | UTC
Commentary on Twitter
Basic #ultrasound skills in #ICU & NCCU, @ESICM consensus & expert recommendations:
➡️brain
➡️lung
➡️heart
➡️abdomen
➡️vascular#FOAMcc #FOAMus #echofirst #POCUS
?️https://t.co/T1IuLlsomS
DO NOT miss supplementary files including additional figures & links to video description! pic.twitter.com/kbuIvuHvGI— Intens Care Med (@yourICM) November 17, 2021
WHO global report on trends in prevalence of tobacco use 2000-2025.
19 Nov, 2021 | 10:43h | UTCNews Release: Tobacco use falling: WHO urges countries to invest in helping more people to quit tobacco – World Health Organization
Commentary on Twitter
Tobacco use is falling by 5⃣ million people per year
? WHO global tobacco trends report released today, shows that there are 1.3 billion tobacco users ? compared to 1.32 billion in 2015, & expected to ↘️ to 1.27 billion by 2025.
? https://t.co/o3bdYaQy84#CommitToQuit ? pic.twitter.com/gSJebhRtYY
— World Health Organization (WHO) (@WHO) November 16, 2021
Recommendations for women with gynecological cancer who received non-standard care during the COVID-19 pandemic.
19 Nov, 2021 | 10:33h | UTC
AAP Clinical Report: Biologics for Asthma and Allergic Skin Diseases in Children.
19 Nov, 2021 | 10:34h | UTCBiologics for Asthma and Allergic Skin Diseases in Children – Pediatrics
AAP Clinical Report: Promoting Human Milk and Breastfeeding for the Very Low Birth Weight Infant.
19 Nov, 2021 | 10:35h | UTCPromoting Human Milk and Breastfeeding for the Very Low Birth Weight Infant – Pediatrics
What is the functional/organic distinction actually doing in psychiatry and neurology?
19 Nov, 2021 | 10:29h | UTC
Commentary on Twitter
Beautiful paper puts nails in coffin of outdated/inaccurate distinction "Functional" Vs "Organic".
Confusion causes great harms:
I've seen many 100s patients mislabeled primary psych disorder whose symptoms were really caused by medical illness/med side effect/drugs.Must read: https://t.co/Fl492ADrjE
— Allen Frances (@AllenFrancesMD) November 12, 2021
M-A: Intravenous iron is associated with increased risk of infection when compared with oral iron or no iron, which must be balanced with the potential benefits of reducing blood transfusion requirements.
19 Nov, 2021 | 10:31h | UTCInvited Commentary: Intravenous Iron and Infection Risk—Still an Unanswered Question – JAMA Network Open
Commentary on Twitter
In this systematic review and meta-analysis, administration of intravenous iron was associated with an increased risk of infection. This risk must be balanced with the potential benefits of treating anemia and reducing blood transfusion requirements. https://t.co/XkNJKCk7M7
— JAMA Network Open (@JAMANetworkOpen) November 12, 2021
RCT: In patients with heart failure and preserved ejection fraction, Sacubitril/Valsartan reduced NT-proBNP, but did not improve exercise capacity and was associated with increased risk of hypotension (14.1% vs 5.5%).
19 Nov, 2021 | 10:27h | UTCEffect of Sacubitril/Valsartan vs Standard Medical Therapies on Plasma NT-proBNP Concentration and Submaximal Exercise Capacity in Patients With Heart Failure and Preserved Ejection Fraction: The PARALLAX Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Quality of Life and Exercise Ability in Heart Failure With Preserved Ejection Fraction: No Time for Therapeutic Complacency – JAMA (free for a limited period)
Commentary on Twitter
Study found treatment w sacubitril/valsartan vs standard treatment w enalapril, valsartan, or placebo resulted in a statistically significant reduction in plasma NT-proBNP levels at 12 wk but no significant change in the 6-minute walking distance at 24 wk https://t.co/rwlOXWwcz2 pic.twitter.com/fRUPgQpU9J
— JAMA (@JAMA_current) November 16, 2021
Pro-Con Debate: Should all babies have their genome sequenced at birth?
19 Nov, 2021 | 10:19h | UTCShould all babies have their genome sequenced at birth? – The BMJ
Related:
Review: Genome sequencing as a diagnostic test.
RCT: In patients with multivessel coronary artery disease, a Fractional Flow Reserve (FFR) guided revascularization strategy did not reduce the risk of ischemic cardiovascular events or death at 1-year follow-up compared to a traditional strategy without FFR.
19 Nov, 2021 | 10:26h | UTCFractional Flow Reserve to Guide Treatment of Patients With Multivessel Coronary Artery Disease – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Related:
Randomized Trial: Five-Year Outcomes with PCI Guided by FFR
Novel gene therapy for hemophilia A leads to sustained expression of clotting factor and reduced bleeding events.
19 Nov, 2021 | 10:25h | UTCOriginal Study: Multiyear Factor VIII Expression after AAV Gene Transfer for Hemophilia A – New England Journal of Medicine
Commentary on Twitter
3.5 years after therapy with factor VIII-containing adeno-associated virus, 16 of 18 men with hemophilia A had enough factor VIII expression that bleeding events were reduced to nearly zero and prophylaxis was discontinued. https://t.co/n3cPyjGDkn pic.twitter.com/vPyz0OmT1S
— NEJM (@NEJM) November 18, 2021
Long-term results of RCT: Chemoradiotherapy plus induction or consolidation chemotherapy as total neoadjuvant therapy for patients with locally advanced rectal cancer.
19 Nov, 2021 | 10:15h | UTCChemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Patients With Locally Advanced Rectal Cancer: Long-term Results of the CAO/ARO/AIO-12 Randomized Clinical Trial – JAMA Oncology (free for a limited period)
Author Interview: Chemoradiotherapy Plus Induction or Consolidation Chemotherapy for Locally Advanced Rectal Cancer – JAMA Oncology
Commentary on Twitter
Secondary analysis of 311 pts on ARO-12 trial of variant approaches to total neoadjuvant therapy (TNT) w/combo of chemo & concurrent chemoradiation (CRT) for rectal cancer shows best results w/up-front CRT then chemo & resection led to best results https://t.co/7cpv5cb1Fr #CRCSM pic.twitter.com/bxfz9Fi5OB
— JAMA Oncology (@JAMAOnc) November 18, 2021
Review: Treatment selection in first-line metastatic renal cell carcinoma—the contemporary treatment paradigm in the age of combination therapy.
19 Nov, 2021 | 10:14h | UTCTreatment Selection in First-line Metastatic Renal Cell Carcinoma—The Contemporary Treatment Paradigm in the Age of Combination Therapy: A Review – JAMA Oncology (free for a limited period)