Daily Archives: November 10, 2021
RCT: Pfizer vaccine shows 90.7% efficacy for preventing Covid-19 in children 5 to 11 years of age.
10 Nov, 2021 | 07:24h | UTC
Commentary on Twitter
In this multi-phase trial, two 10-μg doses of the BNT162b2 vaccine administered 21 days apart were safe, immunogenic, and 90.7% effective against #COVID19 in 5-to-11-year-old children. #Covid19vaccine https://t.co/kuj2eI4YCE pic.twitter.com/BWEkYxn8a0
— NEJM (@NEJM) November 9, 2021
How an outbreak became a pandemic: a chronological analysis of crucial junctures and international obligations in the early months of the COVID-19 pandemic.
10 Nov, 2021 | 07:22h | UTC
Commentary on Twitter
NEW—How an outbreak became a pandemic: an analysis of the early months of #COVID19 by @TheIndPanel.
Authors point to reform & offer a framework for robust future #pandemic preparedness & response. https://t.co/MlW6zXj2Dn @sudhvir pic.twitter.com/rgHu1QggNQ
— The Lancet (@TheLancet) November 9, 2021
[Preprint] RCT: In hypoxic but not critically ill patients with COVID-19, an intervention to increase prone positioning did not improve outcomes.
10 Nov, 2021 | 07:20h | UTCRCT: Prone positioning of patients with moderate hypoxia due to COVID-19 – medRxiv
Related:
RCT: Awake prone positioning reduces the need for intubation in patients with COVID-19.
Commentary from the author on Twitter (thread – click for more)
The results from the COVID-PRONE pragmatic RCT are available @medRxiv! This was a massive team effort with my co-PIs @AmolAVerma, @drfahadrazak. Our goal was to evaluate the effectiveness of prone positioning for pts hospitalized with COVID19. https://t.co/6SpjdPvT2U 🧵 1/5 pic.twitter.com/WH10ciBn4w
— Michael Fralick (@FralickMike) November 8, 2021
French health authority advises against Moderna Covid-19 vaccine for under 30s.
10 Nov, 2021 | 07:18h | UTCFrench Health Authority Advises Against Moderna COVID-19 Vaccine for Under 30s – Reuters
See also: France advises against Moderna for under-30s over rare heart risk – Associated Press
Related: Sweden, Denmark pause Moderna COVID-19 vaccine for younger age groups.
Commentary on Twitter
France's public health authority has recommended people under 30 be given Pfizer's Comirnaty COVID-19 vaccine when available instead of Moderna Inc's Spikevax jab, which carried comparatively higher risks of heart-related problems. https://t.co/4gPTXzEsw0
— Reuters Health (@Reuters_Health) November 9, 2021
A prominent virologist warns new COVID-19 pill could unleash dangerous mutants. Others see little cause for alarm.
10 Nov, 2021 | 07:13h | UTCOriginal viewpoint: Supercharging New Viral Variants: The Dangers Of Molnupiravir (Part 1) – Forbes
Related:
The U.K. approves Merck’s COVID-19 antiviral pill, calling it a world first.
Merck to allow other nations to produce new COVID-19 antiviral.
Video: Merck’s Covid pill could transform treatment. Here’s how it works.
How antiviral pill Molnupiravir shot ahead in the COVID drug hunt.
What we know — and don’t know — about Merck’s new Covid-19 pill.
Merck’s Covid-19 pill is great news but may not be a game-changer.
Video | A Pill For COVID? A Doctor Explains Molnupiravir.
Opinion | Protective immunity after recovery from SARS-CoV-2 infection.
10 Nov, 2021 | 07:15h | UTCProtective immunity after recovery from SARS-CoV-2 infection – The Lancet Infectious Diseases
Commentary on Twitter
"Policy makers should consider recovery from previous SARS-CoV-2 infection equal to immunity from vaccination for purposes related to entry to public events, businesses, and the workplace,or travel requirements"
Do you agree with this?
I don't #IDtwitter https://t.co/FHbgXILD8Z— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) November 9, 2021
Guideline: Nonpharmacological treatment of persistent postconcussion symptoms in adults.
10 Nov, 2021 | 07:07h | UTCInvited commentary: Advances in Clinical Management of Persistent Postconcussion Symptoms—The Danish National Clinical Guideline – JAMA Network Open
Commentary on Twitter
Based on low certainty of evidence or based on consensus, new guideline provides recommendations for commonly applied non-pharmacological interventions to treat persistent post-concussion symptoms in adults. https://t.co/CM1pbMqRXN
— JAMA Network Open (@JAMANetworkOpen) November 9, 2021
Consensus Document: Non-invasive imaging in coronary syndromes.
10 Nov, 2021 | 07:11h | UTC
Consensus Document: Multimodality imaging in patients with heart failure and preserved ejection fraction.
10 Nov, 2021 | 07:09h | UTC
RCT: One-time flexible sigmoidoscopy screening is associated with long-term reduction in colorectal cancer incidence and mortality.
10 Nov, 2021 | 07:04h | UTCCommentaries:
Review: Cardiogenic shock after acute myocardial infarction.
10 Nov, 2021 | 07:03h | UTCCardiogenic Shock After Acute Myocardial Infarction: A Review – JAMA (free for a limited period)
Perspective: Life lessons after a career in intensive care medicine.
10 Nov, 2021 | 06:54h | UTCLife lessons after a career in intensive care medicine – Intensive Care Medicine
Commentary on Twitter
Reflections/lessons from a life in #ICU:
1⃣work with people you like/love
2⃣take sabbaticals to recharge
3⃣prioritize family = those you love most
4⃣live every day as having terminal disease: focus on what most important@JRandallCurtis1 #ICMfromtheInsidehttps://t.co/X2GKXRM3rf pic.twitter.com/ytx1eMLkMW— Intensive Care Medicine (@yourICM) November 8, 2021
Large observational study suggests prolactin-increasing antipsychotics are associated with increased risk of breast cancer (OR=1.56 for over 5 years of exposure); prolactin-sparing antipsychotics (including clozapine, quetiapine, or aripiprazole), on the other hand, were not associated with increased risk.
10 Nov, 2021 | 06:57h | UTCAntipsychotic use and risk of breast cancer in women with schizophrenia: a nationwide nested case-control study in Finland – The Lancet Psychiatry (link to abstract – $ for full-text)
Commentary on Twitter
Nested case-control study: ≥5 years exposure to prolactin-sparing APDs was not associated with an increased risk of breast cancer vs.<1 year exposure (aOR=1.19; 0.90–1.58). The opposite was observed with APDs that increase prolactin (aOR=1.56; 1.27–1.92) https://t.co/LwCVyTH051
— P𝘧OL (@psychopharmacol) September 12, 2021
M-A: Among patients with acute intracerebral hemorrhage, interventions to lower blood pressure within 7 days of the onset had no overall benefit on functional recovery, despite reducing bleeding.
10 Nov, 2021 | 06:55h | UTC
Cohort study: In utero exposure to 17α-hydroxyprogesterone caproate linked to increased risk of cancer in offspring.
10 Nov, 2021 | 06:59h | UTCIn utero exposure to 17α-hydroxyprogesterone caproate and risk of cancer in offspring – American Journal of Obstetrics and Gynecology (link to abstract – $ for full-text)
Review: Uremic Encephalopathy.
10 Nov, 2021 | 06:49h | UTCUremic Encephalopathy – Kidney International
M-A: In adults with sepsis or septic shock, metabolic resuscitation with vitamin C, glucocorticoids, vitamin B1, or combinations of these drugs was not associated with decreased long-term mortality. Adding glucocorticoid to other treatments shortened the duration of vasopressor therapy and ICU stay.
10 Nov, 2021 | 06:52h | UTCRelated:
Commentary on Twitter
Metabolic resuscitation in sepsis/septic shock with
💉vitamin C
💉glucocorticoids
💉vitamin B1
or their combinations not proven to⬇️long-term mortality.
NMA suggests association high dose/very high dose vit C & decreased mortality (low certainty).#FOAMcc https://t.co/tB2KKRjtzc pic.twitter.com/uns9rcmDbA— Intensive Care Medicine (@yourICM) November 9, 2021
Review: Antineutrophil cytoplasmic antibody-associated interstitial lung disease.
10 Nov, 2021 | 06:46h | UTC