Daily Archives: October 31, 2021 | LinksMedicus Free Medical News & Perspectives

Observational study suggests a third dose of the Pfizer COVID-19 vaccine can prevent severe COVID-19-related outcomes, compared with only two doses received at least 5 months before.

31 Oct, 2021 | 20:14h | UTC

Effectiveness of a third dose of the BNT162b2 mRNA COVID-19 vaccine for preventing severe outcomes in Israel: an observational study – The Lancet

Invited Commentary: Boosters appear effective, but are they always needed? – The Lancet

Commentaries on Twitter

Nice analysis of boosters in @TheLancet Fri.: https://t.co/KqXInFa3a9

But I want to highlight one number:

Risk of severe disease w no booster & no coexisting conditions = 1 in 32,000 (3 per 100k).

If you have no other medical problems, this is not an urgent priority. pic.twitter.com/Qwcwsf6LIY

— David Dowdy (@davidwdowdy) October 31, 2021

Study in Israel suggests third dose of BNT162b2 mRNA vaccine effective in protecting individuals against severe COVID-19-related outcomes, compared with receiving only two doses at least 5 months before. https://t.co/g3vFqVFZLI pic.twitter.com/HfbBAPY8qP

— The Lancet (@TheLancet) October 31, 2021

Adding to the body of data for booster shot effectiveness, a new @TheLancet report of over 728,000 people w/ 3 shots vs >728,000 matched controls (2 shots):
93% reduction of Covid hospitalizationshttps://t.co/cVpANpnkHs pic.twitter.com/LlBwWi2Vtw

— Eric Topol (@EricTopol) October 30, 2021

Study shows fully vaccinated individuals can still catch SARS-CoV-2 delta variant and efficiently transmit infection in household settings, including to fully vaccinated contacts.

31 Oct, 2021 | 20:16h | UTC

Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study – The Lancet Infectious Diseases

Commentaries:

COVID vaccines effective but household transmission of delta a risk for 1 in 4 – Imperial College London

What is the vaccine effect on reducing transmission in the context of the SARS-CoV-2 delta variant? – The Lancet Infectious Diseases

CoVID-19 vaccines lower risk of infection with delta variant, but infection can still be passed on in household settings – the Lancet

COVID vaccines protect against Delta but don’t fully stop disease spread – CIDRAP

Covid: Double vaccinated can still spread virus at home – BBC

Commentary on Twitter

NEW—#COVID19 vaccines lower the risk of infection with the #DeltaVariant. However, infection can still be passed on in household settings after two doses.

Authors urge unvaccinated to get vaccinated & those eligible to receive a booster. 1/2 https://t.co/jq8DCK69Ww pic.twitter.com/1XzHnKCF01

— The Lancet (@TheLancet) October 28, 2021

Editorial: Safety and efficacy of antivirals against SARS-CoV-2 – “we need evidence not optimism”.

31 Oct, 2021 | 20:11h | UTC

Safety and efficacy of antivirals against SARS-CoV-2 – The BMJ

Commentary on Twitter

"Effective antivirals have an obvious appeal, but this must not cloud objective and transparent decision making." @dpsg108 and colleagues on the government's stockpiling of molnupiravir and PF-07321332+ritonavir for covid-19https://t.co/JUj1Y9op3P

— The BMJ (@bmj_latest) October 28, 2021

CDC Study: COVID-19 vaccine associated with 5 times the protection of ‘natural immunity’.

31 Oct, 2021 | 20:09h | UTC

Laboratory-Confirmed COVID-19 Among Adults Hospitalized with COVID-19–Like Illness with Infection-Induced or mRNA Vaccine-Induced SARS-CoV-2 Immunity — Nine States, January–September 2021 – CDC Morbidity and Mortality Weekly Report

Commentaries:

COVID-19 vaccine gives 5 times the protection of ‘natural immunity,’ data show – CIDRAP

COVID shots more protective than past infection, study shows – Associated Press

Commentary on Twitter

⚠️BREAKING—REINFECTION & NATURAL IMMUNITY—new CDC study in hospitalized adults finds: unvaccinated people with prior #COVID19 infection recently were **5 times more likely** to be reinfected / get breakthrough versus people recently fully vaccinated! ? https://t.co/VGmWPmm5lE pic.twitter.com/mlt5fJ3643

— Eric Feigl-Ding (@DrEricDing) October 29, 2021

Cohort Study: Among patients with ST-segment elevation myocardial infarction, a concomitant Covid-19 diagnosis is associated with increased in-hospital mortality.

31 Oct, 2021 | 20:10h | UTC

Association Between COVID-19 Diagnosis and In-Hospital Mortality in Patients Hospitalized With ST-Segment Elevation Myocardial Infarction – JAMA

Editorial: Myocardial Infarction During the COVID-19 Pandemic – JAMA

Commentary: STEMI and COVID-19 Often a Lethal Combo, Affirms Largest Study Yet – TCTMD

Commentary from the author on Twitter (thread – click for more)

1/8 It was not unexpected that pts w/ #STEMI would fare worse w/ than w/o #COVID19 https://t.co/B7oWnJunEa

— Herb Aronow, MD, MPH (he/him/his) (@herbaronowMD) October 29, 2021

Opinion | Is Moderna really better than Pfizer—or is it just a higher dose?

31 Oct, 2021 | 20:06h | UTC

Is Moderna Really Better Than Pfizer—Or Is It Just a Higher Dose? – The Atlantic

Commentary on Twitter

Nice piece @theatlantic explores question of: Does Moderna give better protection than Pfizer, which gives better protection than J&J (the data would say yes to both)? And – if so – is it simply a matter of the relative doses? https://t.co/Bqav2pNNi7

— Bob Wachter (@Bob_Wachter) October 30, 2021

NICE Guideline | Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and management.

31 Oct, 2021 | 20:03h | UTC

Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and management – National Institute for Health and Care Excellence

Commentaries:

Chronic fatigue syndrome advice scraps exercise therapy – BBC

ME exercise therapy guidance scrapped by health watchdog Nice – The Guardian

RCT: Targeting higher intraoperative blood pressures does not reduce adverse cardiovascular events following noncardiac surgery.

31 Oct, 2021 | 20:00h | UTC

Targeting Higher Intraoperative Blood Pressures Does Not Reduce Adverse Cardiovascular Events Following Noncardiac Surgery – Journal of the American College of Cardiology

Cardiovascular clinical examination: the need for an evidence-based approach.

31 Oct, 2021 | 19:57h | UTC

Cardiovascular clinical examination: the need for an evidence-based approach – European Heart Journal

Commentary on Twitter

Which role for cardiac clinical examination today?
According to new cardiopulse, cardiac physical diagnosis shold be regarded as a science that can be learnt, rather than an art that can only be aspired to.https://t.co/oG1NJusXrS #cardiotwitter, @ESC_Journals, @escardio. pic.twitter.com/B9iUSv0gnj

— EHJ Editor-in-Chief (@ehj_ed) October 30, 2021

Study suggests smoking cessation, but not reduction, is associated with reduced risk of cardiovascular disease.

31 Oct, 2021 | 19:59h | UTC

Smoking cessation, but not reduction, reduces cardiovascular disease incidence – European Heart Journal (link to abstract – $ for full-text)

Commentary on Twitter

May I just reduce the number of cigarettes? New study shows this is not enough! Smoking cessation, but not reduction, was associated with cardiovascular disease incidence drop.https://t.co/lVgXMwavNs #smoke, #cigarettes, #MI, #cardiotwitter, @ESC_Journals, @escardio. pic.twitter.com/FrqB5V2tx3

— EHJ Editor-in-Chief (@ehj_ed) October 31, 2021

Review: Clinical management of pancreatic premalignant lesions.

31 Oct, 2021 | 19:56h | UTC

Clinical Management of Pancreatic Premalignant Lesions – Gastroenterology

Imaging of congenital lung diseases presenting in the adulthood: a pictorial review.

31 Oct, 2021 | 19:53h | UTC

Imaging of congenital lung diseases presenting in the adulthood: a pictorial review – Insights into Imaging

Review: How I manage a patient with MRSA bacteremia.

31 Oct, 2021 | 19:54h | UTC

How I manage a patient with MRSA bacteraemia – Clinical Microbiology and Infection

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