Daily Archives: August 29, 2021
Study with over 29 million people in England shows Covid-19, not vaccination, presents biggest blood clot risks.
29 Aug, 2021 | 18:57h | UTCPress release: Covid-19, not vaccination, presents biggest blood clot risks – University of Oxford
Editorial: Strengthening international surveillance of vaccine safety – The BMJ
Commentaries:
Covid: Vaccine complications dwarfed by virus risks – BBC
Commentary on Twitter
#BMJInfographic Fast track research looked at patient level data for ~30 million people vaccinated in England and found that thrombosis risks associated with covid-19 vaccines are lower than that associated with covid-19 infection https://t.co/R0JlcuvMez @JuliaHCox pic.twitter.com/XMzXK6UOBc
— The BMJ (@bmj_latest) August 27, 2021
Cohort study: Patients with Covid-19 infected with the Delta variant are twice as likely to need hospital admission or emergency care attendance.
29 Aug, 2021 | 19:02h | UTCCommentaries:
Covid: Delta variant patients twice as likely to need hospital care – BBC
Covid-19 hospitalization risk doubles with Delta variant, UK study suggests – CNN
Commentary on Twitter
The Delta variant is bad enough, but there has been debate as to whether it, per se, carries a higher risk of hospitalization (H) beyond its very high contagiousness. A new, rigorous study shows a doubling of the H rate https://t.co/qom8l6fw4v pic.twitter.com/CwXPOU0YWi
— Eric Topol (@EricTopol) August 27, 2021
Opinion | 10 Images That Illustrate The Shameful Global Vaccine Inequity – “This series of 10 images tell the story behind the great vaccine apartheid – the single biggest moral and scientific failure during this global crisis”.
29 Aug, 2021 | 18:53h | UTC10 Images That Illustrate The Shameful Global Vaccine Inequity – by Madhukar Pai
Commentary on Twitter
Please don't look away!
My new post @NatureMicrobiol offers
10 Images That Illustrate The Shameful Global Vaccine Inequityhttps://t.co/5iwINN1IeN #COVID19 #vaccinequity
— Madhu Pai, MD, PhD (@paimadhu) August 28, 2021
Many predicted some kind of ‘Covid slide’ in learning. Test results show how bad it is.
29 Aug, 2021 | 18:55h | UTCMany predicted some kind of ‘Covid slide’ in learning. Test results show how bad it is – CNN
Report: Learning during COVID-19: Reading and math achievement in the 2020-21 school year – NWEA
Related:
Unvaccinated, unmasked teacher infected more than half of students in class with Covid-19, CDC reports.
29 Aug, 2021 | 18:52h | UTC
#ESCCongress – 2021 ESC/EACTS Guidelines for the management of valvular heart disease – in the new guidelines, more patients are eligible for surgical and transcatheter interventions, based not only on symptoms but also on imaging criteria.
29 Aug, 2021 | 18:23h | UTCNews release: European valvular heart disease Guidelines published today – European Society of Cardiology
Summary: 2021 ESC/EACTS Valvular Heart Disease Guidelines: Key Points – American College of Cardiology
Commentary: Revamped Valve Disease Guideline: Europe Sees Nearly Eye to Eye With U.S. – MedPage Today (free registration required)
“In line with recent U.S. recommendations, the newest European guidelines favor a wider pool of patients eligible for surgical and transcatheter interventions for valvular heart disease.” (from MedPage Today)
Commentaries on Twitter
#ESCCongress new VHD guidelines out ➡️https://t.co/fFkuivAM9E
➡️SAVR in low risk pts <75yrs old
➡️ TAVR in pts >75
➡️ Role of heart team emphasised
➡️ NEW! intervention to be considered with asymptomatic AS with lv <55% IIa@HanCardiomd @Hragy @aayshacader @DrMarthaGulati #TAVR pic.twitter.com/JV1zocQJaK— Mamas Mamas (@mmamas1973) August 28, 2021
?Guidelines for the management of valvular heart disease #ESCCongress @escardio @secardiologia @EACTS
? https://t.co/3FCS8YYKIr @mmamas1973 @shci_sec pic.twitter.com/wxuf3AjVaE
— Alfonso Valle (@ValleAlfonso) August 28, 2021
Optimal antithrombotic therapy for valve prostheses from the 2021 #ESC Guidelines for the management of VHD #ESCCongress @escardio https://t.co/AmQJkZBMoo pic.twitter.com/WK2wQSSlhL
— Roxana Mehran (@Drroxmehran) August 28, 2021
(thread – click for more)
Have there been changes in when to intervene with the new 2021 ESC/EACTS guidelines for the management of valvular heart disease?
Yes, and in general the bar for intervention is now lower
Thread follows…#ESCCongress
1/n pic.twitter.com/iLN9cLCtLj
— Sarah Hudson (@sarahhudsonuk) August 28, 2021
M-A: Factors associated with household transmission of SARS-CoV-2 – recent studies showed higher household secondary attack rates than earliest reports (13.4% vs. 31.1%); more transmissible variants and vaccines may lead to further changes.
29 Aug, 2021 | 18:48h | UTCCommentary: 1 in 5 people with COVID-19 pass it to others in household, study finds – UPI
Commentary on Twitter
The findings of this meta-analysis suggest that the household remains an important site of #SARSCoV2 transmission, and recent studies have higher household secondary attack rates estimates compared with the earliest reports. https://t.co/lFmkaz0zUe
— JAMA Network Open (@JAMANetworkOpen) August 27, 2021
New CDC Guidance says influenza and Covid vaccines can be given together – “COVID-19 vaccines and other vaccines may now be administered without regard to timing”
29 Aug, 2021 | 18:51h | UTCCommentary: Flu shot and a COVID jab? New 2021-2022 flu vaccine guidance points to both – McKnight’s
#ESCCongress – 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy.
29 Aug, 2021 | 18:20h | UTCNews release: ESC Guidelines on cardiac pacing and cardiac resynchronisation therapy launched today – European Society of Cardiology
Commentary on Twitter
NEW: #ESCGuidelines on cardiac pacing and cardiac resynchronisation therapy https://t.co/aJTDQyv5Fz#cardiotwitter #EPeeps #medtwitter pic.twitter.com/GPJt9yRWTn
— European Society of Cardiology (@escardio) August 29, 2021
#ESCCongress – 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure – SGLT2 inhibitors are now recommended for patients with heart failure with reduced ejection fraction regardless of the presence of diabetes.
29 Aug, 2021 | 18:25h | UTCNews release: ESC Guidelines on heart failure management launched today – European Society of Cardiology
Commentary on Twitter
The new heart failure guidelines by @escardio https://t.co/NRvxh8UUxp ready for #ESCCongress https://t.co/NlGYM9DAqA enjoy reading 128 pages. Some important figures pic.twitter.com/6GmRUuSw9z
— rafavidalperez (@rafavidalperez) August 27, 2021
#ESCCongress – Cluster RCT: Among patients at increased risk for stroke, salt substitution (75% sodium chloride and 25% potassium chloride by mass) reduced the rates of stroke, major cardiovascular events, and death from any cause.
29 Aug, 2021 | 19:21h | UTCEffect of Salt Substitution on Cardiovascular Events and Death – New England Journal of Medicine (link to abstract – $ for full-text)
News release: Low-sodium salt prevents stroke – European Society of Cardiology
Commentary: Massive SSaSS Study Shows Switch to Salt Substitute Cuts Stroke, CVD – TCTMD
Commentary on Twitter
SSaSS: In RCT that compared salt substitute w/ regular salt, rates of stroke, major CV events, death lower with salt sub. #ESCCongress https://t.co/Yt6vMrYSDh pic.twitter.com/jtymS36zqs
— NEJM (@NEJM) August 29, 2021
#ESCCongress – RCT: SGLT2 inhibition reduced the combined risk of cardiovascular death or hospitalization in patients with heart failure and a preserved ejection fraction, regardless of the presence or absence of diabetes.
29 Aug, 2021 | 18:19h | UTCEmpagliflozin in Heart Failure with a Preserved Ejection Fraction – New England Journal of Medicine
News release: Trial reports first successful results for heart failure with preserved ejection fraction – European Society of Cardiology
Commentary on Twitter
#FIGARO-DKD #ESCCongress
?in patients w T2D & microalbuminuria & stage 1-4 CKD, finerenone vs placebo led to 13% relative ⬇️in CV events (mostly due to 29%⬇️in HF hospitalizations)
?~2/3 pts +microalbuminuria w normal GFR:? is to✔️in T2D#ESCCongress https://t.co/8oT5s8KjT0 pic.twitter.com/fQbmUzPasD— Ritu Thamman MD (@iamritu) August 28, 2021
#ESCCongress – RCT: In patients with A. Fibrillation who underwent TAVR, Edoxaban was noninferior to Vit. K Antagonist regarding the composite primary outcome of adverse clinical events, but resulted in a higher incidence of major bleeding.
29 Aug, 2021 | 18:17h | UTCCommentaries:
ENVISAGE-TAVI AF: Edoxaban Disappoints in TAVI Setting – TCTMD
#ESCCongress – RCT: In patients who underwent PCI at high bleeding risk, 1 month of dual antiplatelet therapy was noninferior to the continuation of dual therapy for at least 2 additional months and resulted in a lower incidence of bleeding events.
29 Aug, 2021 | 18:16h | UTCCommentaries:
#ESCCongress – RCT: Immediate coronary angiography after out-of-hospital cardiac arrest without ST-segment elevation did not improve outcomes compared to delayed/selective angiography.
29 Aug, 2021 | 18:12h | UTCNews release: Trial does not support early coronary angiography in cardiac arrest without ST elevation – European Society of Cardiology
Commentaries:
Commentary on Twitter
TOMAHAWK: In patients without ST elevation and OHCA, immediate coronary angiography provided no benefit over delayed. #ESCCongress https://t.co/7IKJ1y4B8v pic.twitter.com/H0cyyl18ig
— NEJM (@NEJM) August 29, 2021
#ESCCongress – RCT: Finerenone reduced CV events in patients with kidney disease and type 2 diabetes (12.4% vs. 14.2% during a median follow-up of 3.4 years), but the risk of hyperkalemia was increased (10.8% vs. 5.3%).
29 Aug, 2021 | 18:14h | UTCNews release: Finerenone benefits patients with diabetes across spectrum of kidney disease – European Society of Cardiology
Commentaries:
Related:
Commentary on Twitter
FIGARO-DKD: Among patients with stage 1 to 4 CKD and T2 diabetes, finerenone improved CV outcomes as compared with placebo. #ESCCongress https://t.co/mcfmvftBvy pic.twitter.com/qizit80NBa
— NEJM (@NEJM) August 28, 2021
#ESCCongress – RCT: Initial hypertension treatment with a single pill with 4 drugs at quarter doses (irbesartan 37.5 mg, amlodipine 1.25 mg, indapamide 0.625 mg, and bisoprolol 2.5 mg) achieved better BP lowering vs. standard monotherapy (irbesartan 150 mg).
29 Aug, 2021 | 18:11h | UTCInitial treatment with a single pill containing quadruple combination of quarter doses of blood pressure medicines versus standard dose monotherapy in patients with hypertension (QUARTET): a phase 3, randomised, double-blind, active-controlled trial – The Lancet (link to abstract – $ for full-text)
Commentary: Quadruple UltrA-low-dose tReaTment for hypErTension – QUARTET – American College of Cardiology
#ESCCongress – RCT: Among asymptomatic patients with severe carotid stenosis, carotid surgery and stenting carry similar risks, and the long-term risk of stroke was comparable. There was no medically treated arm in this study.
29 Aug, 2021 | 18:06h | UTC
Commentary on Twitter
#ACST-2 stent CAS ?surgery CEA
For asymptotic carotid stenosis >= 60%https://t.co/lyLBn8C8cv
?No difference in death 30d MI, stroke 5 yr f/u
?Slight ⬆️in minor 30d strokes w Stenting but no QOL change at 6 mo
?no medical Rx arm
?both arms 1% procedural risk #ESCCongress pic.twitter.com/8ptcrstn0D— Ritu Thamman MD (@iamritu) August 29, 2021
#ESCCongress – RCT: Small benefit from systematic screening for atrial fibrillation in older adults – After a median follow-up of 6.9 y there were fewer events (stroke, embolism, bleeding, and death) in the intervention group (31·9%) vs. control group (33·0%).
29 Aug, 2021 | 18:08h | UTCClinical outcomes in systematic screening for atrial fibrillation (STROKESTOP): a multicentre, parallel group, unmasked, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
News release: Screening for atrial fibrillation could reduce risk of stroke – Karolinska Institutet
#ESCCongress – RCT: In patients with heart failure, hemodynamic-guided management was not associated with improved outcomes.
29 Aug, 2021 | 18:03h | UTCHaemodynamic-guided management of heart failure (GUIDE-HF): a randomised controlled trial – The Lancet (free registration required)
Commentary:
Haemodynamic-GUIDEed management of Heart Failure – GUIDE-HF – American College of Cardiology
Commentary on Twitter
The GUIDE-HF trial showed hemodynamic-guided management using remote pulmonary artery pressure monitoring didn't ⬇️ mortality & total #heartfailure events in patients regardless of HF symptom severity compared w/ patients receiving usual care: https://t.co/15Iv1N78sJ #ESCCongress pic.twitter.com/rZSNCfw4kq
— American College of Cardiology (@ACCinTouch) August 27, 2021
#ESCCongress – Pilot study in Sweden showed drones delivered defibrillators faster than ambulances to patients with suspected cardiac arrest.
29 Aug, 2021 | 18:02h | UTCEditorial: Automated external defibrillator delivery by drones: are we ready for prime time?
News releases:
Drones delivered defibrillators to patients with suspected cardiac arrests – Karolinska Institutet
Commentary on Twitter
Just released: #drones are effective in successfully delivering #AEDs to patients with suspected out-of-hospital cardiac arrest #OHCA, with a time benefit compared to emergency medical services https://t.co/D9XOI0Pep4 #EHJ #ESCcongress #ESCYoung @ehj_ed @rladeiraslopes pic.twitter.com/oRSMdQVqAC
— European Society of Cardiology Journals (@ESC_Journals) August 27, 2021
#ESCCongress [not published yet] – Systematic FFR has no additional benefit at diagnostic angiography in patients with chest pain.
29 Aug, 2021 | 18:00h | UTCPress release: Systematic pressure wire assessment has no additional benefit at diagnostic angiography – European Society of Cardiology
Commentaries:
FFR During Angiogram Not Beneficial in Chest Pain Patients: RIPCORD 2 – TCTMD
Related:
Randomized Trial: Five-Year Outcomes with PCI Guided by FFR