Daily Archives: August 4, 2021 | LinksMedicus Free Medical News & Perspectives

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

4 Aug, 2021 | 10:06h | UTC

Illness duration and symptom profile in symptomatic UK school-aged children tested for SARS-CoV-2 – The Lancet Child & Adolescent Health

Invited commentary: Citizen science and biomedical research (free registration required)

Commentaries:

Expert reaction to study looking at long-lasting symptoms from COVID-19 in children – Science Media Centre

Long Covid uncommon in children, analysis finds – King’s College London

Study finds long-term Covid symptoms rare in school-age children – The Guardian

Most children with Covid-19 recover within a week, but a small percentage have long-term symptoms, a study says. – The New York Times

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Cohort study: Risk factors for long covid in previously hospitalized children.

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

Commentary on Twitter

New @LancetChildAdol is a very reassuring prospective study of >250,000 children, >1700 with + covid test, age 5-17, that shows the risk for chronic Covid symptoms is quite low; 4.4% beyond 4 weekshttps://t.co/XVFs0UtHWC pic.twitter.com/XBVH5wmFve

— Eric Topol (@EricTopol) August 3, 2021

AAP Interim guidance on supporting the emotional and behavioral health needs of children, adolescents, and families during the COVID-19 pandemic.

4 Aug, 2021 | 10:03h | UTC

Interim Guidance on Supporting the Emotional and Behavioral Health Needs of Children, Adolescents, and Families During the COVID-19 Pandemic – American Academy of Pediatrics

Opinion (video): “The Delta Surge May Collapse Faster Than You Think.”

4 Aug, 2021 | 09:53h | UTC

The Delta Surge May Collapse Faster Than You Think – ZDoggMD

The study behind new CDC’s mask guidance found vaccinated people can spread delta variant.

How the coronavirus infects cells — and why Delta is so dangerous.

COVID vaccines slash viral spread, but Delta is an unknown – “Studies show that vaccines reduce the spread of SARS-CoV-2 by more than 80%, but the Delta variant is creating fresh uncertainty”.

CDC changes mask guidance in response to threat of Delta variant of Covid-19.

Position statement: Perioperative management of post-COVID-19 surgical patients.

4 Aug, 2021 | 10:00h | UTC

Perioperative management of post-COVID-19 surgical patients: Indian Society of Anaesthesiologists (ISA National) Advisory and Position Statement – Indian Journal of Anaesthesia

Guideline: SARS‐CoV‐2 infection, COVID‐19 and timing of elective surgery

Study from 116 countries suggests surgery should be delayed for at least seven weeks following a COVID-19 diagnosis to reduce mortality risk

Cohort study: Postoperative in-hospital mortality of patients with COVID-19 infection was more than double that in patients without COVID-19

WSES Position Paper: The management of surgical patients in the emergency setting during COVID-19 pandemic

Preparing previously COVID-19-positive patients for elective surgery: A framework for preoperative evaluation

Commentary on Twitter

Interesting position statement (from India) for perioperative management of post-COVID-19 surgical patients. Highlights important points to consider but appears overly cautious, recommending a lot of preop testing. #COVID19 https://t.co/oOR1ik21ha

— Steven Cohn, MD (@preopconsult) August 3, 2021

AAP Guidance: Post-COVID-19 conditions in children and adolescents.

4 Aug, 2021 | 10:01h | UTC

Post-COVID-19 Conditions in Children and Adolescents – American Academy of Pediatrics

Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset.

4 Aug, 2021 | 09:55h | UTC

Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset – eLlife

Exploring the gap between excess mortality and COVID-19 deaths in 67 countries.

Report: Three new estimates of India’s all-cause excess mortality during the COVID-19 Pandemic – pandemic death toll estimated to be between 3.4 million and 4.9 million excess deaths.

COVID-19 has caused 6.9 million deaths globally, more than double what official reports show

Commentary on Twitter (thread – click for more)

Excess mortality across the world with the World Mortality Dataset – officially published at @eLife!https://t.co/bCudrKhZ6d

A thread on data, findings, and more.

1

(Illustration by Gal Kabiri) pic.twitter.com/oqtXRqUQH9

— Ariel Karlinsky (@ArielKarlinsky) August 3, 2021

Antimicrobial stewardship in the ICU in COVID times: the known unknowns.

4 Aug, 2021 | 09:16h | UTC

Antimicrobial stewardship in the ICU in COVID times: the known unknowns – International Journal of Antimicrobial Agents

IDSA Updated Covid-19 Guidance: Co-Infection and Antimicrobial Stewardship – “bacterial coinfections with SARS-CoV-2 infection are relatively infrequent (likely occurring in less than 10% of hospitalized COVID-19 patients)”.

Antimicrobial stewardship in ICUs during the COVID-19 pandemic: back to the 90s?

Another study shows a high frequency of antibiotic use among patients hospitalized with Covid-19 (85.2%), despite low rates of confirmed secondary bacterial infections.

Too many COVID-19 patients get unneeded ‘just in case’ antibiotics

RCT: Text-message reminders can increase COVID-19 vaccinations.

4 Aug, 2021 | 09:12h | UTC

Behavioral Nudges Increase COVID-19 Vaccinations – Nature

Commentaries:

Text-message ‘nudges’ can encourage holdouts to get COVID vaccination, study finds – UCLA

Text reminders boost vaccine appointments – Carnegie Mellon University

Commentary on Twitter

Sometimes the tools that actually work in public health are profoundly boring. Here, a text message reminder system is shown in a randomized trial to increase vaccine uptake. Years of HIV adherence research has shown the value of simple nudges like this.https://t.co/1ndpnQ6Ha6 https://t.co/Gltll8DTJ4

— Natalie E. Dean, PhD (@nataliexdean) August 3, 2021

Cannabis and Cannabinoid Analgesia position statement – “Due to the lack of high-quality clinical evidence, the IASP does not currently endorse general use of cannabis and cannabinoids for pain relief.”

4 Aug, 2021 | 09:07h | UTC

International Association for the Study of Pain Presidential Task Force on Cannabis and Cannabinoid Analgesia position statement – Pain

NCCN Guidelines Insights: Palliative Care.

4 Aug, 2021 | 09:02h | UTC

NCCN Guidelines® Insights: Palliative Care, Version 2.2021 – Journal of the National Comprehensive Cancer Network

Spontaneous pneumomediastinum in patients diagnosed with covid-19: a case series with review of literature.

4 Aug, 2021 | 09:13h | UTC

Spontaneous Pneumomediastinum in Patients Diagnosed with COVID-19: a Case Series with Review of Literature – Academic Radiology

Clinical practice recommendations on the management of perioperative cardiac arrest.

4 Aug, 2021 | 09:03h | UTC

Clinical practice recommendations on the management of perioperative cardiac arrest: A report from the PERIOPCA Consortium – Critical Care

How much worse can the coronavirus get?

4 Aug, 2021 | 09:09h | UTC

How much worse can the coronavirus get? – Vox

SCAI expert consensus update on best practices in the cardiac catheterization laboratory.

4 Aug, 2021 | 09:04h | UTC

SCAI expert consensus update on best practices in the cardiac catheterization laboratory – Catheterization & Cardiovascular Interventions

Commentary: SCAI Expert Consensus Update on Best Practices in the Cardiac Catheterization Laboratory: Optimizing Quality of Care – American College of Cardiology

AHA Scientific Statement: Evidence-based practices in the cardiac catheterization laboratory.

RCT: Effect of an active vs. expectant management strategy on successful resolution of pregnancy among patients with a persisting pregnancy of unknown location.

4 Aug, 2021 | 09:00h | UTC

Effect of an Active vs Expectant Management Strategy on Successful Resolution of Pregnancy Among Patients With a Persisting Pregnancy of Unknown Location: The ACT or NOT Randomized Clinical Trial – JAMA (free for a limited period)

Commentary: Active Management More Effective for Pregnancy of Unknown Location – MedPage Today (free registration required)

RCT: Routine treatment with fluoxetine does not reduce the incidence of depression after stroke.

4 Aug, 2021 | 08:56h | UTC

Depression Outcomes Among Patients Treated With Fluoxetine for Stroke Recovery: The AFFINITY Randomized Clinical Trial – JAMA Neurology (free for a limited period)

Editorial: Poststroke Selective Serotonin Reuptake Inhibitors—Do They Work for Anything? (free for a limited period)

[Abstract Only] Randomized trial: Fluoxetine does not improve functional recovery after acute stroke

Randomized Trial: Effects of Fluoxetine on Functional Outcomes After Acute Stroke

Interpreting the results of intention-to-treat, per-protocol, and as-treated analyses of clinical trials.

4 Aug, 2021 | 08:57h | UTC

Interpreting the Results of Intention-to-Treat, Per-Protocol, and As-Treated Analyses of Clinical Trials – JAMA

Ketogenic Diets and Chronic Disease: Weighing the Benefits Against the Risks – “Given often-temporary improvements, unfavorable effects on dietary intake, and inadequate data demonstrating long-term safety, for most individuals, the risks of ketogenic diets may outweigh the benefits.”

4 Aug, 2021 | 08:53h | UTC

Ketogenic Diets and Chronic Disease: Weighing the Benefits Against the Risks – Frontiers in Nutrition

Commentary: Keto diets review finds heart risks, cancer risk, dangers to pregnant women and kidney patients – Physicians Committee for Responsible Medicine

RCT: Effect of a sedation and ventilator liberation protocol vs. usual care on duration of invasive mechanical ventilation in pediatric intensive care units.

4 Aug, 2021 | 08:59h | UTC

Effect of a Sedation and Ventilator Liberation Protocol vs Usual Care on Duration of Invasive Mechanical Ventilation in Pediatric Intensive Care Units: A Randomized Clinical Trial – JAMA (free for a limited period)

Commentary on Twitter

In this stepped-wedge, cluster RCT, among infants and children anticipated to require prolonged mechanical ventilation, a sedation & ventilator liberation protocol intervention resulted in a reduction in time to first successful extubation https://t.co/oNuOq9CCrs pic.twitter.com/n9l3MOJlop

— JAMA (@JAMA_current) August 3, 2021

RCT: Midodrine can reduce the recurrence of vasovagal syncope.

4 Aug, 2021 | 08:54h | UTC

Midodrine for the Prevention of Vasovagal Syncope: A Randomized Clinical Trial – Annals of Internal Medicine

Commentary: Midodrine Cuts Recurrent Syncope in Young, Healthy Patients – HealthDay

Summary for patients: Summary for Patients: Midodrine to Prevent Fainting – Annals of Internal Medicine

Commentary on Twitter

New research out in Annals found that midodrine reduces fainting recurrence for younger patients with frequent #fainting spells https://t.co/D1crZ97AU2. pic.twitter.com/pZGEoERai6

— Annals of Int Med (@AnnalsofIM) August 3, 2021

Radiologists use structured CT reports to create database of metastatic cancer patterns.

4 Aug, 2021 | 08:51h | UTC

Radiologists use structured CT reports to create database of metastatic cancer patterns – Health Imaging

Original study: Patterns of Metastatic Disease in Patients with Cancer Derived from Natural Language Processing of Structured CT Radiology Reports over a 10-year Period – Radiology (link to abstract – $ for full-text)

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