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Daily Archives: July 28, 2021

CDC changes mask guidance in response to threat of Delta variant of Covid-19.

28 Jul, 2021 | 10:23h | UTC

Commentary: CDC changes mask guidance in response to threat of Delta variant of Covid-19 – CNN

See guidance: Guidance for Implementing COVID-19 Prevention Strategies in the Context of Varying Community Transmission Levels and Vaccination Coverage – Centers for Disease Control and Prevention

 

Commentaries on Twitter

 

Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees.

28 Jul, 2021 | 10:19h | UTC

Very rare thrombosis with thrombocytopenia after second AZD1222 dose: a global safety database analysis – The Lancet

Related:

WHO Guidance for clinical case management of thrombosis with thrombocytopenia syndrome (TTS) following vaccination to prevent coronavirus disease (COVID-19).

AHA/ASA Guidance: Diagnosis and Management of Cerebral Venous Sinus Thrombosis with Vaccine-Induced Thrombotic Thrombocytopenia – “No heparin products in any dose should be given.”

ISTH Interim Guidance for the Diagnosis and Treatment on Vaccine Induced Immune Thrombotic Thrombocytopenia

Case series: therapeutic plasma exchange in 3 patients with vaccine-induced immune thrombotic thrombocytopenia.

Vaccine-induced immune thrombotic thrombocytopenia (VITT) – a novel clinico-pathological entity with heterogeneous clinical presentations.

Case report: Thrombosis with Thrombocytopenia After the Messenger RNA–1273 Vaccine.

Laboratory testing for suspected COVID-19 vaccine–induced (immune) thrombotic thrombocytopenia.

Concerned about the latest AstraZeneca news? These 3 graphics help you make sense of the risk – “Two people in Australia have died from thrombosis with thrombocytopenia after 3.8 million doses of the AstraZeneca vaccine delivered”.

Case series: Adjunct immune globulin for vaccine-induced thrombotic thrombocytopenia.

Case report: Successful treatment of vaccine-induced prothrombotic immune thrombocytopenia (VIPIT).

[Preprint] Meta-analysis of risk of vaccine-induced immune thrombotic thrombocytopenia following ChAdOx1-S recombinant vaccine – Overall risk is 1 in 139,000; for age 65 and over, about 1 in 1,000,000; for age under 55, between 1 in 20,000 to 60,000.

Cohort study: Arterial events, venous thromboembolism, thrombocytopenia, and bleeding after vaccination with Oxford-AstraZeneca ChAdOx1-S. 11 excess venous thromboembolic events per 100 000 vaccinations; 2.5 excess cerebral venous thrombosis per 100 000 vaccinations.

Case series of 12 patients with cerebral venous sinus thrombosis with thrombocytopenia after Ad26.COV2.S vaccination – all women younger than 60 years, with symptoms from 6 to 15 days after vaccination

Vaccine-induced Immune Thrombotic Thrombocytopenia: Frequently Asked Questions

Pathologic Antibodies to Platelet Factor 4 after ChAdOx1 nCoV-19 Vaccination

Editorial: SARS-CoV-2 Vaccine–Induced Immune Thrombotic Thrombocytopenia – “The very low prevalence of this complication of vaccination, however severe, relative to the benefits of preventing Covid-19 must be emphasized”

Case Report: Thrombotic Thrombocytopenia after Johnson & Johnson Vaccine

Papers Confirm Rare Thrombocytopenia Link to AstraZeneca Vaccine

Guidance on syndrome of Thrombosis and Thrombocytopenia occurring after coronavirus Vaccination

 

Commentary on Twitter

 

Editorial: Nine lessons learned from the Covid-19 pandemic for improving hospital care and health care delivery.

28 Jul, 2021 | 10:17h | UTC

Nine Lessons Learned From the COVID-19 Pandemic for Improving Hospital Care and Health Care Delivery – JAMA Internal Medicine

 

Report: Improved ventilation essential to safe use of buildings and public spaces, say leading engineers.

28 Jul, 2021 | 10:16h | UTC

News release: Improved ventilation essential to safe use of buildings and public spaces, say leading engineers – Royal Academy of Engineering

Report: Infection Resilient Environments: Buildings that keep us healthy and safe – National Engineering Policy Centre

Related:

WHO: Roadmap to improve and ensure good indoor ventilation in the context of COVID-19

CDC releases new ventilation guidelines for indoor environments to reduce Covid-19 risk

Guidance: Using Ventilation and filtration to reduce aerosol transmission of COVID-19 in long-term care homes

 

Commentary on Twitter

 

Household transmission of SARS-CoV-2 from children and adolescents.

28 Jul, 2021 | 10:08h | UTC

Household Transmission of SARS-CoV-2 from Children and Adolescents – New England Journal of Medicine

Related:

Effect of Vaccination on Household Transmission of SARS-CoV-2 in England – “the likelihood of household transmission was approximately 40 to 50% lower in households of index patients who had been vaccinated 21 days or more before testing positive than in households of unvaccinated index patients”.

Covid-19 vaccination prevents transmission from vaccinated to unvaccinated household members.

Study in England showed one dose of COVID-19 vaccine can cut household transmission by up to half – This protection is on top of the reduced risk of a vaccinated person developing symptomatic infection, which is around 60 to 65% after the first dose

Study: Household transmission of SARS-CoV-2 and risk factors for susceptibility and infectivity

A meta-analysis on the role of children in SARS-CoV-2 in household transmission clusters

Report: SARS-CoV-2 setting-specific transmission rates. Households showed the highest transmission rates (21.1%). Asymptomatic infections do occur but much less efficiently than symptomatic infection.

CDC Report: Transmission of SARS-COV-2 infections in households

The household secondary attack rate of SARS-CoV-2: A rapid review

 

Commentary on Twitter

 

COVID-19 and mucormycosis superinfection: the perfect storm.

28 Jul, 2021 | 10:09h | UTC

COVID-19 and mucormycosis superinfection: the perfect storm – Infection

Related:

ECMM/ISHAM recommendations for clinical management of COVID -19 associated mucormycosis in low- and middle-income countries.

The “Black Fungus” in India: The Emerging Syndemic of COVID-19–Associated Mucormycosis – careful use of antibiotics and corticosteroids and closely monitoring blood glucose levels are some of the strategies suggested by the authors.

Multicenter Epidemiologic Study of Coronavirus Disease–Associated Mucormycosis, India – Uncontrolled diabetes mellitus was the most common underlying disease; improper glucocorticoid use was independently associated with the disease.

Opinion | “Doctors have been blamed for the rise in black fungus in India, but the COVID treatment guidelines could be contributing” – improper use of antibiotics and higher than usual doses of corticosteroids may be contributing to the emergence of mucormycosis and other fungal co-infections.

What is mucormycosis, the fungal infection affecting COVID patients in India?

[Preprint] The Emergence of COVID-19 Associated Mucormycosis: Analysis of Cases From 18 Countries.

Mucormycosis: The ‘black fungus’ maiming Covid patients in India

Global Guideline for the Diagnosis and Management of Mucormycosis

 

SARS-COV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis.

28 Jul, 2021 | 10:13h | UTC

SARS-COV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis – American Journal of Obstetrics and Gynecology

 

WHO reports progress in the fight against tobacco epidemic – Highlights threats posed by new nicotine and tobacco products.

28 Jul, 2021 | 10:01h | UTC

News release: WHO reports progress in the fight against tobacco epidemic – World Health Organization

Report: WHO report on the global tobacco epidemic 2021: New and Emerging Products – World Health Organization

Commentary: While Global Tobacco Control Measures Improve, Electronic Cigarettes Evade Regulation in Many Countries – Health Policy Watch

 

Commentary on Twitter (thread – click for more)

 

Moral uncertainty: A case study of Covid-19.

28 Jul, 2021 | 10:05h | UTC

Moral uncertainty: A case study of Covid-19 – Patient Education and Counseling

 

Commentary on Twitter

 

RCT: 7 days of antibiotic therapy as good as 14 days for afebrile men with urinary tract infection.

28 Jul, 2021 | 10:03h | UTC

Effect of 7 vs 14 Days of Antibiotic Therapy on Resolution of Symptoms Among Afebrile Men With Urinary Tract Infection: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Shorter Courses of Antibiotics for Urinary Tract Infection in Men (free for a limited period)

Commentary: Study Supports Shorter Antibiotic Course for Afebrile Men With UTI – MPR

 

Commentary on Twitter

 

ESC Consensus Document: Antithrombotic therapies in aortic and peripheral arterial diseases in 2021.

28 Jul, 2021 | 09:56h | UTC

Antithrombotic therapies in aortic and peripheral arterial diseases in 2021: a consensus document from the ESC working group on aorta and peripheral vascular diseases, the ESC working group on thrombosis, and the ESC working group on cardiovascular pharmacotherapy – European Heart Journal

Key Points to remember: ESC Consensus on Antithrombotic Therapies in Aortic and Peripheral Artery Diseases – American College of Cardiology

 

Commentary on Twitter

 

CDC Report: Transmission of pan-resistant Candida auris in health care facilities.

28 Jul, 2021 | 09:59h | UTC

Notes from the Field: Transmission of Pan-Resistant and Echinocandin-Resistant Candida auris in Health Care Facilities ― Texas and the District of Columbia, January–April 2021 – CDC Morbidity and Mortality Weekly Report

Commentaries:

CDC reports two outbreaks of pan-resistant Candida auris – CIDRAP

U.S. sees first cases of dangerous fungus resistant to all drugs in untreated people – STAT

Related:

Case reports: Multidrug-resistant Candida auris infections in critically ill Covid-19 patients

Candida auris: A Review of Recommendations for Detection and Control in Healthcare Settings

Global Epidemiology of Emerging Candida Auris (reviews and commentaries on the subject)

The superbug Candida auris is giving rise to warnings — and big questions – STAT

Candida Auris – “A Mysterious Infection, Spanning the Globe in a Climate of Secrecy” (reviews and commentaries on the subject)

 

Commentaries on Twitter

 

Review: Anabolic Therapy for Osteoporosis.

28 Jul, 2021 | 09:48h | UTC

Anabolic Therapy for Osteoporosis – JAMA (free for a limited period)

Author interview: Anabolic Therapy for Osteoporosis

 

Amazon and Google are finally tackling one of healthcare’s biggest problems: unstructured health data.

28 Jul, 2021 | 09:50h | UTC

Amazon And Google Are Finally Tackling One Of Healthcare’s Biggest Problems: Unstructured Health Data – Forbes

 

Systematic review and meta-analysis of depression, anxiety, and suicidal ideation among Ph.D. students.

28 Jul, 2021 | 09:54h | UTC

Systematic review and meta-analysis of depression, anxiety, and suicidal ideation among Ph.D. students – Science Reports

 

Commentaries on Twitter

 

Expert consensus: Multimodality imaging of myocardial viability.

28 Jul, 2021 | 09:46h | UTC

Multimodality imaging of myocardial viability: an expert consensus document from the European Association of Cardiovascular Imaging (EACVI) – European Heart Journal – Cardiovascular Imaging

Related: Review | Myocardial perfusion and viability imaging in coronary artery disease: clinical value in diagnosis, prognosis and therapeutic guidance.

 

Commentary on Twitter

 

Rheumatoid arthritis-interstitial lung disease: manifestations and current concepts in pathogenesis and management.

28 Jul, 2021 | 09:44h | UTC

Rheumatoid arthritis-interstitial lung disease: manifestations and current concepts in pathogenesis and management – European Respiratory Review

 

The use and impact of monoclonal antibody biologics during pregnancy.

28 Jul, 2021 | 09:43h | UTC

The use and impact of monoclonal antibody biologics during pregnancy – Canadian Medical Association Journal

 

M-A of randomized trials: Conservative oxygen therapy for critically ill patients.

28 Jul, 2021 | 09:41h | UTC

Conservative oxygen therapy for critically ill patients: a meta-analysis of randomized controlled trials – Journal of Intensive Care

 

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