Daily Archives: July 12, 2021
[Preprint] Heparin for Moderately Ill Patients with Covid-19 – “In moderately ill ward patients with Covid-19 and elevated D-dimer level, therapeutic heparin did not significantly reduce the primary outcome but decreased the odds of death at 28 days”.
12 Jul, 2021 | 03:14h | UTCHeparin for Moderately Ill Patients with Covid-19 – medRxiv
Related: RCT: In patients hospitalized with Covid-19 with elevated D-Dimer, a full-dose anticoagulation strategy based on rivaroxaban (full-dose heparins in unstable patients) + rivaroxaban to day 30 was not better than prophylactic anticoagulation and increased bleeding risk. AND [Preprint] Practice Changing RCT: Therapeutic-dose anticoagulation with heparin (LMWH or unfractionated heparin) improves outcomes in non-critically ill patients with Covid-19 – the superiority of therapeutic-dose anticoagulation was seen in both high and low D-dimer groups. AND [Preprint] RCT: Full-dose/therapeutic anticoagulation provides no benefit in critically ill patients with Covid-19
Commentary on Twitter (thread – click for more)
?Final results of the RAPID trial now pub'd @medrxivpreprint ? RAPID was an open-label trial that randomly assigned hospitalized ward patients with COVID-19 and elevated D-dimer levels to therapeutic or prophylactic heparin. ? 1/10 https://t.co/oxiyXQAPeK pic.twitter.com/V2GtruEyM2
— Michelle Sholzberg (@sholzberg) July 9, 2021
New CDC Guidance for COVID-19 prevention in kindergarten schools says safely returning to in-person instruction is a priority.
12 Jul, 2021 | 03:11h | UTCCommentaries: Updated CDC schools guidance prioritizes in-person learning, even if all Covid-19 safety measures aren’t in place – CNN AND The C.D.C. Issues New School Guidance, With Emphasis on Full Reopening – The New York Times AND New CDC guidance says fully vaccinated teachers and students don’t need to wear masks indoors – CNBC AND CDC calls for reopening schools fully, recommends masking – CIDRAP
Related: COVID and schools: the evidence for reopening safely – Nature
[Preprint] Study confirms children’s extremely low risk of death from Covid-19 – “99·995% of children and young people with a positive SARS-CoV-2 test survived”.
12 Jul, 2021 | 03:12h | UTCCommentaries: Risks of severe illness in children from COVID-19 shown to be very low in largest study yet – University of Liverpool AND Covid: Children’s extremely low risk confirmed by study – BBC
Related study from the same group (preprint): Risk factors for intensive care admission and death amongst children and young people admitted to hospital with COVID-19 and PIMS-TS in England during the first pandemic year – medRxiv
RCT: Another study shows Azithromycin does not improve outcomes in patients with Covid-19.
12 Jul, 2021 | 03:09h | UTCCommentaries: Trial shows that the antibiotic azithromycin does not prevent mild COVID cases progressing to hospitalization, death – European Society of Clinical Microbiology and Infectious Diseases AND Azithromycin: can its benefit be ruled out in mild COVID-19? – The Lancet Respiratory Medicine
Related: M-A: Azithromycin does not reduce the need for invasive mechanical ventilation or mortality in patients with Covid-19. AND RCT: Azithromycin provides no benefit for community treatment of patients with suspected COVID-19 AND RECOVERY trial: Azithromycin not beneficial for patients admitted to hospital with COVID-19 AND [Press release – not published yet] Azithromycin and doxycycline are not generally effective against COVID-19 in patients treated at home, shows PRINCIPLE trial AND Coalition Covid-19 Brazil – Randomized trial: Azithromycin not beneficial for patients admitted to the hospital with severe Covid-19 AND Coalition Covid-19 Brazil – Randomized trial: hydroxychloroquine with or without azithromycin in mild-to-moderate Covid-19
Commentary on Twitter
In patients with mild-to-mod #COVID19 managed without hospital admission, azithromycin + SOC did not reduce the risk of subsequent hospital admission or death
Read the ATOMIC2 trial here https://t.co/QXJ7T08JZS, being presented at #ECCMID2021 by lead author Tim Hinks @HinksLab pic.twitter.com/ZDiPhuQqFB
— The Lancet Respiratory Medicine (@LancetRespirMed) July 9, 2021
A correlate of protection for SARS-CoV-2 vaccines is urgently needed – “Recent studies suggest that neutralizing antibodies could serve as a correlate of protection for vaccines against SARS-CoV-2 in humans”.
12 Jul, 2021 | 03:03h | UTCA correlate of protection for SARS-CoV-2 vaccines is urgently needed – Nature Medicine
Public Health England: COVID-19 vaccines highly effective in clinical risk groups.
12 Jul, 2021 | 03:06h | UTCCOVID-19 vaccines highly effective in clinical risk groups – Public Health England
Commentaries: Covid vaccines do work well in clinically vulnerable – BBC AND Public Health England says Pfizer, AstraZeneca vaccines effective in high-risk groups – Reuters
Commentary on Twitter (thread – click for more)
NEWS: #COVID19 #vaccines highly effective in clinical risk groupshttps://t.co/mkVnxTqOrJ pic.twitter.com/M6Me98SRln
— Public Health England (@PHE_uk) July 9, 2021
Pfizer says it’s time for a Covid booster; FDA and CDC say not so fast.
12 Jul, 2021 | 03:08h | UTCPfizer says it’s time for a Covid booster; FDA and CDC say not so fast – CNN
See also: CDC, FDA contradict Pfizer on COVID-19 vaccine booster – CIDRAP AND Do I need a COVID-19 booster shot? 6 questions answered on how to stay protected – The Conversation AND Pfizer suggests booster shots will be needed this year, but government officials say science will dictate the timing – The Washington Post AND Pfizer to seek OK for 3rd vaccine dose; shots still protect – Associated Press AND Citing the Delta Variant, Pfizer Will Pursue Booster Shots and a New Vaccine – The New York Times (a few articles per month are free) AND Question open on need for COVID booster shot, data awaited, WHO says – Reuters
Understanding the Host in the Management of Pneumonia. An Official American Thoracic Society Workshop Report.
12 Jul, 2021 | 01:41h | UTC
Can we stretch existing Covid vaccines to inoculate more people? Experts are divided.
12 Jul, 2021 | 03:05h | UTCCan we stretch existing Covid vaccines to inoculate more people? Experts are divided – STAT
See also: Quarter-dose of Moderna COVID vaccine still rouses a big immune response
Lambda, the Newest WHO Variant of Interest, is Now in 29 Countries.
12 Jul, 2021 | 03:06h | UTCLambda, the Newest WHO Variant of Interest, is Now in 29 Countries – Health Policy Watch
Benefits of mRNA COVID vaccines outweigh rare heart risks, says WHO.
12 Jul, 2021 | 03:02h | UTCBenefits of mRNA COVID vaccines outweigh rare heart risks, says WHO – Reuters
See also: EU finds potential link between heart inflammation and mRNA COVID shots – Reuters AND Heart inflammation link to Pfizer and Moderna jabs – BBC
Ranitidine absolved? FDA study finds Ranitidine does not convert to carcinogen NDMA, regardless of diet.
12 Jul, 2021 | 01:36h | UTCEditorial: Ranitidine and Risk of N-Nitrosodimethylamine (NDMA) Formation
Commentary: Ranitidine: FDA finds no evidence of elevated NDMA, regardless of diet
Commentaries on Twitter
Despite ranitidine (zantac) being pulled from market last year, a new study from the FDA did not find evidence that it increases concentrations of the carcinogenic metabolite people were worried about (i.e., it's probably safe). From @JAMA_current https://t.co/AdRic2GdXS
— Zack Williams (@QuantPsychiatry) June 28, 2021
In this crossover, randomized clinical trial, oral ranitidine did not significantly increase 24-hour urinary excretion of NDMA when administered with a noncured-meats diet or a cured-meats diet. https://t.co/EszRvfJOFJ
— JAMA (@JAMA_current) June 28, 2021
AHA Scientific Statement: Assessing and Addressing Cardiovascular Health in People Who Are Transgender and Gender Diverse.
12 Jul, 2021 | 01:43h | UTCNews release: Discrimination, stress linked to poorer heart health in transgender, gender diverse adults – American Heart Association
Clinical Practice Guideline for Postoperative Rehabilitation in Older Patients With Hip Fractures.
12 Jul, 2021 | 01:39h | UTCRelated: Guideline for the perioperative management of hip fractures 2020
Review: Lipoprotein(a) and cardiovascular diseases.
12 Jul, 2021 | 01:33h | UTCLipoprotein(a) and Cardiovascular Diseases – JAMA (free for a limited period)
Review: Diagnosis and Management of Infertility.
12 Jul, 2021 | 01:34h | UTCDiagnosis and Management of Infertility: A Review – JAMA (free for a limited period)
Commentary on Twitter
Although success rates vary by age and diagnosis, accurate diagnosis and effective therapy along with shared decision-making can facilitate achievement of fertility goals in many couples treated for #infertility https://t.co/7nR0nuFC3K
— JAMA (@JAMA_current) July 9, 2021
RCT: Another study shows that non-antibiotic outpatient treatment in mild acute diverticulitis is safe.
12 Jul, 2021 | 01:29h | UTCEfficacy and Safety of Non-Antibiotic Outpatient Treatment in Mild Acute Diverticulitis (DINAMO-study): A Multicentre, Randomised, Open-Label, Non-Inferiority Trial – Annals of Surgery (link to abstract – $ for full-text)
Related: State of the Art Review: Management of colonic diverticulitis AND Treatment of Uncomplicated Acute Diverticulitis Without Antibiotics: A Systematic Review and Meta-analysis – Diseases of the Colon & Rectum AND Antibiotics Do Not Reduce Length of Hospital Stay for Uncomplicated Diverticulitis in a Pragmatic Double-Blind Randomized Trial – Clinical Gastroenterology and Hepatology AND Randomized Trial: Antibiotic Avoidance Associated with Similar Long-term Outcomes in Uncomplicated Diverticulitis
Commentary on Twitter
Another (final?) nail in the coffin for antibiotics in uncomplicated diverticulitis? DINAMO study from Spain – Outpatient treatment with antibiotics versus symptomatic Tx.
No difference in hospitalization rate or revisits to ER.https://t.co/wOc3tBGfxr @AnnalsofSurgery
— Ville Sallinen (@villesallinen) July 9, 2021
Landmark research integrity survey finds questionable practices are surprisingly common.
12 Jul, 2021 | 01:32h | UTCLandmark research integrity survey finds questionable practices are surprisingly common – Science (a few articles per month are free)
Original studies (preprint): Prevalence of questionable research practices, research misconduct and their potential explanatory factors: a survey among academic researchers in The Netherlands – MetaArXiv AND Prevalence of responsible research practices and their potential explanatory factors: a survey among academic researchers in The Netherlands – MetaArXiv
Related: Opinion | Time to assume that health research is fraudulent until proven otherwise?
Editorial: Aducanumab for Alzheimer’s disease?
12 Jul, 2021 | 01:15h | UTCAducanumab for Alzheimer’s disease? – The BMJ
Related: FDA approvement of Alzheimer’s drug sparks controversy among doctors.
Commentary on Twitter
Our editorial for @bmj_latest on the controversial #Aducanumab approval and what it means for patients, clinicians and researchers.
With @seb_walsh, Richard Milne @ethicsWCS, Carol Brayne @CamPubHealth https://t.co/mnhh4F1gKK— Richard Merrick (@r_merrick) July 9, 2021
RCT: Traditional plaster casting immobilization not superior to removable brace in adults with an ankle fracture.
12 Jul, 2021 | 01:22h | UTCNews release: Cast no better than brace for broken ankles – University of Warwick
Review: most common joint procedures not backed by high quality evidence – “Urgent need exists to prioritize research into common orthopedic interventions”.
12 Jul, 2021 | 01:26h | UTCNews release: Most common joint procedures not backed by high quality evidence – The BMJ
Original study: Common elective orthopaedic procedures and their clinical effectiveness: umbrella review of level 1 evidence – The BMJ
Commentary on Twitter
This review of the 10 most common elective orthopaedic procedures suggests that most of these procedures recommended by national guidelines and used by surgeons have insufficient readily available, high quality evidence on their clinical effectivenesshttps://t.co/63B7XEXeyh
— The BMJ (@bmj_latest) July 10, 2021
Recommendations for including or reviewing patient reported outcome endpoints in grant applications.
12 Jul, 2021 | 01:12h | UTC