Daily Archives: May 27, 2021
Count the cost of disability caused by COVID-19 – “Focusing only on cases and deaths hides the pandemic’s lasting health burden on people, societies and economies”.
27 May, 2021 | 08:35h | UTCCount the cost of disability caused by COVID-19 – Nature
RCT: 2 inactivated SARS-CoV-2 vaccines show efficacy of 72.8% and 78.1% on symptomatic COVID-19 infection in adults.
27 May, 2021 | 08:38h | UTCCommentary: China’s Sinopharm Publishes Awaited Covid Vaccine Study Details – Bloomberg
Commentary on Twitter (thread – click for more)
https://twitter.com/hildabast/status/1397678056270012419
Systematic review of 45 studies including 9751 participants, most of which were hospitalized, found 73% had at least 1 persistent symptom for weeks after Covid-19.
27 May, 2021 | 08:37h | UTCCommentary: Seven out of ten hospitalized COVID-19 patients will have long-haul symptoms – MedicalXpress
Can people vaccinated against COVID-19 still spread the coronavirus? – “Preliminary evidence seems to suggest the COVID-19 vaccines make it less likely someone who’s vaccinated will transmit the coronavirus”.
27 May, 2021 | 08:27h | UTCCan people vaccinated against COVID-19 still spread the coronavirus? – The Conversation
Related: Indirect Protection by Reducing Transmission: Ending the Pandemic with SARS-CoV-2 Vaccination – “Tell the hesitant: the vaccines protect both you and protect others — a lot!”
[Preprint] More data showing a single-dose SARS-CoV-2 mRNA vaccine may be enough in individuals with previous COVID-19.
27 May, 2021 | 08:31h | UTCSingle-dose SARS-CoV-2 vaccine in a prospective cohort of COVID-19 patients – medRxiv
See also: SARS-CoV-2 vaccines for all but a single dose for COVID-19 survivors – EClinicalMedicine
Related: Another study shows a single dose of mRNA vaccine may be enough for patients with previous Covid-19
Commentaries on Twitter
If you had prior covid and you're wondering about getting vaccinated, here's a new prospective study showing single dose -> marked neutralizing antibody protection to the major variants AND again more than without prior covid and 2 mRNA doses https://t.co/k9v5gEDn2M pic.twitter.com/Z8nT3pL04v
— Eric Topol (@EricTopol) May 26, 2021
One dose of vaccine for prior covid.
Change the policy. Avoid unnecessary side effects and instead of wasting vaccine doses get them to the people around the world in needhttps://t.co/ODhx5kgAnq @EBioMedicine @MattFrieman @VivianaSimonLab @florian_krammer pic.twitter.com/oAeju9AASm— Eric Topol (@EricTopol) May 26, 2021
COVID Morbidity – The emerging burden of long COVID is significant, and needs to be considered when evaluating the risk vs. benefit of pandemic measures.
27 May, 2021 | 08:34h | UTCCOVID Morbidity – Science-Based Medicine
Opinion | Rich countries cornered COVID-19 vaccine doses. Four strategies to right a ‘scandalous inequity’.
27 May, 2021 | 08:29h | UTCRich countries cornered COVID-19 vaccine doses. Four strategies to right a ‘scandalous inequity’ – Science (a few articles per month are free)
Commentary on Twitter
Tedros @WHO calls it a "scandalous inequity" that COVID-19 vaccine doses largely have gone to wealthy countries. @kakape and I took a close look at four strategies to improve access and equity–and the likely timelines.
https://t.co/10Os0yCnFE pic.twitter.com/RMeL6t8aCV— Jon Cohen (@sciencecohen) May 26, 2021
Moderna says its Covid vaccine is 100% effective in teens, plans to seek FDA OK in early June.
27 May, 2021 | 08:25h | UTCModerna says its Covid vaccine is 100% effective in teens, plans to seek FDA OK in early June – CNBC
Commentary on Twitter
BREAKING: Moderna study of more than 3,700 12- to 17-year olds found 100% effficacy in those who received 2-dose #covid19 #vaccine, no significant safety problems. Will apply for FDA authorization.https://t.co/l0MHiLjCcA
— Leana Wen, M.D. (@DrLeanaWen) May 25, 2021
RCT: Among patients with prosthetic joint infection, antibiotic therapy for 6 weeks was NOT shown to be noninferior to antibiotic therapy for 12 weeks and resulted in a higher percentage of patients with unfavorable outcomes.
27 May, 2021 | 08:20h | UTCAntibiotic Therapy for 6 or 12 Weeks for Prosthetic Joint Infection – New England Journal of Medicine (link to abstract – $ for full-text)
Study suggests it is safe to discontinue antiseizure medication for most neonates with acute symptomatic seizures prior to discharge from the hospital.
27 May, 2021 | 08:14h | UTCSafety of Early Discontinuation of Antiseizure Medication After Acute Symptomatic Neonatal Seizures – JAMA Neurology (free for a limited period)
Editorial: Discontinuing Antiseizure Medication in Neonates With Acute Symptomatic Seizures—Primum non nocere – JAMA Neurology (free for a limited period)
Commentaries: Stopping Antiseizure Medication After Acute Symptomatic Neonatal Seizures Is Found to Be Safe – Neurology Today AND Babies with Seizures May Be Overmedicated – Michigan Medicine
Commentary on Twitter
New CER study on @JAMANeuro finds no difference in functional neurodevelopment or epilepsy at 24 mnths in children whose antiseizure meds was discont'd vs maintained at discharge after resolution of acute symptomatic neonatal seizures: https://t.co/yvKbrJuCvQ #ebneoalerts #neoEBM pic.twitter.com/810weSUSgb
— Evidence-Based Neo (@EBNEO) May 26, 2021
RCT: First-attempt intubation success is increased with the use an endotracheal tube + stylet vs. an endotracheal tube alone.
27 May, 2021 | 08:16h | UTC
Commentary on Twitter
Endotracheal tube + stylet vs tube alone, RCT
➡️999 critically ill adults
➡️significantly higher first-attempt intubation success 78.2% vs 71.5%
➡️related complications 38.7% vs 40.2%
➡️similar rate of serious adverse events (traumatic injuries) 4% vs 3.6%https://t.co/EQ6sqS75hN pic.twitter.com/zF9PguNCSK— Intensive Care Medicine (@yourICM) May 26, 2021
Global cardiovascular organizations release joint opinion on achieving the ‘tobacco endgame’.
27 May, 2021 | 08:22h | UTCNews release: Global cardiovascular organizations release joint opinion on achieving the ‘tobacco endgame’ – American College of Cardiology
Commentary: The Tobacco Endgame—Eradicating a Worsening Epidemic – American College of Cardiology
RCT: Immediate “kangaroo mother care” improves survival in infants with low birth weight compared to conventional care with “kangaroo mother care” initiated after stabilization.
27 May, 2021 | 08:18h | UTCCommentary: Immediate skin-to-skin contact after birth improves survival of pre-term babies – Karolisnka Institutet
Related: RCT: Community-initiated kangaroo mother care reduced the risk of moderate-to-severe maternal postpartum depressive symptoms among mothers of low-birth-weight infants in low-income areas in India AND WHO: New research highlights risks of separating newborns from mothers during COVID-19 pandemic AND Randomized Trial: Kangaroo Mother Care Improves Survival of Infants with Low Birthweight