Daily Archives: April 23, 2021
Long Covid: Largest post-acute COVID-19 study to date examined the health outcomes in more than 73,000 people who’d had COVID-19 and were not hospitalized
23 Apr, 2021 | 08:48h | UTCHigh-dimensional characterization of post-acute sequalae of COVID-19 – Nature
Commentary on Twitter (thread – click for more)
Happy to share the latest paper from our team in @nature
A comprehensive characterization of post acute sequelae of COVID-19#longcovid #PASChttps://t.co/AGLnYCamWe@VAResearch @vahsrd @WUSTL @WUSTLpubhealth @WUSTLmed @WUSTLnews @VREFSTL @Biostayan @BCBowe
— Ziyad Al-Aly, MD (@zalaly) April 22, 2021
NIH Updates COVID-19 Treatment Guidelines – adds recommendations on colchicine, fluvoxamine, and monoclonal antibodies
23 Apr, 2021 | 08:46h | UTCNIH Coronavirus Disease 2019 (COVID-19)
Treatment Guidelines – National Institutes of Health
RCT: COVID outpatients don’t benefit from hydroxychloroquine, lopinavir-ritonavir
23 Apr, 2021 | 08:42h | UTCCOVID outpatients don’t benefit from hydroxychloroquine, lopinavir-ritonavir – CIDRAP
Commentary on Twitter (thread – Click for more)
1/ No benefit from Hydroxychloroquine or Lopinavir-Ritonavir on Hospitalization/Viral clearance for COVID-19 https://t.co/yhXxv26418 via @JAMANetworkOpen part of @JAMANetwork
— Priya Sampathkumar (@PSampathkumarMD) April 22, 2021
Case series of 18 male adults aged 50 years or younger with acute ischemic stroke during the convalescent phase of asymptomatic Covid-19
23 Apr, 2021 | 08:39h | UTC
Commentary on Twitter
A ?? case series highlights that adults 50 years or younger with asymptomatic COVID-19 infection diagnosed by positive SARS-CoV-2 serological test result may present with ischemic stroke during the convalescent phase of the infection
https://t.co/BVlo7Z1hgn @JAMANetworkOpen— Antibiotic Steward??Bassam Ghanem (@ABsteward) April 22, 2021
Covid-19: More data on the increased risks to pregnant women and their newborn infants
23 Apr, 2021 | 08:44h | UTCEditorial: COVID-19 in Pregnant Women and Their Newborn Infants
Commentaries: Pregnant women with COVID-19 face high mortality rate – University of Washington School of Medicine AND Covid-19 raises risks for expectant mothers and babies, study says – CNN
Commentary on Twitter
18 country study in >2000 pregnant women with and without #COVID19 shows higher complication and death rates in symptomatic, but not asymptomatic, women with COVID-19. Their babies were at greater risk of neonatal complications, mainly due to preterm birth https://t.co/mRl8OOIMsz
— JAMA Pediatrics (@JAMAPediatrics) April 22, 2021
Covid-19: What do we know about airborne transmission of SARS-CoV-2?
23 Apr, 2021 | 08:33h | UTCCovid-19: What do we know about airborne transmission of SARS-CoV-2? – The BMJ
Related: Ten scientific reasons in support of airborne transmission of SARS-CoV-2 AND Editorial: Covid-19 has redefined airborne transmission
COVID vaccines and kids: five questions as trials begin
23 Apr, 2021 | 08:37h | UTCCOVID vaccines and kids: five questions as trials begin – Nature
Related perspective: Do Kids Really Need to Be Vaccinated for Covid? Yes. No. Maybe. – Undark
Systematic review shows there is insufficient evidence on the best approaches to stop long‐term antidepressant use – “Future studies should distinguish carefully between relapse and withdrawal symptoms”
23 Apr, 2021 | 08:19h | UTCAuthor interview: Stopping long-term antidepressants in people with depression or anxiety – Cochrane Library
Commentary: ‘Urgent’ need for more evidence on safely stopping antidepressants, say experts – Metro
“Future studies should distinguish carefully between relapse and withdrawal symptoms and follow emerging guidance to use taper schemes of many weeks or months (or longer for long-term users) down to very low doses before stopping. Such studies would give us a clearer idea of the ability of antidepressants to prevent relapse.”
Commentary on Twitter (thread – click for more)
Outline of the Cochrane study a bit for those scared of its length. Metro article: https://t.co/3c32xjGJsr Lead author: the dauntless Ellen van Leuween. Co-author @tony_kendrick https://t.co/tt4Lzyacq4 While there are hundreds of studies looking at starting antidepressants(1/n)
— Mark Horowitz (@markhoro) April 22, 2021
Viewpoint | Remote Research and Clinical Trial Integrity During and After the Coronavirus Pandemic
23 Apr, 2021 | 08:34h | UTCRemote Research and Clinical Trial Integrity During and After the Coronavirus Pandemic – JAMA
AHA Scientific Statement: Obesity and Cardiovascular Disease
23 Apr, 2021 | 08:22h | UTCNews Release: More belly weight increases danger of heart disease even if BMI does not indicate obesity – American Heart Association
Perioperative hemodynamic optimization: from guidelines to implementation—an experts’ opinion paper
23 Apr, 2021 | 08:21h | UTC
RCT: Treatments for vulnerable older adult women with ovarian cancer compared
23 Apr, 2021 | 08:15h | UTCEfficacy and Safety of First-line Single-Agent Carboplatin vs Carboplatin Plus Paclitaxel for Vulnerable Older Adult Women With Ovarian Cancer: A Randomized Clinical Trial – JAMA Oncology (free for a limited period)
Editorial: Vulnerable Older Adults With Ovarian Cancer—Time to Stop Undertreating (free for a limited period)
Systematic review: Abdominal ultrasound and alpha‐foetoprotein for the diagnosis of hepatocellular carcinoma in adults with chronic liver disease
23 Apr, 2021 | 08:17h | UTC
Systematic Review: PARP (Poly ADP‐Ribose Polymerase) inhibitors for locally advanced or metastatic breast cancer
23 Apr, 2021 | 08:16h | UTCSummary: PARP inhibitors for locally advanced or metastatic breast cancer – Cochrane Library
Survey: Despite guideline recommendations, many patients with low-risk thyroid cancer continue to be treated with suppressive doses of thyroid hormone
23 Apr, 2021 | 08:13h | UTCTSH Suppression for Papillary Thyroid Cancer: A Physician Survey Study – Thyroid (link to abstract – $ for full-text)
Commentary on Twitter
Hot off the press. We found that many patients with low-risk thyroid cancer continue to be treated with suppressive doses of thyroid hormone, emphasizing the need for more research to better guide thyroid cancer management. @AmThyroidAssn @UMRogelCancer https://t.co/iU3ObzQxBQ
— Maria Papaleontiou, MD (@MariaPapaleont1) March 30, 2021
Long-Term Cardiovascular Outcomes in Systemic Lupus Erythematosus
23 Apr, 2021 | 08:08h | UTCCardiovascular Outcomes in Systemic Lupus Erythematosus – American College of Cardiology
Original study: Long-Term Cardiovascular Outcomes in Systemic Lupus Erythematosus – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Do you really need to drink 8 glasses of water a day? An exercise scientist explains why your kidneys say ‘no’
23 Apr, 2021 | 08:11h | UTC
AGA recommends intragastric balloons as an additional weight loss option for obese patients
23 Apr, 2021 | 08:10h | UTCOriginal article: AGA Clinical Practice Guidelines on Intragastric Balloons in the Management of Obesity – Gastroenterology
New-Generation Antibiotics for Treatment of Gram-Positive Infections: A Review with Focus on Endocarditis and Osteomyelitis
23 Apr, 2021 | 08:06h | UTC
An Update on Eight “New” Antibiotics against Multidrug-Resistant Gram-Negative Bacteria
23 Apr, 2021 | 08:05h | UTC