Daily Archives: April 21, 2021
ISTH Interim Guidance for the Diagnosis and Treatment on Vaccine Induced Immune Thrombotic Thrombocytopenia
21 Apr, 2021 | 07:11h | UTCSee also: Diagnostic Flow Chart
Commentary on Twitter
The ISTH has released interim guidance on vaccine-induced immune thrombotic thrombocytopenia (#VITT) to inform the management of suspected thrombosis in subjects who have recently received the AstraZeneca or Johnson & Johnson vaccine. https://t.co/qqtQtpywaf pic.twitter.com/wNmjNNDs4z
— ISTH (@isth) April 20, 2021
NICE Guideline | Neonatal infection: antibiotics for prevention and treatment
21 Apr, 2021 | 06:46h | UTC
NICE Guideline | Postnatal care
21 Apr, 2021 | 06:43h | UTCPostnatal care – National Institute for Health and Care Excellence
Cohort study: Increased bleeding risk with no therapeutic benefit with the addition of aspirin to direct oral anticoagulant therapy when there is not a clear indication
21 Apr, 2021 | 06:34h | UTCAdverse Events Associated With the Addition of Aspirin to Direct Oral Anticoagulant Therapy Without a Clear Indication – JAMA Internal Medicine (free for a limited period)
Commentaries: DOAC + Aspirin Common Without Clear Indication, Tied to More Bleeding – NEJM Journal Watch AND Many AFib patients wrongly prescribed aspirin therapy, study finds – UPI
Commentary on Twitter
Obs study in @JAMAInternalMed finds aspirin is often prescribed along w/ direct acting oral anticoagulant without clear reason and the combo *associates* w higher rates of bleeding https://t.co/nKsWtLnjr9
Good one @GBarnesMD
ASA is the number 1 drug I #deprescribe
— John Mandrola, MD (@drjohnm) April 19, 2021
Systematic review: Thrombolytic therapy for acute massive or submassive pulmonary embolism
21 Apr, 2021 | 06:20h | UTCThrombolytic therapy for pulmonary embolism – Cochrane Library
Summary: Drugs to dissolve pulmonary embolism (blood clot in the lungs) – Cochrane Library
Study: Postprandial glycemic dips predict appetite and energy intake in healthy individuals
21 Apr, 2021 | 06:36h | UTCCommentaries: New research reveals why some of us are hungry all the time – King’s College London AND The easy test that predicts the size of your next few meals – Nature AND Feeling Hungry All The Time? Scientists Have a New Explanation For What’s Going On – Science Alert
Commentary on Twitter
Research published in @NatMetabolism reports that people who experience big dips in blood sugar levels several hours after eating end up feeling hungrier and consume more calories during the day than others. https://t.co/Nee9EYMUZ0 pic.twitter.com/VDgmvwiPjQ
— Nature Research (@nresearchnews) April 14, 2021
Review: Dosing Fluids in Early Septic Shock
21 Apr, 2021 | 06:19h | UTCDosing Fluids in Early Septic Shock – CHEST
USPSTF Draft Statement: Insufficient evidence to recommend screening for atrial fibrillation
21 Apr, 2021 | 06:42h | UTCCommentary: Little evidence supports AFib screening in stroke prevention, group says – UPI
A Knee MRI in Half the Time? It’s Possible
21 Apr, 2021 | 06:24h | UTCA Knee MRI in Half the Time? It’s Possible – Diagnostic Imaging
Original study: Five-Minute Five-Sequence Knee MRI Using Combined Simultaneous Multislice and Parallel Imaging Acceleration: Comparison with 10-Minute Parallel Imaging Knee MRI – Radiology (link to abstract – $ for full-text)
Commentary on Twitter
RADIOLOGY New: Dr. Jan Fritz @NYUImaging, 252 adults assessing a 5 min #MRI protocol, excellent results. https://t.co/hcMY34dJSI @radiology_rsna pic.twitter.com/OPdd7NOUWb
— David Bluemke (@RadiologyEditor) April 13, 2021
COVID-19 Vaccine Janssen: EMA finds possible link to very rare cases of unusual blood clots with low blood platelets
21 Apr, 2021 | 07:07h | UTCCommentary: Johnson & Johnson vaccine: EU regulator says blood clot very rare side effect – BBC
Commentary on Twitter
EMA has concluded there is a possible link between TTS (thrombosis & thrombocytopenia syndrome) & the J&J vaccine, & they will be adding it as a rare side effect to the product information: the same as for AZ, but so far reported at a much lower rate…1/n https://t.co/aonOEObeHR
— Hilda Bastian, PhD (@hildabast) April 20, 2021
Vaccine-induced Immune Thrombotic Thrombocytopenia: Frequently Asked Questions
21 Apr, 2021 | 07:09h | UTC
WHO panel comes out against requiring vaccination proof for travel
21 Apr, 2021 | 07:03h | UTCWHO panel comes out against requiring vaccination proof for travel – The Hill
Related: Opinion | How to lose friends and alienate people? On the problems of vaccine passports (several texts on the subject)
What do we know about India’s Covaxin vaccine?
21 Apr, 2021 | 07:05h | UTCWhat do we know about India’s Covaxin vaccine? – The BMJ
We know a lot about Covid-19. Experts have many more questions
21 Apr, 2021 | 07:02h | UTCWe know a lot about Covid-19. Experts have many more questions – STAT
Bioethics | COVID: Is it OK to manipulate people into getting vaccinated?
21 Apr, 2021 | 07:00h | UTCCOVID: Is it OK to manipulate people into getting vaccinated? – The Conversation
Guideline Synopsis: Management of Acute Coronary Syndromes in Patients Without Persistent ST-Segment Elevation
21 Apr, 2021 | 06:41h | UTCManagement of Acute Coronary Syndromes in Patients Without Persistent ST-Segment Elevation – JAMA (free for a limited period)
Original guideline: #ESCCongress – 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation AND Summary: The ‘Ten Commandments’ for the 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation – European Heart Journal
Another study shows SARS-CoV-2 variant B.1.1.7 is more transmissible than the original virus
21 Apr, 2021 | 06:58h | UTCCommentary: The British variant is 45% more contagious than the original virus – Tel Aviv University
Related: New studies suggest SARS-CoV-2 variant B.1.1.7 is not more deadly, just more transmissible AND Study confirms higher transmissibility of SARS-CoV-2 lineage B.1.1.7
Large clinical trial to study repurposed drugs to treat COVID-19 symptoms
21 Apr, 2021 | 06:59h | UTCLarge clinical trial to study repurposed drugs to treat COVID-19 symptoms – NIH News Releases
Review: Perioperative Management of the Patient With Obstructive Sleep Apnea
21 Apr, 2021 | 06:18h | UTC
M-A: Progestogens for preventing miscarriage
21 Apr, 2021 | 06:22h | UTCProgestogens for preventing miscarriage: a network meta‐analysis – Cochrane Library
Summary: Are progestogen treatments effective in preventing miscarriage? – Cochrane Library
Related Meta-analysis: Evaluating Progestogens for Preventing Preterm birth International Collaborative (EPPPIC): meta-analysis of individual participant data from randomised controlled trials – The Lancet (link to abstract – $ for full-text)
M-A: Portal venous system thrombosis after bariatric surgery
21 Apr, 2021 | 06:16h | UTCPortal venous system thrombosis after bariatric surgery: A systematic review and meta-analysis – Surgery (link to abstract – $ for full-text)