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Daily Archives: April 7, 2021

RCT: Celecoxib for 3 years added to standard adjuvant therapy does not improve disease-free survival among patients with stage III colon cancer

7 Apr, 2021 | 01:28h | UTC

Effect of Celecoxib vs Placebo Added to Standard Adjuvant Therapy on Disease-Free Survival Among Patients With Stage III Colon Cancer: The CALGB/SWOG 80702 (Alliance) Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Celecoxib for Stage III Colon Cancer – JAMA (free for a limited period)

 

RCT: Among patients with peripheral artery disease, low-intensity exercise was significantly less effective than high-intensity exercise for improving 6-minute walk distance

7 Apr, 2021 | 01:31h | UTC

Effect of Low-Intensity vs High-Intensity Home-Based Walking Exercise on Walk Distance in Patients With Peripheral Artery Disease: The LITE Randomized Clinical Trial – JAMA (free for a limited period)

Commentary: No pain, no gain in exercise for peripheral artery disease – ‘You’ve got to walk with pain to reap benefits’ – Northwestern University

 

Commentary on Twitter

 

Short review | Assessment and management of dysphagia and achalasia

7 Apr, 2021 | 01:13h | UTC

Assessment and management of dysphagia and achalasia – Clinical Medicine Journal

 

Commentary on Twitter

 

A method for tapering antipsychotic treatment that may minimize the risk of relapse

7 Apr, 2021 | 01:25h | UTC

A Method for Tapering Antipsychotic Treatment That May Minimize the Risk of Relapse – Schizophrenia Bulletin

Commentary: To avoid withdrawal symptoms, patients should slowly decrease doses of antipsychotics over months or even years – University College London

 

Commentary on Twitter (thread – click for more)

 

Consensus Document: Management of the complications of long term indwelling catheters

7 Apr, 2021 | 01:20h | UTC

British Association of Urological Surgeons (BAUS) and Nurses (BAUN) Consensus Document: Management of the Complications of Long Term Indwelling Catheters – BJU International

 

CDC Updated Guidance: “It is possible for people to be infected through contact with contaminated surfaces or objects, but the risk is generally considered to be low”

7 Apr, 2021 | 02:00h | UTC

Science Brief: SARS-CoV-2 and Surface (Fomite) Transmission for Indoor Community Environments – Centers for Disease Control and Prevention

Related: Catching COVID from surfaces is very unlikely. So perhaps we can ease up on the disinfecting – The Conversation AND Coronavirus is in the air — there’s too much focus on surfaces – Nature AND COVID-19 rarely spreads through surfaces. So why are we still deep cleaning? – Nature

 

M-A: Antenatal corticosteroids for impending late preterm (34-36+6 weeks) deliveries

7 Apr, 2021 | 01:22h | UTC

Antenatal corticosteroids for impending late preterm (34-36+6 weeks) deliveries—A systematic review and meta-analysis of RCTs – PLOS One

 

Identifying and managing functional cardiac symptoms

7 Apr, 2021 | 01:15h | UTC

Identifying and managing functional cardiac symptoms – Clinical Medicine Journal

 

Practical Guide: Perioperative Pain Management and Opioid Stewardship

7 Apr, 2021 | 01:17h | UTC

Perioperative Pain Management and Opioid Stewardship: A Practical Guide – Healthcare

 

Cohort study: Risk of suicide attempt in patients with recent diagnosis of mild cognitive impairment or dementia

7 Apr, 2021 | 01:08h | UTC

Risk of Suicide Attempt in Patients With Recent Diagnosis of Mild Cognitive Impairment or Dementia – JAMA Psychiatry (link to abstract – $ for full-text)

Commentaries: Recent Diagnosis of Cognitive Impairment, Dementia May Increase Suicide Risk – Psychiatric News Alert AND Suicide Attempts Spike Soon After Dementia Diagnosis – HealthDay

 

Systematic review: Selective serotonin re‐uptake inhibitors for premature ejaculation in adult men

7 Apr, 2021 | 01:10h | UTC

Selective serotonin re‐uptake inhibitors for premature ejaculation in adult men – Cochrane Library

 

Differences in susceptibility of circulating SARS-CoV-2 variants B.1.1.7 and B.1.351 to neutralization by convalescent plasma or vaccinee (Sinopharm or Sinovac) serum

7 Apr, 2021 | 01:57h | UTC

Susceptibility of Circulating SARS-CoV-2 Variants to Neutralization – New England Journal of Medicine

Related studies: Another study indicates SARS-CoV-2 variant B.1.351, but not variant B.1.1.7, has partial resistance to neutralizing antibodies generated by natural infection or mRNA vaccination – Nature Medicine AND Pfizer coronavirus vaccine found to be moderately less effective against B.1.351 variant AND SARS-CoV-2 variants B.1.351 and P.1 can escape from therapeutic antibodies and evade antibodies induced by infection or mRNA vaccination AND B.1.351 strain of SARS-CoV-2 neutralization titer reduced 8- to 9-fold for Pfizer and AstraZeneca vaccinees. Convalescent plasma and therapeutic antibodies were less effective against this variant as well. AND RCT: Oxford/AstraZeneca vaccine does not protect against mild-to-moderate Covid-19 due to the B.1.351 variant AND New study of Coronavirus variants predicts virus evolving to escape current vaccines, treatments AND Moderna COVID-19 vaccine may be less effective against variant found in South Africa

 

Commentary on Twitter

 

Guidance on syndrome of Thrombosis and Thrombocytopenia occurring after coronavirus Vaccination

7 Apr, 2021 | 01:48h | UTC

Guidance produced from the Expert Haematology Panel (EHP) focussed on syndrome of Thrombosis and Thrombocytopenia occurring after coronavirus Vaccination – British Society of Haematology

Related: Exceedingly rare side effects reported with AstraZeneca vaccine in the UK – 22 cases of cerebral venous sinus thrombosis with low levels of platelets out of 18 million vaccinated individuals

 

Commentary on Twitter

 

Epidemiology of Multisystem Inflammatory Syndrome in Children: A Step Closer to Understanding Who, Where, and When

7 Apr, 2021 | 01:52h | UTC

Editorial: Epidemiology of Multisystem Inflammatory Syndrome in Children: A Step Closer to Understanding Who, Where, and When – JAMA Pediatrics

Original study: Trends in Geographic and Temporal Distribution of US Children With Multisystem Inflammatory Syndrome During the COVID-19 Pandemic – JAMA Pediatrics

Commentaries: New findings in COVID-related kids’ syndrome, Kawasaki disease – CIDRAP AND Most kids with serious inflammatory illness had mild COVID – Associated Press

 

Opinion | New COVID variants have changed the game, and vaccines will not be enough. We need global ‘maximum suppression’

7 Apr, 2021 | 01:44h | UTC

New COVID variants have changed the game, and vaccines will not be enough. We need global ‘maximum suppression’ – The Conversation

 

Commentary on Twitter

 

Antibody persistence for at least 6 months after the second dose of mRNA vaccine (Moderna) for Covid-19

7 Apr, 2021 | 01:54h | UTC

Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for Covid-19 – New England Journal of Medicine

Commentary: Moderna COVID Vaccine Offers Protection for at Least 6 Months: Study – HealthDay

Related: [Press release – not published yet] Pfizer/BioNTech vaccine is 91% effective for at least 6 months

 

Commentary on Twitter

 

What’s the new coronavirus variant in India and how should it change their COVID response?

7 Apr, 2021 | 01:42h | UTC

What’s the new coronavirus variant in India and how should it change their COVID response? – The Conversation

 

Covid-19: Italy makes vaccination mandatory for healthcare workers

7 Apr, 2021 | 01:39h | UTC

Covid-19: Italy makes vaccination mandatory for healthcare workers – The BMJ

 

Large study showed no association between blood group types and increased risk of Covid-19

7 Apr, 2021 | 01:41h | UTC

Association of Sociodemographic Factors and Blood Group Type With Risk of COVID-19 in a US Population – JAMA Network Open

 

Commentary on Twitter

 

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