Daily Archives: April 5, 2021
M-A: High versus low PEEP levels for mechanically ventilated adult patients with acute lung injury and ARDS
5 Apr, 2021 | 01:19h | UTC
Cohort Study: Selected patients with Covid-19 can be safely discharged on home oxygen, with low mortality and readmission rates
5 Apr, 2021 | 01:52h | UTCVideo: Home Oxygen Instructions for Discharged Patients With COVID-19
Commentaries: Covid-19: Ambulatory Management with Home Oxygen Results in Low Mortality, Low Readmissions – Physician’s Weekly AND Mortality, readmission low with COVID-19 discharge on home oxygen – HealthDay
Commentaries on Twitter
Is “HOME O2” safe in #COVID19? @JAMANetworkOpen
N=621 #COVID Pts D/Ced on O2 instead of being kept in hosp. 20% BMI>30, 33% HTN/DM. Only 1.2% 30-d Mort rate & only 8.5% returned for hosp admission. Safe is done right!https://t.co/clZAzEqWwy#medtwitter #CriticalCare #Nurse pic.twitter.com/EInhCdcN6f— WesElyMD (@WesElyMD) April 3, 2021
Cohort study finds #COVID19 patients discharged with home oxygen from the LA safety net public hospital system using an innovative program had similar outcomes to patients not requiring home oxygen. @BradSpellberg @LACUSCMedCenter https://t.co/kZrxVKHB5F
— JAMA Network Open (@JAMANetworkOpen) April 1, 2021
M-A: Secondary prevention of variceal bleeding in adults with previous esophageal variceal bleeding due to decompensated liver cirrhosis
5 Apr, 2021 | 01:17h | UTC
How mRNA Technology Could Change the World
5 Apr, 2021 | 01:36h | UTCHow mRNA Technology Could Change the World – The Atlantic (a few articles per month are free)
Lamotrigine May Increase Risk for Heart Arrhythmias, FDA Warns
5 Apr, 2021 | 01:12h | UTCLamotrigine May Increase Risk for Heart Arrhythmias, FDA Warns – NEJM Journal Watch
FDA Safety Communication: Lamictal (lamotrigine): Drug Safety Communication – Studies Show Increased Risk of Heart Rhythm Problems in Patients with Heart Disease
Related commentary: Epileptologists Push Back on FDA’s New Cardiac Warning for Lamotrigine – Neurology Today
Recent progress in the treatment of cancer in children
5 Apr, 2021 | 01:15h | UTCRecent progress in the treatment of cancer in children – CA: A Cancer Journal for Clinicians
Cohort Study: DOACs Safe, Effective in Subset of Valvular AF Patients
5 Apr, 2021 | 01:10h | UTCDOACs Safe, Effective in Subset of Valvular AF Patients – TCTMD
Cohort study: High thrombotic risk in cancer patients receiving immunotherapy
5 Apr, 2021 | 01:08h | UTCHigh thrombotic risk in cancer patients receiving immunotherapy – Medical University of Vienna
Original study: Incidence, risk factors, and outcomes of venous and arterial thromboembolism in immune checkpoint inhibitor therapy – Blood
Ebola Virus Transmission Initiated by Relapse of Systemic Ebola Virus Disease
5 Apr, 2021 | 01:05h | UTC
Commentary on Twitter
In this report from the Democratic Republic of Congo, Ebola virus disease developed in a young man, and he recovered after treatment with a monoclonal antibody.
6 months later, EVD recrudesced, and he transmitted the virus to others & died from EVD @NEJM https://t.co/kJSBNdN5bC pic.twitter.com/jDnnGMLmOG— Antibiotic Steward??Bassam Ghanem (@ABsteward) March 31, 2021
RCT: Postoperative pain control is improved with Methadone + Ketamine vs. Methadone alone in spinal surgical patients
5 Apr, 2021 | 00:49h | UTCPerioperative Methadone and Ketamine for Postoperative Pain Control in Spinal Surgical Patients: A Randomized, Double-blind, Placebo-controlled Trial – Anesthesiology (link to abstract – $ for full-text)
Commentary on Twitter
In a randomized trial of 130 spinal surgery patients, adding ketamine to methadone reduced pain scores from 4 to 2 points on an 11-point Likert scale and roughly halved postoperative opioid use https://t.co/vGVuQ7z7HV
— Anesthesiology journal (@_Anesthesiology) March 19, 2021
Early outcomes after lung transplantation for severe COVID-19: a series of the first consecutive cases from four countries
5 Apr, 2021 | 01:49h | UTCCommentary: Criteria for selecting COVID-19 patients for lung lung transplantation – Medical University of Vienna
Commentary on Twitter
NEW Research—Lung transplantation is the only option for survival in some patients with severe, unresolving #COVID19-associated #ARDS
From Ankit Bharat & colleagues https://t.co/7u52IJSOIn, including a fantastic video abstract https://t.co/2cjfTLXR8R
— The Lancet Respiratory Medicine (@LancetRespirMed) April 1, 2021
Perspective | Concerns about SARS-CoV-2 evolution should not hold back efforts to expand vaccination
5 Apr, 2021 | 01:39h | UTCConcerns about SARS-CoV-2 evolution should not hold back efforts to expand vaccination – Nature
Commentary on Twitter
A concern raised about delaying the 2nd vaccine dose is the potential to promote immune escape, new mutations. A new @NatRevImmunol essay argues against that possibility (may even be the opposite) https://t.co/XlCOP5DwTf by @sarahcobey @DanLarremore @yhgrad @mlipsitch pic.twitter.com/ehVOPX9sQv
— Eric Topol (@EricTopol) April 2, 2021
Exceedingly rare side effects reported with AstraZeneca vaccine in the UK – 22 cases of cerebral venous sinus thrombosis with low levels of platelets out of 18 million vaccinated individuals
5 Apr, 2021 | 01:45h | UTCCovid-19: Seven UK blood clot deaths after AstraZeneca vaccine – BBC
Original report: Coronavirus vaccine – weekly summary of Yellow Card reporting – Medicines and Healthcare products Regulatory Agency
Related opinion: Undermining the AstraZeneca jab is a dangerous act of political folly – The Guardian
“Based on current experience, the expected benefits of both COVID-19 vaccines in preventing COVID-19 and its serious complications far outweigh any known side effects”
Using the COVID-19 pandemic to reimagine global health teaching in high-income countries
5 Apr, 2021 | 01:38h | UTC
Commentary on Twitter
Online teaching during this pandemic is a struggle for students & teachers.
These tips from 20 professors in global health might help!https://t.co/pZJQvTgN2V pic.twitter.com/iVJEIlx3Al
— Madhu Pai, MD, PhD (@paimadhu) April 3, 2021
Opinion | The Antiscience Movement Is Escalating, Going Global and Killing Thousands
5 Apr, 2021 | 01:34h | UTCThe Antiscience Movement Is Escalating, Going Global and Killing Thousands – Scientific American
Opinion | How to lose friends and alienate people? On the problems of vaccine passports
5 Apr, 2021 | 01:42h | UTCHow to lose friends and alienate people? On the problems of vaccine passports – The BMJ Opinion
Related: Resistance from health experts and business owners could doom ‘vaccine passports’ even before they launch – STAT AND How Vaccine Passports Will Worsen Inequities In Global Health – Microbiology AND Vaccine certificates: does the end justify the means? – The Lancet Microbe AND Covid-19 vaccine passports will harm sustainable development – The BMJ Opinion AND Covid-19 vaccine passports and vaccine hesitancy: freedom or control? – The BMJ Opinion AND “Vaccine Passport” Certification — Policy and Ethical Considerations – New England Journal of Medicine AND Interim position paper: considerations regarding proof of COVID-19 vaccination for international travellers – World Health Organization
Commentary on Twitter
"All in all, there are reasons to conclude that vaccine passports for basic activities may actually undermine vaccine rollout by disincentivising the very populations who most need incentivising" @ReicherStephen @ProfJohnDrury https://t.co/UL9qfFiOcA
— The BMJ (@bmj_latest) April 2, 2021
Many hospitalized Covid-19 patients are given antibiotics. That’s a problem
5 Apr, 2021 | 01:33h | UTCMany hospitalized Covid-19 patients are given antibiotics. That’s a problem – STAT
What we know so far about the effort to vaccinate children
5 Apr, 2021 | 01:31h | UTCWhat we know so far about the effort to vaccinate children – National Geographic
RCT: Upadacitinib vs. Adalimumab for Psoriatic Arthritis
5 Apr, 2021 | 00:57h | UTCTrial of Upadacitinib and Adalimumab for Psoriatic Arthritis – New England Journal of Medicine (link to abstract – $ for full-text)
RCT: Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1
5 Apr, 2021 | 01:01h | UTCLumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1 – New England Journal of Medicine (link to abstract – $ for full-text)
RCT: Efficacy and safety of a dexamethasone intracanalicular insert in patients with allergic conjunctivitis
5 Apr, 2021 | 00:54h | UTCPhase 3 Randomized Study of Efficacy and Safety of a Dexamethasone Intracanalicular Insert in Patients With Allergic Conjunctivitis – American Journal of Ophthalmology (link to abstract – $ for full-text)
M-A: Similar oncological outcomes with laparoscopic vs. open rectal cancer resections
5 Apr, 2021 | 00:43h | UTC