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Daily Archives: February 25, 2021

Real-world data confirms Pfizer-BioNTech vaccine effectiveness

25 Feb, 2021 | 09:09h | UTC

BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting – New England Journal of Medicine

Audio Interview: The Real-World Effectiveness of Covid-19 Vaccination – New England Journal of Medicine

Commentaries: Real-world trial of Pfizer COVID vaccine finds high 2-dose, good 1-dose protection – CIDRAP AND Pfizer-BioNTech vaccine performs as well in the real world as in clinical trials, new study concludes – STAT AND In boost for COVID-19 battle, Pfizer vaccine found 94% effective in real world – Reuters AND Expert reaction to NEJM paper on Pfizer-BioNTech vaccine roll-out in Israel and COVID-19 outcomes – Science Media Centre

 

Commentary on Twitter (thread – click for more)

 

Ghana receives first historic shipment of COVID-19 vaccinations from international COVAX facility

25 Feb, 2021 | 09:12h | UTC

Ghana receives first historic shipment of COVID-19 vaccinations from international COVAX facility – UN News

See also: Ghana becomes recipient of historic first shipment of COVAX vaccines – World Health Organization

Commentaries: Covax vaccine-sharing scheme delivers first doses to Ghana – BBC AND Covax delivers first Covid vaccines in ‘momentous occasion’ – The Guardian AND COVAX delivers its first vaccine shots with shipment to Ghana – Reuters

 

Series of n-of-1 trials show no difference in muscle symptoms in patients receiving placebo or statins

25 Feb, 2021 | 08:54h | UTC

Statin treatment and muscle symptoms: series of randomised, placebo controlled n-of-1 trials – The BMJ

Commentary: Do statins cause muscle symptom side effects? – The BMJ Opinion AND Study: Muscle Symptoms Didn’t Differ Between Statin and Placebo Periods – NEJM Journal Watch

Related study: #AHA20 – In patients who had discontinued statins because of side effects, a N-of-1 trial of a statin, placebo, or no treatment found that side effects often attributed to statins were the same for those taking a placebo (study and commentaries)

 

Consensus statement on the prevention of opioid‐related harm in adult surgical patients

25 Feb, 2021 | 08:41h | UTC

An international multidisciplinary consensus statement on the prevention of opioid‐related harm in adult surgical patients – Anaesthesia

Commentary: Stopping opioid-related addiction, harm and accidents after surgery – AAGBI

 

Commentary on Twitter

 

RCT: Effect of high-dose subcutaneous Semaglutide vs. placebo in adults with overweight or obesity

25 Feb, 2021 | 08:52h | UTC

Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity: The STEP 3 Randomized Clinical Trial – JAMA

Commentary: Semaglutide paired with intensive behavioral therapy showed triple weight loss vs placebo – University of Pennsylvania School of Medicine

Related study: Once-weekly, high-dose semaglutide is effective for improving overweight or obesity among non-diabetic adults – New England Journal of Medicine (study and commentary)

 

Commentary on Twitter

 

Cohort study: High glycemic index diets are linked to increased risk of cardiovascular disease and death

25 Feb, 2021 | 08:49h | UTC

Glycemic Index, Glycemic Load, and Cardiovascular Disease and Mortality – New England Journal of Medicine

Commentaries: Study finds diet high in poor quality carbohydrates increases heart disease and death – McMaster University AND High Glycemic Index Diets Linked to CVD and Mortality – TCTMD

 

Collaborative statement on mHealth in Arrhythmia Management: Digital Medical Tools for Heart Rhythm Professionals

25 Feb, 2021 | 08:25h | UTC

2021 ISHNE/ HRS/ EHRA/ APHRS collaborative statement on mHealth in Arrhythmia Management: Digital Medical Tools for Heart Rhythm Professionals – European Heart Journal – Digital Health

 

RCT: Hypothermic machine perfusion in liver transplantation

25 Feb, 2021 | 08:44h | UTC

Hypothermic Machine Perfusion in Liver Transplantation — A Randomized Trial – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Cold Perfusion Cuts Liver Transplant Complications – MedPage Today

 

Meta-analysis: Postoperative analgesic effectiveness of quadratus lumborum block for cesarean delivery under spinal anesthesia

25 Feb, 2021 | 08:31h | UTC

Postoperative Analgesic Effectiveness of Quadratus Lumborum Block for Cesarean Delivery under Spinal Anesthesia: A Systematic Review and Meta-analysis – Anesthesiology

 

Commentary on Twitter

 

RCT: Effect of telephone cognitive behavioral therapy for insomnia in older adults with osteoarthritis pain

25 Feb, 2021 | 08:29h | UTC

Effect of Telephone Cognitive Behavioral Therapy for Insomnia in Older Adults With Osteoarthritis Pain: A Randomized Clinical Trial – JAMA Internal Medicine

Commentary: Effective treatment for insomnia delivered in a few short phone calls – University of Washington

 

[Not published yet] Covid-19 vaccine made by China’s Sinopharm has an efficacy rate of 72.5 percent

25 Feb, 2021 | 09:07h | UTC

Covid-19 vaccines made by China’s Sinopharm, CanSino release efficacy data – South China Morning Post

See also: Sinopharm’s Wuhan unit reports 72.5% efficacy for COVID shot, seeks approval in China – Reuters

 

Commentary on Twitter

 

People with SARS-CoV-2 antibodies may have a low risk of future infection

25 Feb, 2021 | 09:04h | UTC

Association of SARS-CoV-2 Seropositive Antibody Test With Risk of Future Infection – JAMA Internal Medicine

Editorial: How to Advise Persons Who Are Antibody Positive for SARS-CoV-2 About Future Infection Risk

Commentaries: Covid-19 antibodies may protect against reinfection later, study suggests – CNN AND NCI study finds that people with SARS-CoV-2 antibodies may have a low risk of future infection – National Cancer Institute

 

FDA scientists endorse J&J’s Covid vaccine, as new data shed light on efficacy

25 Feb, 2021 | 09:06h | UTC

FDA scientists endorse J&J’s Covid vaccine, as new data shed light on efficacy – STAT

See also: FDA says single-dose shot from J&J prevents severe COVID – MedicalXpress

 

Interview: The scientist who’s been right about Covid-19 vaccines predicts what’s next

25 Feb, 2021 | 09:01h | UTC

The scientist who’s been right about Covid-19 vaccines predicts what’s next – Vox

 

Commentary on Twitter (thread – click for more)

 

Massive Google-funded COVID database will track variants and immunity

25 Feb, 2021 | 09:03h | UTC

Massive Google-funded COVID database will track variants and immunity – Nature

See also: Backed by Google, epidemiologists launch a sweeping Covid-19 data platform – STAT

 

Why COVID vaccines are so difficult to compare

25 Feb, 2021 | 09:02h | UTC

Why COVID vaccines are so difficult to compare – Nature

 

Opinion: Importance of non-pharmaceutical interventions in lowering the viral inoculum to reduce susceptibility to infection by SARS-CoV-2 and potentially disease severity

25 Feb, 2021 | 08:57h | UTC

Importance of non-pharmaceutical interventions in lowering the viral inoculum to reduce susceptibility to infection by SARS-CoV-2 and potentially disease severity – The Lancet Infectious Diseases

 

Commentary on Twitter

 

Perspective: Coronavirus reinfection will soon become our reality

25 Feb, 2021 | 08:59h | UTC

Coronavirus reinfection will soon become our reality – The Atlantic (a few articles per month are free)

 

Position Paper: Management of drug-induced liver injury

25 Feb, 2021 | 08:27h | UTC

Drug-induced liver injury: A management position paper from the Latin American Association for Study of the liver – Annals of Hepatology

 

ICU-based renal replacement therapy

25 Feb, 2021 | 08:23h | UTC

ICU-Based Renal Replacement Therapy – Critical Care Medicine

 

Commentary on Twitter

 

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