Daily Archives: February 19, 2021
M-A: Intra-articular saline injection is as effective as corticosteroids, platelet-rich plasma, and hyaluronic acid for hip osteoarthritis pain
19 Feb, 2021 | 02:35h | UTC
Commentary on Twitter
Anyone else buying shares in saline? 👀
Intra-articular saline as effective as corticosteroids, PRP and hyaluronic acid for hip OA pain: a systematic review and network meta-analysis #NoSilverBullet #Paywallhttps://t.co/B6tutNJVDD pic.twitter.com/f75ExkZ2A6
— British Journal of Sports Medicine (BJSM) (@BJSM_BMJ) August 27, 2020
Study: In intensively treated hypertensive patients, a diastolic blood pressure of less than 60 mm Hg was associated with increased risk of cardiovascular events
19 Feb, 2021 | 02:37h | UTCCommentary: Treated Diastolic Blood Pressure: How Low Is Too Low? – NEJM Journal Watch
Commentary on Twitter
Cohort study showed on-treatment diastolic BP <60 was associated with increased risk of adverse outcomes; on-treatment diastolic BP of 70-80 was associated with lowest adverse outcome risk in patients with on-treatment systolic BP <130 mmHg. @MayoClinic https://t.co/0wOfqpMcIH
— JAMA Network Open (@JAMANetworkOpen) February 17, 2021
Guide to statistics and methods: Immortal time bias in observational studies
19 Feb, 2021 | 02:19h | UTCImmortal Time Bias in Observational Studies – JAMA (free for a limited period)
Commentary on Twitter
https://twitter.com/lucasmorin_eolc/status/1361966403985825792
The Lancet Commission on Global Eye Health: Vision Beyond 2020
19 Feb, 2021 | 02:38h | UTCGlobal Eye Health: vision beyond 2020 – The Lancet Global Health
Commentary on Twitter
NEW—Eliminating preventable sight loss could bring economic benefits of US$411 billion a year, unlock human potential & accelerate global development. @LancetGH #GlobalEyeHealth Commission reports on action needed now to deliver key 👁️ health services. https://t.co/aLNmwKVENB pic.twitter.com/u69JFGL2BY
— The Lancet (@TheLancet) February 17, 2021
Global guideline for the diagnosis and management of rare mold infections
19 Feb, 2021 | 02:18h | UTC
Commentary on Twitter
🔥🔥🔥 Global Guideline for Rare Moulds. Endorsed by 55 scientific societies in the field.
All you need to know about Diagnosis and Treatment of Rare Mould infections: from Fusarium to Purpureocillium. @eurconfmedmycol @ISHAM_Mycology @ASMicrobiology
https://t.co/YJ3BX58osW pic.twitter.com/nrAGZl5ox4— Martin Hoenigl🇺🇦🇦🇹 (@martinhoenigl) February 16, 2021
WHO call to action: Vaccine equity declaration – We must accelerate vaccine equity for all health workers – Now
19 Feb, 2021 | 03:03h | UTCCall to Action: Vaccine Equity Declaration – World Health Organization
A single dose of the Pfizer–BioNTech vaccine is 92.6% effective in preventing Covid-19. Is delaying the second dose to get more people vaccinated an alternative?
19 Feb, 2021 | 02:59h | UTCSafety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine – New England Journal of Medicine
Commentary: Researchers urge delaying Pfizer vaccine’s second dose as first highly effective – Reuters
Covid-19: In vitro studies show Pfizer-BioNTech and Moderna vaccines produce fewer antibodies against South African variant
19 Feb, 2021 | 03:01h | UTCCommentaries: Expert reaction to two NEJM Correspondence articles on in vitro studies of the Pfizer-BioNTech and Moderna vaccines and different variants/mutations including mutations on the South Africa variant – Science Media Centre AND Lab studies suggest Pfizer, Moderna vaccines can protect against coronavirus variant – CNN AND Pfizer and Moderna vaccines have reduced effectiveness against South African variant, newly published studies show – The Washington Post AND Pfizer, Moderna vaccines less effective against South African COVID variant – MedicalXpress
Commentary on Twitter
New reports @NEJM today confirming some immune evasion of the B.1.351 variant (identified in South Africa) to both the mRNA vaccines, in vitro data @BioNTech_Group/@Pfizer and @moderna_tx. Less vaccine efficacy vs B.1.351 has been confirmed in clinical trials for 3 vaccines pic.twitter.com/2N7eKDllso
— Eric Topol (@EricTopol) February 17, 2021
Years of life lost to COVID-19 in 81 countries
19 Feb, 2021 | 02:55h | UTCYears of life lost to COVID-19 in 81 countries – Scientific Reports
News release: COVID-19: Over 20.5 million years of life may have been lost due to COVID-19
Commentaries: Expert reaction to study estimating years of life lost globally to COVID-19 – Science Media Centre AND 20.5m years of life may have been lost to Covid across 81 countries, study finds – The Guardian
What does 95% COVID-19 vaccine efficacy really mean?
19 Feb, 2021 | 02:58h | UTCWhat does 95% COVID-19 vaccine efficacy really mean? – The Lancet Infectious Diseases
Related: Pfizer vaccine: what an ‘efficacy rate above 90%’ really means – The Conversation
COVID‐19 convalescent plasma: Interim recommendations from the AABB
19 Feb, 2021 | 02:56h | UTCCOVID‐19 convalescent plasma: interim recommendations from the AABB – Transfusion
News release: AABB panel issues interim recommendations for Covid-19 convalescent plasma use
Fauci: There’s evidence COVID-19 vaccines don’t just protect you — they may stop you from spreading the virus to others, too
19 Feb, 2021 | 02:46h | UTCRelated: [Preprint] Covid-19 vaccination associated with reduced viral load, may reduce transmission (study and commentary)
How many people get ‘long COVID’ – and who is most at risk?
19 Feb, 2021 | 02:54h | UTCHow many people get ‘long COVID’ – and who is most at risk? – The Conversation
The price of success—how to evaluate Covid-19 vaccines when they’re available outside of clinical trials
19 Feb, 2021 | 02:43h | UTC
SOFA score is not accurate enough for mortality prediction in severely ill patients with COVID-19 pneumonia
19 Feb, 2021 | 02:44h | UTC
Commentary on Twitter
'The discriminant accuracy of the #SOFA score for
mortality prediction in patients prior to intubation for#COVID-19 pneumonia was poor and significantly inferior to simply using age.' Age, apparently can't be used because 'discrimination'. #bioethics https://t.co/QJIxqupoVx— udo schuklenk 🏳️🌈🇨🇦🇦🇺🇩🇪 (@schuklenk) February 17, 2021
SR: Integrating palliative care in ambulatory care of noncancer serious chronic illness
19 Feb, 2021 | 02:28h | UTCFull report: Integrating Palliative Care in Ambulatory Care of Noncancer Serious Chronic Illness
Evidence summary: Integrating Palliative Care in Ambulatory Care of Noncancer Serious Illness
Voices in Cardiology: How feeling like an imposter can impede your success
19 Feb, 2021 | 02:26h | UTCHow Feeling Like an Imposter Can Impede Your Success – JACC: Case Reports
Meta-analysis: Sustained lung inflations during neonatal resuscitation at birth
19 Feb, 2021 | 02:21h | UTCSustained Lung Inflations During Neonatal Resuscitation at Birth: A Meta-analysis – Pediatrics (link to abstract – $ for full-text)
Commentaries on Twitter
#Metaanalysis by @KapadiaNeo & @Ilcor_org colleagues finds Sustained lung inflation is a potential harmful intervention in babies, particularly in extreme preterm infants who are at increased risk of death@AAPJournals @EBNEO #NeoEBM @wyllie_jonathan https://t.co/rsDYtDRgm0 pic.twitter.com/fO6mu4ICil
— Abdul Razak (@DrAbdulRazak_MD) December 23, 2020
https://twitter.com/NICU_Musings/status/1347554874125217795
Bleeding in critically ill children—review of literature, knowledge gaps, and suggestions for future investigation
19 Feb, 2021 | 02:23h | UTC
Review: Oxygen administration for patients with ARDS
19 Feb, 2021 | 02:24h | UTCOxygen administration for patients with ARDS – Journal of Intensive Care
A food allergy epidemic… or just another case of overdiagnosis?
19 Feb, 2021 | 02:13h | UTCA food allergy epidemic… or just another case of overdiagnosis? – The BMJ Opinion
Original study: Food anaphylaxis in the United Kingdom: analysis of national data, 1998-2018 – The BMJ
M-A: Risk factors for suicide in prisons
19 Feb, 2021 | 02:10h | UTC
Commentary on Twitter (thread – click for more)
New paper! Meta-analysis of risk factors for completed suicide in prison. Included data on >35,000 suicides, 77 studies from 27 countries. Some potentially important findings, esp. differences with risk factors in general population. #OA @TheLancetPH: https://t.co/G26576gOrH 1/ pic.twitter.com/gB7efLHkqK
— Seena Fazel (@seenafazel) February 10, 2021
M-A: Not enough evidence there are individual differences in response to antidepressants
19 Feb, 2021 | 02:15h | UTCIndividual Differences in Response to Antidepressants: A Meta-analysis of Placebo-Controlled Randomized Clinical Trials – JAMA Psychiatry (free for a limited period)
Editorial: New Directions in Research on Heterogeneity of Treatment Effects for Major Depression (free for a limited period)
Commentary: Antidepressants for MDD: Time to Rethink Personalized Therapy? – Physician’s Weekly
Related studies: What are the chances for personalised treatment with antidepressants? Detection of patient-by-treatment interaction with a variance ratio meta-analysis – BMJ Open AND Individual response to antidepressants for depression in adults-a meta-analysis and simulation study – PLOS One
Commentary on Twitter (thread – click for more)
https://twitter.com/PloederlM/status/1362294365255852032
Defining the optimal total number of chemotherapy courses in younger patients with Acute Myeloid Leukemia: A comparison of 3 vs. 4 courses
19 Feb, 2021 | 02:06h | UTCDefining the Optimal Total Number of Chemotherapy Courses in Younger Patients With Acute Myeloid Leukemia: A Comparison of Three Versus Four Courses – Journal of Clinical Oncology (link to abstract – $ for full-text)
Commentary: Optimal Number of Treatment Courses Explored in Younger Patients with AML – CancerNetwork
Commentary on Twitter
What is the optimal number of chemotherapy courses in younger patients with acute myeloid leukemia (AML)? This study evaluates 3 vs 4 courses https://t.co/peC7Xo3BbX #leusm #JCO pic.twitter.com/OGChNkYS0X
— Journal of Clinical Oncology (@JCO_ASCO) January 6, 2021
RCT: Treatment of uterine fibroid symptoms with Relugolix combination therapy
19 Feb, 2021 | 02:08h | UTC