Daily Archives: February 19, 2021
M-A: Intra-articular saline injection is as effective as corticosteroids, platelet-rich plasma, and hyaluronic acid for hip osteoarthritis pain
19 Feb, 2021 | 02:35h | UTC
Commentary on Twitter
Anyone else buying shares in saline? ?
Intra-articular saline as effective as corticosteroids, PRP and hyaluronic acid for hip OA pain: a systematic review and network meta-analysis #NoSilverBullet #Paywallhttps://t.co/B6tutNJVDD pic.twitter.com/f75ExkZ2A6
— British Journal of Sports Medicine (@BJSM_BMJ) August 27, 2020
Study: In intensively treated hypertensive patients, a diastolic blood pressure of less than 60 mm Hg was associated with increased risk of cardiovascular events
19 Feb, 2021 | 02:37h | UTCCommentary: Treated Diastolic Blood Pressure: How Low Is Too Low? – NEJM Journal Watch
Commentary on Twitter
Cohort study showed on-treatment diastolic BP <60 was associated with increased risk of adverse outcomes; on-treatment diastolic BP of 70-80 was associated with lowest adverse outcome risk in patients with on-treatment systolic BP <130 mmHg. @MayoClinic https://t.co/0wOfqpMcIH
— JAMA Network Open (@JAMANetworkOpen) February 17, 2021
Guide to statistics and methods: Immortal time bias in observational studies
19 Feb, 2021 | 02:19h | UTCImmortal Time Bias in Observational Studies – JAMA (free for a limited period)
Commentary on Twitter
New paper in the "JAMA Guide to Statistics and Methods" series about immortal time bias in observational studies.https://t.co/mxppXGeRcm pic.twitter.com/bY7WmpN9hy
— Lucas Morin (@lucasmorin_eolc) February 17, 2021
The Lancet Commission on Global Eye Health: Vision Beyond 2020
19 Feb, 2021 | 02:38h | UTCGlobal Eye Health: vision beyond 2020 – The Lancet Global Health
Commentary on Twitter
NEW—Eliminating preventable sight loss could bring economic benefits of US$411 billion a year, unlock human potential & accelerate global development. @LancetGH #GlobalEyeHealth Commission reports on action needed now to deliver key ?️ health services. https://t.co/aLNmwKVENB pic.twitter.com/u69JFGL2BY
— The Lancet (@TheLancet) February 17, 2021
Global guideline for the diagnosis and management of rare mold infections
19 Feb, 2021 | 02:18h | UTC
Commentary on Twitter
??? Global Guideline for Rare Moulds. Endorsed by 55 scientific societies in the field.
All you need to know about Diagnosis and Treatment of Rare Mould infections: from Fusarium to Purpureocillium. @eurconfmedmycol @ISHAM_Mycology @ASMicrobiology
https://t.co/YJ3BX58osW pic.twitter.com/nrAGZl5ox4— Martin Hoenigl (@martinhoenigl) February 16, 2021
WHO call to action: Vaccine equity declaration – We must accelerate vaccine equity for all health workers – Now
19 Feb, 2021 | 03:03h | UTCCall to Action: Vaccine Equity Declaration – World Health Organization
A single dose of the Pfizer–BioNTech vaccine is 92.6% effective in preventing Covid-19. Is delaying the second dose to get more people vaccinated an alternative?
19 Feb, 2021 | 02:59h | UTCSafety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine – New England Journal of Medicine
Commentary: Researchers urge delaying Pfizer vaccine’s second dose as first highly effective – Reuters
Covid-19: In vitro studies show Pfizer-BioNTech and Moderna vaccines produce fewer antibodies against South African variant
19 Feb, 2021 | 03:01h | UTCCommentaries: Expert reaction to two NEJM Correspondence articles on in vitro studies of the Pfizer-BioNTech and Moderna vaccines and different variants/mutations including mutations on the South Africa variant – Science Media Centre AND Lab studies suggest Pfizer, Moderna vaccines can protect against coronavirus variant – CNN AND Pfizer and Moderna vaccines have reduced effectiveness against South African variant, newly published studies show – The Washington Post AND Pfizer, Moderna vaccines less effective against South African COVID variant – MedicalXpress
Commentary on Twitter
New reports @NEJM today confirming some immune evasion of the B.1.351 variant (identified in South Africa) to both the mRNA vaccines, in vitro data @BioNTech_Group/@Pfizer and @moderna_tx. Less vaccine efficacy vs B.1.351 has been confirmed in clinical trials for 3 vaccines pic.twitter.com/2N7eKDllso
— Eric Topol (@EricTopol) February 17, 2021
Years of life lost to COVID-19 in 81 countries
19 Feb, 2021 | 02:55h | UTCYears of life lost to COVID-19 in 81 countries – Scientific Reports
News release: COVID-19: Over 20.5 million years of life may have been lost due to COVID-19
Commentaries: Expert reaction to study estimating years of life lost globally to COVID-19 – Science Media Centre AND 20.5m years of life may have been lost to Covid across 81 countries, study finds – The Guardian
What does 95% COVID-19 vaccine efficacy really mean?
19 Feb, 2021 | 02:58h | UTCWhat does 95% COVID-19 vaccine efficacy really mean? – The Lancet Infectious Diseases
Related: Pfizer vaccine: what an ‘efficacy rate above 90%’ really means – The Conversation
COVID‐19 convalescent plasma: Interim recommendations from the AABB
19 Feb, 2021 | 02:56h | UTCCOVID‐19 convalescent plasma: interim recommendations from the AABB – Transfusion
News release: AABB panel issues interim recommendations for Covid-19 convalescent plasma use
Fauci: There’s evidence COVID-19 vaccines don’t just protect you — they may stop you from spreading the virus to others, too
19 Feb, 2021 | 02:46h | UTCRelated: [Preprint] Covid-19 vaccination associated with reduced viral load, may reduce transmission (study and commentary)
How many people get ‘long COVID’ – and who is most at risk?
19 Feb, 2021 | 02:54h | UTCHow many people get ‘long COVID’ – and who is most at risk? – The Conversation
The price of success—how to evaluate Covid-19 vaccines when they’re available outside of clinical trials
19 Feb, 2021 | 02:43h | UTC
SOFA score is not accurate enough for mortality prediction in severely ill patients with COVID-19 pneumonia
19 Feb, 2021 | 02:44h | UTC
Commentary on Twitter
'The discriminant accuracy of the #SOFA score for
mortality prediction in patients prior to intubation for#COVID-19 pneumonia was poor and significantly inferior to simply using age.' Age, apparently can't be used because 'discrimination'. #bioethics https://t.co/QJIxqupoVx— udo schuklenk ?️??????? (@schuklenk) February 17, 2021
SR: Integrating palliative care in ambulatory care of noncancer serious chronic illness
19 Feb, 2021 | 02:28h | UTCFull report: Integrating Palliative Care in Ambulatory Care of Noncancer Serious Chronic Illness
Evidence summary: Integrating Palliative Care in Ambulatory Care of Noncancer Serious Illness
Voices in Cardiology: How feeling like an imposter can impede your success
19 Feb, 2021 | 02:26h | UTCHow Feeling Like an Imposter Can Impede Your Success – JACC: Case Reports
Meta-analysis: Sustained lung inflations during neonatal resuscitation at birth
19 Feb, 2021 | 02:21h | UTCSustained Lung Inflations During Neonatal Resuscitation at Birth: A Meta-analysis – Pediatrics (link to abstract – $ for full-text)
Commentaries on Twitter
#Metaanalysis by @KapadiaNeo & @Ilcor_org colleagues finds Sustained lung inflation is a potential harmful intervention in babies, particularly in extreme preterm infants who are at increased risk of death@AAPJournals @EBNEO #NeoEBM @wyllie_jonathan https://t.co/rsDYtDRgm0 pic.twitter.com/fO6mu4ICil
— Abdul Razak, MD, FRCPCH (@DrAbdulRazak_MD) December 23, 2020
If your center is still using sustained lung inflations this systematic review should give you reason to pause. #neoEBM #Meded #MedTwitter https://t.co/WCHCdHzyGX pic.twitter.com/53lOMIFQas
— Michael Narvey (@NICU_Musings) January 8, 2021
Bleeding in critically ill children—review of literature, knowledge gaps, and suggestions for future investigation
19 Feb, 2021 | 02:23h | UTC
Review: Oxygen administration for patients with ARDS
19 Feb, 2021 | 02:24h | UTCOxygen administration for patients with ARDS – Journal of Intensive Care
A food allergy epidemic… or just another case of overdiagnosis?
19 Feb, 2021 | 02:13h | UTCA food allergy epidemic… or just another case of overdiagnosis? – The BMJ Opinion
Original study: Food anaphylaxis in the United Kingdom: analysis of national data, 1998-2018 – The BMJ
M-A: Risk factors for suicide in prisons
19 Feb, 2021 | 02:10h | UTC
Commentary on Twitter (thread – click for more)
New paper! Meta-analysis of risk factors for completed suicide in prison. Included data on >35,000 suicides, 77 studies from 27 countries. Some potentially important findings, esp. differences with risk factors in general population. #OA @TheLancetPH: https://t.co/G26576gOrH 1/ pic.twitter.com/gB7efLHkqK
— Seena Fazel (@seenafazel) February 10, 2021
M-A: Not enough evidence there are individual differences in response to antidepressants
19 Feb, 2021 | 02:15h | UTCIndividual Differences in Response to Antidepressants: A Meta-analysis of Placebo-Controlled Randomized Clinical Trials – JAMA Psychiatry (free for a limited period)
Editorial: New Directions in Research on Heterogeneity of Treatment Effects for Major Depression (free for a limited period)
Commentary: Antidepressants for MDD: Time to Rethink Personalized Therapy? – Physician’s Weekly
Related studies: What are the chances for personalised treatment with antidepressants? Detection of patient-by-treatment interaction with a variance ratio meta-analysis – BMJ Open AND Individual response to antidepressants for depression in adults-a meta-analysis and simulation study – PLOS One
Commentary on Twitter (thread – click for more)
1/ Treatment effect heterogeneity in antidepressant tx – a retracted paper by Maslej et al. was now re-published, with a complete reversal of the main-findings – no difference in variability in tx outcome bw antidepressant and placebo. https://t.co/ME5qawCQlL https://t.co/IgegV5kZpT
— Pfluft (@PloederlM) February 18, 2021
Defining the optimal total number of chemotherapy courses in younger patients with Acute Myeloid Leukemia: A comparison of 3 vs. 4 courses
19 Feb, 2021 | 02:06h | UTCDefining the Optimal Total Number of Chemotherapy Courses in Younger Patients With Acute Myeloid Leukemia: A Comparison of Three Versus Four Courses – Journal of Clinical Oncology (link to abstract – $ for full-text)
Commentary: Optimal Number of Treatment Courses Explored in Younger Patients with AML – CancerNetwork
Commentary on Twitter
What is the optimal number of chemotherapy courses in younger patients with acute myeloid leukemia (AML)? This study evaluates 3 vs 4 courses https://t.co/peC7Xo3BbX #leusm #JCO pic.twitter.com/OGChNkYS0X
— ASCO Publications (@ASCO_pubs) January 6, 2021
RCT: Treatment of uterine fibroid symptoms with Relugolix combination therapy
19 Feb, 2021 | 02:08h | UTC