Daily Archives: February 10, 2021 | LinksMedicus Free Medical News & Perspectives

RCT: Among patients with acute MI and anemia, a restrictive transfusion strategy resulted in a noninferior rate of major cardiovascular events compared to a liberal transfusion strategy

10 Feb, 2021 | 01:39h | UTC

Effect of a Restrictive vs Liberal Blood Transfusion Strategy on Major Cardiovascular Events Among Patients With Acute Myocardial Infarction and Anemia: The REALITY Randomized Clinical Trial – JAMA (free for a limited period)

Commentary: Restrictive vs. Liberal Blood Transfusion Strategy for MI and Anemia – American College of Cardiology

Commentary on Twitter

Effect of Restrictive vs Liberal Blood Transfusion Strategy on Adults With Myocardial Infarction and Anemia https://t.co/PUtmUj0haw

— JAMA Cardiology (@JAMACardio) February 9, 2021

RCT: In patients with generalized myasthenia gravis prescribed azithromycin, rapid tapering of prednisone is beneficial and safe compared to slow tapering

10 Feb, 2021 | 01:32h | UTC

Comparison of Corticosteroid Tapering Regimens in Myasthenia Gravis: A Randomized Clinical Trial – JAMA Neurology

Commentary on Twitter

Rapid tapering of high-dose #prednisone therapy in patients with moderate to severe generalized #myastheniagravis on azathioprine appears to be well tolerated and associated with good outcome https://t.co/1nHZuy8kPN

— JAMA Neurology (@JAMANeuro) February 8, 2021

Cost-effective analysis suggests incorporating baseline breast density at 40 years to determine the frequency of screening in women at average risk for breast cancer

10 Feb, 2021 | 01:37h | UTC

Incorporating Baseline Breast Density When Screening Women at Average Risk for Breast Cancer: A Cost-Effectiveness Analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Screening based on breast density at age 40 may reduce breast cancer mortality – ACP Internist AND Screening strategy based on baseline breast density at age 40 may be effective for reducing breast cancer mortality – American College of Physicians AND For Mammography: Baseline at 40 Makes Sense – Diagnostic Imaging

Commentary on Twitter

New research led by @TinaShihHSR of @MDAndersonNews found screening strategy based on baseline breast density at age 40 may be effective and cost-effective for reducing #breastcancer mortality https://t.co/9f0P7CSCmD. pic.twitter.com/PemE8XVSqr

— Annals of Int Med (@AnnalsofIM) February 9, 2021

RCT: Among children with Myelomeningocele, long term results confirm the benefits of prenatal repair compared to standard postnatal repair

10 Feb, 2021 | 01:28h | UTC

Prenatal Repair and Physical Functioning Among Children With Myelomeningocele: A Secondary Analysis of a Randomized Clinical Trial – JAMA Pediatrics (free for a limited period)

Editorial: Long-term Outcomes of Children After Fetal Surgery for Spina Bifida—Toward Sustainability – JAMA Pediatrics (free for a limited period)

Commentaries: Spina Bifida Repair: The Sooner the Better – Physician’s Weekly AND Prenatal Myelomeningocele Repair Tied to Better Function – HealthDay

Commentary on Twitter

Previous work reported that prenatal versus postnatal repair of myelomeningocele resulted in improved physical functioning. A secondary analysis at #jamapeds reports that these improvements persist into school age. https://t.co/2aehk5L6pi pic.twitter.com/hASLEUcvqm

— JAMA Pediatrics (@JAMAPediatrics) February 9, 2021

Consensus statement: Cardiovascular health after menopause transition, pregnancy disorders, and other gynecologic conditions

10 Feb, 2021 | 01:25h | UTC

Cardiovascular health after menopause transition, pregnancy disorders, and other gynaecologic conditions: a consensus document from European cardiologists, gynaecologists, and endocrinologists – European Heart Journal

Commentary: ESC Consensus Document Provides Guidance on CV Risk in Women After Menopause, Pregnancy Disorders, Gynecologic Conditions – American College of Cardiology

Commentary on Twitter

Cardiovascular health during menopause, pregnancy, and other gynaecologic conditions: European multidisciplinary consensus is out !https://t.co/fm6EBEbhVO.#cardiotwitter, @ESC_Journals, @escardio, #gynecology pic.twitter.com/WIekM50b07

— EHJ Editor-in-Chief (@ehj_ed) January 26, 2021

Cohort study: Adjunctive clindamycin may benefit beta-lactam antibiotic-treated patients with invasive beta-hemolytic streptococcal infections

10 Feb, 2021 | 01:13h | UTC

Effectiveness of adjunctive clindamycin in β-lactam antibiotic-treated patients with invasive β-haemolytic streptococcal infections in US hospitals: a retrospective multicentre cohort study – The Lancet Infectious Diseases (link to abstract – $ for full-text)

Commentary on Twitter

Our new study in Lancet ID ?? showing a potential role for wider adjunctive use of clindamycin for iGAS even without next fasc or toxic shock. Utility in non-A,non-B strep questionable. Congratulations to stellar first author @Ahmed_HBabiker https://t.co/3t4FsmClWa

— Sameer Kadri (@SameerKadri12) December 15, 2020

SR: Long‐term effects of weight‐reducing diets in people with hypertension

10 Feb, 2021 | 01:23h | UTC

Long‐term effects of weight‐reducing diets in people with hypertension – Cochrane Library

Summary: Do weight-loss diets affect blood pressure, and reduce the effects of high blood pressure (hypertension)? – Cochrane Library

M-A: Interventions to minimize blood loss in very preterm infants

10 Feb, 2021 | 01:19h | UTC

Interventions to minimize blood loss in very preterm infants—A systematic review and meta-analysis – PLOS ONE

PET imaging reveals which breast cancer patients won’t respond to hormone therapy

10 Feb, 2021 | 01:09h | UTC

PET Imaging Reveals Which Breast Cancer Patients Won’t Respond to Hormone Therapy – Diagnostic Imaging

Original study: Association of PET-based estradiol-challenge test for breast cancer progesterone receptors with response to endocrine therapy – Nature Communications

Cohort study: Characteristics and outcomes of pregnant women with type 1 or type 2 diabetes

10 Feb, 2021 | 01:16h | UTC

Characteristics and outcomes of pregnant women with type 1 or type 2 diabetes: a 5-year national population-based cohort study – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Commentaries on Twitter

New #research online: Characteristics and outcomes of #pregnant women with type 1 or type 2 #diabetes: a 5-year national population-based cohort study https://t.co/qCOHToYDEa pic.twitter.com/ENAmhkhKvZ

— The Lancet Diabetes & Endocrinology (@TheLancetEndo) January 29, 2021

Important study from Prof Helen Murphy and colleagues in UK highlighting adverse outcomes in pregnancy with #Type2 and #type1diabetes. Glucose control and #obesity were main determinants. Big challenges ahead with increasing young-onset #type2
#maternalhealth @FIGOadvocacy https://t.co/X99hsN4KcK

— Dr Ronald Ma (@DrRonaldMa1) January 31, 2021

COVAX statement on new variants of SARS-CoV-2

10 Feb, 2021 | 01:53h | UTC

COVAX Statement on New Variants of SARS-CoV-2 – World Health Organization

SARS-CoV-2 seroprevalence study in daycare centers in France suggests low rates of infection in very young children

10 Feb, 2021 | 01:55h | UTC

SARS-CoV-2 seroprevalence study in daycare centres in France suggests low rates of infection in very young children – The Lancet

Original study: SARS-CoV-2 transmission among children and staff in daycare centres during a nationwide lockdown in France: a cross-sectional, multicentre, seroprevalence study – The Lancet Child & Adolescent Health

Commentary on Twitter (thread – click for more)

NEW—Research assessing seroprevalence in daycare centres open during the first lockdown in France suggests the rate of #COVID19 infection was low at 3.7%. Read the @LancetChildAdol study: https://t.co/56qnzdKo14 pic.twitter.com/O2mcnqE42S

— The Lancet (@TheLancet) February 9, 2021