Daily Archives: February 3, 2021
USPSTF recommends against screening for asymptomatic carotid artery stenosis in the general adult population
3 Feb, 2021 | 01:29h | UTCEditorials: Screening for Asymptomatic Carotid Artery Stenosis: Lack of Clinical Benefit, Potential for Harm – JAMA AND Screening for Asymptomatic Carotid Artery Stenosis in Adult Patients: Unclear Benefit but Downstream Risks – JAMA Internal Medicine AND USPSTF Recommendations for Screening for Carotid Stenosis to Prevent Stroke—The Need for More Data – JAMA Network Open
Author interview: USPSTF Recommendation: Carotid Artery Stenosis
JAMA Patient Page: Screening for Carotid Artery Stenosis
Meta-analysis: In patients undergoing major visceral/noncardiac surgery, perioperative goal-directed therapy fluid administration reduces complications but has no effect on mortality
3 Feb, 2021 | 01:24h | UTC
Randomized trial: Similar outcomes with Dexmedetomidine or Propofol for sedation in mechanically ventilated adults with sepsis
3 Feb, 2021 | 01:30h | UTCDexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Study finds recommended ICU sedatives equally safe, effective – Vanderbilt University Medical Center AND PulmCrit Wee – MENDS2: Fentanyl or fentanyl for sedation in mechanically ventilated adults with sepsis
Randomized trial: Chlorhexidine + alcohol better at prevention of short-term peripheral venous catheter infection compared to iodine + alcohol. Innovative devices were associated with less catheter failure
3 Feb, 2021 | 01:26h | UTC
Duration of adjuvant doublet chemotherapy (3 or 6 months) in patients with high-risk stage II colorectal cancer
3 Feb, 2021 | 01:10h | UTC
Meta-analysis: Risk of colorectal cancer and cancer related mortality after detection of low-risk or high-risk adenomas, compared with no adenoma, at index colonoscopy
3 Feb, 2021 | 01:20h | UTCRisk of Colorectal Cancer and Cancer Related Mortality After Detection of Low-risk or High-risk Adenomas, Compared With No Adenoma, at Index Colonoscopy: A Systematic Review And Meta-Analysis – Gastroenterology (link to abstract – $ for full-text)
Related studies: Colorectal Cancer Incidence and Mortality After Removal of Adenomas During Screening Colonoscopies – Gastroenterology AND Long-term Risk of Colorectal Cancer and Related Death After Adenoma Removal in a Large, Community-based Population – Gastroenterology (link to abstract – $ for full-text) AND Baseline Colonoscopy Findings Associated with 10-Year Outcomes in a Screening Cohort Undergoing Colonoscopy Surveillance – Gastroenterology (link to abstract – $ for full-text) AND Association of Colonoscopy Adenoma Findings With Long-term Colorectal Cancer Incidence – JAMA
Related guideline: Recommendations for Follow-Up After Colonoscopy and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer – Gastroenterology
Atrial fibrillation in low- and middle-income countries: a narrative review
3 Feb, 2021 | 01:23h | UTCAtrial fibrillation in low- and middle-income countries: a narrative review – European Heart Journal
ASH ISTH NHF WFH 2021 guidelines on the management of von Willebrand disease
3 Feb, 2021 | 01:07h | UTCASH ISTH NHF WFH 2021 guidelines on the management of von Willebrand disease – Blood
Consensus recommendations: Diagnosis and management of Bartter syndrome
3 Feb, 2021 | 01:04h | UTC
Small study shows feasibility of MRI-guided focused ultrasound ablation for localized intermediate-risk prostate cancer
3 Feb, 2021 | 01:09h | UTCCommentary: Study: MRI-guided ultrasound treats prostate cancer with few side effects – UPI
The AstraZeneca vaccine and over-65s: we may not have all the data yet, but limiting access could be counterproductive
3 Feb, 2021 | 01:46h | UTC
Oxford/AstraZeneca study supports UK decision to delay second doses
3 Feb, 2021 | 01:47h | UTCOxford/AstraZeneca study supports UK decision to delay second doses – Financial Times
Original study (preprint): Single Dose Administration, And The Influence Of The Timing Of The Booster Dose On Immunogenicity and Efficacy Of ChAdOx1 nCoV-19 (AZD1222) Vaccine
See also: Single dose of AstraZeneca vaccine could cut transmission by 67% – The Guardian AND Oxford vaccine could substantially cut spread – BBC
Commentary on Twitter (thread – click for more)
NEW: fresh data from trials in Brazil, South Africa and the UK shows the Oxford/AstraZeneca vaccine is highly effective with a 12 week gap between doses.
Efficacy is in fact much higher with a 12 week interval than a shorter gap
Story by @donatopmancini: https://t.co/PK4NHhGHeH pic.twitter.com/W3urxSECKL
— John Burn-Murdoch (@jburnmurdoch) February 2, 2021
Russia’s Sputnik V COVID-19 vaccine candidate appears safe and is 91.6% effective
3 Feb, 2021 | 01:49h | UTCCommentaries: Sputnik V COVID-19 vaccine candidate appears safe and effective – The Lancet AND Russia’s “Sputnik V” COVID Vaccine Makes Strong 91.6 % Efficacy Showing In Peer-Reviewed Trial Results – Health Policy Watch AND Russia’s COVID vaccine 92% effective, even in those over 60 – CIDRAP AND Russia’s Sputnik V vaccine has 92% efficacy in trial – BBC AND Expert reaction to study looking at preliminary efficacy and safety results from interim analysis of Russian COVID-19 phase 3 vaccine (Sputnik) trial – Science Media Centre
Commentary on Twitter
NEW—Interim analysis of Russian #COVID19 #vaccine phase 3 trial involving nearly 20,000 participants suggests a two-dose regimen has an efficacy of 91.6% against symptomatic #COVID19. No serious adverse events were deemed to be associated with vaccination. https://t.co/40sM7f2nbS pic.twitter.com/Hzrs34uCWr
— The Lancet (@TheLancet) February 2, 2021
Editorial: Coronavirus is in the air — there’s too much focus on surfaces
3 Feb, 2021 | 01:40h | UTCCoronavirus is in the air — there’s too much focus on surfaces – Nature
Related: COVID-19 rarely spreads through surfaces. So why are we still deep cleaning? – Nature
Covid-19: People who have had infection might only need one dose of mRNA vaccine
3 Feb, 2021 | 01:44h | UTCCovid-19: People who have had infection might only need one dose of mRNA vaccine – The BMJ
Original preprint studies: Robust spike antibody responses and increased reactogenicity in seropositive individuals after a single dose of SARS-CoV-2 mRNA vaccine – medRxiv AND Single Dose Vaccination in Healthcare Workers Previously Infected with SARS-CoV-2 – medRxiv
Coronapod: Fixing the world’s pandemic alarm – A year ago the WHO’s coronavirus emergency alarm was largely ignored. Why?
3 Feb, 2021 | 01:43h | UTCCoronapod: Fixing the world’s pandemic alarm – Nature
Observational study: The combination of Immunoglobulins + Methylprednisolone was associated with a better course of fever compared to Immunoglobulins alone in Multisystem Inflammatory Syndrome in children
3 Feb, 2021 | 01:39h | UTC
Commentaries on Twitter
In this cohort study, treatment w IVIG + methylprednisolone was associated w lower risk of treatment failure (defined as fever persistence 2d after start of therapy or fever recrudescence within 7 days) vs IVIG alone among children w MIS-C https://t.co/LjEBFuf33q
— JAMA (@JAMA_current) February 1, 2021
Yes, retrospective, but I find these data interesting as I expect the combined treatment group to be the sicker of the 2
Association of IVIG Plus Methylprednisolone With Persistent or Recurrent Fever in Children With MIS-C https://t.co/Oio8t05zQ1 via @JAMA_current @JAMANetwork
— Joshua Denson MD (@jdensonMD) February 2, 2021
Perspective: We may never get to herd immunity
3 Feb, 2021 | 01:37h | UTCWe May Never Get to Herd Immunity – Think Global Health
Opinion: The Brazil variant is exposing the world’s vulnerability
3 Feb, 2021 | 01:38h | UTCThe Brazil Variant Is Exposing the World’s Vulnerability – The Atlantic
One in three adults report anxiety, depression related to COVID-19
3 Feb, 2021 | 01:35h | UTCOne in three adults report anxiety, depression related to COVID-19 – Duke-NUS Medical School