Daily Archives: January 15, 2021
Observational study: Among patients hospitalized with Covid-19 not receiving mechanical ventilation, transfusion of plasma with higher anti–SARS-CoV-2 IgG antibody levels is linked to lower risk of death than transfusion of plasma with lower antibody levels
15 Jan, 2021 | 08:59h | UTCEditorial: (A Little) Clarity on Convalescent Plasma for Covid-19 – New England Journal of Medicine
Commentaries: Expert reaction to study looking at convalescent plasma antibody levels and risk of death from COVID-19 – Science Media Centre AND Antibody-rich convalescent plasma may lower risk of COVID death – CIDRAP
Opinion: RCTs don’t justify using convalescent plasma or antibody cocktails
15 Jan, 2021 | 08:58h | UTCRCTs don’t justify using convalescent plasma or antibody cocktails – PulmCrit
[Preprint] Past COVID-19 infection provides some immunity but people may still carry and transmit virus
15 Jan, 2021 | 09:02h | UTCSee also: Covid-19: Past infection provides 83% protection for five months but may not stop transmission, study finds – The BMJ AND COVID reinfections are unusual — but could still help the virus to spread – Nature AND COVID-19 infection gives some immunity, but virus can still be spread, study finds – Reuters AND Expert reaction to a preprint from the SIREN study looking at SARS-CoV-2 infection rates in antibody positive healthcare workers – Science Media Centre
Perspective: Ivermectin for COVID-19 — Breakthrough Treatment or Hydroxychloroquine Redux?
15 Jan, 2021 | 08:51h | UTCRelated video: Ivermectin For COVID-19 | A Doctor Explains – ZDoggMD
NIH Guideline Statement: “there are insufficient data to recommend either for or against the use of ivermectin for the treatment of COVID-19”
15 Jan, 2021 | 08:53h | UTC
Covid-19 Vaccine — Frequently Asked Questions
15 Jan, 2021 | 08:49h | UTCCovid-19 Vaccine — Frequently Asked Questions – New England Journal of Medicine
Progression of myopia in school-aged children after COVID-19 home confinement
15 Jan, 2021 | 08:55h | UTCProgression of Myopia in School-Aged Children After COVID-19 Home Confinement – JAMA Ophthalmology
Commentaries: 2020 as the Year of Quarantine Myopia – JAMA Ophthalmology AND How Does Home Confinement Impact Children’s Eyesight? – AJMC AND COVID-19: Home Quarantine Linked to Increase in Myopia Among Younger Children – NEJM Journal Watch AND Vision problems arise in young school kids in COVID-19 quarantine – CIDRAP
Interview: 2020 as the Year of Quarantine Myopia
COVID-19 measures also suppress flu—for now
15 Jan, 2021 | 08:46h | UTCCOVID-19 measures also suppress flu—for now – Science
Meta-analysis of randomized trials: patients adhering to a low carbohydrate diet for six months may experience remission of diabetes without adverse consequences
15 Jan, 2021 | 08:43h | UTCCommentary: Short term low carbohydrate diet linked to remission of type 2 diabetes – The BMJ
Short term low carbohydrate diet linked to remission of type 2 diabetes in new #BMJResearch. But further trials are needed to determine longer term effects, say researchers @methodsnerd et al.
Includes a #VisualAbstract by @will_s_t #BMJInfographichttps://t.co/qihKAib11U pic.twitter.com/3rPH0ZrSGL— The BMJ (@bmj_latest) January 14, 2021
Covid-19: When to start invasive ventilation is “the million dollar question”
15 Jan, 2021 | 08:48h | UTCCovid-19: When to start invasive ventilation is “the million dollar question” – The BMJ
Commentary on Twitter
Options for ventilating covid-19 patients have expanded since the first wave of the pandemic, but doctors are unsure of the best management pathway because evidence is lacking, reports @ingridtorjesenhttps://t.co/iKldASmahF
— The BMJ (@bmj_latest) January 14, 2021
Randomized trial: Naltrexone-Bupropion combination may help some people (13.6% vs. 2.5% with placebo) with methamphetamine use disorder
15 Jan, 2021 | 08:39h | UTCBupropion and Naltrexone in Methamphetamine Use Disorder – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Combination of two drugs can help treat methamphetamine addiction for some, new clinical trial data shows – STAT AND Naltrexone-Bupropion Combination May Help People With Methamphetamine Use Disorder – Psychiatric News Alert
Covid-19 deaths are the highest they’ve ever been — and the more infectious variants could make things much worse
15 Jan, 2021 | 08:45h | UTC
Meta-analysis of randomized trials: SGLT-2 inhibitors and GLP-1 receptor agonists reduce cardiovascular and renal outcomes in type 2 diabetes
15 Jan, 2021 | 08:41h | UTCCalculator based on the results: interactive decision support tool for outcomes
Cohort study: Even small amounts of alcohol consumption linked to increased risk of atrial fibrillation
15 Jan, 2021 | 08:40h | UTCEditorial: Alcohol consumption, atrial fibrillation, and cardiovascular disease: finding the right balance
A new mandate highlights costs, benefits of making all scientific articles free to read
15 Jan, 2021 | 08:30h | UTCA new mandate highlights costs, benefits of making all scientific articles free to read – Science
Related: Open-access Science Funders Announce Price Transparency Rules for Publishers (several resources on the subject)
Dietary Guidelines for Americans, 2020-2025
15 Jan, 2021 | 08:31h | UTCDietary Guidelines for Americans, 2020-2025 – United States Department of Agriculture
Commentary: U.S. Diet Guidelines Sidestep Scientific Advice to Cut Sugar and Alcohol – The New York Times
Clinical trial finds vitamin D does not ward off colds and flu
15 Jan, 2021 | 08:33h | UTC
Study: Pulmonary embolism detected in 6% of patients with COPD admitted to the hospital with acute worsening of respiratory symptoms
15 Jan, 2021 | 08:37h | UTCPrevalence of Pulmonary Embolism Among Patients With COPD Hospitalized With Acutely Worsening Respiratory Symptoms – JAMA (link to abstract – $ for full-text)
Study: Seizure frequency does not increase during Pregnancy
15 Jan, 2021 | 08:28h | UTCChanges in Seizure Frequency and Antiepileptic Therapy during Pregnancy – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: MONEAD Study: Does Pregnancy Lead to Increased Seizure Frequency in Women with Epilepsy? – Physician’s Weekly AND Pregnancy Does Not Increase Seizures in Women With Epilepsy – Medscape
Consequences to patients, clinicians, and manufacturers when very serious adverse drug reactions are identified (1997–2019)
15 Jan, 2021 | 08:26h | UTC
Commentary on Twitter
Great paper with lots of interesting data. What strikes me most: the drawbacks (retaliation) the clinicians experienced who reported the severe adverse drug reactions (several were sued by Big Pharma, one lost his professorship)https://t.co/NimX0rnsAt
— Michael P. Hengartner, PhD (@HengartnerMP) December 26, 2020
Cohort study: Piperacillin/tazobactam linked to increased risk of acute kidney injury when compared to cefepime or meropenem
15 Jan, 2021 | 08:24h | UTC
Commentary on Twitter
NEW ?? #CID @IDSAInfo
Risk of AKI & CDI with piperacillin/tazobactam, cefepime and meropenem with or without vancomycin #IDTwitter @danlivorsi
TZP ⬆️ AKI risk, which was exacerbated by concurrent vancomycin.
FEP&MER ⬆️CDI risk relative to TZP. https://t.co/0pIurl7A7w pic.twitter.com/ZjjvN2rkWP— Antibiotic Steward? Bassam Ghanem (@ABsteward) December 31, 2020
Randomized trial: Biological mesh results in significantly more complications compared to synthetic mesh in noncomplex ventral hernia repair
15 Jan, 2021 | 08:17h | UTCSynthetic Versus Biological Mesh in Laparoscopic and Open Ventral Hernia Repair (LAPSIS): Results of a Multinational, Randomized, Controlled, and Double-blind Trial – Annals of Surgery (link to abstract – $ for full-text)
Commentary on Twitter
The use of biological mesh resulted in significantly more complications (P = 0.013),also after adjusting for hernia type, body mass index,and study site.The trial was prematurely stopped due to unacceptable high recurrence rate in the biological mesh arms https://t.co/P0fV50xopv
— George Ferzli (@drferzli) December 25, 2020
Randomized trial: Surgical and drug treatment options lead to similar outcomes for diabetic eye disease
15 Jan, 2021 | 08:22h | UTCOriginal Study: Effect of Intravitreous Aflibercept vs Vitrectomy With Panretinal Photocoagulation on Visual Acuity in Patients With Vitreous Hemorrhage From Proliferative Diabetic Retinopathy: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentary on Twitter
In this RCT, intravitreous aflibercept vs vitrectomy + panretinal photocoagulation did not improve visual acuity over 24 weeks in patients with vitreous hemorrhage from proliferative diabetic retinopathy; the study may have been underpowered https://t.co/n4px6kFF5Z
— JAMA (@JAMA_current) December 18, 2020
[Abstract Only] A randomized clinical trial of low dose warfarin therapy for improving the longevity of permanent arteriovenous catheters
15 Jan, 2021 | 08:18h | UTCA randomized clinical trial of low dose warfarin therapy for improving the longevity of permanent arteriovenous catheters – Annals of Vascular Surgery (link to abstract – $ for full-text)
CSCO and ASCO Guideline: Chemotherapy in combination with radiotherapy for definitive-intent treatment of stage II-IVA nasopharyngeal carcinoma
15 Jan, 2021 | 08:14h | UTC