Daily Archives: October 25, 2020
Universal mask use could save 130,000 U.S. lives by the end of February, new study estimates
25 Oct, 2020 | 23:51h | UTCUniversal mask use could save 130,000 U.S. lives by the end of February, new study estimates – STAT
Original Study: Modeling COVID-19 scenarios for the United States – Nature Medicine
Commentary on Twitter
Universal mask use could save up to 130k lives from September 22, 2020 through the end of February 2021 in the United States and avoid the need for more strict measures to contain the spread of #COVID19. Read now: https://t.co/TKhSusVnZl @IHME_UW @SimonHayHealer pic.twitter.com/XVS4PgInhT
— Nature Medicine (@NatureMedicine) October 23, 2020
Fauci says it might be time to mandate masks as Covid-19 surges across US
25 Oct, 2020 | 23:50h | UTCFauci says it might be time to mandate masks as Covid-19 surges across US – CNN
[Preprint] Randomized trial: Nitazoxanide does not improve symptoms in mild Covid-19 disease
25 Oct, 2020 | 23:46h | UTCEarly use of nitazoxanide in mild Covid-19 disease: randomized, placebo-controlled trial – medRxiv
Clinical Update: Virology, transmission, and pathogenesis of SARS-CoV-2
25 Oct, 2020 | 23:48h | UTCVirology, transmission, and pathogenesis of SARS-CoV-2 – The BMJ
Commentary on Twitter
Since the emergence of SARS-CoV-2, there has been an unparalleled global effort to characterise the virus and the clinical course of disease. What do we know about the pathophysiology of the virus so far?https://t.co/fEoVfu0rrB
— The BMJ (@bmj_latest) October 25, 2020
SARS-CoV-2 seroprevalence worldwide: a systematic review and meta-analysis
25 Oct, 2020 | 23:44h | UTC
Perspective: The race to make COVID antibody therapies cheaper and more potent
25 Oct, 2020 | 23:43h | UTCThe race to make COVID antibody therapies cheaper and more potent – Nature
Steroids boost survival of preterm babies in low-resource settings, new study finds
25 Oct, 2020 | 23:38h | UTCOriginal Study: Antenatal Dexamethasone for Early Preterm Birth in Low-Resource Countries – New England Journal of Medicine
Commentary on Twitter (thread – click for more)
? clinical trial shows that dexamethasone can boost survival of premature babies when given to pregnant women at risk of preterm birth in low-resource settings
? https://t.co/qKvDKMkrkd pic.twitter.com/hjmf01J4B1
— World Health Organization (WHO) (@WHO) October 23, 2020
[Abstract Only] Randomized trial: Effect of Finerenone on chronic kidney disease outcomes in Type 2 diabetes
25 Oct, 2020 | 23:34h | UTCEffect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Finerenone Linked to Reduced Cardiorenal Events for Chronic Kidney Disease – HCPLive
Commentary on Twitter (thread – click for more)
‼️Effect of Finerenone on CKD outcomes in T2DM
⚡️Finerenone decreased risk of CKD progression by 18%
⚡️Finerenone decreased CV morbidity & mortality by 14%
Published in @NEJM today https://t.co/XvshpZZCK4@ASNKidney #Kidneywk pic.twitter.com/FOkxnG1enz
— Aisha Shaikh (@aishaikh) October 23, 2020
Perspective: Why COVID outbreaks look set to worsen this winter
25 Oct, 2020 | 23:41h | UTCWhy COVID outbreaks look set to worsen this winter – Nature
Related: WHO warns of tough months ahead as COVID tops 42 million – CIDRAP
Perspective: COVID-19 can affect the heart
25 Oct, 2020 | 23:39h | UTCCOVID-19 can affect the heart – Science
Commentary from the author
What we know about the heart and #COVID19.
The problem is there's way too much we don't know.https://t.co/b1AR2of0gL@ScienceMagazine— Eric Topol (@EricTopol) October 25, 2020
Review: How to ventilate obese patients in the ICU
25 Oct, 2020 | 23:30h | UTCHow to ventilate obese patients in the ICU – Intensive Care Medicine (free for a limited period)
Commentary on Twitter
Ventilating obese pts in #ICU?
➡️ NIV to prevent/treat ARF + vs re-intubation
➡️ airways: evaluate, pre-oxygenate, choose devices
➡️ careful RM (case-by-case)
➡️ (moderate to high) PEEP vs collapse
➡️ low Vt (PBW!) in non-ARDS/ARDS
➡️ proning (severe ARDS)https://t.co/wKOfrSpjBC pic.twitter.com/pl92CgLHaV— Intens Care Med (@yourICM) October 23, 2020
Narrative systematic review: Benefits of medication charts provided at transitions of care
25 Oct, 2020 | 23:29h | UTC
The ‘Ten Commandments’ for the 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation
25 Oct, 2020 | 23:25h | UTCOriginal guideline and commentaries: 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation
Randomized trial: Effects of regional citrate anticoagulation vs. systemic heparin anticoagulation on dialysis filter life span and mortality among critically ill patients with acute kidney injury
25 Oct, 2020 | 23:32h | UTC
Commentary on Twitter
In this RCT, anticoagulation with regional citrate, compared with systemic heparin, resulted in longer filter life span in patients with acute kidney injury receiving continuous kidney replacement therapy https://t.co/fmkawnqjmM #VisualAbstract
— JAMA (@JAMA_current) October 23, 2020
Systematic review: Laparoscopic surgery for pain and infertility associated with endometriosis
25 Oct, 2020 | 23:23h | UTCLaparoscopic surgery for pain and infertility associated with endometriosis – Cochrane Library
Original study: Laparoscopic surgery for endometriosis – Cochrane Library
Commentary on Twitter
Updated priority #Cochrane review published "Laparoscopic surgery for #endometriosis" Laparoscopic excision or ablation probably increases #pregnancy rate compared to diagnostic laparoscopy only. No data were reported on live birth. https://t.co/OaIduKN0B8 @JamesMNDuffy pic.twitter.com/C3EnffV4d3
— CochraneCGF (@CochraneCGF) October 25, 2020
[Abstract only] Preliminary study suggests age-adjusted D-dimer can exclude left atrial thrombus in patients with atrial fibrillation
25 Oct, 2020 | 23:26h | UTCD-dimer blood concentrations to exclude left atrial thrombus in patients with atrial fibrillation – Heart (link to abstract – $ for full-text)
Commentary on Twitter
A nice study on the use of D-dimer for excluding left atrial thrombus.
Patients with D-dimer < (10 x patient's age) had 100% sensitivity and NPV for excluding LA thrombus.
This represented 60% of the population, who could in theory safely avoid TOE. https://t.co/OFUy9caWd0
— Mark Mills (@DrMarkMills) October 25, 2020
Meta-analysis: Preventive malaria treatment among school-aged children in sub-Saharan Africa
25 Oct, 2020 | 23:22h | UTCCommentaries: Landmark Study Suggests Malaria-Preventive Drugs Dramatically Reduce Infections and Improve Health of School Children – University of Maryland AND Back to school for malaria prevention: a new tool in the era of malaria elimination? – The Lancet Global Health
Commentary on Twitter
Conclusion of a new systematic review and meta-analysis: "Preventive treatment of malaria among school-aged children reduces the burden of malaria in this age group and could be a key intervention to decrease P falciparum transmission…" https://t.co/UaNBdsKaze pic.twitter.com/82e1OMX7TF
— The Lancet Global Health (@LancetGH) October 23, 2020