Daily Archives: May 3, 2020
Characteristics of 100 Children with Covid-19
3 May, 2020 | 22:29h | UTCChildren with Covid-19 in Pediatric Emergency Departments in Italy – New England Journal of Medicine
Related Systematic Review: SARS-CoV-2 Infection in Children and Adolescents (study and commentaries)
New NICE Coronavirus Rapid Guidelines
3 May, 2020 | 22:46h | UTC- COVID-19 rapid guideline: antibiotics for pneumonia in adults in hospital – National Institute for Health and Care Excellence
- COVID-19 rapid guideline: gastrointestinal and liver conditions treated with drugs affecting the immune response – National Institute for Health and Care Excellence
- COVID-19 rapid guideline: children and young people who are immunocompromised – National Institute for Health and Care Excellence
See Previous NICE Coronavirus Guidelines: Rapid guidelines and evidence summaries – National Institute for Health and Care Excellence
Consensus Document: Restarting Planned Surgery in the Context of the COVID-19 Pandemic
3 May, 2020 | 22:43h | UTCRelated: New Scoring System to Prioritize Medically Necessary Operations (report and commentary)
Report: The Future of the COVID-19 Pandemic – Lessons Learned from Pandemic Influenza
3 May, 2020 | 22:36h | UTCNews Release: COVID-19: The CIDRAP Viewpoint
New Observational Studies Confirm the Safety of Renin–Angiotensin–Aldosterone System Blockers in Patients with Covid-19
3 May, 2020 | 22:32h | UTCStudy 3: Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19 – New England Journal of Medicine
Commentary: Blood Pressure Drugs Don’t Increase Coronavirus Risk, Studies Find – The New York Times
See also: Observational Study: Renin-Angiotensin System Inhibitors are Not Associated with Severity or Mortality in Hospitalized Patients with Coronavirus Disease (2 other studies on the subject)
Cohort Study: Respiratory Pathophysiology of Mechanically Ventilated Patients with COVID-19
3 May, 2020 | 22:25h | UTCCommentary: PulmCrit – Is COVID-19 ARDS, pseudoARDS, L, or H? Physiology data from Boston – PulmCrit
Related Commentary on Twitter
COVID-19 patients do not fall into distinct "phenotypes" of high and low compliance. They exhibit a continuum of compliance, mostly low, and entirely consistent with non-COVID ARDS cohorts.
https://t.co/KiHjWvIjX3 pic.twitter.com/g7FuhrlL49
— Robert Dickson (@robertpdickson) April 30, 2020
Public Health Measures and the Reproduction Number of SARS-CoV-2
3 May, 2020 | 22:23h | UTCPublic Health Measures and the Reproduction Number of SARS-CoV-2 – JAMA
Related Editorial: Public Health Interventions for COVID-19: Emerging Evidence and Implications for an Evolving Public Health Crisis – JAMA
Case Series: Characteristics of Ischemic Stroke Associated with COVID-19
3 May, 2020 | 22:18h | UTCCommentary: Expert reaction to study looking at COVID-19, ischaemic stroke and blood clots – Science media Centre
Related: Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young – New England Journal of Medicine AND Coronavirus’s new mystery: It’s causing strokes in healthy people – Vox AND What’s Behind the Sharp Increase in Large-Vessel Stroke Risk in Young, Healthy COVID-19 Patients? – Neurology Today
Guideline: Treatment of Patients with Nonsevere and Severe Coronavirus Disease 2019
3 May, 2020 | 22:10h | UTC
Preprint Study Estimates at 10-11 Years That Each of Those Dying of Covid-19 Have Lost
3 May, 2020 | 22:21h | UTCCOVID-19 – exploring the implications of long-term condition type and extent of multimorbidity on years of life lost: a modelling study – Wellcome Open Research (via @EricTopol see Tweet – Thread)
Commentary: Coronavirus deaths ‘result in more than 10 years of life lost per person’ – Express & Star
Short Review: Coagulopathy Associated with COVID-19
3 May, 2020 | 22:09h | UTCCoagulopathy associated with COVID-19 – Canadian Medical Association Journal
Case Series: QT Intervals in Patients with COVID-19 Treated with Hydroxychloroquine Alone or in Combination with Azithromycin
3 May, 2020 | 22:01h | UTCCommentary: Beth Israel Deaconess Medical Center – Beth Israel Deaconess Medical Center
Related Studies: The Effect of Chloroquine, Hydroxychloroquine and Azithromycin on the Corrected QT Interval in Patients with SARS-CoV-2 Infection – Circulation: Arrhythmia and Electrophysiology (link to abstract – $ for full-text) AND [Preprint] QT Interval Prolongation and Torsade De Pointes in Patients with COVID-19 treated with Hydroxychloroquine/Azithromycin – medRxiv
Offline: A Global Health Crisis? No, Something far Worse
3 May, 2020 | 21:58h | UTCOffline: A global health crisis? No, something far worse – The Lancet
FDA Issues Emergency Use Authorization for the Use of Remdesivir to Treat COVID-19
3 May, 2020 | 22:03h | UTCSee also: Remdesivir: A Non-Antiviral Antiviral Drug? – Forbes
Drive-Through Testing for SARS-CoV-2
3 May, 2020 | 21:54h | UTC
Opinion: Pregnant Women Should be Given the Opportunity to be Included in Clinical Trials for COVID-19
3 May, 2020 | 21:51h | UTC“We recommend and urge the scientific community and professional societies that, without clear justification for exclusion, pregnant women should be given the opportunity to be included in clinical trials for COVID-19 based on the concepts of justice, equity, autonomy, and informed consent.”
SARS-CoV-2 Productively Infects Human Gut Enterocytes
3 May, 2020 | 21:52h | UTCSARS-CoV-2 productively infects human gut enterocytes – Science
Commentaries: SARS-CoV-2 Infection of Gut Organoids Bolsters Case for Intestinal Transmission – GEN AND Coronavirus SARS-CoV-2 infects cells of the intestine – Hubrecht Institute
Randomized Trial: Fluid Response Evaluation in Sepsis Hypotension and Shock
3 May, 2020 | 21:47h | UTCFluid Response Evaluation in Sepsis Hypotension and Shock: A Randomized Clinical Trial – Chest
[Abstract Only] Meta-Analysis: Prevalence of Harmful Diagnostic Errors in Hospitalized Adults
3 May, 2020 | 21:45h | UTCPrevalence of harmful diagnostic errors in hospitalised adults: a systematic review and meta-analysis – BMJ Quality & Safety (link to abstract – $ for full-text) (via @brhospitalist)
Related Commentary on Twitter
Systematic review of 22 UK studies found that 14 common diagnoses, including malignancy and pulmonary embolism, accounted for more than half of missed or delayed diagnoses in hospital patients. @BMJ_Qual_Saf https://t.co/1JypG7idlJ pic.twitter.com/YxKeiZr5x0
— AHRQ (@AHRQNews) May 1, 2020
Mon May 04 – 10 Stories of The Day!
3 May, 2020 | 22:51h | UTC
1 – New NICE Coronavirus Rapid Guidelines
- COVID-19 rapid guideline: antibiotics for pneumonia in adults in hospital – National Institute for Health and Care Excellence
- COVID-19 rapid guideline: gastrointestinal and liver conditions treated with drugs affecting the immune response – National Institute for Health and Care Excellence
- COVID-19 rapid guideline: children and young people who are immunocompromised – National Institute for Health and Care Excellence
See Previous NICE Coronavirus Guidelines: Rapid guidelines and evidence summaries – National Institute for Health and Care Excellence
Related: New Scoring System to Prioritize Medically Necessary Operations (report and commentary)
News Release: COVID-19: The CIDRAP Viewpoint
4 – New Observational Studies Confirm the Safety of Renin–Angiotensin–Aldosterone System Blockers in Patients with Covid-19
Study 3: Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19 – New England Journal of Medicine
Commentary: Blood Pressure Drugs Don’t Increase Coronavirus Risk, Studies Find – The New York Times
See also: Observational Study: Renin-Angiotensin System Inhibitors are Not Associated with Severity or Mortality in Hospitalized Patients with Coronavirus Disease (2 other studies on the subject)
Related Systematic Review: SARS-CoV-2 Infection in Children and Adolescents (study and commentaries)
Commentary: PulmCrit – Is COVID-19 ARDS, pseudoARDS, L, or H? Physiology data from Boston – PulmCrit
7 – Public Health Measures and the Reproduction Number of SARS-CoV-2 – JAMA
Related Editorial: Public Health Interventions for COVID-19: Emerging Evidence and Implications for an Evolving Public Health Crisis – JAMA
8 – COVID-19 – exploring the implications of long-term condition type and extent of multimorbidity on years of life lost: a modelling study – Wellcome Open Research (via @EricTopol see Tweet – Thread)
Commentary: Coronavirus deaths ‘result in more than 10 years of life lost per person’ – Express & Star
Commentary: Expert reaction to study looking at COVID-19, ischaemic stroke and blood clots – Science media Centre
Related: Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young – New England Journal of Medicine AND Coronavirus’s new mystery: It’s causing strokes in healthy people – Vox AND What’s Behind the Sharp Increase in Large-Vessel Stroke Risk in Young, Healthy COVID-19 Patients? – Neurology Today
10 – Coronavirus Disease (COVID-19) Updates / 04 May 2020 Edition
04 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)