Daily Archives: April 13, 2020
IDSA Guidelines on the Treatment and Management of Patients with COVID-19 Infection
13 Apr, 2020 | 00:27h | UTC
Related Commentary on Twitter
NEW: IDSA Guidelines on the Treatment & Management of Patients with COVID-19 Infection. These evidence-based rapid guidelines, updated in real-time, will address pressing clinical questions related to caring for patients w/ COVID-19: https://t.co/mvi9Paa8Xv #COVID19Guidelines pic.twitter.com/NKbYAbO21J
— IDSA (@IDSAInfo) April 11, 2020
Mon April 13 – 10 Stories of The Day!
13 Apr, 2020 | 00:31h | UTC
Commentaries: 40% of people with severe COVID-19 experience neurological complications – UPI AND AND Expert reaction to paper on neurological manifestations of patients hospitalised with COVID-19 in Wuhan, China – Science Media Centre
Commentaries: PulmCrit – Eleven reasons the NEJM paper on remdesivir reveals nothing AND Expert reaction to a study about compassionate use of remdesivir for patients with severe COVID-19 – Science Media Centre AND What Do the New Remdesivir Data Mean? – Science Translational Medicine
Related Observational Studies: Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia – Journal of Thrombosis and Haemostasis AND Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy – Journal of Thrombosis and Haemostasis AND Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia – Journal of Thrombosis and Haemostasis
5 – D-dimer cutoffs to predict thrombosis in COVID-19 – PulmCrit
Note: this link is not an endorsement of the algorithm.
Related Guidance: Practical guidance for the prevention of thrombosis and management of coagulopathy and disseminated intravascular coagulation of patients infected with COVID-19 – Thrombosis UK AND ISTH interim guidance on recognition and management of coagulopathy – Journal of Thrombosis and Haemostasis
7 – Mechanical Ventilators Adapted from BiPAP machines?
Modified Sleep Apnea Machines May Ease the Ventilator Crunch – Wired
Mechanical ventilators based on a simple modification of CPAP and BiPAP machines – News Medical
Turning sleep apnea machines into ventilators – Berkley Engineering
See instructions and protocols developed by Mount Sinai Health System: Repurposing bi-level ventilators for use with intubated patients while minimizing risk to health care works during insufficient supply of conventional ventilation for patients with COVID-19
We want to learn more about this interesting initiative!
8 – Studies: Obesity Increases the Risk of Complications in Patients with Covid-19
2 – Obesity in patients younger than 60 years is a risk factor for Covid-19 hospital admission – Clinical Infectious Diseases AND Commentary: In New York, obesity appears to raise COVID-19 risk – CIDRAP
9 – Studies: Diabetes Increases the Risk of Complications in Patients with Covid-19
1 – Prevalence and impact of diabetes among people infected with SARS-CoV-2 – Journal of Endocrinological Investigation AND Commentary: Diabetes Could Increase Severity of COVID-19, Including Risk of ICU Admission and Death – MedicalResearch.com
2 – Evidence Reviews: Diabetes and risks from COVID-19 – CEBM University of Oxford AND Managing diabetes during the COVID-19 pandemic – CEBM University of Oxford
10 – Coronavirus Disease (COVID-19) Updates / 13 April 2020 Edition
13 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)
Compassionate Use of Remdesivir for Patients with Severe Covid-19
13 Apr, 2020 | 00:23h | UTCCompassionate Use of Remdesivir for Patients with Severe Covid-19 – New England Journal of Medicine
Commentaries: PulmCrit – Eleven reasons the NEJM paper on remdesivir reveals nothing AND Expert reaction to a study about compassionate use of remdesivir for patients with severe COVID-19 – Science Media Centre AND What Do the New Remdesivir Data Mean? – Science Translational Medicine
Study: Neurologic Manifestations Common in Hospitalized Patients with Covid-19
13 Apr, 2020 | 00:25h | UTCCommentaries: 40% of people with severe COVID-19 experience neurological complications – UPI AND AND Expert reaction to paper on neurological manifestations of patients hospitalised with COVID-19 in Wuhan, China – Science Media Centre
Possible Algorithm to Empiric Anticoagulation in COVID-19 Based on D-Dimer
13 Apr, 2020 | 00:20h | UTCD-dimer cutoffs to predict thrombosis in COVID-19 – PulmCrit
Note: this link is not an endorsement of the algorithm.
Related Guidance: Practical guidance for the prevention of thrombosis and management of coagulopathy and disseminated intravascular coagulation of patients infected with COVID-19 – Thrombosis UK AND ISTH interim guidance on recognition and management of coagulopathy – Journal of Thrombosis and Haemostasis
Incidence of Thrombotic Complications in Critically ill ICU Patients with COVID-19
13 Apr, 2020 | 00:22h | UTCRelated Observational Studies: Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia – Journal of Thrombosis and Haemostasis AND Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy – Journal of Thrombosis and Haemostasis AND Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia – Journal of Thrombosis and Haemostasis
Implementation Guide: Optimizing Medication Management during the COVID-19 Pandemic
13 Apr, 2020 | 00:18h | UTC
Related Commentary on Twitter
Task force recommendations about managing meds in post-acute and long-term care during COVID-19. https://t.co/yoU76suVYo
Summary of recommendations in thread below:
— Mike Steinman (@MikeSteinman) April 10, 2020
Studies: Obesity Increases the Risk of Complications in Patients with Covid-19
13 Apr, 2020 | 00:14h | UTC2 – Obesity in patients younger than 60 years is a risk factor for Covid-19 hospital admission – Clinical Infectious Diseases AND Commentary: In New York, obesity appears to raise COVID-19 risk – CIDRAP
Mechanical Ventilators Adapted from BiPAP machines?
13 Apr, 2020 | 00:17h | UTC- Modified Sleep Apnea Machines May Ease the Ventilator Crunch – Wired
- Mechanical ventilators based on a simple modification of CPAP and BiPAP machines – News Medical
- A NYC hospital has figured out how to turn sleep apnea machines it got from Elon Musk into ventilators for coronavirus patients – Business Insider
- Turning sleep apnea machines into ventilators – Berkley Engineering
See instructions and protocols developed by Mount Sinai Health System: Repurposing bi-level ventilators for use with intubated patients while minimizing risk to health care works during insufficient supply of conventional ventilation for patients with COVID-19
We want to learn more about this interesting initiative!
Study: Antibody Tests Reveal 14% are Immune to Covid-19 in German Town
13 Apr, 2020 | 00:10h | UTC- Blood tests show 14% of people are now immune to covid-19 in one town in Germany – MIT Technology Review
- COVID antibody test in German town shows 15 percent infection rate – Spectator
- Expert reaction to unpublished preliminary findings looking at the presence of antibodies to SARS-CoV-2 virus in residents of Gangelt, in Germany – Science Media Centre
The original report can be found here (in German)
Studies: Diabetes Increases the Risk of Complications in Patients with Covid-19
13 Apr, 2020 | 00:12h | UTC1 – Prevalence and impact of diabetes among people infected with SARS-CoV-2 – Journal of Endocrinological Investigation AND Commentary: Diabetes Could Increase Severity of COVID-19, Including Risk of ICU Admission and Death – MedicalResearch.com
2 – Evidence Reviews: Diabetes and risks from COVID-19 – CEBM University of Oxford AND Managing diabetes during the COVID-19 pandemic – CEBM University of Oxford
[Preprint] Factors Associated with Worse Outcomes Among 4,103 Patients with COVID-19 in New York City
13 Apr, 2020 | 00:09h | UTC
Apple and Google are Launching a Joint COVID-19 Tracing Tool for iOS and Android
13 Apr, 2020 | 00:08h | UTCApple and Google are launching a joint COVID-19 tracing tool for iOS and Android – TechCrunch
See also: Will We Accept Being Monitored Via Our Smartphones As A Way Out Of The Pandemic, And Will We Have Any Say In The Matter? – Forbes AND Apple and Google team up in bid to use smartphones to track coronavirus spread – The Guardian AND Apple, Google Bring Covid-19 Contact-Tracing to 3 Billion People – Bloomberg AND How Apple and Google Are Enabling Covid-19 Contact-Tracing – Wired AND How Apple And Google’s COVID-19 Tracing Works While Still Protecting Your Privacy – Forbes AND Apple and Google Team Up to ‘Contact Trace’ the Coronavirus – The New York Times AND Coronavirus: UK confirms plan for its own contact tracing app – BBC
News Release: Apple and Google partner on COVID-19 contact tracing technology – Google
Opinion – BCG Against Coronavirus: Less Hype and More Evidence, Please
13 Apr, 2020 | 00:06h | UTCSee new Preprints suggesting caution in correlating BCG vaccination policies with COVID-19 incidence and mortality:
- [Preprint] BCG protects against COVID-19? A word of caution – medRxiv
- [Preprint] Exercising caution in correlating COVID-19 incidence and mortality rates with BCG vaccination policies due to variable rates of SARS CoV-2 testing – medRxiv
- [Preprint] Association Between BCG Policy is Significantly Confounded by Age and is Unlikely to Alter Infection or Mortality Rates – medRxiv
See previous studies suggesting a benefit from BCG vaccination:
- Observational Studies: Countries with Universal BCG Vaccination Policy May Have Reduced Mortality from COVID-19 (preprints on the subject)
Updated Guidance on Personal Protective Equipment (PPE) for Clinicians
13 Apr, 2020 | 00:02h | UTCUpdated guidance on Personal Protective Equipment (PPE) for clinicians – Intensive Care Society
Related: Clinical guidance for intensive care and anesthetics AND COVID-19: guidance for health professionals – GOV.UK
Surgery in COVID-19 Patients: Operational Directives
13 Apr, 2020 | 00:03h | UTCSurgery in COVID-19 patients: operational directives – World Journal of Emergency Surgery
COVID-19 Testing: The Threat of False-Negative Results
13 Apr, 2020 | 00:04h | UTCCOVID-19 Testing: The Threat of False-Negative Results – Mayo Clinic Proceedings
Commentary: False-negative COVID-19 test results may lead to false sense of security – Mayo Clinic
Op-ed by Bill Gates: Why we Need a Global Approach to Fighting Covid-19 Now
13 Apr, 2020 | 00:00h | UTC