Mon April 13 – 10 Stories of The Day!

1 – Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19 Infection

2 – Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China – JAMA Neurology

Editorial: The Spectrum of Neurologic Disease in the Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic Infection: Neurologists Move to the Frontlines

Commentaries: 40% of people with severe COVID-19 experience neurological complications – UPI AND AND Expert reaction to paper on neurological manifestations of patients hospitalised with COVID-19 in Wuhan, China – Science Media Centre

Related: Preparing a neurology department for SARS-CoV-2 (COVID-19): Early experiences at Columbia University Irving Medical Center and the New York Presbyterian Hospital in New York City – Neurology

3 – Compassionate Use of Remdesivir for Patients with Severe Covid-19 – New England Journal of Medicine

Commentaries: PulmCrit – Eleven reasons the NEJM paper on remdesivir reveals nothing AND Expert reaction to a study about compassionate use of remdesivir for patients with severe COVID-19 – Science Media Centre AND What Do the New Remdesivir Data Mean? – Science Translational Medicine

4 – Incidence of thrombotic complications in critically ill ICU patients with COVID-19 – Thrombosis Research

Related Observational Studies: Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia – Journal of Thrombosis and Haemostasis AND Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy – Journal of Thrombosis and Haemostasis AND Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia – Journal of Thrombosis and Haemostasis

5 – D-dimer cutoffs to predict thrombosis in COVID-19 – PulmCrit

Note: this link is not an endorsement of the algorithm.

Related Guidance: Practical guidance for the prevention of thrombosis and management of coagulopathy and disseminated intravascular coagulation of patients infected with COVID-19 – Thrombosis UK AND ISTH interim guidance on recognition and management of coagulopathy – Journal of Thrombosis and Haemostasis

6 – Optimizing Medication Management during the COVID-19 Pandemic: Implementation Guide for Post-Acute and Long-Term Care – University of Maryland School of Pharmacy

7 – Mechanical Ventilators Adapted from BiPAP machines?

Modified Sleep Apnea Machines May Ease the Ventilator Crunch – Wired

Mechanical ventilators based on a simple modification of CPAP and BiPAP machines – News Medical

A NYC hospital has figured out how to turn sleep apnea machines it got from Elon Musk into ventilators for coronavirus patients – Business Insider

Turning sleep apnea machines into ventilators – Berkley Engineering

See instructions and protocols developed by Mount Sinai Health System: Repurposing bi-level ventilators for use with intubated patients while minimizing risk to health care works during insufficient supply of conventional ventilation for patients with COVID-19

We want to learn more about this interesting initiative!

8 – Studies: Obesity Increases the Risk of Complications in Patients with Covid-19

1 – High prevalence of obesity in severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) requiring invasive mechanical ventilation – Obesity

2 – Obesity in patients younger than 60 years is a risk factor for Covid-19 hospital admission – Clinical Infectious Diseases AND Commentary: In New York, obesity appears to raise COVID-19 risk – CIDRAP

9 – Studies: Diabetes Increases the Risk of Complications in Patients with Covid-19

1 – Prevalence and impact of diabetes among people infected with SARS-CoV-2 – Journal of Endocrinological Investigation AND Commentary: Diabetes Could Increase Severity of COVID-19, Including Risk of ICU Admission and Death – MedicalResearch.com

2 – Evidence Reviews: Diabetes and risks from COVID-19 – CEBM University of Oxford AND Managing diabetes during the COVID-19 pandemic – CEBM University of Oxford

10 – Coronavirus Disease (COVID-19) Updates / 13 April 2020 Edition

13 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)