Daily Archives: April 7, 2020

Coronavirus Disease (COVID-19) Updates / 07 April 2020 Edition

7 Apr, 2020 | 02:01h | UTC

7 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives.

 

Coronavirus Tracked: The Latest Figures

• Coronavirus tracked: the latest figures as the pandemic spreads – Financial Times
• Johns Hopkins Coronavirus Interactive Map
• Coronavirus Map: Tracking the Global Outbreak – The New York Times
• Coronavirus Disease (COVID-19) – Statistics and Research – Our World in Data
• WHO: Latest COVID-19 Situation Report – 06 April 2020

WHO Director-General’s Statement

• WHO Director-General’s opening remarks at the media briefing on COVID-19 – 6 April 2020

Podcasts: 

• COVID-19 from a global health perspective – Stanford Medicine

Videos:

• (for patients) How Coronavirus Attacks the Body – The New York Times

Guidelines & Reports:

• Triage Considerations for Patients Referred for Structural Heart Disease Intervention During the Coronavirus Disease 2019 (COVID-19) Pandemic: An ACC /SCAI Consensus Statement – JACC: Cardiovascular Interventions AND Commentary: ACC/SCAI Consensus Document Guides Triage For Structural Heart Disease During COVID-19 Pandemic
• Guidance for the management of myasthenia gravis (MG) and Lambert Eaton myasthenic syndrome (LEMS) during the COVID-19 pandemic – Journal of Neurological Sciences
• Recommendations for the surgical management of gynecological cancers during the COVID-19 pandemic – FRANCOGYN group for the CNGOF – Journal of Gynecology Obstetrics and Human Reproduction

COVID‐19: ATS Interim Guidance on Management Pending Empirical Evidence

• COVID‐19: Interim Guidance on Management Pending Empirical Evidence. From an American Thoracic Society‐led International Task Force
• Commentary: ATS publishes new guidance on COVID-19 management – American Thoracic Society

AAP Guideline: Management of Infants Born to Mothers with COVID-19

• Management of Infants Born to Mothers with COVID-19 – American Academy of Pediatrics
• News Release: AAP issues guidance on infants born to mothers with suspected or confirmed COVID-19 – American Academy of Pediatrics
• FAQs: Management of Infants Born to Mothers with Suspected or Confirmed COVID-19 – American Academy of Pediatrics
• Commentary: Policy statement outlines recommendations on management of infants born to mothers with COVID-19 – 2 Minute Medicine

Guidelines for Managing the Airway in Children with COVID-19:

• Consensus guidelines for managing the airway in children with COVID-19 – Intensive Care Society

Global Interim Guidance on COVID‐19 During Pregnancy and Puerperium:

• Global interim guidance on coronavirus disease 2019 (COVID‐19) during pregnancy and puerperium from FIGO and allied partners: Information for healthcare professionals – International Journal of Gynecology & Obstetrics

Editorial: Is CPR Justified for Hospital Patients with Covid-19?

• Editorial: Cardiopulmonary Resuscitation after Hospital Admission with Covid-19 – The BMJ

“This pandemic has changed the risk-benefit balance for CPR: from “there is no harm in trying” to “there is little benefit to the patient, and potentially significant harm to staff.””

Study: Effectiveness of Surgical and Cotton Masks in Blocking SARS–CoV-2

• Effectiveness of Surgical and Cotton Masks in Blocking SARS–CoV-2: A Controlled Comparison in 4 Patients – Annals of Internal Medicine
• Commentary: Neither surgical nor cotton masks effectively filter SARS COV-2 – American College of Physicians

Opinions on Lifting Coronavirus Pandemic Lockdowns:

• How Will We Know When It’s Time to Reopen the Nation? – The New York Times
• Lockdown Can’t Last Forever. Here’s How to Lift It. – The New York Times
• When Can We Lift the Coronavirus Pandemic Restrictions? Not Before Taking These Steps – Scientific American

Covid-19: More Opinions on Hydroxychloroquine

• Hydroxychloroquine Update For April 6 – Science Translational Medicine
• The Debacle of Hydroxychloroquine and Azithromycin for COVID19 – Dr. John M.

Summary: wait for proper studies before prescribing.

Meta-Analysis: Medical Masks vs N95 Respirators for Preventing COVID‐19 in Health Care Workers

• Medical Masks vs N95 Respirators for Preventing COVID‐19 in Health Care Workers: A Systematic Review and Meta‐Analysis of Randomized Trials – Influenza
• Commentary: Surgical masks likely good for most COVID-19 treatment – McMaster University

Observational Studies: Countries with Universal BCG Vaccination Policy May Have Reduced Mortality from COVID-19

• [Preprint] Differential COVID-19-attributable mortality and BCG vaccine use in countries – medRxiv
• [Preprint] Association of BCG vaccination policy with prevalence and mortality of COVID-19 – medRxiv
• See also: [Preprint] Observational Study: Countries with Universal BCG Vaccination Policy May Have Reduced Morbidity and Mortality for COVID-19 (study and commentaries)

A New Normal With COVID-19: The Next Steps We Must Take

• A New Normal With COVID-19: The Next Steps We Must Take – Think Global Health

Richard Lehman’s Covid-19 Reviews—6 April 2020:

• Richard Lehman’s covid-19 reviews, 6 April 2020 – The BMJ Opinion

In this weekly round-up, Richard Lehman looks at a personal selection of articles of relevance to clinicians dealing with covid-19.

CDC Study: Coronavirus Disease 2019 in Children

• Coronavirus Disease 2019 in Children — United States, February 12–April 2, 2020 – Centers for Disease Control and Prevention
• Commentaries: U.S. Children With COVID-19 Less Likely To Be Hospitalized Than Adults – NPR AND Why Children Seem to Be Less Affected By the Coronavirus – TIME

Study: Convalescent Plasma Therapy in Severe COVID-19 Patients

• Effectiveness of convalescent plasma therapy in severe COVID-19 patients – Proceedings of the National Academy of Sciences

Latest Articles:

• The COVID-19 Pandemic in the US: A Clinical Update – JAMA
• Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy – JAMA AND Editorial: Critical Illness in Patients With COVID-19: Mounting an Effective Clinical and Research Response – JAMA
• Sample Pooling as a Strategy to Detect Community Transmission of SARS-CoV-2 – JAMA
• Psychological Impact of the COVID-19 Pandemic on Health Care Workers in Singapore – Annals of Internal Medicine
• COVID-19: Peer Support and Crisis Communication Strategies to Promote Institutional Resilience – Annals of Internal Medicine
• Covid-19: NICE advises against using NSAIDs for fever in patients with suspected cases – The BMJ
• Covid-19: Use radiotherapy only if “unavoidable,” says NICE – The BMJ
• Precautions for Operating Room Team Members during the COVID-19 Pandemic – Journal of the American College of Surgeons AND News Release: New algorithm aims to protect surgical team members against infection with COVID-19 virus – American College of Surgeons
• Rapid Sentinel Surveillance for COVID-19 — Santa Clara County, California, March 2020 – Centers for Disease Control and Prevention AND Commentary: COVID-19 studies focus on whether sentinel surveillance, school closings work – CIDRAP
• Protecting healthcare workers from SARS-CoV-2 infection: practical indications – European Respiratory Reviews
• COVID-19 and experiences of moral injury in front-line key workers – Occupational Medicine
• Coronavirus Disease 2019 (COVID-19): Epidemiology, Clinical Spectrum and Implications for the Cardiovascular Clinician – American College of Cardiology
• Pancreatic injury patterns in patients with COVID-19 pneumonia – Gastroenterology
• SARS-CoV-2 Vaccines: Status Report – Immunity
• Cancer guidelines during the COVID-19 pandemic – The Lancet Oncology
• D-dimer is Associated with Severity of Coronavirus Disease 2019: A Pooled Analysis – Thrombosis and Haemostasis
• A Systematic Review of COVID-19 Epidemiology Based on Current Evidence – Journal of Clinical Medicine
• The Laboratory Diagnosis of COVID-19 Infection: Current Issues and Challenges – Journal of Clinical Microbiology
• Personal protective equipment during the COVID‐19 pandemic – a narrative review – Anaesthesia
• The use of high-flow nasal oxygen in COVID-19 – Anaesthesia
• Comparison of Hospitalized Patients with Acute Respiratory Distress Syndrome Caused by COVID-19 and H1N1 – CHEST
• One more paper towel, longer protection – Journal of the American Academy of Dermatology
• The novel zoonotic COVID-19 pandemic: An expected global health concern – The Journal of Infection in Developed Countries
• Peer Review: Publishing in the time of COVID-19 – eLife
• Covid-19: PHE upgrades PPE advice for all patient contacts with risk of infection – The BMJ
• Clinical characteristics and outcomes of patients undergoing surgeries during the incubation period of COVID-19 infection – eClinicalMedicine
• Dementia care during COVID-19 – The Lancet
• Insight into 2019 novel coronavirus – an updated intrim review and lessons from SARS-CoV and MERS-CoV – International Journal of Infectious Diseases

Preprints:

• Widespread use of face masks in public may slow the spread of SARS CoV-2: an ecological study – medRxiv
• Facemasks and similar barriers to prevent respiratory illness such as COVID-19: A rapid systematic review – medRxiv AND Commentary: Expert reaction to a preprint about facemask effectiveness – Science Media Centre
• Angiotensin II Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors Usage is Associated with Improved Inflammatory Status and Clinical Outcomes in COVID-19 Patients With Hypertension – medRxiv AND Commentary: Expert reaction to preprint on COVID-19, high blood pressure, and high blood pressure drugs – Science Media Centre
• Estimating the presymptomatic transmission of COVID19 using incubation period and serial interval data – medRxiv
• Capacities and predicted demands of Brazil’s health system in view of the novel coronavirus disease outbreak – medRxiv
• Therapeutic Management of COVID-19 Patients: A systematic review – medRxiv
• Patient-collected tongue, nasal, and mid-turbinate swabs for SARS-CoV-2 yield equivalent sensitivity to health care worker collected nasopharyngeal swabs – medRxiv
• Sustainable social distancing through facemask use and testing during the Covid-19 pandemic – medRxiv
• Flattening the curve before it flattens us: hospital critical care capacity limits and mortality from novel coronavirus (SARS-CoV2) cases in US counties – medRxiv
• Acute liver injury and its association with death risk of patients with COVID-19: a hospital-based prospective case-cohort study – medRxiv
• Optimal COVID-19 epidemic control until vaccine deployment – medRxiv
• Could SARS-CoV-2 be transmitted via speech droplets? – medRxiv
• Urinalysis, but not blood biochemistry, detects the early renal-impairment in patients with COVID-19 – medRxiv

Selected News & Perspectives:

• Coronavirus: Africa will not be testing ground for vaccine, says WHO – BBC
• Easter Bunny and Tooth Fairy Deemed ‘Essential Workers’ in New Zealand – The New York Times
• The Rising Heroes of the Coronavirus Era? Nations’ Top Scientists – The New York Times
• Masks should be prioritized for health workers to avoid shortage against coronavirus: WHO – Reuters
• How to make a non-medical coronavirus face mask – no sewing required – The Guardian
• What we know about the tiger with Covid-19 — and how the disease affects other animals – Vox
• Why Researchers Are Exploring Antibodies From Recovered Patients For Possible Treatment And Prevention Of COVID-19 – Forbes
• The COVID-19 Nursing Home Nightmare – Forbes
• How Antibody Tests Can Be Used To Fight COVID-19 – Forbes
• These Eye Problems Could Be Symptoms Of COVID-19 Coronavirus – Forbes
• Experts urge smokers and tobacco firms to quit for COVID-19 – Reuters
• A coronavirus spike may put ICU beds in short supply. But that doesn’t mean the elderly shouldn’t get them – The Conversation
• The ‘certified recovered’ from Covid-19 could lead the economic recovery – STAT
• WHO director-general endorses a voluntary intellectual property pool to develop Covid-19 products – STAT
• Responding to COVID-19 in the Developing World – Yale Insights
• COMMENTARY: Respirators can be reused, but decontamination not well studied – CIDRAP
• Advice on masks is changing as coronavirus knowledge evolves – The Globe and Mail

 

6 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives.

 

Coronavirus Tracked: The Latest Figures

• Coronavirus tracked: the latest figures as the pandemic spreads – Financial Times
• Johns Hopkins Coronavirus Interactive Map
• Coronavirus Map: Tracking the Global Outbreak – The New York Times
• Coronavirus Disease (COVID-19) – Statistics and Research – Our World in Data
• WHO: Latest COVID-19 Situation Report – 05 April 2020

Podcasts:

• Practice Made Perfect: What You Need to Know Now About Managing Individuals With COVID-19 – American College of Cardiology

Guidelines & Reports:

• COVID-19 pandemic and cardiac imaging: EACVI recommendations on precautions, indications, prioritization, and protection for patients and healthcare personnel – European Heart Journal – Cardiovascular Imaging
• Disability considerations during the COVID-19 outbreak – World Health Organization
• A Practical Approach to the Management of Cancer Patients During the Novel Coronavirus Disease 2019 (COVID-19) Pandemic: An International Collaborative Group – The Oncologist
• European Society For Emergency Medicine position paper on emergency medical systems response to COVID-19 – European Journal of Emergency Medicine
• Personal Protective Equipment (PPE) for clinicians – Intensive Care Society

NICE Publishes new COVID-19 Guidelines:

• News Release: NICE publishes new COVID-19 guidelines on severe asthma, pneumonia, rheumatological disorders and symptom management – National Institute for Health and Care Excellence
• COVID-19 rapid guideline: severe asthma
• COVID-19 rapid guideline: managing suspected or confirmed pneumonia in adults in the community
• COVID-19 rapid guideline: rheumatological autoimmune, inflammatory and metabolic bone disorders
• COVID-19 rapid guideline: managing symptoms (including at the end of life) in the community
• See other recent NICE Guidelines on COVID-19: COVID-19 rapid guideline: critical care in adults AND COVID-19 rapid guideline: haematopoietic stem cell transplantation AND COVID-19 rapid guideline: dialysis service delivery AND COVID-19 rapid guideline: delivery of radiotherapy AND COVID-19 rapid guideline: delivery of systemic anticancer treatments

CDC Now Recommends Everyone Wears Cloth Face Coverings in Public:

• Recommendation Regarding the Use of Cloth Face Coverings, Especially in Areas of Significant Community-Based Transmission – Centers – Centers for Disease Control and Prevention
• Commentaries: The CDC Now Recommends Americans Wear Face Masks – Wired AND Everyone should wear face ‘masks’ in public, CDC now recommends – Live Science AND CDC Now Recommends Americans Consider Wearing Cloth Face Coverings In Public – NPR AND The CDC now recommends everyone use cloth masks in public – Vox AND The CDC is recommending that people wear face coverings or cloth masks if they go out in public – Business Insider

“CDC recommends wearing cloth face coverings in public settings where other social distancing measures are difficult to maintain (e.g., grocery stores and pharmacies) especially in areas of significant community-based transmission.”

CDC Guideline: Use of Cloth Face Coverings to Help Slow the Spread of COVID-19

• Use of Cloth Face Coverings to Help Slow the Spread of COVID-19 – Centers for Disease Control and Prevention
• Commentary: What’s the Best Material for a Mask? – The New York Times

Wearing Surgical Masks in Public Could Help Slow Spreading of COVID-19:

• Respiratory virus shedding in exhaled breath and efficacy of face masks – Nature
• Commentaries: Why wear face masks in public? Here’s what the research shows – The Conversation AND The new coronavirus might spread when people talk, but scientists say masks can help – The Telegraph AND Wearing surgical masks in public could help slow COVID-19 pandemic’s advance – University of Maryland
• Related: Stability of SARS-CoV-2 in different environmental conditions – National Geographic

COVID-19: Thrombosis, Coagulopathy and Disseminated Intravascular Coagulation

• Guideline: Practical guidance for the prevention of thrombosis and management of coagulopathy and disseminated intravascular coagulation of patients infected with COVID-19 – Thrombosis UK
• Observational Studies: Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy – Journal of Thrombosis and Haemostasis AND Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia – Journal of Thrombosis and Haemostasis (free PDF)
• Q & A: COVID-19 and Coagulopathy: Frequently Asked Questions – American Society of Hematology

COVID-19 Pneumonia: Different Respiratory Treatment for Different Phenotypes?

• Editorial: COVID-19 pneumonia: different respiratory treatment for different phenotypes? – Intensive Care Medicine
• Related: Covid-19 Does Not Lead to a “Typical” Acute Respiratory Distress Syndrome – American Journal of Respiratory and Critical Care Medicine

In Vitro Study: Ivermectin Inhibits Replication of SARS-CoV-2

• The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro – Antiviral Research
• Commentary: Possible coronavirus drug identified by Australian scientists – Monash University

Study: No Benefit from Hydroxychloroquine and Azithromycin in COVID-19

• No Evidence of Rapid Antiviral Clearance or Clinical Benefit with the Combination of Hydroxychloroquine and Azithromycin in Patients with Severe COVID-19 Infection – Médecine et Maladies Infectieuses

Viewpoint: COVID-19 and Renin Angiotensin System Blockers

• Coronavirus Disease 2019 (COVID-19) Infection and Renin Angiotensin System Blockers – JAMA Cardiology
• Related: The Dilemma of Coronavirus Disease 2019, Aging, and Cardiovascular Disease: Insights From Cardiovascular Aging Science – JAMA Cardiology AND Controversies of renin–angiotensin system inhibition during the COVID-19 pandemic – Nature Reviews Nephrology

The Variety of Cardiovascular Presentations of COVID-19:

• The Variety of Cardiovascular Presentations of COVID-19 – Circulation
• News Release: New York City physicians note multiple cardiovascular presentations of COVID-19, impact of pre-existing CVD – American Heart Association

Google COVID-19 Community Mobility Reports:

• Google COVID-19 Community Mobility Reports – See how your community is moving around differently due to COVID-19
• Commentaries: New Google site shows where people in a community are taking social distancing seriously — and where they’re not – CNBC AND Google data shines light on whether coronavirus lockdowns worldwide are working – Reuters

Modelling the Models:

• Modelling the models – CEBM University of Oxford

“Modelling the models. We reviewed 43 models indexed on PubMed, and 13 released by Imperial College to show the significant variation, lack of limitations and lack of references to each other.” (via @carlheneghan see Tweet)

COVID-19: Rapidly Converting to “Virtual Practices”

• Rapidly Converting to “Virtual Practices”: Outpatient Care in the Era of Covid-19 – NEJM Catalyst
• Related: Telemedicine in the Time of Coronavirus – Journal of Pain and Symptom Management AND The rise of telemedicine: How COVID-19 is fundamentally changing healthcare for all of us – Medium AND Telemedicine is essential amid the covid-19 crisis and after it – The Economist AND Virtually Perfect? Telemedicine for Covid-19 – New England Journal of Medicine AND Doctors and Patients Turn to Telemedicine in the Coronavirus Outbreak – The New York Times AND Telemedicine Arrives in the U.K.: ‘10 Years of Change in One Week’ – New York Times AND The Coronavirus Outbreak Could Finally Make Telemedicine Mainstream in the U.S. – TIME (free)

Covid-19: How a Virus is Turning the World Upside Down

• Editorial: Covid-19: how a virus is turning the world upside down – The BMJ

Opinion: Doctors Need Room to Make the Wrenching Decisions They Face

• Doctors Need Room to Make the Wrenching Decisions They Face – The New York Times

“New York is granting health care providers civil and criminal immunity during the coronavirus emergency. So should other states.”

The Covid-19 Crisis too Few are Talking About: Health Care Workers’ Mental Health

• The Covid-19 crisis too few are talking about: health care workers’ mental health – STAT
• Related: Impact on mental health and perceptions of psychological care among medical and nursing staff in Wuhan during the 2019 novel coronavirus disease outbreak: A cross-sectional study – Brain, Behavior, and Immunity AND Mental Health Needs of Health Care Workers Providing Frontline COVID-19 Care – JAMA Health Forum AND Managing mental health challenges faced by healthcare workers during covid-19 pandemic – The BMJ AND Factors Associated With Mental Health Outcomes Among Health Care Workers Exposed to Coronavirus Disease 2019 – JAMA Network Open

Latest Articles:

• Projecting hospital utilization during the COVID-19 outbreaks in the United States – Proceedings of the National Academy of Sciences AND News Release: Yale study finds self-isolation would dramatically reduce ICU bed demand – Yale News
• Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan: A Retrospective Observational Study – American Journal of Respiratory and Critical Care Medicine AND Commentary: New Study Identifies Characteristics of Patients With Fatal COVID-19 – American Thoracic Society
• Editorial: Covid-19 in China: ten critical issues for intensive care medicine – Critical Care
• The Invisible Hand — Medical Care during the Pandemic – New England Journal of Medicine
• Barrier Enclosure during Endotracheal Intubation – New England Journal of Medicine
• COVID-19 Research in Brief: 28 March to 3 April, 2020 – Nature Medicine
• How sewage could reveal true scale of coronavirus outbreak – Nature
• Cancer, COVID-19 and the precautionary principle: prioritizing treatment during a global pandemic – Nature Reviews Clinical Oncology
• Detection of SARS-CoV-2 Among Residents and Staff Members of an Independent and Assisted Living Community for Older Adults — Seattle, Washington, 2020 – CDC Morbidity and Mortality Weekly Report
• Gargle lavage as a safe and sensitive alternative to swab samples to diagnose COVID-19: a case report in Japan – Clinical Infectious Diseases
• SARS-CoV-2, COVID-19 and inherited arrhythmia syndromes – Heart Rythm
• Stability of SARS-CoV-2 in different environmental conditions – The Lancet Microbe
• Developing antibody tests for SARS-CoV-2 – The Lancet
• Redefining vulnerability in the era of COVID-19 – The Lancet
• Impact of school closures for COVID-19 on the US health-care workforce and net mortality: a modelling study – The Lancet Public Health AND Commentary: US modelling study estimates impact of school closures for COVID-19 on US health-care workforce and associated mortality – The Lancet
• Why inequality could spread COVID-19 – The Lancet Public Health
• Evolving epidemiology and transmission dynamics of coronavirus disease 2019 outside Hubei province, China: a descriptive and modelling study – The Lancet Infectious Diseases
• Using observational data to quantify bias of traveller-derived COVID-19 prevalence estimates in Wuhan, China – The Lancet Infectious Diseases
• COVID-19 pandemic in west Africa – The Lancet Global Health
• Personal Risk and Societal Obligation Amidst COVID-19 – JAMA
• Governmental Public Health Powers During the COVID-19 Pandemic: Stay-at-home Orders, Business Closures, and Travel Restrictions – JAMA
• Editorial: Neurologists and Covid-19: A note on courage in a time of uncertainty – Neurology
• Nervous system involvement after infection with COVID-19 and other coronaviruses – Brain, Behavior, and Immunity
• COVID-19 and the Inpatient Dialysis Unit – Clinical Journal of the American Society of Nephrology
• Avoiding pitfalls in the pursuit of a COVID-19 vaccine – Proceedings of the National Academy of Sciences
• Coronavirus Disease 2019 in elderly patients: characteristics and prognostic factors based on 4-week follow-up – The Journal of Infection
• COVID-19 and Liver Dysfunction: Current Insights and Emergent Therapeutic Strategies – Journal of Clinical and Translational Hepatology

Preprints:

• Clinical features, Diagnosis, and Treatment of COVID-19: A systematic review of case reports and case series – medRxiv
• Interleukin-6 in COVID-19: A Systematic Review and Meta-Analysis – medRxiv
• Clinical Manifestations of Children with COVID-19: a Systematic Review – medRxiv
• Modelling the COVID-19 epidemics in Brasil: Parametric identification and public health measures influence – medRxiv
• COVID-19 infection during pregnancy: a systematic review to summarize possible symptoms, treatments, and pregnancy outcomes – medRxiv
• The QT Interval in Patients with SARS-CoV-2 Infection Treated with Hydroxychloroquine/Azithromycin – medRxiv
• A Mini Review on Current Clinical and Research Findings for Children Suffering from COVID-19 – medRxiv
• Level of IL-6 predicts respiratory failure in hospitalized symptomatic COVID-19 patients – medRxiv
• Feasibility Study of Mitigation and Suppression Intervention Strategies for Controlling COVID-19 Outbreaks in London and Wuhan – medRxiv
• Modeling the COVID-19 outbreaks and the effectiveness of the containment measures adopted across countries – medRxiv

Selected News & Perspectives:

• Can You Be Re-Infected After Recovering From Coronavirus? Here’s What We Know About COVID-19 Immunity – TIME
• WHO opens door to broader use of masks to limit spread of coronavirus – Reuters
• Italy starts to look ahead to ‘phase two’ as COVID-19 death toll slows – Reuters
• US COVID-19 total tops 300,000; European nations eye longer lockdown – CIDRAP
• We could be vastly overestimating the death rate for COVID-19. Here’s why – World Economic Forum
• Are Countries Flattening the
  Curve for the Coronavirus? – The New York Times
• What’s Next in the War on Covid-19? – The New York Times
• What We Pretend to Know About the Coronavirus Could Kill Us – The New York Times
• Bad News Wrapped in Protein: Inside the Coronavirus Genome – The New York Times
• In Italy, Going Back to Work May Depend on Having the Right Antibodies – The New York Times
• Google Searches Can Help Us Find Emerging Covid-19 Outbreaks – The New York Times
• A German Exception? Why the Country’s Coronavirus Death Rate Is Low – The New York Times
• The Pandemic Is Turning the Natural World Upside Down – The Atlantic
• An interview with the CDC director on coronavirus, masks, and an agency gone quiet – STAT
• CDC launches studies to get more precise count of undetected Covid-19 cases – STAT
• Tech companies are stepping up in the coronavirus pandemic response. Here’s how they’re dedicating resources – STAT
• EMA Releases Guidelines For Compassionate Use of Remdesivir for COVID-19 – Health Policy Watch
• COVID-19 Has Benched A Critical Volunteer Workforce – Seniors – Forbes
• Two Doctors Who Treated SARS: Beware These Behavioral Changes That Could Make The Coronavirus Pandemic Worse – Forbes
• No lockdown, please, we’re Swedish – Spectator
• 7 case studies that show how coronavirus spreads before you know you’re sick – Vox
• The CDC has begun testing blood for immunity against coronavirus – Vox
• New York is merging all its hospitals to battle the coronavirus – Vox
• Coronavirus FAQs: Is A Homemade Mask Effective? And What’s The Best Way To Wear One? – NPR
• Data Should Drive COVID-19 Mitigation Strategies in Lower- and Middle-Income Countries – DHS Program

 

3 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives.

 

Coronavirus Tracked: The Latest Figures

• Coronavirus tracked: the latest figures as the pandemic spreads – Financial Times
• Johns Hopkins Coronavirus Interactive Map
• Coronavirus Map: Tracking the Global Outbreak – The New York Times
• Coronavirus Disease (COVID-19) – Statistics and Research – Our World in Data
• WHO: Latest COVID-19 Situation Report – 02 April 2020

Guidelines & Reports:

• Allocation of Scarce Critical Care Resources During a Public Health Emergency – University of Pittsburg AND Commentary: A system to allocate scarce ventilators and ICU beds gains traction for not counting any group out – STAT
• Temporary Emergency Guidance to US Stroke Centers During the COVID-19 Pandemic – American Heart Association / American Stroke Association AND News Release: Interim guidance issued on stroke care during COVID-19 pandemic – American Heart Association
• Interim Guidance for Healthcare Providers Caring for Pediatric Patients to Reduce COVID-19 transmission – American Heart Association AND News Release: Interim guidance for pediatric resuscitation care to reduce COVID-19 transmission – American Heart Association AND Commentary: How to provide emergency cardiovascular care, including CPR, for children with COVID-19 – Cardiovascular Business
• Care of patients with liver disease during the COVID-19 pandemic: EASL-ESCMID Position Paper – European Association for the Study of the Liver (EASL) AND News Release: Patients with advanced liver disease and transplant recipients require specific care during COVID-19 – European Association for the Study of the Liver (EASL)

Videos:

• Coronavirus (COVID-19) Update: Epidemics in History – JAMA

Podcasts:

• Guidance Evolves On How To Battle The Coronavirus Outbreak – NPR

Opinion: Covid-19 Does Not Lead to a “Typical” Acute Respiratory Distress Syndrome

• Covid-19 Does Not Lead to a “Typical” Acute Respiratory Distress Syndrome – American Journal of Respiratory and Critical Care Medicine

“After considering that, all we can do ventilating these patients is “buying time” with minimum additional damage: the lowest possible PEEP and gentle ventilation. We need to be patient.”

Observational Study: Universal BCG Vaccination May Protect Against COVID-19

• [Preprint] Correlation between universal BCG vaccination policy and reduced morbidity and mortality for COVID-19: an epidemiological study – medRxiv
• Commentaries: Universal BCG vaccination and protection against COVID-19: critique of an ecological study – Nature Microbiology Community AND A Vaccine From The 1920s Is Now Being Tested For Use Against The Coronavirus Pandemic – Forbes AND Nations with Mandatory TB Vaccines Show Fewer Coronavirus Deaths

UK Guidance on Infection Prevention and Control for COVID-19:

• COVID-19: infection prevention and control – Public Health England

How to Protect Frontline Healthcare Workers From COVID-19:

• How Hospitals Can Protect Frontline Healthcare Workers From COVID-19 – Medium (via @EricTopol see Tweet)

COVID-19 Contact Tracing Apps:

• COVID-19 contact tracing apps: 8 privacy questions governments should ask – Imperial College London
• In Germany, High Hopes For New COVID-19 Contact Tracing App That Protects Privacy – NPR
• Covid-19 spreads too fast for traditional contact tracing. New digital tools could help – STAT
• Quantifying SARS-CoV-2 transmission suggests epidemic control with digital contact tracing – Science

Covid-19: Four Fifths of Cases are Asymptomatic, China Figures Indicate

• Covid-19: four fifths of cases are asymptomatic, China figures indicate – The BMJ

New Choosing Wisely COVID-19 Recommendations:

• Choosing Wisely COVID-19 Recommendations – Choosing Wisely Canada

Is the Coronavirus Airborne?

• Is the coronavirus airborne? Experts can’t agree – Nature

Opinion: Don’t Believe the COVID-19 Models

• Don’t Believe the COVID-19 Models: That’s not what they’re for – The Atlantic

The Mystery of the Missing STEMIs During the COVID-19 Pandemic:

• The Mystery of the Missing STEMIs During the COVID-19 Pandemic – TCTMD

Coronavirus Can Infect Cats:

• Coronavirus can infect cats — dogs, not so much – Nature

Guide to Lung Ultrasound in COVID-19 Patients:

• Complete GUIDE to Lung Ultrasound in COVID-19 (Coronavirus) Patients – POCUS 101
• Related: Proposal for international standardization of the use of lung ultrasound for COVID‐19 patients; a simple, quantitative, reproducible method – Journal of Ultrasound in Medicine AND Findings of lung ultrasonography of novel corona virus pneumonia during the 2019–2020 epidemic – Intensive Care Medicine AND Can Lung US Help Critical Care Clinicians in the Early Diagnosis of Novel Coronavirus (COVID-19) Pneumonia? – Radiology AND Point-of-Care Lung Ultrasound findings in novel coronavirus disease-19 pnemoniae: a case report and potential applications during COVID-19 outbreak – European Review for Medical and Pharmacological Sciences AND ACEP Guideline on COVID-19: Ultrasound Machine and Transducer Cleaning

New Website: How to Decontaminate and Reuse N95 masks

• News Release: New website explains how hospitals can decontaminate and reuse scarce N95 masks to fight COVID-19 – Stanford News
• See Website: N95DECON: A scientific consortium for data-driven study of N95 filtering facepiece respirator decontamination

More on the Use of Face Masks by the Public:

• Opinion: Wearing Masks Must Be a National Policy – The New York Times
• Coronavirus: Expert panel to assess face mask use by public – BBC
• Expert comment clarifying situation with face masks and WHO
• Should Everyone Wear A Mask In Public? Maybe—But It’s Complicated – Forbes
• White House expected to recommend Americans wear cloth masks to prevent coronavirus spread – STAT

Editorial: Endocrinologists Perspective on the COVID-19 Pandemic

• Our Response to COVID-19 as Endocrinologists and Diabetologists – The Journal of Clinical Endocrinology & Metabolism
• Commentaries: Medical teams need to be alert to the extra risks faced by diabetics from COVID-19 – University of Leeds AND Individuals taking class of steroid medications at high risk for COVID-19 – The Endocrine Society

Realistic Alternatives for COVID-19 Response in Low-Income Countries:

• Does One Size Fit All? Realistic Alternatives for COVID-19 Response in Low-Income Countries – Center for Global Development

Latest Articles:

• Covid-19 and Health Care’s Digital Revolution – New England Journal of Medicine
• Flattening the Curve for Incarcerated Populations — Covid-19 in Jails and Prisons – New England Journal of Medicine
• Offline: COVID-19—what countries must do now – The Lancet
• Implement Critical Care Surge Strategies Now To Save Lives – Health Affairs
• Towards an Artificial Intelligence Framework for Data-Driven Prediction of Coronavirus Clinical Severity – CMC-Computers, Materials & Continua AND Commentary: Data-Driven Ai May Help Predict Severity of Coronavirus – MedicalResearch.com
• Editorial: Social media for rapid knowledge dissemination: early experience from the COVID‐19 pandemic – Anaesthesia
• Mental Health Needs of Health Care Workers Providing Frontline COVID-19 Care – JAMA Health Forum
• Extraordinary times: coping psychologically through the impact of covid-19 – The BMJ Opinion
• Essential care of critical illness must not be forgotten in the COVID-19 pandemic – The Lancet
• Strategic plan for management of COVID-19 in paediatric haematology and oncology departments – The Lancet Haematology
• Communication Skills in the Age of COVID-19 – Annals of Internal Medicine
• Collision of the COVID-19 and Addiction Epidemics – Annals of Internal Medicine
• When Epidemics Collide: Coronavirus Disease 2019 (COVID-19) and the Opioid Crisis – Annals of Internal Medicine
• An Epidemic in the Midst of a Pandemic: Opioid Use Disorder and COVID-19 – Annals of Internal Medicine
• Environment and Personal Protective Equipment Tests for SARS-CoV-2 in the Isolation Room of an Infant With Infection – Annals of Internal Medicine
• ‘We have no choice.’ Pandemic forces polio eradication group to halt campaigns – Science
• Responding to COVID‐19: How to Navigate a Public Health Emergency Legally and Ethically – Hastings Center Report AND News Release: Responding to Covid-19: How to navigate a public health emergency legally and ethically
• How to improve adherence with quarantine: Rapid review of the evidence – Public Health AND Commentary: Clear messages about quarantine are key to success, research finds – Reuters
• Clinical Outcomes in 55 Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Who Were Asymptomatic at Hospital Admission in Shenzhen, China – The Journal of Infectious Diseases
• SARS-CoV-2: an Emerging Coronavirus that Causes a Global Threat – International Journal of Biological Sciences
• Clinical characteristics of COVID-19-infected cancer patients: A retrospective case study in three hospitals within Wuhan, China – Annals of Oncology
• Diagnosing COVID-19: The Disease and Tools for Detection – ACS Nano
• Angiotensin-Converting Enzyme 2 and Anti-Hypertensives (Angiotensin Receptor Blockers and Angiotensin Converting Enzyme Inhibitors) in Coronavirus Disease 2019 (COVID-19) – Mayo Clinic Proceedings AND Commentary: Blood Pressure Meds ACEIS and ARBS and Covid-19 Infection – MedicalResearch.com
• The Late Arrival of COVID-19 in Africa – Mitigating Pan-Continental Spread – Clinical Infectious Diseases
• Novel Coronavirus Pneumonia (COVID-19) Progression Course in 17 Discharged Patients: Comparison of Clinical and Thin-Section CT Features During Recovery – Clinical Infectious Diseases
• Characteristics of peripheral lymphocyte subset alteration in COVID-19 pneumonia – The Journal of Infectious Diseases
• Translating COVID-19 Pandemic Surge Theory to Practice in the Emergency Department: How to Expand Structure – Disaster Medicine and Public Health Preparedness AND Commentary: Checklist for emergency department team’s COVID-19 surge – Society for Disaster Medicine And Public Health

Preprints:

• Growth rate and acceleration analysis of the COVID-19 pandemic reveals the effect of public health measures in real time – medRxiv
• Flattening the curve is not enough, we need to squash it. An explainer using a simple model – medRxiv
• Importance of suppression and mitigation measures in managing COVID-19 outbreaks – medRxiv
• Monitoring trends and differences in COVID-19 case fatality rates using decomposition methods: Contributions of age structure and age-specific fatality – medRxiv
• Clinical features and outcomes of 2019 novel coronavirus-infected patients with high plasma BNP levels – medRxiv
• Population based estimates of comorbidities affecting risk for complications from COVID-19 in the US – medRxiv
• Detection of Air and Surface Contamination by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Hospital Rooms of Infected Patients – medRxiv

Selected News & Perspectives:

• If it comes to rationing, I shouldn’t have to be the one deciding who should live and who should die – STAT
• COVID-19 Infections Hit One Million Mark; Seven-Fold Increase In New Cases For South-East Asia – Europe & USA Remain Epicentres – Health Policy Watch
• 12 things everyone needs to know about the coronavirus pandemic – Vox
• Calling health care workers “heroes” erases just how terrified and exposed they really are – Vox
• You’re single. You live alone. Are you allowed to have a coronavirus buddy? – Vox
• Before-symptom spread may complicate COVID-19 containment – CIDRAP
• Some Coronavirus Patients Show Signs of Brain Ailments – The New York Times
• Patient Has Virus and Serious Cancer. Should Doctors Withhold Ventilator? – The New York Times
• In a Pandemic, Do Doctors Still Have a Duty to Treat? – The New York Times
• Bringing Needed Structure to COVID-19 Drug Development – NIH Director’s Blog
• 1 Million Coronavirus Cases Have Now Been Reported Worldwide – NPR
• Ventilators Are No Panacea for Critically Ill COVID-19 Patients – NPR
• As Coronavirus Strains Hospitals, Cancer Patients Face Treatment Delays, Uncertainty – NPR
• Why You Should Flush With The Lid Down: Experts Warn Of Fecal-Oral Transmission Of Covid-19 – Forbes
• Confronting COVID-19: My Experience On The Front Line – Forbes
• Italy Appears to be Flattening the Curve. What Did the Country Do Right? – TIME
• A Covid-19 Vaccine Will Need Equitable, Global Distribution – Harvard Business Review
• Bill Gates: Here’s how to make up for lost time on covid-19 – The Washington Post
• The Korean clusters: How coronavirus cases exploded in South Korean churches and hospitals – Reuters
• Singapore’s coronavirus struggle shows colossal task of global containment – Reuters
• What you need to know about the coronavirus right now – Reuters

 

2 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives.

 

Coronavirus Tracked: The Latest Figures

• Coronavirus tracked: the latest figures as the pandemic spreads – Financial Times
• Johns Hopkins Coronavirus Interactive Map
• Coronavirus Map: Tracking the Global Outbreak – The New York Times
• Coronavirus Disease (COVID-19) – Statistics and Research – Our World in Data
• WHO: Latest COVID-19 Situation Report – 01 April 2020

WHO Director-General’s Opening Remarks:

• WHO Director-General’s opening remarks at the media briefing on COVID-19 – 1 April 2020- World Health Organization

Guidelines & Reports:

• AGA Institute Rapid Recommendations for Gastrointestinal Procedures During the COVID-19 Pandemic – American Gastroenterological Association AND News Release: AGA issues formal recommendations for PPE during gastrointestinal procedures
• Guidance for Cardiac Electrophysiology During the Coronavirus (COVID-19) Pandemic from the Heart Rhythm Society COVID-19 Task Force; Electrophysiology Section of the American College of Cardiology; and the Electrocardiography and Arrhythmias Committee of the Council on Clinical Cardiology, American Heart Association – Heart Rhythm

Videos:

• Coronavirus (COVID-19) Update: Critical Care Management – JAMA
• Ways to Communicate Intensive Care Unit (ICU) Prognosis – JAMA

Podcasts:

• Audio Interview: Lessons from Covid-19 Hotspots – New England Journal of Medicine
• Podcast 262: COVID-19’s larger lessons – NEJM Journal Watch Clinical Conversations
• Coronavirus (COVID-19) Update: The Near Future – JAMA

Editorial: Ten Weeks to Crush the Curve

• Ten Weeks to Crush the Curve – New England Journal of Medicine

COVID-19: Ethical Guidance for Frontline Staff

• Ethical guidance published for frontline staff dealing with pandemic – Royal College of Physicians

CDC Guidance: Decontamination and Reuse of Filtering Facepiece Respirators

• Decontamination and Reuse of Filtering Facepiece Respirators using Contingency and Crisis Capacity Strategies – Centers for Disease Control and Prevention

Universal Masking in Hospitals in the Covid-19 Era

• Universal Masking in Hospitals in the Covid-19 Era – New England Journal of Medicine
• Related: The Joint Commission issues statement supporting use of personal face masks provided from home amid COVID-19 pandemic

Use of Face Masks by the Population: The Debate Continues

• Everyone Thinks They’re Right About Masks – The Atlantic
• COMMENTARY: Masks-for-all for COVID-19 not based on sound data – CIDRAP
• You Still Probably Don’t Need A Mask For COVID-19 – Medium
• Everything you need to know about making your own face mask – Vox
• All Israelis must wear face-masks in public as virus precaution: Netanyahu – Reuters
• C.D.C. Weighs Advising Everyone to Wear a Mask – The New York Times

Another Study Shows Presymptomatic Transmission of SARS-CoV-2:

• Presymptomatic Transmission of SARS-CoV-2 — Singapore, January 23–March 16, 2020 – CDC Morbidity and Mortality Weekly Report AND Commentaries: Coronavirus can spread one to three days before symptoms appear: CDC study – Reuters AND CDC Director warns 25 percent of COVID-19 cases may present no symptoms – New Atlas AND SARS-CoV-2 Readily Shed Early in Infection, Transmissible Before Symptoms Emerge – NEJM Journal Watch
• Related: Iceland lab’s testing suggests 50% of coronavirus cases have no symptoms – CNN AND Yes, You Can Spread Coronavirus Even If You Don’t Have Symptoms – Self AND Infected but Feeling Fine: The Unwitting Coronavirus Spreaders – The New York Times AND COVID-19: Undocumented Infections are the Infection Source for 79% of Documented Cases

Virological Assessment of Hospitalized Patients with COVID-2019:

• Virological assessment of hospitalized patients with COVID-2019 – Nature
• Commentaries: People with coronavirus may be most infectious in the first week of symptoms – MIT Technology Review AND Expert reaction to paper on ‘shedding’ of SARS-CoV-2 virus in 9 patients with COVID-19 – Science Media Centre

Featured Commentaries:

• These Coronavirus Exposures Might Be the Most Dangerous – The New York Times
• If You Have Coronavirus Symptoms, Assume You Have the Illness, Even if You Test Negative – The New York Times
• The Coronavirus Patients Betrayed by Their Own Immune Systems – The New York Times
• CDC Director On Models For The Months To Come: ‘This Virus Is Going To Be With Us’ – NPR

Latest Articles:

• Medicine: before COVID-19, and after – The Lancet
• Treatment with convalescent plasma for critically ill patients with SARS-CoV-2 infection – CHEST
• Covid-19 Does Not Lead to a “Typical” Acute Respiratory Distress Syndrome – American Journal of Respiratory and Critical Care Medicine
• Use of Hydroxychloroquine and Chloroquine During the COVID-19 Pandemic: What Every Clinician Should Know – Annals of Internal Medicine
• Novel Coronavirus Infection (COVID-19) in Humans: A Scoping Review and Meta-Analysis – Journal of Clinical Medicine
• Should we give priority care to healthcare workers in the covid-19 pandemic? – The BMJ Opinion
• Patient Page: Testing Individuals for Coronavirus Disease 2019 (COVID-19) – JAMA
• Environment and Personal Protective Equipment Tests for SARS-CoV-2 in the Isolation Room of an Infant With Infection – Annals of Internal Medicine
• Resident Response During Pandemic: This Is Our Time – Annals of Internal Medicine
• Potential Legal Liability for Withdrawing or Withholding Ventilators During COVID-19: Assessing the Risks and Identifying Needed Reforms – JAMA
• Active and Effective Measures for the Care of Patients With Cancer During the COVID-19 Spread in China – JAMA Oncology
• Absence of contamination of personal protective equipment (PPE) by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) – Infection Control & Hospital Epidemiology
• Coronavirus Lockdowns Have Changed the Way Earth Moves – Nature
• Strategies for the prevention and management of coronavirus disease 2019 – European Respiratory Journal
• An Uncomplicated Delivery in a Patient with Covid-19 in the United States – New England Journal of Medicine
• Creating a Framework for Conducting Randomized Clinical Trials during Disease Outbreaks – New England Journal of Medicine
• Harnessing Our Humanity — How Washington’s Health Care Workers Have Risen to the Pandemic Challenge – New England Journal of Medicine
• Digestive Symptoms in COVID-19 Patients with Mild Disease Severity: Clinical Presentation, Stool Viral RNA Testing, and Outcomes – American Journal of Gastroenterology
• Acute pulmonary embolism and COVID-19 pneumonia: a random association? – European Heart Journal
• COVID-19, SARS and MERS: are they closely related? – Clinical Microbiology and Infection
• Timely Diagnosis and Treatment Shortens the Time to Resolution of Coronavirus Disease (COVID-19) Pneumonia and Lowers the Highest and Last CT Scores From Sequential Chest CT – American Journal of Roentgenology AND Commentary: New CT scoring criteria for timely diagnosis, treatment of coronavirus disease (COVID-19) – American Roentgen Ray Society
• The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The Perspectives of clinical immunologists from China – Clinical Immunology

Preprints:

• Demand for hospitalization services for COVID-19 patients in Brazil – MedRxiv
• How lethal is the novel coronavirus, and how many undetected cases there are? The importance of being tested. – medRxiv
• Predicting Mortality Risk in Patients with COVID-19 Using Artificial Intelligence to Help Medical Decision-Making – medRxiv
• Clinical observations of low molecular weight heparin in relieving inflammation in COVID-19 patients: A retrospective cohort study – medRxiv
• A phased lift of control: a practical strategy to achieve herd immunity against Covid-19 at the country level – medRxiv
• The Institutional and Cultural Context of Cross-National Variation in COVID-19 Outbreaks – medRxiv
• How will this continue? Modelling interactions between the COVID-19 pandemic and policy responses – medRxiv
• Assessing the interactions between COVID-19 and influenza in the United States – medRxiv
• Transmission Dynamics of COVID-19 and Impact on Public Health Policy – medRxiv
• Transmission Dynamics and Control Methodology of COVID-19: a Modeling Study – medRxiv
• Analytical sensitivity and efficiency comparisons of SARS-COV-2 qRT-PCR assays – medRxiv
• Optimal timing for social distancing during an epidemic – medRxiv
• Global versus focused isolation during the SARS-CoV-2 pandemic-A cost-effectiveness analysis – medRxiv
• Why is chest CT important for early diagnosis of COVID-19? Prevalence matters – medRxiv
• Understanding COVID-19 spreading through simulation modeling and scenarios comparison: preliminary results – medRxiv

Selected News & Perspectives:

• Five world leaders: No time for geopolitical turf battles – Financial Times
• Preparing for the COVID-19 Surge in the United States – Think Global Health
• The Science Behind A 14-Day Quarantine After Possible COVID-19 Exposure – NPR
• Navigating the Covid-19 pandemic: We’re just clambering into a life raft. Dry land is far away – STAT
• Lessons from a different war for preventing moral injury among clinicians treating Covid-19 – STAT
• The coronavirus is washing over the U.S. These factors will determine how bad it gets in each community – STAT
• Covid-19 Changed How the World Does Science, Together – The New York Times
• Experts question practicality of testing in COVID-19 response – CIDRAP
• Rapid COVID-19 escalation pushes world past 900,000 cases – CIDRAP
• White House hints at COVID-19 mask use as cases top 200,000 – CIDRAP
• Fear Clouds Doctors’ Thinking. One Remedy Is As Old As Medicine Itself. – Forbes
• Europe to launch coronavirus contact tracing app initiative – Reuters
• Loss of taste and smell key COVID-19 symptoms, app study finds – Reuters
• Mass testing, empty ICUs: Germany scores early against virus – Associated Press
• Why Jails Are So Important in the Fight Against Coronavirus – The New York Times
• The stark differences in countries’ coronavirus death rates, explained – Vox
• COVID-19 infections growing exponentially, deaths nearing 50,000: WHO – Reuters
• The World’s Sports Stadiums Are Being Converted Into Hospitals to Fight the Coronavirus Outbreak – TIME
• DIY Alternatives for When Stores Are Out of Coronavirus-Fighting Products – TIME
• Antibiotic Resistance Could Lead to More COVID-19 Deaths – Scientific American
• Cats can infect each other with coronavirus, Chinese study finds – The Guardian
• The lockdown only buys us time: to really defeat the virus we need mass testing now – The Guardian

 

1 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives.

 

Coronavirus Tracked: The Latest Figures

• Coronavirus tracked: the latest figures as the pandemic spreads – Financial Times
• Johns Hopkins Coronavirus Interactive Map
• Coronavirus Map: Tracking the Global Outbreak – The New York Times
• Coronavirus Disease (COVID-19) – Statistics and Research – Our World in Data
• WHO: Latest COVID-19 Situation Report – 31 March 2020

Guidelines & Reports:

• Recommendations from the Peking Union Medical College Hospital for the management of acute myocardial infarction during the COVID-19 outbreak – European Heart Journal
• Consensus guidelines for managing the airway in patients with COVID‐19 – Anaesthesia

Videos:

• COVID-19 – Social Networks – JAMA

Podcasts:

• Episode 8 – Rapid Fire: COVID-19 Part 2 – HealthyDebate

More Opinions on the Use of Facemasks by the Population:

• Article: COVID-19 epidemic: disentangling the re-emerging controversy about medical facemasks from an epidemiological perspective – International Journal of Epidemiology
• Perspectives: CDC considering recommending general public wear face coverings in public – The Washington Post AND Wear a face mask if you feel it’s necessary, but know it won’t necessarily help – The Globe and Mail AND It’s Time to Face Facts, America: Masks Work – Wired AND Should We All Be Wearing Masks In Public? Health Experts Revisit The Question – NPR AND Should I Make My Own Mask? – The New York Times

‘Panic Prescribing’ Untested Coronavirus Treatments:

• ‘Panic Prescribing’ Untested Coronavirus Treatments: A Danger To Patients Today and Tomorrow – Health Affairs
• We shouldn’t rush to use an unproven malaria drug to treat the coronavirus – STAT
• See also: Twitter Thread on the Latest Study Testing Hydroxychloroquine, by Lucas Morin

U.S. Prevalence of Underlying Health Conditions Among Patients with COVID-19:

• Preliminary Estimates of the Prevalence of Selected Underlying Health Conditions Among Patients with Coronavirus Disease 2019 — United States, February 12–March 28, 2020 – CDC Morbidity and Mortality Weekly Report
• Commentaries: More than 70% of Americans hospitalized with COVID-19 had at least 1 underlying health condition, the CDC says — here’s the breakdown – Business Insider AND People With Underlying Health Conditions Are At Risk Of More Severe COVID-19, Says New CDC Report – Forbes AND Who’s Sickest From COVID-19? These Conditions Tied To Increased Risk – NPR

Pandemic Palliative Care: Beyond Ventilators and Saving Lives

• Pandemic palliative care: beyond ventilators and saving lives – Canadian Medical Association Journal AND Commentary: A COVID-19 palliative care pandemic plan: An essential tool – Canadian Medical Association Journal
• Related: The Importance of Addressing Advance Care Planning and Decisions About Do-Not-Resuscitate Orders During Novel Coronavirus 2019 (COVID-19) – JAMA AND Covid-19: The role of palliative care had to be adapted to manage this “ultra-emergency” – The BMJ Opinion AND COVID-19: decision making and palliative care – Swiss Medical Weekly AND COVID-19 pandemic: palliative care for elderly and frail patients at home and in residential and nursing homes – Swiss Medical Weekly AND End-of-life care in the Emergency Department for the patient imminently dying of a highly transmissible acute respiratory infection (such as COVID-19) – Canadian Journal of Emergency Medicine

Characteristics of Ocular Findings of Patients with Coronavirus Disease:

• Characteristics of Ocular Findings of Patients With Coronavirus Disease 2019 (COVID-19) in Hubei Province, China – JAMA Ophthalmology
• Invited Commentary: Humans, Viruses, and the Eye—An Early Report From the COVID-19 Front Line – JAMA Ophthalmology
• See also: Perspectives on Coronavirus Disease 2019 Control Measures for Ophthalmology Clinics Based on a Singapore Center Experience – JAMA Ophthalmology

Surgery of the Head and Neck During the COVID-19 Pandemic:

• Safety Recommendations for Evaluation and Surgery of the Head and Neck During the COVID-19 Pandemic – JAMA Otolaryngology Head & Neck Surgery
• Author Interview: Safety Recommendations for Evaluation and Surgery of the Head and Neck During the COVID-19 Pandemic
• Related: Surgical Considerations for Tracheostomy During the COVID-19 Pandemic: Lessons Learned From the Severe Acute Respiratory Syndrome Outbreak – JAMA Otolaryngology Head & Neck Surgery

COVID-19 in Older Adults: Key Points for Emergency Department Providers

• COVID-19 in Older Adults: Key Points for Emergency Department Providers – Journal of Geriatric Emergency Medicine
• Commentary: Caring for seniors during COVID-19 pandemic – Regenstrief Institute

COVID-19–associated Acute Hemorrhagic Necrotizing Encephalopathy:

• COVID-19–associated Acute Hemorrhagic Necrotizing Encephalopathy: CT and MRI Features – Radiology

The Economic and Social Consequences of Responses to COVID-19 Pandemic:

• Urgent Call for an Exit Plan: The Economic and Social Consequences of Responses to COVID-19 Pandemic – Center for Global Development

Latest Articles:

• Quantifying SARS-CoV-2 transmission suggests epidemic control with digital contact tracing – Science
• Clinical and immunologic features in severe and moderate Coronavirus Disease 2019 – The Journal of Clinical Investigation AND Commentary: SARS-CoV-2: A Storm is Raging – The Journal of Clinical Investigation
• Turbulent Gas Clouds and Respiratory Pathogen Emissions: Potential Implications for Reducing Transmission of COVID-19 – JAMA AND Related Video: Respiratory Pathogen Emission Dynamics – JAMA
• Life-threatening cardiac tamponade complicating myo-pericarditis in COVID-19 – European Heart Journal
• Review article: gastrointestinal features in COVID‐19 and the possibility of faecal transmission – Alimentary Pharmacology and Therapeutics
• Safe Delivery for COVID‐19 Infected Pregnancies – Obstetrics & Gynaecology
• Pragmatic Recommendations for Intubating Critically Ill Patients with Suspected COVID‐19 – Journal of the American College of Emergency Physicians Open
• Prevent, detect, respond: How community health workers can help in the fight against covid-19 – The BMJ Opinion
• Dawn P. Richards: Covid-19 is bringing unpredictability and fear to the rheumatology community – The BMJ Opinion
• Community Prevalence of SARS-CoV-2 Among Patients With Influenzalike Illnesses Presenting to a Los Angeles Medical Center in March 2020 – JAMA
• Medical Student Education in the Time of COVID-19 – JAMA
• Coronavirus Disease 2019 (COVID-19) Pandemic and Pregnancy – American Journal of Obstetrics and Gynecology
• Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019 – Clinical Infectious Diseases
• Quantitative Detection and Viral Load Analysis of SARS-CoV-2 in Infected Patients – Clinical Infectious Diseases
• 1.3 billion people. A 21-day lockdown. Can India curb the coronavirus? – Science
• Can China return to normalcy while keeping the coronavirus in check? – Science
• Quantifying SARS-CoV-2 transmission suggests epidemic control with digital contact tracing – Science
• How sick will the coronavirus make you? The answer may be in your genes – Science
• Neuroinfection may potentially contribute to pathophysiology and clinical manifestations of COVID‐19 – Acta Physiologica
• Mental health considerations for children quarantined because of COVID-19 – The Lancet Child & Adolescent Health
• Physiotherapy management for COVID-19 in the acute hospital setting: clinical practice recommendations – Journal of Physiotherapy
• Data-based analysis, modelling and forecasting of the COVID-19 outbreak – PLOS One
• Association of radiologic findings with mortality of patients infected with 2019 novel coronavirus in Wuhan, China – PLOS One
• ‘We need to be alert’: Scientists fear second coronavirus wave as China’s lockdowns ease – Nature
• Peter Brindley: Covid-19—Healthcare workers are scared but, in some ways, also lucky – The BMJ Opinion

Preprints:

• Estimating the size of COVID-19 epidemic outbreak – medRxiv
• Determination of daily reproduction numbers of SARS-CoV2 based on death cases suggests more rapid initial spread in Italy and the United States – medRxiv
• The Novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Directly Decimates Human Spleens and Lymph Nodes – medRxiv
• Targeted adaptive isolation strategy for Covid-19 pandemic – medRxiv

Selected News & Perspectives:

• Latest on the spread of the coronavirus around the world – Reuters
• If You Get Critically Ill With COVID-19, How Far Should Doctors Go To Keep You Alive? – wbur
• How would overwhelmed hospitals decide who to treat first? – Associated Press
• Experts Race to Set Rules For Deciding Who Lives and Who Dies – Undark
• The rise of telemedicine: How COVID-19 is fundamentally changing healthcare for all of us – Medium
• Strong Age-Linked COVID-19 Death Risk Confirmed By Largest-Ever Study Of Chinese Population Infected – Health Policy Watch
• Telemedicine is essential amid the covid-19 crisis and after it – The Economist
• Why Sub-Saharan Africa needs a unique response to COVID-19 – World Economic Forum
• How some cities ‘flattened the curve’ during the 1918 flu pandemic – National Geographic
• New reports on early symptoms, cardiac complications of COVID-19 – ACP Internist
• ACP, other groups address shortages of PPE, medications, tests during COVID-19 pandemic – ACP Internist
• D.I.Y. Coronavirus Solutions Are Gaining Steam – The New York Times
• Not Winning This Fight: This chart shows why – The New York Times
• Test makers are moving fast, but the coronavirus may be moving faster – STAT
• A new Covid-19 problem: Shortages of medicines needed for placing patients on ventilators – STAT
• Covid-19 testing: overcoming challenges in the next phase of the epidemic – STAT
• What explains Covid-19’s lethality for the elderly? Scientists look to ‘twilight’ of the immune system – STAT
• STAT’s guide to how hospitals are using AI to fight Covid-19 – STAT
• Big Data In The Time Of Coronavirus (COVID-19) – Forbes
• US COVID-19 deaths top China’s; data show impact on those with chronic disease – CIDRAP
• What can hospitals still do to prep for COVID-19? – CIDRAP
• As global COVID-19 total passes 850,000, study shows 1.4% fatality rate – CIDRAP
• Social distancing won’t just save lives. It might be better for the economy in the long run – Vox
• ‘No One Mentions the People Who Clean It Up’: What It’s Like to Clean Professionally During the COVID-19 Outbreak – TIME
• Coronavirus: just letting children play will help them, and their parents, cope – The Conversation
• Coronavirus death rate is lower than previously reported, study says, but it’s still deadlier than seasonal flu – CNN

 

31 March 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives.

 

Coronavirus Tracked: The Latest Figures

• WHO: Latest COVID-19 Situation Report – 30 March 2020

WHO Director-General’s Remarks:

• WHO Director-General’s opening remarks at the media briefing on COVID-19 – 30 March 2020 – World Health Organization

Guidelines & Reports:

• Practical Manual: Severe Acute Respiratory Infections Treatment Centre – World Health Organization
• CSC Expert Consensus on Principles of Clinical Management of Patients with Severe Emergent Cardiovascular Diseases during the COVID-19 Epidemic – Circulation

Podcasts:

• John Ioannidis vs. Sten Vermund: Be it resolved, we are making high-stakes decisions about the COVID-19 pandemic without reliable data. – Munk Debates Podcast
• Annals On Call – Protecting Health Care Workers From COVID-19 – Annals of Internal Medicine
• World Health Organization Antimicrobial Expert Explains Transmission Of Coronavirus – NPR
• Podcast 261: COVID-19 as a medical disaster – NEJM Journal Watch Clinical Conversations

Imperial College London Report:

• Report 13: ­­Estimating the number of infections and the impact of non-pharmaceutical interventions on COVID-19 in 11 European countries – Imperial College London
• See also: Summary

Estimates of the Severity of COVID-19:

• Estimates of the severity of coronavirus disease 2019: a model-based analysis – The Lancet Infectious Diseases
• Commentaries: Likelihood of survival of coronavirus disease 2019 – The Lancet Infectious Diseases AND New coronavirus study reveals increased risks from middle age – The Guardian

COVID-19: Hydroxychloroquine Beneficial in Small Trial

• Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial – medRxiv

COVID-19: Risks Related to the Use of Hydroxychloroquine:

• Ventricular Arrhythmia Risk Due to Hydroxychloroquine-Azithromycin Treatment For COVID-19 – American College of Cardiology
• A Rush to Judgment? Rapid Reporting and Dissemination of Results and Its Consequences Regarding the Use of Hydroxychloroquine for COVID-19 – Annals of Internal Medicine

“Immunity Certificates” to Leave Lockdown?

• ‘Immunity passports’ could speed up return to work after Covid-19 – The Guardian
• How Covid-19 immunity testing can help people get back to work – Vox
• Germany will issue coronavirus antibody certificates to allow quarantined to re-enter society – The Telegraph
• Germany could issue thousands of people coronavirus ‘immunity certificates’ so they can leave the lockdown early – Business Insider

The Mathematics of Predicting the Course of the Coronavirus:

• The Mathematics of Predicting the Course of the Coronavirus – Wired
• See also: Mathematics of life and death: How disease models shape national shutdowns and other pandemic policies – Science AND How to model a pandemic – The Conversation AND Coronavirus exposes the problems and pitfalls of modelling – The Guardian AND Systematic review and critical appraisal of prediction models for diagnosis and prognosis of COVID-19 infection – medRxiv

Annals Graphic Medicine:

• Annals Graphic Medicine – True Tales From the Outbreak: Life in the Hot Zone – Annals of Internal Medicine

COVID-19: Controversies on the Use of Face Masks by the Population

• WHO stands by recommendation to not wear masks if you are not sick or not caring for someone who is sick – CNN
• COVID-19: Why We Should All Wear Masks — There Is New Scientific Rationale – Medium

COVID-19 and Renin-Angiotensin System Blockers:

• Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19 – New England Journal of Medicine

Latest Articles:

• Richard Lehman’s covid-19 reviews—30 March 2020 – The BMJ Opinion
• Covid-19 in Critically Ill Patients in the Seattle Region — Case Series – New England Journal of Medicine
• Developing Covid-19 Vaccines at Pandemic Speed – New England Journal of Medicine
• Feeding Low-Income Children during the Covid-19 Pandemic – New England Journal of Medicine
• Older Clinicians and the Surge in Novel Coronavirus Disease 2019 (COVID-19) – JAMA
• Optimizing the Trade-off Between Learning and Doing in a Pandemic – JAMA
• New coronavirus leaves pregnant women with wrenching choices—but little data to guide them – Science
• Special attention to nurses’ protection during the COVID-19 epidemic – Critical Care
• Ethical considerations in the allocation of critical care resources when capacity is overwhelmed – Canadian Journal of Emergency Medicine
• We practised for a pandemic, but didn’t brace – Nature
• More on Chloroquine/Azithromycin. And On Dr. Raoult. – Science Translational Medicine
• Love in the Time of Corona – Annals of Internal Medicine
• The Italian coronavirus disease 2019 outbreak: recommendations from clinical practice – Anaesthesia

Preprints:

• Global, Regional and National Incidence and Case-fatality rate of Novel Coronavirus (COVID-19) across 154 countries and territories: A systematic assessment of cases reported from January to March 16, 2020 – medRxiv
• Laboratory findings, signs and symptoms, clinical outcomes of Patients with COVID-19 Infection: an updated systematic review and meta-analysis – medRxiv
• Role of Chloroquine and Hydroxychloroquine in the Treatment of COVID-19 Infection- A Systematic Literature Review – medRxiv
• The comparative superiority of IgM-IgG antibody test to real-time reverse transcriptase PCR detection for SARS-CoV-2 infection diagnosis – medRxiv
• Climate effect on COVID-19 spread rate: an online surveillance tool – medRxiv
• Children are unlikely to have been the primary source of household SARS-CoV-2 infections – medRxiv
• Effects of hypertension, diabetes and coronary heart disease on COVID-19 diseases severity: a systematic review and meta-analysis – medRxiv
• Development and external validation of a prognostic multivariable model on admission for hospitalized patients with COVID-19 – medRxiv
• Symptom-Based Isolation Policies: Evidence from a Mathematical Model of Outbreaks of Influenza and COVID-19 – medRxiv
• Analysis and Prediction of False Negative Results for SARS-CoV-2 Detection with Pharyngeal Swab Specimen in COVID-19 Patients: A Retrospective Study – medRxiv
• Causal empirical estimates suggest COVID-19 transmission rates are highly seasonal – medRxiv
• Which Measures are Effective in Containing COVID-19? Empirical Research Based on Prevention and Control Cases in China – medRxiv
• Inclusive Costs of NPI Measures for COVID-19 Pandemic: Three Approaches – medRxiv
• Physical interventions to interrupt or reduce the spread of respiratory viruses. Part 1 – Face masks, eye protection and person distancing: systematic review and meta-analysis – medRxiv
• Virus shedding patterns in nasopharyngeal and fecal specimens of COVID-19 patients – medRxiv
• Clinical and Paraclinical Characteristics of COVID-19 patients: A systematic review and meta-analysis – medRxiv
• Doubling time tells how effective Covid-19 prevention works – medRxiv
• Mitigation and herd immunity strategy for COVID-19 is likely to fail – medRxiv
• Effects of temperature on COVID-19 transmission – medRxiv
• Prognostic factors for COVID-19 pneumonia progression to severe symptom based on the earlier clinical features: a retrospective analysis – medRxiv
• Analysis of the scientific literature in the first 30 Days of the novel coronavirus outbreak. – medRxiv
• Temperature dependence of COVID-19 transmission – medRxiv
• Forecasting the Worldwide Spread of COVID-19 based on Logistic Model and SEIR Model – medRxiv
• Dynamic Modeling to Identify Mitigation Strategies for Covid-19 Pandemic – medRxiv
• Evaluating the effectiveness of social distancing interventions against COVID-19 – medRxiv
• Diagnostic Indexes of a Rapid IgG/IgM Combined Antibody Test for SARS-CoV-2 – medRxiv
• Evaluation the auxiliary diagnosis value of antibodies assays for detection of novel coronavirus (SARS-Cov-2) causing an outbreak of pneumonia (COVID-19) – medRxiv
• COVID-19 Modelling: the Effects of Social Distancing – medRxiv
• What is required to prevent a second major outbreak of the novel coronavirus SARS-CoV-2 upon lifting the metropolitan-wide quarantine of Wuhan city, China – medRxiv
• A model to estimate regional demand for COVID-19 related hospitalizations – medRxiv
• Estimation of protection for COVID-19 in children from epidemiological information and estimate effect of policy in Japan – medRxiv
• A mathematical model of COVID-19 transmission between frontliners and the general public – medRxiv
• SARS-CoV-2 asymptomatic and symptomatic patients and risk for transfusion transmission – medRxiv
• Potential roles of social distancing in mitigating the spread of coronavirus disease 2019 (COVID-19) in South Korea – medRxiv
• A COVID-19 Infection Risk Model for Frontline Health Care Workers – medRxiv
• Extrapolation of Infection Data for the CoVid-19 Virus and Estimate of the Pandemic Time Scale. – medRxiv
• Evaluations of serological test in the diagnosis of 2019 novel coronavirus (SARS-CoV-2) infections during the COVID-19 outbreak – medRxiv
• When will the Covid-19 epidemic fade out? – medRxiv
• COVID-19 transmission in Mainland China is associated with temperature and humidity: a time-series analysis – medRxiv
• Public events and delayed flight restrictions were the turning point of the COVID-19 mitigation policy of Israel – medRxiv
• Mobility traces and spreading of COVID-19 – MedRxiv

Selected News & Perspectives:

• COVID-19 Testing Trends – Globally & Regionally – Health Policy Watch
• Testing is Just the Beginning in the Battle Against Covid-19 – The New York Times
• Officials watch for COVID-19 to stabilize in Europe; rapid growth shifts to other areas – CIDRAP
• Scientists search for ways to impede, treat COVID-19 – CIDRAP
• It’s Time to Get Serious About End-of-Life Care for High-Risk Coronavirus Patients – TIME
• Two new road maps lay out possible paths to end coronavirus lockdowns – STAT
• Debate flares over using AI to detect Covid-19 in lung scans – STAT
• Fact check: will Covid-19 fade in the summer – then return later like the flu? – The Guardian
• Coronavirus vaccine: here are the steps it will need to go through during development – The Conversation
• Why Is Germany’s Coronavirus Death Rate So Low? – TIME
• To Flatten the COVID-19 Curve, Target the Subconscious – Scientific American
• Can Survivors of the Coronavirus Help Cure the Disease and Rescue the Economy? – The New Yorker
• AIDS, TB And Malaria: Coronavirus Threatens The Endgame – Forbes

 

30 March 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives.

 

Coronavirus Tracked: The Latest Figures

• Coronavirus tracked: the latest figures as the pandemic spreads – Financial Times
• Johns Hopkins Coronavirus Interactive Map
• Coronavirus Map: Tracking the Global Outbreak – The New York Times
• Coronavirus Disease (COVID-19) – Statistics and Research – Our World in Data
• WHO: Latest COVID-19 Situation Report – 29 March 2020

Guidelines & Reports:

• WHO Scientific Brief: Modes of transmission of virus causing COVID-19: implications for IPC precaution recommendations – World Health Organization
• Consensus Statement on Multiple Patients Per Ventilator – Society of Critical Care Medicine
• Expert consensus for managing pregnant women and neonates born to mothers with suspected or confirmed novel coronavirus (COVID-19) infection – Gynecology & Obstetrics
• Clinical guide for the management of palliative care in hospital during the coronavirus pandemic – NHS
• Society of Cardiovascular Computed Tomography Guidance for Use of Cardiac Computed Tomography Amidst the COVID-19 Pandemic – Journal of Cardiovascular Computed Tomography AND Commentary: ACC Endorses Clinical Guidance on Cardiovascular CT – American College of Cardiology
• COVID-19: guidance for the public on mental health and wellbeing – Public Health England

Videos:

• Coronavirus (COVID-19) Update: Fairly Rationing ICU Care – JAMA

Featured Commentaries:

• The next frontier in coronavirus testing: Identifying the full scope of the pandemic, not just individual infections – STAT
• The two tests that will help to predict spread of Covid-19 – The Guardian
• Coronavirus: What we still don’t know about Covid-19 – BBC

COVID-19: Controversies on the Use of Face Masks

• Would everyone wearing face masks help us slow the pandemic? – Science
• Not wearing masks to protect against coronavirus is a ‘big mistake,’ top Chinese scientist says – Science
• More Americans Should Probably Wear Masks for Protection – The New York Times
• Experts say face masks can help slow COVID-19, despite previous claims – New York Post
• Coronavirus: Chinese scientist advises people in Europe, US to wear face masks in public – South China Morning Post

Related Guidance: WHO Recommendations on when and how to use masks – World Health Organization AND Strategies for Optimizing the Supply of Facemasks – Centers for Disease Control and Prevention

N95 Re-Use Instructions:

• N95 Re-Use Instructions – SAGES
• Related: Conserving Supply of Personal Protective Equipment—A Call for Ideas – JAMA AND N95 mask can be decontaminated without decreasing filtration efficiency – Stanford Medicine

COVID-19 and Renin-Angiotensin System Blockers:

• Renin-Angiotensin System Blockers and the COVID-19 Pandemic: At Present There Is No Evidence to Abandon Renin-Angiotensin System Blockers – Hypertension AND Commentary: COVID-19 alert: Heart and kidney patients should keep taking their medicines – University of Miami Miller School of Medicine
• Related: Is There an Association Between COVID-19 Mortality and the Renin-Angiotensin System—a Call for Epidemiologic Investigations – Clinical Infectious Diseases

Primary Care & COVID-19:

• Primary care & Coronavirus (COVID 19): key guidance, information and support – Medium
• Related: Coronavirus disease 2019 (covid-19): a guide for UK GPs – The BMJ AND Covid-19: a remote assessment in primary care – The BMJ

Latest Articles:

• Epidemiology of Covid-19 in a Long-Term Care Facility in King County, Washington – New England Journal of Medicine
• Defining the Epidemiology of Covid-19 — Studies Needed – New England Journal of Medicine
• A War on Two Fronts: Cancer Care in the Time of COVID-19 – Annals of Internal Medicine
• Coronavirus disease 2019 (COVID-19): update for anesthesiologists and intensivists March 2020 – Der Anaesthesist
• Editorial: Sourcing Personal Protective Equipment During the COVID-19 Pandemic – JAMA
• The Importance of Addressing Advance Care Planning and Decisions About Do-Not-Resuscitate Orders During Novel Coronavirus 2019 (COVID-19) – JAMA
• Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma – JAMA AND Editorial: Convalescent Plasma to Treat COVID-19: Possibilities and Challenges Commentaries: A new report raises hope that the blood of recovered patients can help treat severe coronavirus cases – Business Insider AND Plasma transfusion shows promise for COVID-19 treatment, says China study – UPI
• A Framework for Rationing Ventilators and Critical Care Beds During the COVID-19 Pandemic – JAMA
• Novel 2019 Coronavirus SARS-CoV-2 (COVID-19): An Updated Overview for Emergency Clinicians – 03-23-20 – Emergency Medicine Practice
• Estimating the infection and case fatality ratio for coronavirus disease (COVID-19) using age-adjusted data from the outbreak on the Diamond Princess cruise ship, February 2020 – Eurosurveillance
• Recommendations for Endotracheal Intubation of COVID-19 Patients – Anesthesia & Analgesia
• Coronavirus Disease 2019 in Geriatrics and Long‐term Care: The ABCDs of COVID‐19 – Journal of the American Geriatrics Society
• Could chloroquine /hydroxychloroquine be harmful in Coronavirus Disease 2019 (COVID-19) treatment? – Clinical Infectious Diseases
• COVID-19: faecal–oral transmission? – Nature Gastroenterology and Hepatology
• The Rheumatologist’s Role in Covid-19 – The Journal of Rheumatology
• On the Frontline of the COVID-19 Outbreak: Keeping Patients on Long-Term Dialysis Safe – Clinical Journal of the American Society of Nephrology
• Editorial: COVID-19: learning from experience – The Lancet
• No time for dilemma: mass gatherings must be suspended – The Lancet
• COVID-19 gives the lie to global health expertise – The Lancet
• A role for CT in COVID-19? What data really tell us so far – The Lancet
• Deciphering the power of isolation in controlling COVID-19 outbreaks – The Lancet Global Health
• Considering inequalities in the school closure response to COVID-19 – The Lancet Global Health
• COVID-19 infection in children – The Lancet Respiratory Medicine
• The many estimates of the COVID-19 case fatality rate – The Lancet Infectious Diseases
• Epidemic preparedness in urban settings: new challenges and opportunities – The Lancet Infectious Diseases
• COVID-19 in gastroenterology: a clinical perspective – Gut
• Autopsy in suspected COVID-19 cases – Journal of Clinical Pathology
• Practical laboratory considerations amidst the COVID-19 outbreak: early experience from Singapore – Journal of Clinical Pathology
• Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis – Clinica Chimica Acta
• Disseminated intravascular coagulation in patients with 2019‐nCoV pneumonia – Journal of Thrombosis and Haemostasia
• Covid‐19 and the Digestive System – Journal of Gastroenterology and Hepatology
• Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms – Gut
• Practical considerations for performing regional anesthesia: lessons learned from the COVID-19 pandemic – Canadian Journal of Anesthesia
• COVID-19: Advice from the Canadian Association of Gastroenterology for Endoscopy Facilities, as of March 16, 2020 – Journal of the Canadian Association of Gastroenterology

Preprints:

• Severe airport sanitarian control could slow down the spreading of COVID-19 pandemics in Brazil – medRxiv
• A New Predictor of Disease Severity in Patients with COVID-19 in Wuhan, China – medRxiv
• Prevalence, Severity and Mortality associated with COPD and Smoking in patients with COVID-19: A Rapid Systematic Review and Meta-Analysis – medRxiv
• Systematic review and critical appraisal of prediction models for diagnosis and prognosis of COVID-19 infection – medRxiv
• Pandemics Depress the Economy, Public Health Interventions Do Not: Evidence from the 1918 Flu – SSRN
• Impact of changing case definitions for COVID-19 on the epidemic curve and transmission parameters in mainland China – medRxiv
• Modelling strategies to organize healthcare workforce during pandemics: application to COVID-19 – medRxiv
• A demographic adjustment to improve measurement of COVID-19 severity at the developing stage of the pandemic – medRxiv
• Delaying the COVID-19 epidemic in Australia: Evaluating the effectiveness of international travel bans – medRxiv
• Climate affects global patterns of COVID-19 early outbreak dynamics – medRxiv
• The Effect of Large-Scale Anti-Contagion Policies on the Coronavirus (COVID-19) Pandemic – medRxiv
• Coincidence of COVID-19 epidemic and olfactory dysfunction outbreak – medRxiv
• Age-dependent effects in the transmission and control of COVID-19 epidemics – medRxiv
• Transmission dynamics of SARS-COV-2 in China: impact of public health interventions – medRxiv
• Lactate dehydrogenase, a Risk Factor of Severe COVID-19 Patients – medRxiv

Selected News & Perspectives:

• A letter to the UK from Italy: this is what we know about your future – The Guardian
• We’ll lose ‘World War C’ against the coronavirus if we don’t fight the right way – The Hill
• COVID-19 Policy Must Take All Impacts into Account – Scientific American
• Duke researchers are decontaminating N95 masks so doctors can reuse them to treat coronavirus patients – CNN
• Global COVID-19 total tops 600,000, US surpasses 120,000 – CIDRAP
• As the rest of Europe lives under lockdown, Sweden keeps calm and carries on – The Guardian
• Life is carrying on as normal in Sweden – scientists explain the controversial approach – World Economic Forum
• In the Coronavirus Fight in Scandinavia, Sweden Stands Apart – The New York Times
• Some U.S. Cities Could Have Coronavirus Outbreaks Worse Than Wuhan’s – The New York Times
• Unprepared for the Worst: World’s Most Vulnerable Brace for Virus – The New York Times
• Our best defense against Covid-19? Science – STAT
• What if hydroxychloroquine doesn’t work? What if it does? Right now, we don’t know – STAT
• Two new roadmaps lay out possible paths to end coronavirus lockdowns – STAT
• ‘Just one case’: fears coronavirus may spread like wildfire in world’s refugee camps – Reuters
• COVID-19: Neurologists in Italy to Colleagues in US: Look for Poorly-Defined Neurologic Conditions in Patients with the Coronavirus – Neurology Today
• Lessons from Italy’s Response to Coronavirus – Harvard Business Review
• The Science of This Pandemic Is Moving at Dangerous Speeds – Wired
• Study: Low Risk Of COVID-19 Transmission Via Tears, Eyewear Is Still Important – Forbes

 

27 March 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives.

 

Coronavirus Tracked: The Latest Figures

• Coronavirus tracked: the latest figures as the pandemic spreads – Financial Times
• Johns Hopkins Coronavirus Interactive Map
• Coronavirus Map: Tracking the Global Outbreak – The New York Times
• Coronavirus Disease (COVID-19) – Statistics and Research – Our World in Data
• WHO: Latest COVID-19 Situation Report – 26 March 2020

Guidelines & Reports:

• Report 12: The Global Impact of COVID-19 and Strategies for Mitigation and Suppression – Imperial College London AND Summary AND Commentaries: Coronavirus: ‘Act early to save more than 30 million lives’ – BBC AND Study sees ‘severe and acute’ emergency for world in coronavirus pandemic – Reuters
• IHME Report: News Release: US Hospitals Could Be Overwhelmed in the Second Week of April by Demand for ICU Beds, and US Deaths Could Total 81,000 by July – Institute for Healthcare and Evaluation AND Abstract: Forecasting COVID-19 impact on hospital bed-days, ICU-days, ventilator days and deaths by US state in the next 4 months – Institute for Health Metrics and Evaluation AND Preprint: Forecasting COVID-19 impact on hospital bed-days, ICU-days, ventilator days and deaths by US state in the next 4 months (PDF) AND Commentaries: A new report warns that the coronavirus pandemic will overwhelm US hospitals and kill 81,000 people by July – Business Insider AND Coronavirus could kill 81,000 in U.S., subside in June – Washington University analysis – Reuters
• COVID-19: Operational guidance for maintaining essential health services during an outbreak – World Health Organization
• Radiological Society of North America Expert Consensus Statement on Reporting Chest CT Findings Related to COVID-19. Endorsed by the Society of Thoracic Radiology, the American College of Radiology, and RSNA. – Radiology
• COVID-19 Guidelines for Triage of Emergency General Surgery Patients – American College of Surgeons
• COVID-19: Managing the COVID-19 pandemic in care homes – British Geriatrics Society

Videos:

• Perspectives on the Pandemic with Dr. John Ioannidis
• Related Article: Editorial by John P.A. Ioannidis: COVID-19: The Harms of Exaggerated Information and Non‐evidence‐based Measures (free study and commentaries)

Podcasts:

• Dr. Anthony Fauci Discusses The Latest Coronavirus Facts – NPR
• #201: COVID Narratives: Stories from Physicians at the Front Lines – The Curbsiders Internal Medicine Podcast

How Disease Models Shape National Shutdowns and Other Pandemic Policies:

• Mathematics of life and death: How disease models shape national shutdowns and other pandemic policies – Science
• See also: How to model a pandemic – The Conversation AND Coronavirus exposes the problems and pitfalls of modelling – The Guardian

Rapid Review: Standard Face Masks vs. Respirator Masks in Primary Care

• What is the efficacy of standard face masks compared to respirator masks in preventing COVID-type respiratory illnesses in primary care staff? – Oxford COVID-19 Evidence Service

COVID-19: Mental Health Faced by Healthcare Workers:

• Managing mental health challenges faced by healthcare workers during covid-19 pandemic – The BMJ

Featured Commentaries:

• What we’ve learned about the coronavirus — and what we still need to know – STAT
• Lockdowns work against coronavirus. But they take a few weeks to show they’re working – Vox
• Anthony Fauci Shows Us the Right Way to Be an Expert – Scientific American

“He’s grounded in humility and humanity; he uses plain language; he admits uncertainties and failings; and he refuses to make the science overtly political”

Latest Articles:

• What the cruise-ship outbreaks reveal about COVID-19 – Nature
• Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study – The BMJ AND Editorial: Covid-19: risk factors for severe disease and death – The BMJ
• Covid-19: identifying and isolating asymptomatic people helped eliminate virus in Italian village – The BMJ
• The world’s largest refugee camp prepares for covid-19 – The BMJ
• Abraar Karan: Covid-19—on trust, experts, and the brilliance of everyday people – The BMJ Opinion
• Self-reported olfactory and taste disorders in SARS-CoV-2 patients: a cross-sectional study – Clinical Infectious Diseases
• Don’t overlook digestive symptoms in patients with 2019 novel coronavirus disease (COVID-19) – Clinical Gastroenterology and Hepatology
• Parenting in a time of COVID-19 – The Lancet
• The Italian health system and the COVID-19 challenge – The Lancet Public Health
• The official French guidelines to protect patients with cancer against SARS-CoV-2 infection – The Lancet Oncology
• Neonatal Early-Onset Infection With SARS-CoV-2 in 33 Neonates Born to Mothers With COVID-19 in Wuhan, China – JAMA Pediatrics AND Commentaries: Coronavirus transmission during pregnancy rare but possible: study – MedicalXpress AND Neonatal Early-Onset Infection With SARS-CoV-2 in 33 Neonates Born to Mothers With COVID-19 in Wuhan, China – CIDRAP
• Editorial: Can SARS-CoV-2 Infection Be Acquired In Utero? More Definitive Evidence Is Needed – JAMA
• Antibodies in Infants Born to Mothers With COVID-19 Pneumonia – JAMA
• Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn – JAMA
• Interrupting COVID-19 transmission by implementing enhanced traffic control bundling: Implications for global prevention and control efforts – Journal of Microbiology, Immunology and Infection
• COVID-19 infection: the perspectives on immune responses – Cell Death & Differentiation
• Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study – The Lancet Infectious Diseases
• To Help Develop The Safest, Most Effective Coronavirus Tests, Treatments, And Vaccines, Ensure Public Access To Clinical Research Data – Health Affairs

Preprints:

• Transmission Potential of SARS-CoV-2 in Viral Shedding Observed at the University of Nebraska Medical Center – medRxiv
• A model to estimate bed demand for COVID-19 related hospitalization – medRxiv
• Fundamental principles of epidemic spread highlight the immediate need for large-scale serological surveys to assess the stage of the SARS-CoV-2 epidemic – medRxiv
• Comorbid Diabetes Mellitus was Associated with Poorer Prognosis in Patients with COVID-19: A Retrospective Cohort Study – medRxiv
• Mathematical modeling of COVID-19 transmission and mitigation strategies in the population of Ontario, Canada – medRxiv
• COVID-19 infection induces readily detectable morphological and inflammation-related phenotypic changes in peripheral blood monocytes, the severity of which correlate with patient outcome – medRxiv
• Effectiveness and safety of antiviral or antibody treatments for coronavirus: A rapid review – medRxiv
• Estimating the maximum daily number of incident COVID-19 cases manageable by a healthcare system – medRxiv
• Modes of contact and risk of transmission in COVID-19 among close contacts – medRxiv
• COVID-19 clinical characteristics, and sex-specific risk of mortality: Systematic Review and Meta-analysis – medRxiv
• Early chest computed tomography to diagnose COVID-19 from suspected patients: A multicenter retrospective study – medRxiv
• Estimating the number of undetected COVID-19 cases exported internationally from all of China – medRxiv
• Risk Factors Associated with Clinical Outcomes in 323 COVID-19 Patients in Wuhan, China – medRxiv

Selected News & Perspectives:

• Global COVID-19 cases spike — now more than a half million – CIDRAP
• Harvard researchers: Social distancing during COVID-19 may have to be turned on and off like a spigot – ZDNet
• Covid-19’s resurgence in Hong Kong holds a lesson: Defeating it demands persistence – STAT
• To get on top of the coronavirus, we also need to test people without symptoms – The Conversation
• Is Loss Of Smell And Taste A Symptom Of COVID-19? Doctors Want To Find Out – NPR
• People with a disability are more likely to die from coronavirus – but we can reduce this risk – The Conversation
• COVID-19 treatment might already exist in old drugs – we’re using pieces of the coronavirus itself to find them – The Conversation
• Testing For Coronavirus – Can Latin America and Africa Build Upon The Asian Model? – Health Policy Watch
• Modelling study estimates impact of physical distancing measures on progression of COVID-19 epidemic in Wuhan – London School of Hygiene & Tropical Medicine
• Blood Plasma Treatment For Coronavirus Set to Get Its First Trial Run in New York – TIME
• Mass testing explains Germany’s relatively low death rate from coronavirus: virologist – Reuters
• The Coronavirus Pandemic May Be Causing an Anxiety Pandemic – TIME
• Men are much more likely to die from coronavirus – but why? – The Guardian
• Social distancing can’t last forever. Here’s what should come next. – Vox
• Doctors and nurses treating coronavirus report high rates of depression and anxiety – Vox
• Beware second waves of COVID-19 if lockdowns eased early: study – Reuters
• Genomic Study Points to Natural Origin of COVID-19 – NIH Director’s Blog
• Mayo Clinic provides urgent guidance, approach to identify patients at risk of drug-induced sudden cardiac death from use of off-label COVID-19 treatments – Mayo Clinic
• Lost Smell and Taste Hint COVID-19 Can Target the Nervous System – The Scientist

 

26 March 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives.

 

Coronavirus Tracked: The Latest Figures

• Coronavirus tracked: the latest figures as the pandemic spreads – Financial Times
• Johns Hopkins Coronavirus Interactive Map
• Coronavirus Map: Tracking the Global Outbreak – The New York Times
• Coronavirus Disease (COVID-19) – Statistics and Research – Our World in Data
• WHO: Latest COVID-19 Situation Report – 25 March 2020

WHO Director-General’s:

• WHO Director-General’s opening remarks at the media briefing on COVID-19 – 25 March 2020

“Asking people to stay at home and shutting down population movement is buying time and reducing the pressure on health systems. But on their own, these measures will not extinguish epidemics.”

Guidelines & Reports:

• Report 11: Evidence of initial success for China exiting COVID-19 social distancing policy after achieving containment – Imperial College London (PDF) AND Summary AND Commentaries: Initial success for COVID-19 social distancing in China – Imperial College London AND China shows way to ease lockdowns before vaccine, says report – The Guardian AND When can we let up? Health experts craft strategies to safely relax coronavirus lockdowns – STAT
• Maintaining a safe and adequate blood supply during the pandemic outbreak of coronavirus disease (COVID-19) – World Health Organization
• Resuscitation Council UK Statements on COVID-19 (Coronavirus), CPR and Resuscitation

Videos:

• Coronavirus (COVID-19) Update: Vaccines and Immunity – JAMA

Podcasts:

• Audio Interview: Practical Measures to Help Prevent Covid-19 – New England Journal of Medicine
• The Lancet Voice: Pregnancy and COVID-19
• Coronavirus Disease 2019 (COVID-19) Update: How the VA Is Preparing – JAMA

What is the Risk of Dying from COVID-19?

• What do we know about the risk of dying from COVID-19? – Our World in Data

Hydroxychloroquine: Small Study Shows No Benefit

• A pilot study of hydroxychloroquine in treatment of patients with common coronavirus disease-19 (COVID-19) – Journal of Zhejiang University (abstract)
• Commentary: Chloroquine Use For COVID-19 Shows No Benefit In First Small—But Limited—Controlled Trial – Forbes
• Related: Coronavirus treatment hype can lead to harm – Lown Institute AND No, These Medicines Cannot Cure Coronavirus – The New York times

To Stop COVID-19, Test Everyone, Repeatedly:

• Preprint: To stop COVID-19, test everyone, repeatedly – Medium

Covid-19: A Remote Assessment in Primary Care

• Covid-19: a remote assessment in primary care – The BMJ

Study: Prolonged Presence of SARS-CoV-2 Viral RNA in Fecal Samples

• Prolonged presence of SARS-CoV-2 viral RNA in faecal samples – The Lancet Gastroenterology & Hepatology

“Very important article about viral shedding. Spoiler alert: quarantine may need to be much longer than 14 days. Virus is detectible in feces for up to 5 weeks. Caveat: virus not necessarily viable” (via @figgyjam see Tweet)

Practical Advice: PPE Pearls

• Personal Protective Equipment (PPE) Pearls – COVID-19 – emDocs

COVID Ethics: Should clinicians see patients without appropriate PPE?

• COVID Ethics: Should clinicians see patients without appropriate PPE? – First10EM

Latest Articles:

• The effect of human mobility and control measures on the COVID-19 epidemic in China – Science AND Commentary: Travel restrictions are most useful in the early and late phase of an epidemic – University of Oxford
• Editorial: Covid-19 — Navigating the Uncharted – New England Journal of Medicine
• Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia – New England Journal of Medicine
• Defining the Epidemiology of Covid-19 — Studies Needed – New England Journal of Medicine
• Novel Coronavirus and Old Lessons — Preparing the Health System for the Pandemic – New England Journal of Medicine
• Critical Supply Shortages — The Need for Ventilators and Personal Protective Equipment during the Covid-19 Pandemic – New England Journal of Medicine
• Covid-19 and long term conditions: what if you have cancer, diabetes, or chronic kidney disease? – The BMJ
• Postacute Care Preparedness for COVID-19: Thinking Ahead – JAMA
• Preserving Clinical Trial Integrity During the Coronavirus Pandemic – JAMA
• Training and Fit Testing of Health Care Personnel for Reusable Elastomeric Half-Mask Respirators Compared With Disposable N95 Respirators – JAMA
• Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China – JAMA Cardiology AND Commentaries: Cardiac injury linked to increased mortality in COVID-19 – MedicalXpress AND Cardiac injury in COVID-19 patients associated with higher in-hospital mortality – Cardiovascular Business AND Cardiac Injury and Mortality in Hospitalized COVID-19 Patients – American College of Cardiology
• Cardiac troponin I in patients with coronavirus disease 2019 (COVID-19): Evidence from a meta-analysis – Progress in Cardiovascular Diseases AND Commentary: Meta-Analysis on Troponin I in Patients With Coronavirus – Latest in Cardiology
• Viewpoint: An Acute Respiratory Infection Runs Into the Most Common Noncommunicable Epidemic—COVID-19 and Cardiovascular Diseases – JAMA Cardiology
• SARS-CoV-2 Transmission in Patients With Cancer at a Tertiary Care Hospital in Wuhan, China – JAMA Oncology AND Commentary: Cancer linked to increased COVID-19 risk – MedwireNews
• Prolonged presence of SARS-CoV-2 viral RNA in faecal samples – The Lancet Gastroenterology & Hepatology
• How blood from coronavirus survivors might save lives – Nature
• COVID-19 and Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers: What Is the Evidence? – JAMA
• COVID-19 Illness and Heart Failure: A Missing Link? – JACC: Heart Failure
• Assessing Viral Shedding and Infectivity of Tears in Coronavirus Disease 2019 (COVID-19) Patients – Ophthalmology AND Commentary: Low risk of coronavirus spreading through tears – American Academy of Ophthalmology
• Ventilatory Ratio in Hypercapnic Mechanically Ventilated Patients with COVID-19 Associated ARDS – American Journal of Respiratory and Critical Care Medicine
• Lung Recruitability in SARS-CoV-2 Associated Acute Respiratory Distress Syndrome: A Single-center, Observational Study – American Journal of Respiratory and Critical Care Medicine AND Commentary: Wuhan study shows lying face down improves breathing in severe COVID-19 – American Thoracic Society
• Time Kinetics of Viral Clearance and Resolution of Symptoms in Novel Coronavirus Infection – American Journal of Respiratory and Critical Care Medicine
• Rising to the Challenge of the Novel SARS-coronavirus-2 (SARS-CoV-2): Advice for Pulmonary and Critical Care and an Agenda for Research – American Journal of Respiratory and Critical Care Medicine
• National UK programme of community health workers for COVID-19 response – The Lancet
• COVID-19 and the liver: little cause for concern – The Lancet Gastroenterology & Hepatology
• The effect of control strategies to reduce social mixing on outcomes of the COVID-19 epidemic in Wuhan, China: a modelling study – The Lancet Public Health
• Policies on the use of respiratory protection for hospital health workers to protect from coronavirus disease (COVID-19) – International Journal of Nursing Sciences
• Early in the epidemic: impact of preprints on global discourse about COVID-19 transmissibility – The Lancet Global Health
• Patients with mental health disorders in the COVID-19 epidemic – The Lancet Psychiatry
• Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: a retrospective, single-centre, descriptive study – The Lancet Infectious Diseases
• Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents – The Journal of Hospital Infection AND Commentary: Coronavirus: household cleaning products can kill the virus – an expert on which ones to use – The Conversation AND One graphic shows how long the coronavirus lives on surfaces like cardboard, plastic, and steel – Business Insider

Preprints:

• Modelling transmission and control of the COVID-19 pandemic in Australia – arXiv (PDF) Commentaries: Social distancing could stop coronavirus in just 13 weeks – News Medical AND Data shows coronavirus can only be controlled if 8 out of 10 Australians stay home – ABC News

Selected News & Perspectives:

• How the Pandemic Will End – The Atlantic
• ECDC warns of overwhelmed hospitals, Italy-type COVID-19 pattern – CIDRAP
• A virology expert answers key questions on COVID-19 – World Economic Forum
• How Will Doctors Allocate Scarce Medical Resources During The COVID-19 Coronavirus Pandemic? – Forbes
• What we know about ACE inhibitors, high blood pressure and COVID-19 – The Conversation
• Protect older and vulnerable health care workers from Covid-19 – STAT
• We need smart coronavirus testing, not just more testing – STAT
• Assisted living and Covid-19: the next Kirkland might not be a nursing home – STAT
• Blood From Covid-19 Survivors May Point the Way to a Cure – Wired
• How South Korea Flattened the Curve – The New York Times
• Locked-down no longer, China’s Hubei begins return to normal – Reuters
• The Blind Leading the Blind: COVID-19, Cancer, and the Need for More Data – ASCO Daily News
• Expert comment on the need for accurate tests to detect COVID-19 antibodies – Science Media Centre
• Doctors Are Hoarding Unproven Coronavirus Medicine by Writing Prescriptions for Themselves and Their Families – ProPublica
• Dealing With Frustration: You Can’t Visit Your Aging Parents – Forbes
• Why Germany’s Coronavirus Death Rate Is Far Lower Than In Other Countries – NPR
• Coronavirus exposes the problems and pitfalls of modelling – The Guardian

 

25 March 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives.

 

Coronavirus Tracked: The Latest Figures

• Coronavirus tracked: the latest figures as the pandemic spreads – Financial Times
• Johns Hopkins Coronavirus Interactive Map
• Coronavirus Map: Tracking the Global Outbreak – The New York Times
• Coronavirus Disease (COVID-19) – Statistics and Research – Our World in Data
• WHO: Latest COVID-19 Situation Report – 24 March 2020

Guidelines & Reports:

• Interim Guidance for Healthcare Providers during COVID-19 Outbreak – American Heart Association AND News Release: Interim guidance to reduce COVID-19 transmission during resuscitation care – American Heart Association
• Interim Guidance for Emergency Medical Services (EMS) Systems and 911 Public Safety Answering Points (PSAPs) for COVID-19 in the United States – Centers for Disease Control and Prevention
• Criteria for Return to Work for Healthcare Personnel with Confirmed or Suspected COVID-19 (Interim Guidance) – Centers for Disease Control and Prevention
• Updated SOGC Committee Opinion – COVID-19 in Pregnancy – Society of Obstetricians and Gynaecologists of Canada
• General Guidance on Deferring Non-Urgent CV Testing and Procedures During the COVID-19 Pandemic – American College of Cardiology
• Full guidance on staying at home and away from others – Gov.uk
• COVID-19 – guidance for paediatric services – Royal College of Paediatrics and Child Health
• Interim Guidance for COVID-19 and Persons with HIV – AIDSinfo
• Investigational COVID-19 Convalescent Plasma – Emergency INDs – U.S. Food & Drug Administration AND Commentary: FDA will allow doctors to treat critically ill coronavirus patients with blood from survivors – NBC News

Podcasts:

• Coronavirus (COVID-19) Update: Chloroquine / Hydroxychloroquine and Azithromycin – JAMA

N95 Mask Decontamination:

• Report: N95 mask can be decontaminated without decreasing filtration efficiency – Stanford Medicine

“Stanford: N95 masks can be decontaminated without decreasing filtration efficiency using 70C heat for 30 min. Alcohol and bleach should not be used.” (via @CMichaelGibson see Tweet)

Assessing Dyspnea by Telephone or Video:

• Are there any evidence-based ways of assessing dyspnoea (breathlessness) by telephone or video – CEBM University of Oxford

CKD and Dialysis in the Time of COVID-19:

• CKD and Dialysis in the Time of COVID-19 – NephJC

Study Estimates Impact of Social Distancing on Reducing Spread of COVID-19:

• Interventions to mitigate early spread of SARS-CoV-2 in Singapore: a modelling study – The Lancet Infectious Diseases

Commentaries: Singapore modelling study estimates impact of physical distancing on reducing spread of COVID-19 – The Lancet AND Scientific and ethical basis for social-distancing interventions against COVID-19 – The Lancet Infectious Diseases AND Study: Social distancing might reduce COVID-19 spread by as much as 99% – UPI

Featured Commentaries on Social Distancing:

• When will the coronavirus pandemic and social distancing end? – Science News
• Social distancing: What it is and why it’s the best tool we have to fight the coronavirus – World Economic Forum
• Coronavirus plea from Johns Hopkins: please take social distancing seriously to save lives – The Baltimore Sun

Latest Articles:

• Viewpoint: Treating COVID-19—Off-Label Drug Use, Compassionate Use, and Randomized Clinical Trials During Pandemics – JAMA

“New drugs during this pandemic? First do not harm. If seeking benefit, do not assume no harm. We have the tools to do research. Emergency situations not an excuse for shortcuts” (via @DrMCecconi see Tweet)

• Coronavirus Disease 2019 (COVID-19) and Cardiovascular Disease – Circulation
• Can a century-old TB vaccine steel the immune system against the new coronavirus? – Science
• The Latest Coronavirus Clinical Trials – Science Translational Medicine
• Updated approaches against SARS-CoV-2 – Antimicrobial Agents and Chemotherapy
• Effect of gastrointestinal symptoms on patients infected with COVID-19 – Gastroenterology (PDF)
• Global epidemiology of coronavirus disease 2019: disease incidence, daily cumulative index, mortality, and their association with country healthcare resources and economic status – International Journal of Antimicrobial Agents
• At the Epicenter of the Covid-19 Pandemic and Humanitarian Crises in Italy: Changing Perspectives on Preparation and Mitigation – NEJM Catalyst
• Immunosuppression for hyperinflammation in COVID-19: a double-edged sword? – The Lancet
• The outbreak of Coronavirus Disease 2019 (COVID-19)—An emerging global health threat – Journal of Infection and Public Health
• From SARS to COVID-19: A previously unknown SARS- related coronavirus (SARS-CoV-2) of pandemic potential infecting humans – Call for a One Health approach – One Health
• Society of Cardiovascular Computed Tomography Guidance for Use of Cardiac Computed Tomography Amidst the COVID-19 Pandemic – Journal of Cardiovascular Computed Tomography
• COVID-19: Epidemiology, Evolution, and Cross-Disciplinary Perspectives – Trends in Molecular Medicine
• Imaging Features of Coronavirus disease 2019 (COVID-19): Evaluation on Thin-Section CT – Academic Radiology
• A review of the 2019 Novel Coronavirus (COVID-19) based on current evidence – International Journal of Antimicrobial Agents
• Responding to the COVID-19 pandemic in complex humanitarian crises – International Journal for Equity in Health AND Commentary: COVID-19: The time is now to prepare for people affected by humanitarian crises – Dartmouth College
• The characteristics and clinical value of chest CT images of novel coronavirus pneumonia – Clinical Radiology

Preprints:

• How to improve adherence with quarantine: Rapid review of the evidence – medRxiv
• Social distancing strategies for curbing the COVID-19 epidemic – medRxiv
• Mechanistic-statistical SIR modelling for early estimation of the actual number of cases and mortality rate from COVID-19 – medRxiv
• A comparative multi-centre study on the clinical and imaging features of comfirmed and uncomfirmed patients with COVID-19 – medRxiv
• Hypertension and Diabetes Delay the Viral Clearance in COVID-19 Patients – medRxiv
• From a single host to global spread. The global mobility based modelling of the COVID-19 pandemic implies higher infection and lower detection rates than current estimates – medRxiv
• Climatic influences on the worldwide spread of SARS-CoV-2 – medRxiv
• Epidemiological parameters of coronavirus disease 2019: a pooled analysis of publicly reported individual data of 1155 cases from seven countries – medRxiv
• Myocardial injury is associated with in-hospital mortality of confirmed or suspected COVID-19 in Wuhan, China: A single center retrospective cohort study – medRxiv
• A New, Simple Projection Model for COVID-19 Pandemic – medRxiv
• Characterizing occupations that cannot work from home: a means to identify susceptible worker groups during the COVID-19 pandemic – medRxiv
• Infection Control of 2019 Novel Corona Virus Disease (COVID-19) in Cancer Patients undergoing Radiotherapy in Wuhan – medRxiv
• Mathematical Predictions for Covid-19 as a Global Pandemic – medRxiv
• Predicting the number of reported and unreported cases for the COVID-19 epidemic in South Korea, Italy, France and Germany – medRxiv
• Window of Opportunity for Mitigation to Prevent Overflow of ICU capacity in Chicago by COVID-19 – medRxiv
• The impact of temperature and absolute humidity on the coronavirus disease 2019 (COVID-19) outbreak – evidence from China – medRxiv

Selected News & Perspectives:

• World COVID-19 total surges past 400,000; more nations lock down – CIDRAP
• Italian doctors note high COVID-19 death rate, urge action – CIDRAP
• Who Should Be Saved First? Experts Offer Ethical Guidance – The New York Times
• Coronavirus: India enter ‘total lockdown’ after spike in cases – BBC
• India Declares ‘Total’ Lockdown In Bid To Prioritize Coronavirus Fight – NPR
• As Coronavirus Spreads, It’s Time To Diagnose & Treat Our Broken Primary Health Care Systems – Health Policy Watch
• Factbox: How vulnerable is Latin America to coronavirus? Key data shed light – Reuters
• Coronavirus spreads fear, isolation, death to elderly worldwide – Reuters
• United States could become coronavirus epicenter: WHO – Reuters
• Italian coronavirus cases seen “10 times higher” than official tally – Reuters
• Expert reaction to CDC report on COVID-19 outbreaks on cruise ships, which includes that SARS-CoV-2 RNA was identified on surfaces in cabins up to 17 days after they were vacated – Science Media Centre
• CDC says coronavirus RNA found in Princess Cruise ship cabins up to 17 days after passengers left – CNBC
• When might experimental drugs to treat Covid-19 be ready? A forecast – STAT
• Desperate for Covid-19 answers, U.S. doctors turn to colleagues in China – STAT
• Can location data from smartphones help slow the coronavirus? Facebook is giving academics a chance to try – STAT
• Arizona man dies after self-medicating with chloroquine to treat coronavirus – CNN
• How Long Can the Virus That Causes COVID-19 Live On Surfaces? – Johns Hopkins
• “The babies keep coming”: What the coronavirus pandemic means for people giving birth – Vox
• Tokyo 2021? The decision to postpone the Summer Olympics, explained – Vox
• You’ve Got Mail. Will You Get the Coronavirus? – The New York Times
• Overweight and obese people at higher risk of COVID-19 – News Medical
• Can I get coronavirus from mail or package deliveries? Should I disinfect my phone? – The Conversation
• Why a one-size-fits-all approach to COVID-19 could have lethal consequences – The Conversation
• I’m on the Front Lines. I Have No Plan for This. – The New York Times

 

24 March 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives.

 

World Health Organization COVID-19 Situation Report:

• WHO: Latest COVID-19 Situation Report – 23 March 2020
• WHO Director-General’s opening remarks at the media briefing on COVID-19 – 23 March 2020

“The pandemic is accelerating. It took 67 days from the first reported case to reach the first 100,000 cases, 11 days for the second 100,000 cases and just 4 days for the third 100,000 cases. You can see how the virus is accelerating.”

• Pass the message: Five steps to kicking out coronavirus
• WHO Homepage on the Coronavirus disease (COVID-19) outbreak

Guidelines & Reports:

• Ventilator Supply Mitigation Strategies: Letter to Health Care Providers – U.S. Food & Drug Administration
• Medical Glove Conservation Strategies: Letter to Health Care Providers – U.S. Food & Drug Administration
• FDA advises patients on use of non-steroidal anti-inflammatory drugs (NSAIDs) for COVID-19 – U.S. Food & Drug Administration
• Guidance on shielding and protecting people defined on medical grounds as extremely vulnerable from COVID-19 – Public Health England
• Troponin and BNP Use in COVID-19 – Cardiology Magazine, American College of Cardiology AND Commentary: COVID-19: ACC Advises Caution on Use of Troponin, Natriuretic Peptide Tests – Medscape (free registration required)

“…among patients with COVID-19 infection, clinicians are advised to only measure troponin if the diagnosis of acute MI is being considered on clinical grounds and an abnormal troponin should not be considered evidence for an acute MI without corroborating evidence.”

Videos:

• Coronavirus in New York – Report from The Front Lines – JAMA

Podcasts:

• Coronapod: “Test, test, test!” – Nature

Featured Commentaries:

• Will the Coronavirus Ever Go Away? Here’s What One of the WHO’s Top Experts Thinks – TIME
• COVID19: A Path Forward – Medium

CDC Recommends Deferring All Cruise Travel Worldwide:

• Public Health Responses to COVID-19 Outbreaks on Cruise Ships — Worldwide, February–March 2020 – CDC Morbidity and Mortality Weekly Report

Disruption of Clinical Trials:

• Coronavirus pandemic leads big drugmakers to hit pause on clinical trials – Reuters
• As Covid-19 spreads, disruptions to clinical trial and drug development accelerate – STAT

Italy’s Coronavirus Deaths Slow:

• Italy’s coronavirus deaths slow, offering glimmer of hope – Reuters
• COVID-19 in Europe: the Italian lesson – The Lancet

CDC Guidance: Preparing Long-term Care Facilities and Nursing Homes for COVID-19:

• Preparing for COVID-19: Long-term Care Facilities, Nursing Homes – Centers for Disease Control and Prevention
• Related Guideline: Infection Prevention and Control guidance for Long-Term Care Facilities in the context of COVID-19 – World Health Organization (PDF)
• Related Article: COVID-19 in a Long-Term Care Facility — King County, Washington, February 27–March 9, 2020 – CDC Morbidity and Mortality Weekly Report
• Related Perspective: The Coronavirus’s Rampage Through a Suburban Nursing – The New York Times

What About Prisons?

• Prisons and custodial settings are part of a comprehensive response to COVID-19 – The Lancet Public Health
• Preventing COVID-19 outbreak in prisons: a challenging but essential task for authorities – WHO/Europe
• COVID-19: prisons and other prescribed places of detention guidance – Public Health England
• A coronavirus outbreak in jails or prisons could turn into a nightmare – Vox
• ‘A Storm Is Coming’: Fears of an Inmate Epidemic as the Virus Spreads in the Jails – The New York Times
• ‘Everyone will be contaminated’: prisons face strict coronavirus controls – The Guardian

Chloroquine for COVID-19: Cutting Through the Hype:

• Chloroquine for COVID-19: Cutting Through the Hype – The Scientist
• Statistical review of Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial – Zenodo

Latest Articles:

• He’s Back! Richard Lehman’s covid-19 reviews—23 March 2020
• Preprint: Incidence, clinical characteristics and prognostic factor of patients with COVID-19: a systematic review and meta-analysis – medRxiv (PDF) AND Commentary: Study Calculates Just How Much Age, Medical Conditions Raise Odds Of Severe COVID-19 – NPR (free)
• Preprint: A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing AND Commentary: Scientists Identify 69 Drugs to Test Against the Coronavirus – The New York Times
• WHO launches global megatrial of the four most promising coronavirus treatments – Science
• The standard coronavirus test, if available, works well—but can new diagnostics help in this pandemic? – Science
• Cellphone tracking could help stem the spread of coronavirus. Is privacy the price? – Science
• ‘I’m going to keep pushing.’ Anthony Fauci tries to make the White House listen to facts of the pandemic – Science
• The Toughest Triage — Allocating Ventilators in a Pandemic – New England Journal of Medicine
• Fair Allocation of Scarce Medical Resources in the Time of Covid-19 – New England Journal of Medicine AND Commentary: Life, or death? Experts guide pandemic medical equipment decisions – CIDRAP
• COVID-19 in Europe: the Italian lesson – The Lancet
• Planning and provision of ECMO services for severe ARDS during the COVID-19 pandemic and other outbreaks of emerging infectious diseases – The Lancet Respiratory Medicine
• Rational use of face masks in the COVID-19 pandemic – The Lancet Respiratory Medicine
• More awareness is needed for severe acute respiratory syndrome coronavirus 2019 transmission through exhaled air during non-invasive respiratory support: experience from China – European Respiratory Review
• COVID-19 Treatment: A Review of Early and Emerging Options – Open Forum Infectious Diseases
• The pandemic pipeline – Nature Biotechnology
• Fast, portable tests come online to curb coronavirus pandemic – Nature Biotechnology
• Coronavirus tests: researchers chase new diagnostics to fight the pandemic – Nature
• Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy – JAMA
• Social Media and Emergency Preparedness in Response to Novel Coronavirus – JAMA
• Coronaviruses and immunosuppressed patients. The facts during the third epidemic – Liver Transplantation

“Coronaviruses have not shown to cause a more severe disease in immunosuppressed patients. For this family of viruses the host innate immune response appears the main driver of lung tissue damage during infection.”

• Underpromise, overdeliver – Science
• Deciphering the power of isolation in controlling COVID-19 outbreaks – The Lancet Global Health
• Factors Associated With Mental Health Outcomes Among Health Care Workers Exposed to Coronavirus Disease 2019 – JAMA Network Open AND Commentary: Survey Finds COVID-19 Takes Heavy Psychological Toll on Health Care Workers – Psychiatric News Alert
• What Should Gastroenterologists and Patients Know About COVID-19? – Clinical Gastroenterology and Hepatology

Preprints:

• Assessing the potential impacts of COVID-19 in Brasil: Mobility, Morbidity and Impact to the Health System – medRxiv
• The feasibility of convalescent plasma therapy in severe COVID-19 patients: a pilot study – medRxiv
• The Effectiveness of Social Distancing in Mitigating COVID-19 Spread: a modelling analysis – medRxiv
• High incidence of asymptomatic SARS-CoV-2 infection, Chongqing, China – medRxiv
• Trend analysis of the COVID-19 pandemic in China and the rest of the world – medRxiv
• Effectiveness and cost-effectiveness of public health measures to control COVID-19: a modelling study – medRxiv

Selected News & Perspectives:

• Is the Math Too Hard For People To Understand COVID-19 Coronavirus? – Forbes
• What Singapore can teach the U.S. about responding to Covid-19 – STAT
• Antibiotic resistance: the hidden threat lurking behind Covid-19 – STAT
• For people with underlying health conditions, the coronavirus presents ‘all the ingredients’ for danger – STAT
• Covid-19 is reshaping the world of bioscience publishing – STAT
• The Virus Can be Stopped, but Only with Harsh Steps, Experts Say – The New York Times
• ‘Covid-19 Kills Only Old People.’ Only? – The New York Times
• How the Virus Got Out – The New York Times
• Supplements for Coronavirus Probably Won’t Help, and May Harm – The New York Times
• Olympics likely to be postponed; global COVID-19 cases top 375,000 – CIDRAP
• This virus is ravaging rich countries. What happens when it hits the poor ones? – The Guardian
• ICU doctors now face the toughest decisions they will ever have to make – The Guardian
• Germany’s low coronavirus mortality rate intrigues experts – The Guardian
• Social distancing isn’t enough – we need to ramp up testing and transparency – The Globe and Mail
• Coronavirus: are people with blood group A really at higher risk of catching COVID-19? – The Conversation
• The Covid-19 risks for different age groups, explained – Vox
• 7 coronavirus cleaning questions, answered by an expert – Vox

 

23 March 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives.

 

World Health Organization COVID-19 Situation Report:

• WHO: Latest COVID-19 Situation Report – 22 March 2020
• WHO Homepage on the Coronavirus disease (COVID-19) outbreak

Guidelines & Reports:

• Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19) – Intensive Care Medicine (PDF) AND Infographics: The Surviving Sepsis Campaign Rapid Guidelines on the Management of Critically Ill Adults with COVID-19
• COVID-19 rapid guideline: critical care – National Institute for Health and Care Excellence
• COVID-19 rapid guideline: dialysis service delivery – National Institute for Health and Care Excellence
• COVID-19 rapid guideline: delivery of systemic anticancer treatments – National Institute for Health and Care Excellence
• Infection Prevention and Control guidance for Long-Term Care Facilities in the context of COVID-19 – World Health Organization (PDF)
• Novel coronavirus (SARS-CoV-2) – Discharge criteria for confirmed COVID-19 cases – European Centre for Disease Prevention and Control
• Interim Guidance on Scaling-up COVID-19 Outbreak in Readiness and Response Operations in Camps and Camp-like Settings (jointly developed by IFRC, IOM, UNHCR and WHO)
• Recommendations for the prevention, mitigation and containment of the emerging SARS-CoV-2 (COVID-19) pandemic in haemodialysis centres – Nephrology Dialysis Transplantation
• Coronavirus infection and pregnancy: Information for pregnant women and their families – Royal College of Obstetricians and Gynaecologists
• Q&A on COVID-19, pregnancy, childbirth and breastfeeding – World Health Organization
• Information for Clinicians on Therapeutic Options for COVID-19 Patients – Centers for Disease Control and Prevention

Podcasts:

• #200 COVID-19 Update with Paul Sax MD – The Curbsiders Internal Medicine Podcast

Loss of Smell and Taste Could be a Sign of COVID-19:

• Position Statement: Loss of sense of smell as marker of COVID-19 infection – ENTUK
• There’s An Unexpected Loss Of Smell And Taste In Coronavirus Patients – Forbes
• If you’ve lost your sense of smell or taste, you could be a ‘hidden carrier’ of the coronavirus – Business Insider

CEBM Estimates Infection Rate Fatality (IFR) at 0,19%:

• Global Covid-19 Case Fatality Rates – Centre for Evidence-Based Medicine, University of Oxford

New Editorial by John P.A. Ioannidis:

• Coronavirus disease 2019: the harms of exaggerated information and non‐evidence‐based measures – European Journal of Clinical Investigation (PDF)
• Related Opinion Piece: A fiasco in the making? As the coronavirus pandemic takes hold, we are making decisions without reliable data – STAT
• Rebuttal 1: We know enough now to act decisively against Covid-19. Social distancing is a good place to start – STAT
• Rebuttal 2: A Rebuttal to “A Fiasco in the Making?” – Hilda Bastian

Featured Commentaries:

• Former CDC director: There’s a long war ahead and our Covid-19 response must adapt – CNN
• Is Our Fight Against Coronavirus Worse Than the Disease? – The New York Times
• Coronavirus: The Hammer and the Dance – Medium
• Keeping the Coronavirus from Infecting Health-Care Workers – The New Yorker

Latest Articles:

• Preprint: Favipiravir versus Arbidol for COVID-19: A Randomized Clinical Trial – medRxiv
• Supporting Clinicians During the COVID-19 Pandemic – Annals of Internal Medicine
• Covert coronavirus infections could be seeding new outbreaks – Nature
• Misguided drug advice for COVID-19 – Science
• New blood tests for antibodies could show true scale of coronavirus pandemic – Science
• Rhabdomyolysis as Potential Late Complication Associated with COVID-19 – CDC Emerging Infectious Diseases
• Serial Interval of COVID-19 among Publicly Reported Confirmed Cases – CDC Emerging Infectious Diseases
• Evaluation of the Effectiveness of Surveillance and Containment Measures for the First 100 Patients with COVID-19 in Singapore — January 2–February 29, 2020 – CDC Morbidity and Mortality Weekly Report
• Viral dynamics in mild and severe cases of COVID-19 – The Lancet Infectious Diseases
• Covid-19 and the Stiff Upper Lip — The Pandemic Response in the United Kingdom – New England Journal of Medicine
• Treatment for severe acute respiratory distress syndrome from COVID-19 – The Lancet Respiratory Medicine
• Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host−Virus Interaction, and Proposed Neurotropic Mechanisms – ACS Chemical Neuroscience
• COVID-19: Knowns, Unknowns, and Questions – mSphere
• Managing Cancer Care During the COVID-19 Pandemic: Agility and Collaboration Toward a Common Goal – Journal of the National Comprehensive Cancer Network (PDF)
• COVID‐19 pandemic: perspectives on an unfolding crisis – British Journal of Surgery (PDF)
• Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis – Clinica Chimica Acta
• JAMA Patient Page: Stopping the Spread of COVID-19
• High-dose intravenous immunoglobulin as a therapeutic option for deteriorating patients with Coronavirus Disease 2019 – Open Forum Infectious Diseases
• Minimally invasive surgery and the novel coronavirus outbreak: lessons learned in China and Italy – Annals of Surgery (PDF)
• Host susceptibility to severe COVID-19 and establishment of a host risk score: findings of 487 cases outside Wuhan – Critical Care
• COVID-19 pneumonia: infection control protocol inside computed tomography suites – Japanese Journal of Radiology
• Early Clinical and CT Manifestations of Coronavirus Disease 2019 (COVID-19) Pneumonia – American Journal of Roentgenology
• ERA-EDTA sharing Milan experience on coronavirus management in dialysis centres – Clinical Kidney Journal
• Profiling Early Humoral Response to Diagnose Novel Coronavirus Disease (COVID-19) – Clinical Infectious Diseases
• Artificial Intelligence Distinguishes COVID-19 from Community Acquired Pneumonia on Chest CT – Radiology
• Mitigating Risk of COVID-19 in Dialysis Facilities – Clinical Journal of the American Society of Nephrology
• The impact of high-flow nasal cannula (HFNC) on coughing distance: implications on its use during the novel coronavirus disease outbreak – Canadian Journal of Anesthesia
• Recommendation of low-dose CT in the detection and management of COVID-2019 – European Radiology
• COVID-19 and the consequences of isolating the elderly – The Lancet Public Health

Selected News & Perspectives:

• The 9 most important unanswered questions about Covid-19 – Vox
• Why we’re not overreacting to the coronavirus, in one chart – Vox
• As Italy COVID-19 cases soar, WHO tackles PPE, test shortages – CIDRAP
• What Have Scientists Learned About COVID-19 And Coronavirus By Using Cruise Ship Data ? – Forbes
• Italy Considers Adopting South Korean Model For Coronavirus Containment – Forbes
• A Different Way to Chart the Spread of Coronavirus – The New York Times
• You Can Help Break the Chain of Transmission – The New York Times
• In Italy, Coronavirus Takes a Higher Toll on Men – The New York Times
• Italy, Pandemic’s New Epicenter, Has Lessons for the World – The New York Times
• The Hardest Questions Doctors May Face: Who Will Be Saved? Who Won’t? – The New York Times
• Global COVID-19 total tops 300,000; FDA OKs rapid test – CIDRAP
• Millennials Aren’t Taking Coronavirus Seriously, a Top WHO Official Warns – TIME
• A plea from doctors in Italy: To avoid Covid-19 disaster, treat more patients at home – STAT
• New coronavirus test returns results in 45 minutes, but it may be limited to hospitals – STAT
• Why the Coronavirus Has Been So Successful – The Atlantic
• How the Coronavirus Became an American Catastrophe – The Atlantic
• Coronavirus deaths: What we don’t know – BBC

 

20 March 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives.

 

World Health Organization COVID-19 Situation Report:

• WHO: Latest COVID-19 Situation Report – 19 March 2020 (free PDF)
• WHO Homepage on the Coronavirus disease (COVID-19) outbreak (free resources)

Guidelines & Reports:

• Strategies for Optimizing the Supply of Facemasks – Centers for Disease Control and Prevention (free)
• COVID-19 Prioritization of Diagnostic Testing – Infectious Diseases Society of America (free PDF) AND Summary: IDSA Statement On COVID-19 Testing Recommendations – Infectious Diseases Society of America (free)

Featured Commentaries:

• Palliative Care in The Time Of COVID – The Ink Vessel (free)
• Which Country Has Flattened the Curve for the Coronavirus? – The New York Times (10 articles per month are free)
• Understanding what works: How some countries are beating back the coronavirus – STAT (free)
• This Is How We Can Beat the Coronavirus – The Atlantic (free)
• Who gets a ventilator? Hospitals facing coronavirus surge are preparing for life-or-death decisions – NBC News (free)
• Coronavirus vaccines: five key questions as trials begin – Nature (free)
• The coronavirus pandemic in five powerful charts – Nature (free)
• Understanding the Coronavirus Pandemic, in Five Charts – TIME (free)
• What are the prospects for a Covid-19 treatment? – The Guardian (free)
• Mass testing, school closings, lockdowns: Countries pick tactics in ‘war’ against coronavirus – Science (free)

Videos:

• Coronavirus (COVID-19) Mitigation: Preparing Hospitals and Health Systems – JAMA (free)

Podcasts:

• COVID-19 in Seattle: Clinical Features and Managing the Outbreak – JAMA (free)
• TWiV 592: Coronavirus update – dangerous curve ahead – This Week in Virology (free)
• EMCrit 268 – COVID Airway, Cardiac Arrest, Some Ethical Questions, etc. (free)
• Podcast 258 — One clinician’s experience of the early days of the COVID-19 epidemic in the U.S. – NEJM Journal Watch Clinical Conversations (free)

New COVID-19 Self Triage Tool:

• Online Tool: COVID-19 Self Triage Tool – Keck School of Medicine of USC (free)
• Commentary: A new self-triage tool can help you decide if you need medical care for Covid-19 – STAT (free)

New Preliminary Studies with Hydroxychloroquine:

• Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open label non-randomized clinical trial – International Journal of Antimicrobial Agents (free PDF)

This was an open-label study with only 42 patients, without patient-relevant endpoints. The 6 patients that received Hydroxychloroquine + Azithromycin achieved more efficient virus elimination than control patients.

• New in Vitro Study: Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro – Cell Discovery (free)
• Related Articles: AND In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) – Clinical Infectious Diseases (free PDF) AND New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? – International Journal of Antimicrobial Agents (free) AND A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19 – Journal of Critical Care (free) AND Of chloroquine and COVID-19 – Antiviral Research (free)

COVID-19 Glossaries:

• A Guide to Coronavirus-Related Words – Meriam-Webster (free)
• From Flattening the Curve to Pandemic: A Coronavirus Glossary – The New York Times (10 articles per month are free)
• Coronavirus: A Glossary of Terms to Help You Understand the Unfolding Crisis – TIME (free)
• Coronavirus (COVID-19) Outbreak Glossary – Global Health Policy (free)

China Reports No New Domestic Cases:

• China reports no new local coronavirus transmissions for first time – Reuters (free)
• China Reports No New Domestic Cases, But Battles Coronavirus Imported From Abroad – NPR (free)

Latest Articles:

• Estimating clinical severity of COVID-19 from the transmission dynamics in Wuhan, China – Nature Medicine (free) AND Commentaries: Coronavirus Death Rate in Wuhan Is Lower than Previously Thought, Study Finds – The New York Times (10 articles per month are free) AND The probability of dying after developing coronavirus symptoms is 1.4% in Wuhan, China, new research suggests — far lower than initial estimates – Business Insider (free)
• Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the Coronavirus Disease 2019 (COVID-19) Pandemic – Journal of the American College of Cardiology (free) AND Commentary: CVD in the Setting of COVID-19: Considerations to Prepare Patients, Providers, Health Systems – American College of Cardiology (free)
• Covid-19: how doctors and healthcare systems are tackling coronavirus worldwide – The BMJ (free)
• What is the evidence for social distancing during global pandemics? – Oxford COVID-19 Evidence Service (free)
• Estimating the asymptomatic proportion of coronavirus disease 2019 (COVID-19) cases on board the Diamond Princess cruise ship, Yokohama, Japan, 2020 – Eurosurveillance (free) AND Commentary: Study: 17.9% Of People With COVID-19 Coronavirus Had No Symptoms – Forbes (free)
• Lower mortality of COVID-19 by early recognition and intervention: experience from Jiangsu Province – Annals of Intensive Care (free)
• COVID-19 in Children: Initial Characterization of the Pediatric Disease – Pediatrics (free PDF) AND Commentary: Understanding how COVID-19 affects children vital to slowing pandemic, doctors say – University of Virginia Health System (free)
• Drive-Through Screening Center for COVID-19: a Safe and Efficient Screening System against Massive Community Outbreak – Journal of Korean Medical Science (free)
• Treatment of COVID-19: old tricks for new challenges – Critical Care (free)
• Safe patient transport for COVID-19 – Critical Care (free)
• COVID-19 infection: origin, transmission, and characteristics of human coronaviruses – Journal of Advanced Research (free)
• Perinatal Transmission of COVID-19 Associated SARS-CoV-2: Should We Worry? – Clinical Infectious Diseases (free PDF)
• Coronavirus (COVID-19) outbreak: what the department of endoscopy should know – Gastrointestinal Endoscopy (free PDF) AND Commentary: Endoscopy During the COVID-19 Pandemic – NEJM Journal Watch (free)
• Securing the Safety Net and Protecting Public Health During a Pandemic: Medicaid’s Response to COVID-19 – JAMA (free)
• Characteristics and Outcomes of 21 Critically Ill Patients With COVID-19 in Washington State – JAMA (free)
• Mass gathering events and reducing further global spread of COVID-19: a political and public health dilemma – The Lancet (free PDF)
• Health security capacities in the context of COVID-19 outbreak: an analysis of International Health Regulations annual report data from 182 countries – The Lancet (free)
• Will COVID-19 generate global preparedness? – The Lancet (free)
• COVID-19: protecting health-care workers – The Lancet (free)
• COVID-19 cacophony: is there any orchestra conductor? – The Lancet (free)
• The global community needs to swiftly ramp up the response to contain COVID-19 – The Lancet (free)
• Clinical course and mortality risk of severe COVID-19 – The Lancet (free)
• Use of antiviral drugs to reduce COVID-19 transmission – The Lancet Global Health (free)
• COVID-19 in Italy: momentous decisions and many uncertainties – The Lancet Global Health (free)
• Estimation of COVID-19 outbreak size in Italy – The Lancet Infectious Diseases (free)
• Viral dynamics in mild and severe cases of COVID-19 – The Lancet Infectious Diseases (free)
• Prisons and custodial settings are part of a comprehensive response to COVID-19 – The Lancet Public Health (free)
• COVID-19 and the consequences of isolating the elderly – The Lancet Public Health (free)
• Prolonged presence of SARS-CoV-2 viral RNA in faecal samples – The Lancet Gastroenterology & Hepatology (free)
• Prevention of SARS-CoV-2 infection in patients with decompensated cirrhosis – The Lancet Gastroenterology & Hepatology (free)
• Coronavirus in pregnancy and delivery: rapid review – Ultrasound in Obstetrics & Gynecology (free PDF)
• How do we plan hematopoietic cell transplant and cellular therapy with the looming COVID‐19 threat? – British Journal of Haematology (free PDF)
• The positive impact of lockdown in Wuhan on containing the COVID-19 outbreak in China – Journal of Travel Medicine (free)
• The cancellation of mass gatherings (MGs)? Decision making in the time of COVID-19 – Travel Medicine and Infectious Disease (free)
• SARS-CoV-2 and COVID-19: The most important research questions – Cell & Bioscience (free)

Preprints:

• Is a 14-day quarantine period optimal for effectively controlling coronavirus disease 2019 (COVID-19)? – medRxiv (free PDF)
• High transmissibility of COVID-19 near symptom onset – medRxiv (free PDF)

Selected News & Perspectives:

• Coronavirus means difficult, life-changing decisions for me and my cancer patients – The Guardian (free)
• The science behind coronavirus testing, and where the U.S. went wrong – Medium (free)
• Explainer: What is herd immunity and will it affect the pandemic? – Reuters (free)
• COVID-19’s Stop-Gap Solution Until Vaccines and Antivirals Are Ready – Global Health NOW (free)
• To Beat COVID-19, Social Distancing is a Must – NIH Director’s Blog (free)
• Children’s COVID-19 risks unique, Chinese studies find – CIDRAP (free)
• Italian COVID-19 deaths pass China’s total; cases surge in Europe – CIDRAP (free)
• Coronavirus: why should we stay 1.5 metres away from each other? – The Conversation (free)
• Coronavirus pandemic is a disaster for the world, but a few good things might emerge from it – The Conversation (free)
• Deciding How Much Distance You Should Keep – The New York Times (10 articles per month are free)
• There’s A Shortage Of Ventilators For Coronavirus Patients, So This International Group Invented An Open Source Alternative That’s Being Tested Next Week – Forbes (free)
• Opinion: Telehealth overpromises during the Covid-19 pandemic – STAT (free)
• Coronavirus Hits Older People Hardest. But Millennials, Gen Xers Can Be Vulnerable – NPR (free)
• People With Mild Symptoms Can Spread Coronavirus, European Researchers Warn – NPR (free)

 

19 March 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives.

 

World Health Organization COVID-19 Situation Report:

• WHO: Latest COVID-19 Situation Report – 18 March 2020 (free PDF)
• WHO Director-General’s opening remarks at the media briefing on COVID-19 – 18 March 2020 (free)
• WHO Homepage on the Coronavirus disease (COVID-19) outbreak (free resources)

Videos:

• Coronavirus Update with Anthony Fauci, MD – March 18, 2020 – JAMA (free)
• COVID-19 Emergency Intubation Sim video by Glenfield Hospital – ICM Anaesthesia COVID-19 (free)
• How soap kills the coronavirus – Vox (free)

Podcast:

• Interview with Dr. Eric Rubin and Dr. Lindsey Baden on new research on possible treatments for Covid-19 – New England Journal of Medicine (free)

Featured Commentaries:

• Tom Frieden: The Three Essential Questions about COVID-19 – Project Syndicate (free)

– First, do people without symptoms and children spread the novel coronavirus?

– Second, how is the virus spreading in hospitals?

– Third, who is most likely to die from COVID-19?

• Scientists warn we may need to live with social distancing for a year or more – Vox (free)
• Why Covid-19 is worse than the flu, in one chart – Vox (free)
• 99% of Those Who Died From Virus Had Other Illness, Italy Says – Bloomberg (free)
• Higher co-infection rates in COVID19 – Medium (free)

Japanese Flu Drug ‘Effective’ Against Coronavirus:

• China to use anti-flu drug Avigan to treat virus – NHK World-Japan (free)
• Japanese Flu Drug ‘Effective’ Against Coronavirus In Clinical Trials, Chinese Officials Say – Forbes (free)
• Japanese flu drug ‘clearly effective’ in treating coronavirus, says China – The Guardian (free)

Ibuprofen Controversy:

• WHO Now Officially Recommends to Avoid Taking Ibuprofen For COVID-19 Symptoms – ScienceAlert (free)
• EMA gives advice on the use of non-steroidal anti-inflammatories for COVID-19 – European Medicines Agency (free)
• EU drugs watchdog says currently no evidence ibuprofen worsens COVID-19 – Reuters (free)
• Advice From France To Avoid Ibuprofen For COVID-19 Leaves Experts Baffled – NPR (free)

Featured Twitter Thread Explaining the Imperial College London Report:

• Twitter Thread – Imperial College COVID-19 Report by Francois Balloux (free)

“The report by the ‘Imperial College COVID-19 Response Team’ has been released on March 16th. Now that things have calmed down a bit, I felt I should produce a thread summarizing my personal take on it. (1/15)”

Original report and commentaries: Impact of Non-pharmaceutical Interventions to Reduce COVID19 Mortality and Healthcare Demand (free)

Disruption of Clinical Trials:

• Coronavirus (COVID-19) Update: FDA Issues Guidance for Conducting Clinical Trials – U.S Food & Drug Administration (free)
• FDA Issues Guidelines on Conducting Trials During COVID-19 Pandemic – ContagionLive (free)
• Coronavirus will have a ‘big impact’ on one-third of U.S. clinical trial sites, survey finds – STAT (free)
• FDA urges virtual patient visits as coronavirus disrupts clinical trials – Reuters (free)

Opinion Piece from Renowned Researcher Sparks Controversy:

• Opinion Piece: A fiasco in the making? As the coronavirus pandemic takes hold, we are making decisions without reliable data – STAT (free)
• Rebuttal 1: We know enough now to act decisively against Covid-19. Social distancing is a good place to start – STAT (free)
• Rebuttal 2: A Rebuttal to “A Fiasco in the Making?” – Hilda Bastian (Free)

Guidelines & Reports:

• New CDC Guideline: Disinfecting your home if someone is sick – Centers for Disease Control and Prevention (free)
• Video Consultations: A Guide for Practice – British Journal of General Practice (free)
• NHS Specialty Guides (free resources)
• NHS Coronavirus guidance for clinicians (free resources)

Latest Articles:

• A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19 – New England Journal of Medicine (free) AND Editorial: Covid-19 — The Search for Effective Therapy (free) AND Commentary: A Promising Treatment for Coronavirus Fails – The New York Times (10 articles per month are free)
• SARS-CoV-2 Infection in Children – New England Journal of Medicine (free)
• SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients – New England Journal of Medicine (free)
• Facing Covid-19 in Italy — Ethics, Logistics, and Therapeutics on the Epidemic’s Front Line – New England Journal of Medicine (free)
• Am I Part of the Cure or Am I Part of the Disease? Keeping Coronavirus Out When a Doctor Comes Home – New England Journal of Medicine (free)
• Covid-19 — The Law and Limits of Quarantine – New England Journal of Medicine (free)
• COVID-19 in a Long-Term Care Facility — King County, Washington, February 27–March 9, 2020 – CDC Morbidity and Mortality Weekly Report (free)

“Introduction of COVID-19 into a long-term residential care facility in Washington resulted in cases among 81 residents, 34 staff members, and 14 visitors; 23 persons died”

• Severe Outcomes Among Patients with Coronavirus Disease 2019 (COVID-19) — United States, February 12–March 16, 2020 – CDC Morbidity and Mortality Weekly Report (free) Commentary: US studies offer clues to COVID-19 swift spread, severity – CIDRAP (free)
• Initial Investigation of Transmission of COVID-19 Among Crew Members During Quarantine of a Cruise Ship — Yokohama, Japan, February 2020 – CDC Morbidity and Mortality Weekly Report (free) AND Commentary: Princess Cruises Food Workers Spread Coronavirus, Study Finds – Bloomberg (free)
• Identifying and Interrupting Superspreading Events—Implications for Control of Severe Acute Respiratory Syndrome Coronavirus 2 – CDC Emerging Infectious Diseases (free)
• Editorial: Coronavirus: three things all governments and their science advisers must do now – Nature (Free)

– Follow the World Health Organization’s advice

– Publish the evidence and embrace open research

– International cooperation will save lives

• Presidential Powers and Response to COVID-19 – JAMA (free)
• Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study – American Journal of Gastroenterology (free PDF) AND Commentaries: Study from The American Journal of Gastroenterology Reveals Diarrhea is a Prominent Symptom of COVID-19 – American College of Gastroenterology (free) AND Diarrhea a key symptom in 1 of 4 COVID-19 patients, study finds – UPI (free)
• Covid-19: The painful price of ignoring health inequities – The BMJ (free)
• Impact of Coronavirus Disease 2019 (COVID-19) Outbreak on ST-Segment–Elevation Myocardial Infarction Care in Hong Kong, China – Circulation: Cardiovascular Quality and Outcomes (free PDF)
• Cardiologists and Coronavirus: Looking after ourselves and each other so we can continue to look after patients – Heart (free)
• Coronaviruses and the cardiovascular system: acute and long-term implications – European Heart Journal (free)

Preprints:

• A serological assay to detect SARS-CoV-2 seroconversion in humans – medRxiv (free PDF)
• Correcting under-reported COVID-19 case numbers – medRxiv (free PDF)
• Routes for COVID-19 importation in Brazil – medRxiv (free PDF)
• Stability of SARS-CoV-2 in different environmental conditions – medRxiv (free PDF)
• Coronavirus disease-19: The First 7,755 Cases in the Republic of Korea – medRxiv (free PDF)
• Acute myelitis after SARS-CoV-2 infection: a case report. – medRxiv (free PDF)
• Effects of temperature variation and humidity on the mortality of COVID-19 in Wuhan – medRxiv (free PDF)
• Demographic science aids in understanding the spread and fatality rates of COVID-19 – medRxiv (free PDF)
• Understanding Epidemic Data and Statistics: A case study of COVID-19 – medRxiv (free PDF)
• Propagation analysis and prediction of the COVID-19 – medRxiv (free PDF)
• Coronavirus disease-19: Summary of 2,370 Contact Investigations of the First 30 Cases in the Republic of Korea – medRxiv (free PDF)

Selected News & Perspectives:

• More COVID-19 News – Science-Based Medicine (free)
• Modeling study suggests 18 months of COVID-19 social distancing, much disruption – CIDRAP (free)
• Global COVID-19 total tops 200,000; WHO unveils massive treatment study – CIDRAP (free)
• Why Singapore’s coronavirus response worked – and what we can all learn – The Conversation (free)
• Scott Morrison has said we’ll face at least 6 months of disruption. Where does that number come from? – The Conversation (free)
• Worldwide Shortage Of COVID-19 Test Agents Plagues Health Systems – Even As Infections Surpass 200,000 – Health Policy Watch (free)
• WHO Announces New International Trial To Search For COVID-19 Treatments – Health Policy Watch (free)
• U.S. official says data show severe coronavirus infections among millennials, not just older Americans – STAT (free)
• New analysis breaks down age-group risk for coronavirus — and shows millennials are not invincible – STAT (free)
• Mitigating the Spread of COVID-19 and Its Impact on Cancer: How Cancer Centers Are Preparing for the Coronavirus – The ASCO Post (free)
• The Treatment of Patients With Cancer and Containment of COVID-19: Experiences From Italy – ASCO Daily News (free)
• Patients with breathing, lung problems at highest risk with COVID-19: study – Reuters (free)
• Scientists say mass tests in Italian town have halted Covid-19 there – The Guardian (free)
• Almost 25 million jobs could be lost worldwide as a result of COVID-19, says ILO – International Labour Organization (free)
• NIH Director: ‘We’re on an Exponential Curve’ – The Atlantic (free)
• U.S. Virus Plan Anticipates 18-Month Pandemic and Widespread Shortages – The New York Times (10 articles per month are free)
• Younger Adults Make Up Big Portion of Coronavirus Hospitalizations in U.S. – The New York Times (10 articles per month are free)
• Coronavirus Infection Mild In Over Half Of Children, Infants At Slightly More Risk, Study Finds – Forbes (free)

 

18 March 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives.

 

World Health Organization COVID-19 Situation Report:

• WHO: Latest COVID-19 Situation Report – 17 March 2020 (free PDF)
• WHO calls for urgent, aggressive actions to combat COVID-19, as cases soar in South-East Asia Region (free)
• WHO Homepage on the Coronavirus disease (COVID-19) outbreak (free resources)

Video:

• Coronavirus Testing – JAMA Network (free)
• COVID-19: Johns Hopkins University Experts Discuss Pandemic Response, Social Distancing, and More (free)

Podcast:

• Annals On Call – Understanding the Spread of COVID-19 – Annals of Internal Medicine (free)

Guidelines & Reports:

• Interim Infection Prevention and Control Recommendations for Patients with Suspected or Confirmed Coronavirus Disease 2019 (COVID-19) in Healthcare Settings – Centers for Disease Control and Prevention (free) AND See also: CDC Guidance for Healthcare Professionals (free guidelines)
• Chinese Clinical Guidance for COVID-19 Pneumonia Diagnosis and Treatment (7th edition) AND Commentary: Chinese Clinical Guidance For COVID-19 Pneumonia Diagnosis and Treatment – American College of Cardiology (free)
• HFSA/ACC/AHA Statement Addresses Concerns Re: Using RAAS Antagonists in COVID-19 – American College of Cardiology (free) AND Commentaries: Patients with COVID-19 should keep taking key CVD medications – Cardiovascular Business (free) AND Patients taking ACE-i and ARBs who contract COVID-19 should continue treatment, unless otherwise advised by their physician – American Heart Association (free)
• The Renal Association, UK position statement on COVID-19 and ACE Inhibitor/Angiotensin Receptor Blocker use (free)

Featured Commentaries:

• US, UK coronavirus strategies shifted following UK epidemiologists’ ominous report – CNN (free)
• New Analysis Suggests Months Of Social Distancing May Be Needed To Stop Virus – NPR (free)
• Why ‘Exponential Growth’ Is So Scary For The COVID-19 Coronavirus – Forbes (free)

Latest Articles:

• Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1 – New England Journal of Medicine (free) AND Commentaries: New coronavirus stable for hours on surfaces – NIH News Releases (free) AND How Long Will Coronavirus Live on Surfaces or in the Air Around You? – The New York Times (10 articles per month are free) AND New coronavirus can persist in air for hours and on surfaces for days: study – Reuters (free)
• The proximal origin of SARS-CoV-2 – Nature Medicine (free) AND Commentary: The COVID-19 coronavirus epidemic has a natural origin, scientists say – Scripps Research Institute (free)

“Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus.” (via @NatureNews see Tweet)

• Infographic: Coronavirus Disease 2019 (COVID-19) in Italy – JAMA (free)
• A year without conferences? How the coronavirus pandemic could change research – Nature (free)
• Coronavirus cases have dropped sharply in South Korea. What’s the secret to its success? – Science (free)
• Helen Salisbury: What might we learn from the covid-19 pandemic? – The BMJ (free)
• Opinion: To control the covid-19 outbreak, young, healthy patients should avoid the emergency department – The BMJ (free)
• Covid-19: ibuprofen should not be used for managing symptoms, say doctors and scientists – The BMJ (free)
• Don’t rush to deploy COVID-19 vaccines and drugs without sufficient safety guarantees – Nature (free)
• Creating the New Normal: The Clinician Response to Covid-19 – NEJM Catalyst (free)
• Investigation of three clusters of COVID-19 in Singapore: implications for surveillance and response measures – The Lancet (free)
• Preparedness is essential for malaria-endemic regions during the COVID-19 pandemic – The Lancet (free)
• SARS-CoV-2 RNA more readily detected in induced sputum than in throat swabs of convalescent COVID-19 patients – The Lancet Infectious Diseases (free)
• COVID-19: the need for continuous medical education and training – The Lancet Respiratory Medicine (free)
• Screening of faecal microbiota transplant donors during the COVID-19 outbreak: suggestions for urgent updates from an international expert panel – The Lancet Gastroenterology & Hepatology (free)
• Asymptomatic carrier state, acute respiratory disease, and pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): Facts and myths – Journal of Microbiology, Immunology and Infection (free)
• The SARS-CoV-2 outbreak: what we know – International Journal of Infectious Diseases (free)
• Prevalence of comorbidities in the novel Wuhan coronavirus (COVID-19) infection: a systematic review and meta-analysis – International Journal of Infectious Diseases (free PDF)
• Report on the Epidemiological Features of Coronavirus Disease 2019 (COVID-19) Outbreak in the Republic of Korea from January 19 to March 2, 2020 – Journal of Korean Medical Science (free PDF)
• Novel Coronavirus COVID-19: An Overview for Emergency Clinicians – EXTRA Supplement – Emergency Medicine Practice (free)
• Coronavirus Disease 2019 (COVID-19): A Systematic Review of Imaging Findings in 919 Patients – American Journal of Roentgenology (free)
• Clinical Features and Chest CT Manifestations of Coronavirus Disease 2019 (COVID-19) in a Single-Center Study in Shanghai, China – American Journal of Roentgenology (Free)
• The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak – an update on the status – Military Medical Research (free)
• Post-discharge surveillance and positive virus detection in two medical staff recovered from coronavirus disease 2019 (COVID-19), China, January to February 2020 – Eurosurveillance (free)
• Chest computed tomography images of early coronavirus disease (COVID-19) – Canadian Journal of Anesthesia (free)
• New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? – International Journal of Antimicrobial Agents (free)
• Limiting spread of COVID-19 from cruise ships – lessons to be learnt from Japan – QJM: An International Journal of Medicine (free PDF)
• Initial Investigation of Transmission of COVID-19 Among Crew Members During Quarantine of a Cruise Ship — Yokohama, Japan, February 2020 – CDC Morbidity and Mortality Weekly Report (free)
• Clinical outcome of 55 asymptomatic cases at the time of hospital admission infected with SARS-Coronavirus-2 in Shenzhen, China – The Journal of Infectious Diseases (free PDF)
• Prominent changes in blood coagulation of patients with SARS-CoV-2 infection – Clinical Chemistry and Laboratory Medicine (free PDF)
• Can the Coronavirus Disease 2019 (COVID-19) Affect the Eyes? A Review of Coronaviruses and Ocular Implications in Humans and Animals – Ocular Immunology and Inflammation (free PDF)

Preprints:

• Expected impact of COVID-19 outbreak in a major metropolitan area in Brazil – medRxiv (free PDF)
• If containment is not possible, how do we minimize mortality for COVID-19 and other emerging infectious disease outbreaks? – medRxiv (free PDF)
• The effects of border control and quarantine measures on global spread of COVID-19 – medRxiv (free PDF)
• Impact of city and residential unit lockdowns on prevention and control of COVID-19 – medRxiv (free PDF)
• Impact of the contact and exclusion rates on the spread of COVID-19 pandemic – medRxiv (free PDF)
• Impacts of social and economic factors on the transmission of coronavirus disease (COVID-19) in China – medRxiv (free PDF)
• Covid-19 pandemic: on a simple way to visualize the epidemic states and trajectories of some European countries, and to assess the effect of delays in official response – medRxiv (free PDF)
• Epidemiological Trends of Coronavirus Disease 2019 in China – medRxiv (free PDF)

Selected News & Perspectives:

• A coronavirus outbreak in jails or prisons could turn into a nightmare – Vox (free)
• COVID-19 Coronavirus And Tuberculosis: We Need A Damage Control Plan – Forbes (free)
• A fiasco in the making? As the coronavirus pandemic takes hold, we are making decisions without reliable data – STAT (free)
• Having Brushed Off Coronavirus Threat, Southeast Asia Begins to Confront It – The New York Times (10 articles per month are free)
• Hundreds of Scientists Scramble to Find a Coronavirus Treatment – The New York Times (10 articles per month are free)
• Is Ibuprofen Really Risky for Coronavirus Patients? – The New York Times (10 articles per month are free)
• Call to protect hospital staff from coronavirus contamination – The Guardian (free)
• Doctors Fear Bringing Coronavirus Home – The New York Times (10 articles per month are free)
• Costs Of COVID-19 Tests Could Be Limiting Scale-Up in Europe; WHO Says ‘Herd Immunity’ Approach Lacks Evidence Base – Health Policy Watch (free)
• COMMENTARY: Strange COVID-19 bedfellows: gnawing anxiety and under-reaction – CIDRAP (free)
• EU closes borders to slow COVID-19; activity escalates in South Asia – CIDRAP (free)
• Why are there so few coronavirus cases in Russia and Africa? – The Conversation (free)
• Can coronavirus spread through food? Can anti-inflammatories like ibuprofen make it worse? Coronavirus claims checked by experts – The Conversation (free)
• Factbox: COVID-19 and the new coronavirus – Fact versus fiction – Reuters (free)
• Self-Isolation Orders Pit Civil Liberties Against Public Good In Coronavirus Pandemic – NPR (free)
• German institute: Two years for pandemic to run its course – Reuters (free)
• Factbox: What Africa is doing to fight coronavirus – Reuters (free)

 

17 March 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives.

 

World Health Organization COVID-19 Situation Report:

• WHO: Latest COVID-19 Situation Report – 16 March 2020 (free PDF)
• WHO Director-General’s opening remarks at the media briefing on COVID-19 – 16 March 2020 (free)

“We have a simple message for all countries: test, test, test. Test every suspected case.”

• WHO Homepage on the Coronavirus disease (COVID-19) outbreak (free resources)

Guidelines & Reports:

• Report 9: Impact of non-pharmaceutical interventions (NPIs) to reduce COVID19 mortality and healthcare demand – Imperial College London (free PDF) AND Summary: Report 9 (free)

“…in an unmitigated epidemic, we would predict approximately 510,000 deaths in GB and 2.2 million in the US, not accounting for the potential negative effects of health systems being overwhelmed on mortality.”

• Guidance on social distancing for everyone in the UK and protecting older people and vulnerable adults – Public Health England (free)
• COVID-19: guidance for households with possible coronavirus infection – Public Health England (free)
• Radiology Department Preparedness for COVID-19: Radiology Scientific Expert Panel – Radiology (free) AND Commentary: Experts stress radiology preparedness for COVID-19 – Radiology Society of North America (free)
• Surgical Mask and Gown Conservation Strategies – Letter to Healthcare Providers – U.S. Food & Drug Administration (free)
• COVID-19: Recommendations for Management of Elective Surgical Procedures – American College of Surgeons (free) AND Commentary: U.S. hospitals, patients cancel elective surgery as coronavirus spreads – Reuters (free)
• Consensus statement: Safe Airway Society principles of airway management and tracheal intubation specific to the COVID-19 adult patient group – Medical Journal of Australia (free)

COVID-19 Hospital Impact Model for Epidemics:

• COVID-19 Hospital Impact Model for Epidemics – Penn Medicine (free tool – does not work properly on the cell phone, try it on your desktop) AND Commentary: Coronavirus model shows individual hospitals what to expect in the coming weeks – STAT (free)

Clinical Trial of Investigational Vaccine Begins:

• NIH clinical trial of investigational vaccine for COVID-19 begins – NIH News Releases (free)
• Related: When will a coronavirus vaccine be ready? – The Guardian (free) AND First in Human: COVID-19 Vaccines & Tales of Phase 1 Clinical Trials Past – Absolutely Maybe Blog (free) AND A coronavirus vaccine will take at least 18 months—if it works at all – MIT Technology Review (free)

Medical Blogs:

• An Illustrated Guide to the Chest CT in COVID-19 – PulmCCM (free)

Featured Commentaries:

• Infected people without symptoms might be driving the spread of coronavirus more than we realized – CNN (free)
• COVID-19: Who Is Infectious? – Forbes (free)
• The Workers Who Face the Greatest Coronavirus Risk – The New York Times (10 articles per month are free)

COVID-19 and Bioethics:

• ‘Is Ordering Takeout Unethical?’ A Medical Ethicist Answers Some of the Most Common Moral Questions Around Coronavirus – TIME (free)
• What if Two COVID-19 Victims Need Ventilators and Just One Is Available? – Scientific American (free)

Latest Articles:

• Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV2) – Science (free) AND Commentaries: 80% of COVID-19 spreads from people who don’t know they are sick – UPI (free) AND Coronavirus Is Hiding in Plain Sight – The New York Times (10 articles per month are free)
• Epidemiological Characteristics of 2143 Pediatric Patients With 2019 Coronavirus Disease in China – Pediatrics (free PDF) AND Commentary: Children with COVID-19 Impacted Less Severely Than Adults: Study – American Academy of Pediatrics (free)
• Why do dozens of diseases wax and wane with the seasons—and will COVID-19? – Science (free)
• ‘A ticking time bomb’: Scientists worry about coronavirus spread in Africa – Science (free)
• Viewpoint: Managing COVID-19 in Low- and Middle-Income Countries – JAMA (free)
• Editorial Concern: Possible Reporting of the Same Patients With COVID-19 in Different Reports – JAMA (free)
• COVID-19: towards controlling of a pandemic – The Lancet (free PDF)
• Care of haematology patients in a COVID‐19 epidemic – British Journal of Haematology (free PDF)
• Infants Born to Mothers With a New Coronavirus (COVID-19) – Frontiers in Pediatrics (free) AND Commentary: Chinese case study suggests COVID-19 is not transmitted from pregnant mothers to newborns – Frontiers (free)
• Clinical and CT features in pediatric patients with COVID‐19 infection: Different points from adults – Pediatric Pulmonology (free)
• COVID-19 and the Risk to Health Care Workers: A Case Report – Annals of Internal Medicine (free)
• Estimation of Coronavirus Disease 2019 (COVID-19) Burden and Potential for International Dissemination of Infection From Iran – Annals of Internal Medicine (free)
• Ian Hamilton: Covid-19—are we rationing who we care about? – The BMJ Opinion (free)
• Doctors’ wellbeing: self care during the covid-19 pandemic – The BMJ Opinion (free)
• On the front lines of coronavirus: the Italian response to covid-19 – The BMJ (free)
• Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, China – Clinical Infectious Diseases (free PDF)
• Review: Liver injury during highly pathogenic human coronavirus infections – Liver International (free)
• Coronavirus fulminant myocarditis saved with glucocorticoid and human immunoglobulin – European Heart Journal (free PDF)
• Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19 – Nature Medicine (free)
• COVID-19: consider cytokine storm syndromes and immunosuppression – The Lancet (free)
• Experience of different upper respiratory tract sampling strategies for detection of COVID-19 – Journal of Hospital Infection (free)
• Association between 2019-nCoV transmission and N95 respirator use – Journal of Hospital Infection (free)
• Impact of international travel and border control measures on the global spread of the novel 2019 coronavirus outbreak – PNAS (free)

Preprints:

• Demographic science aids in understanding the spread and fatality rates of COVID-19 – OSF (free PDF)

“Real-time evidence of flattening the curve. Lodi had the first Covid-19 case in Italy, and implemented a shutdown on Feb 23. Bergamo waited until March 8. Look at the difference. Incredible research by @drjenndowd, @melindacmills & co-authors.” (via @donmoyn see Tweet)

• Systematic review and meta-analysis of predictive symptoms and comorbidities for severe COVID-19 infection – medRxiv (free PDF)
• Clinical features and outcomes of 2019 novel coronavirus-infected patients with cardiac injury – medRxiv (free PDF)
• Environmental contamination of the SARS-CoV-2 in healthcare premises: An urgent call for protection for healthcare workers – medRxiv (free PDF)
• Impact of self-imposed prevention measures and short-term government intervention on mitigating and delaying a COVID-19 epidemic – medRxiv (free PDF)
• Triaging patients in the outbreak of the 2019 novel coronavirus – medRxiv (free PDF)
• Impact assessment of non-pharmaceutical interventions against COVID-19 and influenza in Hong Kong: an observational study – medRxiv (free PDF)
• Ocular manifestations and clinical characteristics of 534 cases of COVID-19 in China: A cross-sectional study – medRxiv (free PDF)
• Strongly heterogeneous transmission of COVID-19 in mainland China: local and regional variation – medRxiv (free PDF)
• Duration of viral detection in throat and rectum of a patient with COVID-19 – medRxiv (free PDF)
• Active or latent tuberculosis increases susceptibility to COVID-19 and disease severity – medRxiv (free PDF)
• Relationship between the ABO Blood Group and the COVID-19 Susceptibility – medRxiv (free PDF)
• Estimation of the final size of the second phase of the coronavirus epidemic by the logistic model – medRxiv (free PDF)
• Clinical Characteristics of 34 Children with Coronavirus Disease-2019 in the West of China: a Multiple-center Case Series – medRxiv (free PDF)
• Influence factors of death risk among COVID-19 patients in Wuhan, China: a hospital-based case-cohort study – medRxiv (free PDF)
• Spread of SARS-CoV-2 Coronavirus likely to be constrained by climate – medRxiv (free PDF)
• Social distance and SARS memory: impact on the public awareness of 2019 novel coronavirus (COVID-19) outbreak – medRxiv (free PDF)
• Generalized logistic growth modeling of the COVID-19 outbreak in 29 provinces in China and in the rest of the world – medRxiv (free PDF)
• Immune phenotyping based on neutrophil-to-lymphocyte ratio and IgG predicts disease severity and outcome for patients with COVID-19 – medRxiv (free PDF)
• Preliminary evaluation of voluntary event cancellation as a countermeasure against the COVID-19 outbreak in Japan as of 11 March, 2020 – medRxiv (free PDF)
• Health, distress, and life satisfaction of people one-month into COVID-19 outbreak in China – medRxiv (free PDF)
• A Method to Model Outbreaks of New Infectious Diseases with Pandemic Potential such as COVID-19 – medRxiv (free PDF)
• Evaluating the effect of public health intervention on the global-wide spread trajectory of Covid-19 – medRxiv (free PDF)
• Rational evaluation of various epidemic models based on the COVID-19 data of China – medRxiv (free PDF)
• Recommendations for standardized management of CML patients in the core epidemic area of COVID-19 (Multi-center survey results in Hubei Province, China) – medRxiv (free PDF)

Selected News & Perspectives:

• Expert reaction to reports that the French Health Minister recommended use of paracetamol for fever from COVID-19 rather than ibuprofen or cortisone – Science Media Centre (free)
• So you have been asked to self-isolate or quarantine. What now? – News GP (free)
• Coronavirus reality check: 7 myths about social distancing, busted – USA Today (free)
• How long will social distancing for coronavirus have to last? Depends on these factors. – The Washington Post (free)
• COMMENTARY: COVID-19 transmission messages should hinge on science – CIDRAP (free)
• Trump backtracks on COVID-19 severity as White House tightens guidance – CIDRAP (free)
• Doctors: COVID-19 pushing Italian ICUs toward collapse – CIDRAP (free)
• France orders lockdown to slow COVID-19 spread – CIDRAP (free)
• Wondering About Social Distancing? – The New York Times (free)
• “Test, Test, Test” for COVID-19, Says WHO; Canada, EU & African Countries Introduce Sweeping New Travel Restrictions – Health Policy Watch (free)
• Remote Work and Best Practices: The Coronavirus Workplace Series – Forbes (free)
• COVID-19: Who Is Infectious? – Forbes (free)
• Coronavirus: The World Health Organization Is Becoming The Planet’s Most Important Social Media Influencer – Forbes (free)
• How Epidemiologists Understand the Novel Coronavirus – The New Yorker (free)
• To Stop Coronavirus In Its Tracks, Here’s Your Guide To 5 Degrees Of Separation – Kaiser Health News (free)
• Coronavirus: How to protect your mental health – BBC (free)
• An expert guide to social distancing – and what to do if friends and family aren’t onboard – The Guardian (free)
• The pros and cons of coronavirus school closures, explained – Vox (free)
• The U.K.’s Coronavirus ‘Herd Immunity’ Debacle – The Atlantic (free)
• We doctors are scared of the coronavirus crisis. How could we not be? – The Guardian (free)
• Self-Service Diagnosis of COVID-19—Ready for Prime Time? – JAMA Health Forum (free)
• Coronavirus while pregnant or giving birth: here’s what you need to know – The Conversation (free)
• Can I take the dog for a walk? Can I put the kids to bed? What you should and shouldn’t do if you’re in coronavirus self-isolation – The Conversation (free)
• Coronavirus: why are we cancelling large gatherings? And what other ‘social distancing’ options are left? – The Conversation (free)

 

16 March 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives.

 

World Health Organization COVID-19 Situation Report:

• WHO: Latest COVID-19 Situation Report – 15 March 2020 (free PDF)
• WHO Director-General’s opening remarks at the media briefing on COVID-19 – 13 March 2020 (free)

“Europe has now become the epicenter of the pandemic, with more reported cases and deaths than the rest of the world combined, apart from China.”

• WHO Homepage on the Coronavirus disease (COVID-19) outbreak (free resources)

Guidelines & Reports:

• COVID 19 – BMJ Best Practice (free)
• Interim Guidance: Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected – World Health Organization (free PDF)
• Mental Health and Psychosocial Considerations During COVID-19 Outbreak – World Health Organization (free PDF)

“Minimize watching, reading or listening to news that causes you to feel anxious or distressed; seek information only from trusted sources and mainly to take practical steps to prepare your plans and protect yourself and loved ones.”

• Guidance: COVID-19 Airway Management Principles AND Summary: COVID-19 Airway Management Principles (free PDF) – From the Intensive Care Society; The Faculty of Intensive Care Management; Association of Anaesthetists; and Royal College of Anaesthetists.
• Considerations relating to social distancing measures in response to the COVID-19 epidemic – European Centre for Disease Prevention and Control (free)
• Get Your Mass Gatherings or Large Community Events Ready – Centers for Disease Control and Prevention (free) AND Commentary: The CDC recommends organizers cancel or postpone events with 50 people or more for 8 weeks – CNN (free)
• ABM Statement on Coronavirus 2019 (COVID-19) – Academy of Breastfeeding Medicine (free)
• Alert: Important coronavirus updates for ophthalmologists – American Academy of Ophthalmology (free)

Videos:

• Coronavirus in Italy – Report From The Front Lines – JAMA (free)
• Coronavirus and COVID-19: your questions answered by virus experts – The Conversation (free)

Podcasts:

• Covid-19 Podcast from Italy with Roberto Cosentini – St Emlyn’s (free)

Featured Commentaries:

• Why outbreaks like coronavirus spread exponentially, and How to Flatten the Curve – The Washington Post (Great Article! – free)
• How Much Worse the Coronavirus Could Get, in Charts – The New York Times (10 articles per month are free)
• From Flattening the Curve to Social Distancing: a Coronavirus Glossary – The New York Times (10 articles per month are free)

On the Use of ACE-Inhibitors, Angiotensin Receptor Blockers and Anti-inflammatories:

• Position Statement of the ESC Council on Hypertension on ACE-Inhibitors and Angiotensin Receptor Blockers – European Society of Cardiology (free)
• The Coronavirus Conundrum: ACE2 and Hypertension Edition-NephJC (free)
• France warns against use of anti-inflammatory drugs to tackle coronavirus – Reuters (free)
• Deeply concerned about this bold statement by the French MoH with no reference to the claim, which is causing public concern. There’s no scientific evidence I am aware of that ibuprofen cause worst outcomes in #COVID19. (via @mugecevik see Tweet)

Britain’s ‘Herd Immunity’ Coronavirus Plan:

• I’m an epidemiologist. When I heard about Britain’s ‘herd immunity’ coronavirus plan, I thought it was satire – The Guardian (free)
• Coronavirus: Some scientists say UK virus strategy is ‘risking lives’ – BBC (free)
• What does Britain know about coronavirus that the rest of Europe doesn’t? – CNN (free)
• Expert comments about herd immunity – Science Media Centre (free)
• Expert comment on UK government response to COVID-19 – Science Media Centre (free)

New COVID-19 Ethics Resource Center:

• COVID-19 Ethics Resource Center – AMA Journal of Ethics (free articles)

Latest Articles:

• Critical Care Utilization for the COVID-19 Outbreak in Lombardy, Italy: Early Experience and Forecast During an Emergency Response – JAMA (free)
• Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding – Nature Medicine (free) AND Commentary: How Does The Coronavirus Affect Kids? What We Know So Far About COVID-19 In Children – Forbes (free) AND Coronavirus study finds children with COVID-19 show milder symptom pattern – Reuters (free)

“Children infected with the #COVID19 outbreak coronavirus, SARS-CoV-2, show mild symptoms but prolonged shedding of viral RNA in feces, suggesting that the fecal–oral route might play a role in virus transmission #CORONAVIRUS” (via @NatureMedicine see Tweet)

• Coronavirus Infections in Children Including COVID-19: An Overview of the Epidemiology, Clinical Features, Diagnosis, Treatment and Prevention Options in Children – The Pediatric Infectious Diseases Journal (free PDF) AND Commentary: COVID-19 appears less severe in children – Wolters Kluwer Health (free)
• A Review of Coronavirus Disease-2019 (COVID-19) – Indian Journal of Pediatrics (free)
• Editorial: COVID-19: delay, mitigate, and communicate – The Lancet (free PDF)
• Editorial: Bearing the brunt of covid-19: older people in low and middle income countries – The BMJ (free) AND Commentary: Call for older people in poor countries to be considered in global responses to COVID-19 – University of East Anglia (free)
• In the fight against the new coronavirus outbreak, we must also struggle with human bias – Nature (free)
• From Containment to Mitigation of COVID-19 in the US – JAMA (free)
• The convalescent sera option for containing COVID-19 – The Journal of Clinical Investigation (free)
• Preparing for a COVID-19 pandemic: a review of operating room outbreak response measures in a large tertiary hospital in Singapore – Canadian Journal of Anaesthesia (free)
• Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases – American Chemical Society (free) AND Commentaries: Potential therapeutic agents, vaccines for COVID-19 – American Chemical Society (free) AND COVID-19: Research and Development on Therapeutic Agents and Vaccines – MedicalResearch.com (free)
• In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) – Clinical Infectious Diseases (free)
• Protecting Health Care Workers during the COVID-19 Coronavirus Outbreak –Lessons from Taiwan’s SARS response – Clinical Infectious Diseases (free)
• A Novel Approach for a Novel Pathogen: using a home assessment team to evaluate patients for 2019 novel coronavirus (SARS-CoV-2) – Clinical Infectious Diseases (free)
• A case report of neonatal COVID-19 infection in China – Clinical Infectious Diseases (free PDF)
• A comparative study on the clinical features of COVID-19 pneumonia to other pneumonias – Clinical Infectious Diseases (free PDF)
• Dysregulation of immune response in patients with COVID-19 in Wuhan, China – Clinical Infectious Diseases (free PDF)
• COVID-19 – the role of mass gatherings – Travel Medicine and Infectious Disease (free)
• Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China – JAMA Internal Medicine (free)
• A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19 – Journal of Critical Care (free)
• Effect of delay in diagnosis on transmission of COVID-19 – Mathematical Biosciences and Engineering (free PDF)
• Indirect Virus Transmission in Cluster of COVID-19 Cases, Wenzhou, China, 2020 – CDC Emerging Infectious Diseases (free)
• Estimating Risk for Death from 2019 Novel Coronavirus Disease, China, January–February 2020 – CDC Emerging Infectious Diseases (free)
• Case-Fatality Risk Estimates for COVID-19 Calculated by Using a Lag Time for Fatality – CDC Emerging Infectious Diseases (free)
• Patient Page: What Does the Coronavirus Disease 2019 (COVID-19) Mean for Families? – JAMA Pediatrics (free)
• Why do dozens of diseases wax and wane with the seasons—and will COVID-19? – Science (free)
• How much is coronavirus spreading under the radar? – Nature (free)
• SARS-CoV-2 Infection among Travelers Returning from Wuhan, China – New England Journal of Medicine (free)
• 2019 novel coronavirus patients’ clinical characteristics, discharge rate and fatality rate of meta‐analysis – Journal of Medical Virology (free PDF)
• Involving Antimicrobial Stewardship Programs in COVID-19 Response Efforts: All Hands on Deck – Infection Control & Hospital Epidemiology (free PDF)
• Chest computed tomography in children with COVID-19 respiratory infection – Pediatric Radiology (free)
• Can Lung US Help Critical Care Clinicians in the Early Diagnosis of Novel Coronavirus (COVID-19) Pneumonia? – Radiology (free)
• Revisiting the One Health Approach in the Context of COVID-19: A Look into the Ecology of this Emerging Disease – Advances in Animal and Veterinary Sciences (free PDF)
• The emergence of a novel coronavirus (SARS-CoV-2), their biology and therapeutic options – Journal of Clinical Microbiology (free PDF)
• Coronavirus Disease 2019 (COVID-19): Emerging and Future Challenges for Dental and Oral Medicine – Journal of Dental Research (free)
• Novel Coronavirus (COVID‐19) Epidemic: What Are the Risks for Older Patients? – Journal of the American Geriatric Society (free)
• Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China – Clinical Research in Cardiology (free)
• Interrupting transmission of COVID-19: lessons from containment efforts in Singapore – Journal of Travel Medicine (free PDF)

Preprints:

• Estimates of the severity of COVID-19 disease – medRxiv (free PDF)
• Epidemiological, Clinical Characteristics and Outcome of Medical Staff Infected with COVID-19 in Wuhan, China: A Retrospective Case Series Analysis – medRxiv (free PDF)
• Effectiveness of isolation and contact tracing for containment and slowing down a COVID-19 epidemic: a modelling study – medRxiv (free PDF)
• The time scale of asymptomatic transmission affects estimates of epidemic potential in the COVID-19 outbreak – medRxiv (free PDF)
• Lessons drawn from China and South Korea for managing COVID-19 epidemic: insights from a comparative modeling study – medRxiv (free PDF)
• Novel Coronavirus (COVID-19) Knowledge and Perceptions: A Survey on Healthcare workers – medRxiv (free PDF)
• The demand for inpatient and ICU beds for COVID-19 in the US: lessons from Chinese cities – medRxiv (free PDF)
• Genomic epidemiology of a densely sampled COVID19 outbreak in China – medRxiv (free PDF)
• Age specificity of cases and attack rate of novel coronavirus disease (COVID-19) – medRxiv (free PDF)
• Prolonged presence of SARS-CoV-2 in feces of pediatric patients during the convalescent phase – medRxiv (free PDF)
• The Prediction for Development of COVID-19 in Global Major Epidemic Areas Through Empirical Trends in China by Utilizing State Transition Matrix Model – medRxiv (free PDF)
• Modeling the situation of COVID-19 and effects of different containment strategies in China with dynamic differential equations and parameters estimation – medRxiv (free PDF)
• Predicting the cumulative number of cases for the COVID-19 epidemic in China from early data – medRxiv (free PDF)
• Inferring the number of COVID-19 cases from recently reported deaths – medRxiv (free PDF)
• Estimation of instant case fatality rate of COVID-19 in Wuhan and Hubei based on daily case notification data – medRxiv (free PDF)
• Prediction of the COVID-19 outbreak based on a realistic stochastic model – medRxiv (free PDF)
• Virus strain of a mild COVID-19 patient in Hangzhou representing a new trend in SARS-CoV-2 evolution related to Furin cleavage site – medRxiv (free PDF)
• Maternal and neonatal outcomes of pregnant women with COVID-19 pneumonia: a case-control study – medRxiv (free PDF)
• Analysis clinical features of COVID-19 infection in secondary epidemic area and report potential biomarkers in evaluation – medRxiv (free PDF)
• The Impact of School Closure for COVID-19 on the US Healthcare Workforce and the Net Mortality Effects – medRxiv (free PDF)

Selected News & Perspectives:

• A visual history of pandemics – World Economic Forum (free)
• How many tests for COVID-19 are being performed around the world? – Our World in Data (free)
• A COVID-19 coronavirus update from concerned physicians – KevinMD (free)
• US takes more big pandemic response steps; Europe COVID-19 cases soar – CIDRAP (free)
• WHO: Europe now world’s COVID-19 epicenter – CIDRAP (free)
• World closes borders, restricts travel to contain coronavirus spread – Reuters (free)
• As The Pandemic Spreads, Will There Be Enough Ventilators? – NPR (free)
• The New Coronavirus Can Live On Surfaces For 2-3 Days — Here’s How To Clean Them – NPR (free)
• The COVID-19 Coronavirus Is Now A Pandemic – Can We Ethically Deal With Lockdowns? – Forbes (free)
• What Is Social Distancing? Here Are 10 Ways To Keep The Coronavirus Away – Forbes (free)
• Coronavirus Drug Update: The Latest Info On Pharmaceutical Treatments And Vaccines – Forbes (free)
• Behavioural scientists form new front in battle against coronavirus – The Guardian (free)
• Coronavirus and social distancing: is it risky to go to the pub or gym? – The Guardian (free)
• The coronavirus pandemic: visualising the global crisis – The Guardian (free)
• Can a face mask stop coronavirus? Covid-19 facts checked – The Guardian (free)
• What We Can Learn From Singapore, Taiwan and Hong Kong About Handling Coronavirus – TIME (free)
• Coronavirus: not all hand sanitisers work against it – here’s what you should use – The Conversation (free)
• Coronavirus with a baby: what you need to know to prepare and respond – The Conversation (free)
• With Odds Against It, Taiwan Keeps Coronavirus Corralled – NPR (free)
• This Coronavirus Is Unlike Anything in Our Lifetime, and We Have to Stop Comparing It to the Flu – ProPublica (free)
• Q&A: WHO’s Mike Ryan on how countries in crisis can prepare for a coronavirus epidemic – The New Humanitarian (free)
• China’s Draconian Lockdown Is Getting Credit for Slowing Coronavirus. Would It Work Anywhere Else? – TIME (free)
• They Say Coronavirus Isn’t Airborne—but It’s Definitely Borne By Air – Wired (free)
• ‘We are making difficult choices’: Italian doctor tells of struggle against coronavirus – The Independent (free)
• Opinion: Medical students can help combat Covid-19. Don’t send them home – STAT (free)
• ‘Over-reacting is better than non-reacting’ – academics around the world share thoughts on coronavirus – World Economic Forum (free)
• Should you take public transit during a pandemic? – Vox (free)
• The Exponential Power of Now – The New York Times (10 articles per month are free)
• They’ve Contained the Coronavirus. Here’s How. – The New York Times (free)
• How to Protect Older People From the Coronavirus – The New York Times (10 articles per month are free)
• Mapping the Social Network of Coronavirus – The New York Times (10 articles per month are free)
• Worst-Case Estimates for U.S. Coronavirus Deaths – The New York Times (10 articles per month are free)
• How the World’s Largest Coronavirus Outbreaks Are Growing – The New York Times (10 articles per month are free)
• How the Coronavirus May Force Doctors to Decide Who Can Live and Who Dies – The New York Times (10 articles per month are free)
• Social Distancing: This is Not a Snow Day – Medium (free)
• Lessons from Ebola: The secret of successful epidemic response – CNN (free)
• Former CDC director: Covid-19 is different from flu and we must respond differently – CNN (free)
• Coronavirus in South Korea: How ‘trace, test and treat’ may be saving lives – BBC (free)

 

13 March 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives.

 

World Health Organization COVID-19 Situation Report:

• WHO: Latest COVID-19 Situation Report – 12 March 2020 (free PDF)
• WHO Director-General’s opening remarks at the Mission briefing on COVID-19 – 12 March 2020

“This is a controllable pandemic. Countries that decide to give up on fundamental public health measures may end up with a larger problem, and a heavier burden on the health system that requires more severe measures to control.

All countries must strike a fine balance between protecting health, preventing economic and social disruption, and respecting human rights.”

• WHO Homepage on the Coronavirus disease (COVID-19) outbreak (free resources)

Featured Commentary:

• Here’s the Biggest Thing to Worry About With Coronavirus – The New York Times (10 articles per month are free)
• See also: Tweeter thread from the author explaining his concerns (free)

Guidelines & Reports:

• Rapid risk assessment: Novel coronavirus disease 2019 (COVID-19) pandemic: increased transmission in the EU/EEA and the UK – sixth update – European Centre for Disease Prevention and Control (free) AND Commentary: ECDC: COVID-19 not containable, set to overwhelm hospitals – CIDRAP (free)
• COVID-19: stay at home guidance – Public Health England (free)
• Guidance for Infection Control and Prevention of Coronavirus Disease 2019 (COVID-19) in dialysis facilities – Centers for Medicare & Medicaid Services (free PDF) AND News Release: CMS Sends More Detailed Guidance to Providers about COVID-19 (free)
• ISUOG Interim Guidance on 2019 novel coronavirus infection during pregnancy and puerperium: information for healthcare professionals (free PDF)
• Surgical Mask and Gown Conservation Strategies – Letter to Healthcare Providers – U.S. Food & Drug Administration (free)

Podcasts:

• Episode 175: Beth Linas On COVID19 Epidemiology & Flattening The Curve – Explore Exchange (free)
• Listen: Voices from the coronavirus pandemic, in Italy, New York, and the high seas – STAT (free)

New Cochrane Library Special Collection:

• Coronavirus (COVID-19): infection control and prevention measures – Cochrane Library (free articles) AND News Release (free)

Latest Articles:

• Detection of Covid-19 in Children in Early January 2020 in Wuhan, China – New England Journal of Medicine (free)
• History in a Crisis — Lessons for Covid-19 – The New England Journal of Medicine (free)
• Supporting the Health Care Workforce During the COVID-19 Global Epidemic – JAMA (free)
• COVID-19 and Italy: what next? – The Lancet (free PDF)
• First known person-to-person transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the USA – The Lancet (free PDF) AND Commentary: Study details first known person-to-person transmission of new coronavirus in the USA – The Lancet (free)

“First known person-to-person SARS-CoV-2 transmission in USA occurred between 2 people with prolonged, unprotected exposure when 1st patient was symptomatic. No further transmission detected in 372 contacts of both cases” (via @TheLancet see Tweet)

• Airport screening is largely futile, research shows – Science (free)
• Editorial: Video consultations for covid-19 – The BMJ (free)
• Covid-19: is CT scanning ready to answer a diagnostic call? – The BMJ Opinion (free)
• To wear or not to wear: WHO’s confusing guidance on masks in the covid-19 pandemic – The BMJ Opinion (free)
• Histopathologic Changes and SARS–CoV-2 Immunostaining in the Lung of a Patient With COVID-19 – Annals of Internal Medicine (free)
• Discovering drugs to treat coronavirus disease 2019 (COVID-19) – Drug Discoveries & Therapeutics (free PDF)
• The transmission and diagnosis of 2019 novel coronavirus infection disease (COVID‐19): A Chinese perspective – Journal of Medical Virology (free PDF)
• Transmission dynamics of the COVID‐19 outbreak and effectiveness of government interventions: A data‐driven analysis – Journal of Medical Virology (free PDF)
• On a knife’s edge of a COVID-19 pandemic: is containment still possible? – Public Health Research & Practice (free PDF)
• COVID-19: An Urgent Call for Coordinated, Trusted Sources to Tell Everyone What They Need to Know and Do – National Academy of Medicine (free) AND Commentary: Public health leaders call for coordinated communication response to COVID-19 – CUNY Graduate School of Public Health and Health Policy (free)
• Findings of lung ultrasonography of novel corona virus pneumonia during the 2019–2020 epidemic – Intensive Care Medicine (free)
• Emergency management of the prevention and control of novel coronavirus pneumonia in specialized branches of hospital – Academic Emergency Medicine (free)
• A confirmed asymptomatic carrier of 2019 novel coronavirus (SARS-CoV-2) – Chinese Medical Journal (free PDF)
• Contact Transmission of COVID-19 in South Korea: Novel Investigation Techniques for Tracing Contacts – Osong Public Health and Research Perspectives (free)
• COVID‐19: Emerging compassion, courage and resilience in the face of misinformation and adversity – Journal of Clinical Nursing (free)
• Performance of radiologists in differentiating COVID-19 from viral pneumonia on chest CT – Radiology (free)
• The SARS-CoV-2 Outbreak: Diagnosis, Infection Prevention, and Public Perception – Clinical Chemistry (free)
• Fear can be more harmful than the severe acute respiratory syndrome coronavirus 2 in controlling the corona virus disease 2019 epidemic – World Journal of Clinical Cases (free)
• Severe Acute Respiratory Syndrome Coronavirus 2 from Patient with 2019 Novel Coronavirus Disease, United States – CDC Emerging Infectious Diseases (free)

Preprints:

• Early, low-dose and short-term application of corticosteroid treatment in patients with severe COVID-19 pneumonia: single-center experience from Wuhan, China – medRxiv (free PDF)
• First 12 patients with coronavirus disease 2019 (COVID-19) in the United States – medRxiv (free PDF)
• Retrospective Analysis of Clinical Features in 101 Death Cases with COVID-19 – medRxiv (free PDF)
• Epidemiological and clinical characteristics of COVID-19 in adolescents and young adults – medRxiv (free PDF)
• The effect of control strategies that reduce social mixing on outcomes of the COVID-19 epidemic in Wuhan, China – medRxiv (free PDF)
• Revealing the influence of national public health policies for the outbreak of the SARS-CoV-2 epidemic in Wuhan, China through status dynamic modeling – medRxiv (free PDF)
• The effectiveness of full and partial travel bans against COVID-19 spread in Australia for travellers from China. – medRxiv (free PDF)
• Quantifying dynamics of SARS-CoV-2 transmission suggests that epidemic control and avoidance is feasible through instantaneous digital contact tracing – medRxiv (free PDF)
• Effects of Chinese strategies for controlling the diffusion and deterioration of novel coronavirus-infected pneumonia in China – medRxiv (free PDF)

Selected News & Perspectives:

• Distance learning solutions to mitigate COVID-19 school closures – UNESCO (free)
• Home-Schooling Tweens and Teens During Coronavirus Closings – The New York Times (10 articles per month are free)
• COVID-19 spares children but they play a crucial role in its spread – What can be done? – News Medical (free)
• When Should Schools Close For Coronavirus? – NPR (free)
• Will the coronavirus make online education go viral? – Times Higher Education (free)
• Coronavirus: What public health workers are telling their children – NBC News (free)
• Will warmer weather help fight the coronavirus? Singapore and Australia suggest maybe not – CNN (free)
• Coronavirus: seven ways collective intelligence is tackling the pandemic – The Conversation (free)
• How does the coronavirus test work? 5 questions answered – The Conversation (free)
• Study: COVID-19 may spread in several different ways – CIDRAP (free)
• From Broadway to baseball, US events canceled over COVID-19 – CIDRAP (free)
• Coronavirus: many infections spread by people yet to show symptoms – scientists – The Guardian (free)
• The family lockdown guide: how to emotionally prepare for coronavirus quarantine – The Guardian (free)
• Q&A: How to care for the elderly without putting them at risk of coronavirus – STAT (free)
• CDC developing serologic tests that could reveal full scope of U.S. coronavirus outbreak – STAT (free)
• 7 reasons why it’s hard to control your coronavirus anxiety – STAT (free)
• As pressure for coronavirus vaccine mounts, scientists debate risks of accelerated testing – Reuters (free)
• Special Report: Italy and South Korea virus outbreaks reveal disparity in deaths and tactics – Reuters (free)
• Hospitals plan for ‘COVID cabanas,’ conference rooms to house patients – Reuters (free)
• Weather modeling data helps predict potential spread and seasonality for COVID-19 – News Medical (free)
• What to expect: Oncology’s response to coronavirus in Italy – The Cancer Letter (free)
• Coronavirus will also cause a loneliness epidemic – Vox (free)
• The Dos and Don’ts of ‘Social Distancing’ – The Atlantic (free)
• 12 Steps to Tackle the Coronavirus – The New York Times (10 articles per month are free)
• India Is the World’s Second-Most Populous Country. Can It Handle the Coronavirus Outbreak? – TIME (free)
• Why Covid-19 is so dangerous for older adults – Vox (free)
• COVID-19 and the Heart: Insights From the Front Lines – TCTMD (free)

 

12 March 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives.

 

WHO characterizes COVID-19 as a pandemic:

• WHO Director-General’s opening remarks at the media briefing on COVID-19 – 11 March 2020 (free)

“We have therefore made the assessment that COVID-19 can be characterized as a pandemic.

Pandemic is not a word to use lightly or carelessly. It is a word that, if misused, can cause unreasonable fear, or unjustified acceptance that the fight is over, leading to unnecessary suffering and death.

Describing the situation as a pandemic does not change WHO’s assessment of the threat posed by this virus. It doesn’t change what WHO is doing, and it doesn’t change what countries should do.”

World Health Organization COVID-19 Situation Report:

• WHO: Latest COVID-19 Situation Report – 11 March 2020 (free PDF)
• See also: WHO Homepage on the Coronavirus disease (COVID-19) outbreak (free resources) AND Seven simple steps to protect yourself and others from COVID-19 – World Health Organization (free)

Featured Commentaries – Flattening the Curve:

• Coronavirus: Why You Must Act Now – Medium (free)

“The only way to prevent this is social distancing today. Not tomorrow. Today. That means keeping as many people home as possible, starting now.”

• Why ‘flattening the curve’ may be the world’s best bet to slow the coronavirus – STAT (free)
• Flattening the Coronavirus Curve – The New York Times (10 articles per month are free)
• Covid-19 outbreak: what do health experts mean by ‘flattening the curve’? – The Guardian (free)
• How canceled events and self-quarantines save lives, in one chart – Vox (free)

Videos:

• CROI 2020: COVID-19 session explores how we got here, and where we’re going – Conference on Retroviruses and Opportunistic Infections (free video) AND Commentary: CROI 2020: COVID-19 session explores how we got here, and where we’re going – Conference on Retroviruses and Opportunistic Infections (free text)

Podcasts:

• Interview with Dr. Eric Rubin and Dr. Lindsey Baden on making decisions about Covid-19 testing and treatment for your patients – New England Journal of Medicine (free)

Latest Articles:

• Care for Critically Ill Patients With COVID-19 – JAMA (free)
• Detection of SARS-CoV-2 in Different Types of Clinical Specimens – JAMA (free)
• Virtually Perfect? Telemedicine for Covid-19 – New England Journal of Medicine (free)
• Editorial: New coronavirus outbreak: Framing questions for pandemic prevention – Science (free)
• How Should U.S. Hospitals Prepare for Coronavirus Disease 2019 (COVID-19)? – Annals of Internal Medicine (free)
• Coronavirus Disease 2019 (COVID-19): Protecting Hospitals From the Invisible – Annals of Internal Medicine (free)
• Early dynamics of transmission and control of COVID-19: a mathematical modelling study – The Lancet Infectious Diseases (free)
• The value of early transmission dynamic studies in emerging infectious diseases – The Lancet Infectious Diseases (free)
• COVID-19: the medium is the message – The Lancet (free)
• Sex difference and smoking predisposition in patients with COVID-19 – The Lancet Respiratory Medicine (free)
• Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? – The Lancet Respiratory Medicine (free)
• Adoption of COVID-19 triage strategies for low-income settings – The Lancet Respiratory Medicine (free)
• COVID-19: a potential public health problem for homeless populations – The Lancet Global & Public Health (free)
• Implications of COVID-19 for patients with pre-existing digestive diseases – The Lancet Gastroenterology & Hepatology (free)
• Preparing for COVID-19: early experience from an intensive care unit in Singapore – Critical Care (free)
• How to balance acute myocardial infarction and COVID-19: the protocols from Sichuan Provincial People’s Hospital – Intensive Care Medicine (free)
• Of chloroquine and COVID-19 – Antiviral Research (free)
• Covid-19: What’s the current advice for UK doctors? – The BMJ (free)
• Carl Heneghan: Assessing mortality during the covid-19 outbreak – The BMJ Opinion (free)
• Slowing down the covid-19 outbreak: changing behaviour by understanding it – The BMJ Opinion (free)

Preprints:

• Aerosol and surface stability of HCoV-19 (SARS-CoV-2) compared to SARS-CoV-1 – medRxiv (free PDF) AND Commentary: Novel Coronavirus Can Live on Some Surfaces for Up to 3 Days, New Tests Show – TIME (free)
• Clinical Characteristics of 2019 Coronavirus Pneumonia (COVID-19): An Updated Systematic Review – medRxiv (free PDF)
• Clinical Characteristics on 25 Discharged Patients with COVID-19 Virus Returning – medRxiv (free PDF)
• Analysis of early renal injury in COVID-19 and diagnostic value of multi-index combined detection – medRxiv (free PDF)
• The epidemiological characteristics of 2019 novel coronavirus diseases (COVID-19) in Jingmen,Hubei,China – medRxiv (free PDF)
• A retrospective study of the clinical characteristics of COVID-19 infection in 26 children – medRxiv (free PDF)
• Prediction of COVID-19 Spreading Profiles in South Korea, Italy and Iran by Data-Driven Coding – medRxiv (free PDF)
• Estimation of incubation period distribution of COVID-19 using disease onset forward time: a novel cross-sectional and forward follow-up study – medRxiv (free PDF)
• Clinical outcomes of 402 patients with COVID-2019 from a single center in Wuhan, China – medRxiv (free PDF)
• Data-driven discovery of clinical routes for severity detection in COVID-19 pediatric cases – medRxiv (free PDF)
• Clinical Characteristics of Two Human to Human Transmitted Coronaviruses: Corona Virus Disease 2019 versus Middle East Respiratory Syndrome Coronavirus. – medRxiv (free PDF)
• Prognostic value of NT-proBNP in patients with severe COVID-19 – medRxiv (free PDF)

Selected News & Perspectives:

• NIH official suggests large gatherings should be canceled due to coronavirus outbreak – STAT (free)
• A coronavirus vaccine will take at least 18 months—if it works at all – MIT Technology Review (free)
• These underlying conditions make coronavirus more severe, and they’re surprisingly common – National Geographic (free)
• The coronavirus pandemic is forcing us to ask some very hard questions. But are we ready for the answers? – The Conversation (free)
• Does screening travelers for disease and infection really work? – The Conversation (free)
• ‘The doctor will Skype you now’: telehealth may limit coronavirus spread, but there’s more we can do to protect health workers – The Conversation (free)
• Coronavirus: Care home residents could be ‘cocooned’ – BBC (free)
• Italy’s coronavirus crisis could be America’s – Vox (free)
• Why the new coronavirus is so hard to cure – Vox (free)
• The Extraordinary Decisions Facing Italian Doctors – The Atlantic (free)
• Research finds huge impact of interventions on spread of Covid-19 – The Guardian (free)
• World Scrambles to Fight Pandemic as Countries Lock Down and Markets Plunge – The New York Times (10 articles per month are free)
• Opinion: We Don’t Need to Close Schools to Fight the Coronavirus – The New York Times (10 articles per month are free)
• Doctors and Patients Turn to Telemedicine in the Coronavirus Outbreak – The New York Times (10 articles per month are free)
• How Coronavirus Hijacks Your Cells – The New York Times (10 articles per month are free)
• What Does the Coronavirus Do to the Body? – The New York Times (10 articles per month are free)
• Infections And Incarceration: Why Jails And Prisons Need To Prepare For COVID-19 Now – Forbes (free)
• Inside the Efforts to Prepare African Countries for COVID-19 – TIME (free)
• This One Science Lesson Shows How Isolation Can Stop The COVID-19 Coronavirus – Forbes (free)
• 6 Ways Universities Are Responding To Coronavirus – NPR (free)
• Life During Coronavirus: What Different Countries Are Doing To Stop The Spread – NPR (free)
• Surging Health Care Worker Quarantines Raise Concerns As Coronavirus Spreads – Kaiser Health News (free)

WHO characterizes COVID-19 as a pandemic – Commentaries:

• WHO Declares COVID-19 “Pandemic”; European Countries & Iran Adopt Aggressive Measures To Contain Growing Threat – Health Policy News (free)
• WHO declares the coronavirus outbreak a pandemic  – STAT (free)
• ‘Deeply concerned’ WHO declares COVID-19 pandemic – CIDRAP (free)
• COVID-19 is a pandemic, WHO says – Science Speaks: Global ID News (free)
• Coronavirus: COVID-19 Is Now Officially A Pandemic, WHO Says – NPR (free)
• WHO declares coronavirus pandemic – The Guardian (free)
• Expert reaction to WHO say COVID-19 can be characterised as a pandemic – Science Media Centre (free)
• WHO calls coronavirus a pandemic as Britain, Italy shore up defenses – Reuters (free)
• Coronavirus confirmed as pandemic by World Health Organization – BBC (free)
• World Health Organization Declares COVID-19 a ‘Pandemic.’ Here’s What That Means – TIME (free)
• The WHO just declared the coronavirus a pandemic. Here’s what that means – Vox (free)

 

11 March 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives.

 

World Health Organization COVID-19 Situation Report:

• WHO: Latest COVID-19 Situation Report – 10 March 2020 (free PDF)
• See also: WHO Homepage on the Coronavirus disease (COVID-19) outbreak (free resources)

Guidelines, Reports & Consensus Statements:

• Key messages and actions for COVID-19 prevention and control in schools – World Health Organization (free PDF) AND News Release: COVID-19: IFRC, UNICEF and WHO issue guidance to protect children and support safe school operations – World Health Organization (free)
• Interim Additional Guidance for Infection Prevention and Control Recommendations for Patients with Suspected or Confirmed COVID-19 in Outpatient Hemodialysis Facilities – Centers for Disease Control and Prevention (free)

Podcasts:

• Podcast 256 — Anthony Fauci: Talking with patients about COVID-19 – NEJM Journal Watch Clinical Conversations (free)
• Nonpharmaceutical Measures for Pandemic Flu and COVID-19 – Centers for Disease Control and Prevention (free) (via @greg_folkers)
• Annals On Call – Understanding the Spread of COVID-19 – Annals of Internal Medicine (free)

Medical Blogs:

• The idiot’s guide to coronavirus from an emergency physician – KevinMD (free)
• Some Additional COVID Airway Management Thoughts – EMCrit (free)

Latest Articles:

• Chloroquine and hydroxychloroquine as available weapons to fight COVID-19 – International Journal of Antimicrobial Agents (free)
• Of chloroquine and COVID-19 – Antiviral Research (free)
• In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) – Clinical Infectious Diseases (free)
• Remdesivir as a possible therapeutic option for the COVID-19 – Travel Medicine and Infectious Disease (free)
• Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019-novel coronavirus (2019-nCoV) related coronavirus model – Chinese Medical Journal (free PDF)
• Understanding the emerging coronavirus: what it means for health security and infection prevention – Journal of Hospital Infection (free)
• Clinical manifestations and outcome of SARS-CoV-2 infection during pregnancy – Journal of Infection (free)
• Lymphopenic community acquired pneumonia as signature of severe COVID-19 infection: Lymphopenia in severe COVID-19 infection – Journal of Infection (free)
• The Novel Coronavirus – A Snapshot of Current Knowledge – Microbial Biotechnology (free)
• Containing 2019-nCoV (Wuhan) coronavirus – Health Care Management Science (free)
• Emerging zoonoses: A one health challenge – EClinicalMedicine (free)
• Serial interval of novel coronavirus (COVID-19) infections – International Journal of Infectious Diseases (free) AND Commentary: Coronavirus spreads even without symptoms and how Hangzhou province contained virus spread – News Medical (free)
• Should we wave goodbye to the handshake? – The BMJ Opinion (free)
• SARS-CoV-2 and COVID-19: facing the pandemic together as citizens and cardiovascular practitioners – Minerva Cardiologica (free PDF)
• A conceptual model for the coronavirus disease 2019 (COVID-19) outbreak in Wuhan, China with individual reaction and governmental action – International Journal of Infectious Diseases (free)
• Déjà Vu or Jamais Vu? How the Severe Acute Respiratory Syndrome Experience Influenced a Singapore Radiology Department’s Response to the Coronavirus Disease (COVID-19) Epidemic – American Journal of Roentgenology (free)
• Genomic diversity of SARS-CoV-2 in Coronavirus Disease 2019 patients – Clinical Infectious Diseases (free PDF)
• 2019 novel coronavirus is undergoing active recombination – Clinical Infectious Diseases (free PDF)
• The explosive epidemic outbreak of novel coronavirus disease 2019 (COVID-19) and the persistent threat of respiratory tract infectious diseases to global health security – Current Opinion in Pulmonary Medicine (free PDF)
• Protecting Chinese Healthcare Workers While Combating the 2019 Novel Coronavirus – Infection Control & Hospital Epidemiology (free)
• Public health might be endangered by possible prolonged discharge of SARS-CoV-2 in stool – Journal of Infection (free)
• Procalcitonin in patients with severe coronavirus disease 2019 (COVID-19): a meta-analysis – Clinica Chimica Acta (free)
• Molecular immune pathogenesis and diagnosis of COVID-19 – Journal of Pharmaceutical Analysis (free)
• FDG PET/CT of COVID-19 – Radiology (free)
• Clinical strategies for treating pediatric cancer during the outbreak of 2019 novel coronavirus infection – Pediatric Blood & Cancer (free)
• “The Art of War” in the Era of Coronavirus Disease 2019 (COVID-19) – Clinical Infectious Diseases (free PDF)

Selected News & Perspectives:

• What does the coronavirus mean for the U.S. health care system? Some simple math offers alarming answers – STAT (free)
• If Covid-19 gets bad, triage will be needed. Are we ready for that? – STAT (free)
• Cancel Everything – The Atlantic (free)
• Could Coronavirus Kill a Million Americans? – Think Global Health (free)
• Old age, sepsis tied to poor COVID-19 outcomes, death – CIDRAP (free)
• Italy COVID-19 total tops 10,000; funding grows for treatments, vaccines – CIDRAP (free)
• The Best Response to the Coronavirus? Altruism, Not Panic – The New York Times (10 articles per month are free)
• 8 Questions Parents May Have About Coronavirus – The New York Times (10 articles per month are free)
• ‘No More Visits’ Urges Nursing Home Industry in Wake of Virus – The New York Times (10 articles per month are free)
• Coronavirus is past containment, but America can limit epidemic: Q&A with former FDA chief – USA Today (free)
• Covid-19 outbreak: what do health experts mean by ‘flattening the curve’? – The Guardian (free)
• People ‘should work from home’ to tackle coronavirus spread – The Guardian (free)
• No elevated risk of coronavirus in pregnancy, experts say – The Guardian (free)
• I Lived Through SARS and Reported on Ebola. These Are the Questions We Should Be Asking About Coronavirus – ProPublica (free)
• Italy’s coronavirus crisis could be America’s – Vox (free)
• Taiwan has millions of visitors from China and only 45 coronavirus cases. Here’s how. – Vox (free)
• It’s time we invest in healthy food systems for a safer world – World Bank Blogs (free)
• How hospitals can increase capacity to cope with coronavirus – The Globe and Mail (free)
• Coronavirus Drug and Vaccine Studies Are Recruiting Their First Volunteers – TIME (free)

 

10 March 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives.

 

World Health Organization COVID-19 Situation Report:

• WHO: Latest COVID-19 Situation Report – 09 March 2020 (free PDF)
• See also: WHO Director-General’s opening remarks at the media briefing on COVID-19 – 9 March 2020 (free) AND WHO Homepage on the Coronavirus disease (COVID-19) outbreak (free resources)

Guidelines, Reports & Consensus Statements:

• Coronavirus (COVID-19) infection and pregnancy – Royal College of Obstetricians & Gynaecologists (free) AND News Release: National guidance on managing coronavirus infection in pregnancy published (free)
• Updated Guidance on Evaluating and Testing Persons for Coronavirus Disease 2019 (COVID-19) – Centers for Disease Control and Prevention (free)
• People at Risk for Serious Illness from COVID-19 – Centers for Disease Control and Prevention (free) AND Commentaries: COVID-19 continues spread in U.S., CDC issues recommendations for high-risk patients – ACP Internist (free) AND Are You At Higher Risk For Serious COVID-19 Illness? Here Is What To Do – Forbes (free)

Video:

• Hand Hygiene VIDEOS in The New England Journal of Medicine in YOUR language – World Health Organization (free)

“Hand hygiene is critical in helping stop the spread of germs and in preventing health care–associated infections. In partnership with WHO, we produced hand hygiene videos in 14 languages to educate providers and reduce the threat of infection” (via @NEJM see Tweet)

Latest Articles:

• The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application – Annals of Internal Medicine (free) AND Commentaries: New Study on Covid-19 Estimates 5.1 Days for Incubation Period – Johns Hopkins Bloomberg School of Public Health (free) AND Coronavirus symptoms usually take 5 days to appear, study says – CNN (free)

“The median incubation period was estimated to be 5.1 days (95% CI, 4.5 to 5.8 days), and 97.5% of those who develop symptoms will do so within 11.5 days (CI, 8.2 to 15.6 days) of infection.”

• Diagnostic Testing for the Novel Coronavirus – JAMA (free)

“There is a risk that widespread testing & test-seeking will overwhelm medical services needed for patients who have more severe symptoms. Furthermore, once in a waiting room, a patient with mild or no illness may actually be exposed to #COVID19 from infected patients” (via @ABsteward see Tweet)

• Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study – The Lancet (free PDF) AND Commentaries: First study identifies risk factors associated with death in adults hospitalised with new coronavirus disease in Wuhan – The Lancet (free) AND Older age, history of sepsis, heart trouble elevate COVID-19 death risk – UPI (free)

“The Lancet report on the clinical course of patients hospitalized with #COVID19 explains why hospitals are strained in Wuhan and Italy, and why we should be very concerned here. Average hospital length of stay is 11 days w/ 26% admitted to the ICU” (via @AnilMakan see Tweet)

• Comorbidities and multi-organ injuries in the treatment of COVID-19 – The Lancet (free PDF)
• Can we contain the COVID-19 outbreak with the same measures as for SARS? – The Lancet Infectious Diseases (free PDF)
• Respiratory support for patients with COVID-19 infection – The Lancet Respiratory Medicine (free)
• Taking the right measures to control COVID-19 – The Lancet Infectious Diseases (free)
• Why airport screening won’t stop the spread of coronavirus – Science (free)
• Quarantined at home now, U.S. scientist describes his visit to China’s hot zone – Science (free)
• What we do when a COVID-19 patient needs an operation: operating room preparation and guidance – Canadian Journal of Anesthesia (free)
• Covid-19: How to triage effectively in a pandemic – The BMJ Opinion (free)
• Covid-19: are we getting the communications right? – The BMJ (free)
• Mutations can reveal how the coronavirus moves—but they’re easy to overinterpret – Science (free)
• Diagnosis and Management of First Case of COVID-19 in Canada: Lessons applied from SARS – Clinical Infectious Diseases (free PDF)
• The outbreak of SARS-CoV-2 pneumonia calls for viral vaccines – NPJ Vaccines (free)
• Detection of Novel Coronavirus by RT-PCR in Stool Specimen from Asymptomatic Child, China – CDC Emerging Infectious Diseases (free)
• An outbreak of COVID‐19 caused by a new coronavirus: what we know so far – Medical Journal of Australia (free)
• Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing, China – Science China Life Sciences (free)

Preprints:

• Clinical presentation and virological assessment of hospitalized cases of coronavirus disease 2019 in a travel-associated transmission cluster – medRxiv (free PDF) AND Commentary:  People ‘shed’ high levels of coronavirus, study finds, but most are likely not infectious after recovery begins – STAT (free)
• Estimating the scale of COVID-19 Epidemic in the United States: Simulations Based on Air Traffic directly from Wuhan, China – medRxiv (free) AND Commentary: COVID-19 infections in U.S. may be much higher, new estimates show – Cedars-Sinai Medical Center (free)
• Estimating the infection and case fatality ratio for COVID-19 using age-adjusted data from the outbreak on the Diamond Princess cruise ship – medRxiv (free PDF)
• Comparison of severe and non-severe COVID-19 pneumonia: review and meta-analysis – medRxiv (free PDF)
• Clinical characterization and chest CT findings in laboratory-confirmed COVID-19: a systematic review and meta-analysis – medRxiv (free PDF)
• Modeling the Comparative Impact of Individual Quarantine vs. Active Monitoring of Contacts for the Mitigation of COVID-19 – medRxiv (free PDF)
• A preliminary study on serological assay for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 238 admitted hospital patients – medRxiv (free PDF)

Selected News & Perspectives:

• How big will the coronavirus epidemic be? An epidemiologist updates his concerns – The Conversation (free)
• What’s the difference between pandemic, epidemic and outbreak? – The Conversation (free)
• Coronavirus latest: a weekly update from The Conversation’s global network of academics – The Conversation (free)
• All of Italy is in lockdown as coronavirus cases rise – CNN (free)
• Former CDC director: It’s time to restrict visits to nursing homes – CNN (free)
• Latest on the spread of coronavirus around the world – Reuters (free)
• China reports no new locally transmitted coronavirus cases outside epicenter – Reuters (free)
• Study highlights ease of spread of COVID-19 viruses – CIDRAP (free)
• Italy expands COVID-19 lockdown to whole country – CIDRAP (free)
• CDC urges readiness as US COVID-19 count passes 600 – CIDRAP (free)
• Doctors working while sick is bad enough in ordinary times. During the Covid-19 outbreak it could be catastrophic – STAT (free)
• Coronavirus spread could last into next year, but impact could be blunted, CDC official says – STAT (free)
• Pace of medical conference shutdowns is accelerating as the coronavirus outbreak spreads – STAT (free)
• STAT’s guide to health care conferences disrupted by the coronavirus crisis – STAT (free)
• ACC, EHRA Cancel 2020 Meetings Over COVID-19 – TCTMD (free)
• Not His First Epidemic: Dr. Anthony Fauci Sticks to the Facts – The New York Times (10 articles per month are free)
• How Deadly Is Coronavirus? What We Know and What We Don’t – The New York Times (10 articles per month are free)
• How Does the Coronavirus Compare With the Flu? – The New York Times (10 articles per month are free)
• U.S. Health Experts Say Stricter Measures Are Required to Limit Coronavirus’s Spread – The New York Times (10 articles per month are free)
• As Testing Ramps Up, Diagnoses of Coronavirus Disease in the U.S. Will Soon Increase Substantially — How Will We Respond? – HIV and ID Observations Blog (free)
• How did China get to grips with its coronavirus outbreak? – The Guardian (free)
• Can a face mask stop coronavirus? Covid-19 facts checked – The Guardian (free)
• How Covid-19 led to a nationwide work-from-home experiment – BBC (free)
• Standard methods rid hospital rooms of coronavirus, slashing transmission rates – MedicalXpress (free)
• You Might Be Buying a Hand Sanitizer That Won’t Work for Coronavirus – ProPublica (free)
• We Predicted a Coronavirus Pandemic. Here’s What Policymakers Could Have Seen Coming – Politico (free)
• To develop a coronavirus vaccine, synthetic biologists try to outdo nature – STAT (free)
• Coronavirus: Italy extends emergency measures nationwide – BBC (free)
• The Workplace In The Time Of Coronavirus (Part I): Legal Guidelines For Navigating The Upheaval – Forbes (free)
• ‘World Is Inching Towards a COVID-19 Pandemic – But One We Can Control’, Says WHO – Health Policy News (free)
• Why the WHO won’t call the coronavirus a pandemic – Vox (free)
• Why we should stop comparing the Covid-19 coronavirus outbreak to the 1918 Spanish flu – Vox (free)
• Coronavirus ‘highly sensitive’ to high temperatures, but don’t bank on summer killing it off, studies say – South China Morning Post (free)

 

9 March 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives.

 

World Health Organization COVID-19 Situation Report:

• WHO: Latest COVID-19 Situation Report – 08 March 2020 (free PDF)
• See also: WHO statement on cases of COVID-19 surpassing 100 000 (free) AND WHO Homepage on the Coronavirus disease (COVID-19) outbreak (free resources)

NEW: WHO Interim Guidance on Critical Preparedness, Readiness and Response Actions:

• Critical preparedness, readiness and response actions for COVID-19: Interim guidance – World Health Organization (free PDF)
• Responding to community spread of COVID-19 Interim guidance – World Health Organization (free PDF)

Guidelines, Reports & Consensus Statements:

• The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2 – Nature Microbiology / Coronaviridae Study Group of the International Committee on Taxonomy of Viruses (free)
• COVID-19 Clinical Guidance For the Cardiovascular Care Team – American College of Cardiology (free PDF) AND Commentary: ACC President Message: ACC Issues COVID-19 Clinical Guidance For the CV Care Team – American College of Cardiology (free)

Videos:

• Coronavirus Update with Anthony Fauci, MD – March 2020 – JAMA (free)
• Coronavirus v Influenza: How do the two viruses compare? – BBC News (free)
• Watch: Flu has a season, but will Covid-19 melt away with the spring? It’s not so simple – STAT (free)

Latest Articles:

• How will country-based mitigation measures influence the course of the COVID-19 epidemic? – The Lancet (free PDF) AND Commentary: Individual response to COVID-19 ‘as important’ as government action – Imperial College London (free)
• Are high-performing health systems resilient against the COVID-19 epidemic? – The Lancet (free PDF)
• COVID-19: the gendered impacts of the outbreak – The Lancet (free)
• SARS-CoV-2 is an appropriate name for the new coronavirus – The Lancet (free)
• Mitigate the effects of home confinement on children during the COVID-19 outbreak – The Lancet (free)
• Risk of COVID-19 for patients with cancer – The Lancet Oncology (free)
• Patients with RT-PCR Confirmed COVID-19 and Normal Chest CT – Radiology (free)
• Corona Virus Disease 2019, a growing threat to children? – Journal of Infection (free)
• Arguments in favor of remdesivir for treating SARS-CoV-2 infections – International Journal of Antimicrobial Agents (free)
• Why does the coronavirus spread so easily between people? – Nature (free)
• What can early Canadian experience screening for COVID-19 teach us about how to prepare for a pandemic? – Canadian Medical Association Journal (free PDF)
• The effect of travel restrictions on the spread of the 2019 novel coronavirus (COVID-19) outbreak – Science (free)
• Editorial: Coronavirus response: a focus on containment is still apt – Nature (free)
• The race to unravel the United States’ biggest coronavirus outbreak – Nature (free)
• Review of the Clinical Characteristics of Coronavirus Disease 2019 (COVID-19) – Journal of General Internal Medicine (free PDF)
• Hospital Emergency Management Plan During the COVID-19 Epidemic – Academic Emergency Medicine (free PDF)
• COVID-19 and the cardiovascular system – Nature Reviews Cardiology (free PDF)
• Coronavirus Disease 2019 (COVID-19) Provides Potent Reminder of the Risk of Infectious Agents – ACC Cardiology Magazine (free)
• Liver injury in COVID-19: management and challenges – The Lancet Gastroenterology & Hepatology (free)
• Novel corona virus disease (COVID-19) in pregnancy: What clinical recommendations to follow? – Acta Obstetricia et Gynecologica Scandinavica (free)
• From the frontlines of COVID‐19 – How prepared are we as obstetricians: a commentary – British Journal of Obstetrics and Gynaecology (free PDF)
• SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor – Cell (free)
• Practical experiences and suggestions on the eagle-eyed observer, a novel promising role for controlling nosocomial infection of the COVID-19 outbreak – The Journal of Hospital Infection (free)
• Unique epidemiological and clinical features of the emerging 2019 novel coronavirus pneumonia (COVID-19) implicate special control measures – Journal of Medical Virology (free PDF)
• The Wuhan SARS‐CoV‐2 – What’s Next for China – Journal of Medical Virology (free PDF)
• Analyzing the Epidemiological Outbreak of COVID-19: A Visual Exploratory Data Analysis (EDA) Approach – Journal of Medical Virology (free PDF)
• Asymptomatic coronavirus infection: MERS-CoV and SARS-CoV-2 (COVID-19) – Travel Medicine and Infectious Disease (free PDF)
• Novel coronavirus infection and pregnancy – Ultrasound in Obstetrics and Gynecology (free)
• Clinical and CT features in pediatric patients with COVID-19 infection: Different points from adults – Pediatric Pulmonology (free)
• CT Features of Coronavirus Disease 2019 (COVID-19) Pneumonia in 62 Patients in Wuhan, China – American Journal of Roentgenology (free)
• Clinical and High-Resolution CT Features of the COVID-19 Infection: Comparison of the Initial and Follow-up Changes – Investigative Radiology (free PDF)
• Potential Factors Influencing Repeated SARS Outbreaks in China – International Journal of Environmental Research and Public Health (free)
• What we know so far: COVID-19 current clinical knowledge and research – Clinical Medicine Journal (free PDF)
• The novel Coronavirus (SARS-CoV-2) is a one health issue – One Health (free)
• Emergency management for preventing and controlling nosocomial infection of 2019 novel coronavirus: implications for the dermatology department – British Journal of Dermatology (free PDF)
• The transmission and diagnosis of 2019 novel coronavirus infection disease (COVID-19): A Chinese perspective – Journal of Medical Virology (free PDF)
• Transmission dynamics of the COVID-19 outbreak and effectiveness of government interventions: A data-driven analysis – Journal of Medical Virology (free PDF)
• Fecal specimen diagnosis 2019 Novel Coronavirus-Infected Pneumonia – Journal of Medical Virology (free PDF)
• Effective strategies to prevent coronavirus disease-2019 (COVID-19) outbreak in hospital – Journal of Hospital Infection (free)
• Insights into the cross-species evolution of 2019 novel coronavirus – Journal of Infection (free)
• Optimization Method for Forecasting Confirmed Cases of COVID-19 in China – Journal of Clinical Medicine (free PDF)
• Proposal for prevention and control of the 2019 novel coronavirus disease in newborn infants – ADC Fetal & Neonatal (free)
• Improved molecular diagnosis of COVID-19 by the novel, highly sensitive and specific COVID-19-RdRp/Hel real-time reverse transcription-polymerase chain reaction assay validated in vitro and with clinical specimens – Journal of Clinical Microbiology (free PDF)
• The Effects of Social Support on Sleep Quality of Medical Staff Treating Patients with Coronavirus Disease 2019 (COVID-19) in January and February 2020 in China – Medical Science Monitor (free PDF)
• Coronavirus Disease 2019 (COVID-19): A critical care perspective beyond China – Anaesthesia Critical Care & Pain Medicine (free PDF)
• Identification of COVID-19 Can be Quicker through Artificial Intelligence framework using a Mobile Phone-Based Survey in the Populations when Cities/Towns Are Under Quarantine – Infection Control & Hospital Epidemiology (free)
• Epidemiological Identification of A Novel Pathogen in Real Time: Analysis of the Atypical Pneumonia Outbreak in Wuhan, China, 2019-2020 – Journal of Clinical Medicine (free PDF)
• Backcalculating the Incidence of Infection with COVID-19 on the Diamond Princess – Journal of Clinical Medicine (free PDF)
• Outbreak of Novel Coronavirus (SARS-Cov-2): First Evidences From International Scientific Literature and Pending Questions – Healthcare (free PDF)
• On the Coronavirus (COVID-19) Outbreak and the Smart City Network: Universal Data Sharing Standards Coupled with Artificial Intelligence (AI) to Benefit Urban Health Monitoring and Management – Healthcare (free PDF)
• Public’s early response to the novel coronavirus-infected pneumonia – Emerging Microbes & Infections (free)
• Novel Coronavirus and Hospital Infection Prevention: Preparing for the Impromptu Speech – Infection Control& Hospital Epidemiology (free PDF)
• Stepping up infection control measures in ophthalmology during the novel coronavirus outbreak: an experience from Hong Kong – Graefe’s Archive for Clinical and Experimental Ophthalmology (free)
• Clinical trials for the treatment of Coronavirus disease 2019 (COVID-19): A rapid response to urgent need – Science China Life Sciences (free PDF)
• Tom Jefferson: Covid 19—we live in surreal times – The BMJ Opinion (free)
• Covid-19 Small Molecule Therapies Reviewed – Science Translational Medicine (free)
• Differential diagnosis of illness in patients under investigation for the novel coronavirus (SARS-CoV-2), Italy, February 2020 – Eurosurveillance (free)

Preprints:

• Case fatality risk of novel coronavirus diseases 2019 in China – medRxiv (free PDF)
• Adjusted age-specific case fatality ratio during the COVID-19 epidemic in Hubei, China, January and February 2020 – medRxiv (free PDF)
• Evolving Epidemiology and Impact of Non-pharmaceutical Interventions on the Outbreak of Coronavirus Disease 2019 in Wuhan, China – medRxiv (free PDF)
• Acute Myocardial Injury of Patients with Coronavirus Disease 2019 – medRxiv (free PDF)
• COVID-19 early warning score: a multi-parameter screening tool to identify highly suspected patients – medRxiv (free PDF)Transmission of corona virus disease 2019 during the incubation period may lead to a quarantine loophole – medRxiv (free PDF)
• CORONAVIRUS IN PREGNANCY AND DELIVERY: RAPID REVIEW AND EXPERT CONSENSUS – medRxiv (free PDF)
• Estimating the generation interval for COVID-19 based on symptom onset data – medRxiv (free PDF)
• A mathematical model for estimating the age-specific transmissibility of a novel coronavirus – medRxiv (free PDF)
• Estimating the scale of COVID-19 Epidemic in the United States: Simulations Based on Air Traffic directly from Wuhan, China – medRxiv (free PDF)
• A data-driven assessment of early travel restrictions related to the spreading of the novel COVID-19 within mainland China – medRxiv (free PDF)
• Evaluating the secondary transmission pattern and epidemic prediction of the COVID-19 in metropolitan areas of China – medRxiv (free PDF)
• The prevalence and influencing factors for anxiety in medical workers fighting COVID-19 in China: A cross-sectional survey – medRxiv (free PDF)
• Role of temperature and humidity in the modulation of the doubling time of COVID-19 cases – medRrxiv (free PDF)
• Emotional responses and coping strategies of nurses and nursing college students during COVID-19 outbreak – medRxiv (free PDF)
• Clinical characteristics of 101 non-surviving hospitalized patients with COVID-19: A single center, retrospective study – medRxiv (free PDF)
• How to differentiate COVID-19 pneumonia from heart failure with computed tomography at initial medical contact during epidemic period – medRxiv (free PDF)
• Epidemiology and Transmission of COVID-19 in Shenzhen China: Analysis of 391 cases and 1,286 of their close contacts – medRxiv (free PDF)
• COVID-19 Epidemic Outside China: 34 Founders and Exponential Growth – medRxiv (free PDF)
• Appealing for Efficient, Well Organized Clinical Trials on COVID-19 – medRxiv (free PDF)
• Human Kidney is a Target for Novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection – medRxiv (free PDF)
• Caution: The clinical characteristics of COVID-19 patients at admission are changing – medRxiv (free PDF)
• Projecting the transmission dynamics of SARS-CoV-2 through the post-pandemic period – medRxiv (free PDF)
• Psychological impact of the coronavirus disease 2019 (COVID-19) outbreak on healthcare workers in China – medRxiv (free PDF)
• Preliminary estimating the reproduction number of the coronavirus disease (COVID-19) outbreak in Republic of Korea from 31 January to 1 March 2020 – medRxiv (free PDF)
• Immunodepletion with Hypoxemia: A Potential High Risk Subtype of Coronavirus Disease 2019 – medRxiv (free PDF)
• The potential role of IL-6 in monitoring coronavirus disease 2019. – medRxiv (free PDF)
• Modelling-based evaluation of the effect of quarantine control by the Chinese government in the coronavirus disease 2019 outbreak – medRxiv (free PDF)
• Clinical features and outcomes of 221 patients with COVID-19 in Wuhan, China – medRxiv (free PDF)
• Effect of non-pharmaceutical interventions for containing the COVID-19 outbreak: an observational and modelling study – medRxiv (free PDF)
• Preliminary epidemiological analysis on children and adolescents with novel coronavirus disease 2019 outside Hubei Province, China: an observational study utilizing crowdsourced data – medRxiv (free PDF)
• Exuberant elevation of IP-10, MCP-3 and IL-1ra during SARS-CoV-2 infection is associated with disease severity and fatal outcome – medRxiv (free PDF)
• Restoration of leukomonocyte counts is associated with viral clearance in COVID-19 hospitalized patients – medRxiv (free PDF)
• How does the outbreak of 2019-nCoV spread in mainland China? A retrospective analysis of the dynamic transmission routes – medRxiv (free PDF)
• Transmission interval estimates suggest pre-symptomatic spread of COVID-19 – medRxiv (free PDF)
• Close contacts and household transmission of SARS-CoV-2 in China: a content analysis based on local Heath Commissions’ public disclosures – medRxiv (free PDF)
• SOCRATES: An online tool leveraging a social contact data sharing initiative to assess mitigation strategies for COVID-19 – medRxiv (free PDF)
• The effect of human mobility and control measures on the COVID-19 epidemic in China – medRxiv (free PDF)

Selected News & Perspectives:

• Silly songs, dances, and skits: The world is using humor to curb coronavirus’s spread – Vox (free)
• At Harvard forum, three who know warn of ‘most daunting virus’ in half a century – STAT (free)
• We’re learning a lot about the coronavirus. It will help us assess risk – STAT (free)
• Dr. Tom Frieden on 19 Critical Data Gaps Limiting our Effectiveness Responding to the COVID-19 Pandemic (free)
• Coronavirus: nine reasons to be reassured – The Guardian (free)
• COVID-19 Begs the Question: If Medical Meetings Go Virtual, What Do We Gain and Lose? – TCTMD (free)
• U.S. telehealth companies brace for demand spike as coronavirus spread accelerates – Reuters (free)
• What coronavirus is teaching us about telehealth – KevinMD (free)
• What you need to know about coronavirus right now – Reuters (free)
• The Unknown Unknowns: Diagnosing the New Coronavirus – Global Health NOW (free)
• Nurses Battling Coronavirus Beg for Protective Gear and Better Planning – The New York Times (10 articles per month are free)
• Coronavirus in N.Y.C.: Why Closing Public Schools Is a ‘Last Resort’ – The New York Times (10 articles per month are free)
• The Coronavirus, by the Numbers – The New York Times (10 articles per month are free)
• The Handshake Is on Hold – The New York Times (10 articles per month are free)
• Coronavirus: China struggling to deal with mountain of medical waste created by epidemic – South China Morning Post (free)
• Dialysis Facilities Brace for COVID-19 – Renal & Urology News (free)
• On Front Lines, First Responders Brace For Coronavirus ― And Their Own Protection – Kaiser Health News (free)
• Why COVID-19 Coronavirus Infections Are So Serious In The Elderly – Forbes (free)
• As the coronavirus outbreak evolves, we answer some key questions – Science News (free)
• Just how contagious is COVID-19? This chart puts it in perspective – Popular Science (free) (via @ABsteward see Tweet)
• China May Be Beating the Coronavirus, at a Painful Cost – The New York Times (10 articles per month are free)
• Susan Desmond-Hellmann: The coronavirus is alarming. Here’s why you should not panic – STAT (free)
• “Our new life of isolation”: 5 people across the world on staying inside to avoid Covid-19 – Vox (free)
• Experts unsure if ‘cured’ COVID-19 patients are reinfected or relapsed – UPI (free)
• Global COVID-19 cases pass 100,000 mark – CIDRAP (free)

 

6 March 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives.

 

World Health Organization COVID-19 Situation Report:

• WHO: Latest COVID-19 Situation Report – 05 March 2020 (free PDF)
• See also: WHO Director-General’s opening remarks at the media briefing on COVID-19 – 5 March 2020 (free) AND WHO Homepage on the Coronavirus disease (COVID-19) outbreak (free resources)

“We are calling on every country to act with speed, scale and clear-minded determination.”

“This is not a drill.

This is not the time to give up.

This is not a time for excuses.

This is a time for pulling out all the stops.

Countries have been planning for scenarios like this for decades. Now is the time to act on those plans.”

(from WHO Director-General’s opening remarks)

Infographic:

• Recommendations for COVID-19 Intubation – CanadianEM (free)

Video:

• Watch: Flu has a season, but will Covid-19 melt away with the spring? It’s not so simple – STAT (free)

New Resource:

• Coronavirus Disease (COVID-19) – Our World in Data (free)

Latest Articles:

• Coronavirus disease 2019 (covid-19): a guide for UK GPs – The BMJ (free)
• Editorial: COVID-19: too little, too late? – The Lancet (free)
• Coronavirus latest: children are as susceptible as adults, study suggests – Nature (free)
• Evidence for gastrointestinal infection of SARS-CoV-2 – Gastroenterology (free PDF) AND Commentary: Gastrointestinal manifestations and fecal-oral transmission of novel coronavirus – New Medical (free)
• COVID-19: Gastrointestinal manifestations and potential fecal-oral transmission – Gastroenterology (free PDF)
• Escalating infection control response to the rapidly evolving epidemiology of the Coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 in Hong Kong – Infection Control & Hospital Epidemiology (free PDF) AND Commentary: Best practices shown to protect healthcare workers from COVID-19 – News Medical (free)
• Lack of Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2, China – CDC Emerging Infectious Diseases (free)
• Coronavirus Disease 2019 (COVID-19): Role of Chest CT in Diagnosis and Management – American Journal of Roentgenology (free) AND Commentary: Wuhan CT scans reliable for coronavirus (COVID-19) diagnosis, limited for differentiation – American Roentgen Ray Society (free)
• COVID-19: An Urgent Call for Coordinated, Trusted Sources to Tell Everyone What They Need to Know and Do – National Academy of Medicine (free) AND Commentary: Public health experts call for coordinated communication and outreach on COVID-19 – News Medical (free)
• Potential scenarios for the progression of a COVID-19 epidemic in the European Union and the European Economic Area, March 2020 – Eurosurveillance (free)

Selected News & Perspectives:

• Coronavirus: South Korea’s aggressive testing gives clues to true fatality rate – South China Morning Post (free)
• Opinion: A coronavirus vaccine should be for everyone, not just those who can afford it – STAT (free)
• How blood plasma from recovered patients could help treat the new coronavirus – STAT (free)
• $194 for hand sanitizer? You must be joking – Reuters (free)
• Coronavirus and handwashing: research shows proper hand drying is also vital – The Conversation (free)
• Why there’s still no single, accurate coronavirus death rate – Vox (free)
• Coronavirus – this is how the world is responding – World Economic Forum (free)
• What Pregnant Women Should Know About Coronavirus – The New York Times (10 articles per month are free)
• Short time between serial COVID-19 cases may hinder containment – CIDRAP (free)
• WHO urges whole-government COVID-19 tack as cases climb globally – CIDRAP (free)
• How Computer Modeling Of COVID-19’s Spread Could Help Fight The Virus – NPR (free)
• As Coronavirus Looms, Many Nursing Homes Fall Short On Infection Prevention – NPR (free)
• As Schools Close Because Of Coronavirus, Nearly 300 Million Kids Aren’t In Class – NPR (free)
• Here’s How to Self-Quarantine If You Get Exposed to Coronavirus – TIME (free)
• The Cornoavirus (COVID-19) outbreak highlights serious deficiencies in scholarly communication – LSE (free)
• Coronavirus: Not ill? Then wearing a mask is ‘a poor use of a very limited resource’ – Montreal Gazette (free)
• WHO calls on all nations to ‘pull out all the stops’ to fight coronavirus – CNBC (free)
• Expert reaction to reports that the (previously reported) pet dog in Hong Kong has repeatedly tested ‘weak positive’ for COVID-19 virus – Science Media Centre (free)

 

5 March 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives.

 

World Health Organization COVID-19 Situation Report:

• WHO: Latest COVID-19 Situation Report – 04 March 2020 (free PDF)
• See also: WHO Director-General’s opening remarks at the Mission briefing on COVID-19 – 4 March 2020 (free) AND WHO Homepage on the Coronavirus disease (COVID-19) outbreak (free resources)

Podcast:

• Interview with Dr. Eric Rubin and Dr. Lindsey Baden on what clinicians need to know in diagnosing and treating Covid-19 – New England Journal of Medicine (free)

Guidelines & Reports:

• Evaluating and Reporting Persons Under Investigation (PUI) – Centers for Disease Control and Prevention (free)
• What US Hospitals Should Do Now to Prepare for a COVID-19 Pandemic – Johns Hopkins Center for Health Security (free) AND Commentary: Flood of COVID-19 Patients Could Swamp Hospitals – Medscape (free registration required)
• Coronavirus (COVID-19) – 5 things you can do to protect yourself and your community – Public Health England (free)
• Alert: Important coronavirus updates for ophthalmologists – American Academy of Ophthalmologists (free)

Latest Articles:

• On the origin and continuing evolution of SARS-CoV-2 – National Science Review (free) AND Commentaries: Researchers identify two coronavirus strains as China cases dwindle – Reuters (free) AND Scientists discover two major subtypes of COVID-19 – ChinaDaily (free) AND Chinese scientists identify two strains of the coronavirus, indicating it’s already mutated at least once – CNBC (free) AND Discovery Of 2 Strains Of COVID-19 Coronavirus Hints At How It Evolved – Forbes (free) AND Expert reaction to study looking at whether there are two strains of the novel coronavirus – Science Media Centre (free)
• Air, Surface Environmental, and Personal Protective Equipment Contamination by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) From a Symptomatic Patient – JAMA (free) AND Commentary: Coronavirus lingers in rooms and toilets, but disinfectants kill it: study – MedicalXpress (free)
• JAMA Patient Page: Medical Masks (free)
• Abraar Karan: To control the covid-19 outbreak, young, healthy patients should avoid the emergency room – The BMJ Opinion (free)
• Covid-19: hoarding and misuse of protective gear is jeopardising the response, WHO warns – The BMJ (free)
• Coronavirus puts drug repurposing on the fast track – Nature Biotechnology (free)
• Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2 – Science (free)
• Clinical and CT imaging features of 2019 novel coronavirus disease (COVID-19) – Journal of Infection (free)
• A glimpse into the origins of genetic diversity in SARS-CoV-2 – Clinical Infectious Diseases (free)
• Novel coronavirus (2019-nCoV): Update on 3rd Coronavirus Outbreak of 21st Century – QJM: An International Journal of Medicine (free PDF)
• ‘We had to act.’ How coronavirus fears forced physics society to nix giant meeting – Science (free)

Selected News & Perspectives:

• COVID-19 Isn’t As Deadly As We Think – Slate (free) (recommended by @PaulSaxMD see Tweet)
• Column: COVID-19 could kill the for-profit science publishing model. That would be a good thing – Los Angeles Times (free)
• With COVID-19 Coronavirus, Here Are 15 Ways To Avoid Shaking Hands – Forbes (free)
• COVID-19 Begins To Impact Drug Supplies; Infections Accelerate in Iran, Across Europe & United States – Health Policy Watch (free)
• Diamond Princess Cruise ship – new estimates highlight the successes and failures of the COVID-19 quarantine – London School of Hygiene & Tropical Medicine (free)
• Facts, not fear, will stop COVID-19 – so how should we talk about it? – World Economic Forum (free)
• Coronavirus: 5 ways to put evidence into action during outbreaks like COVID-19 – The Conversation (free)
• Nursing Homes Are Starkly Vulnerable to Coronavirus – The New York Times (10 articles per month are free)
• Why the New Coronavirus (Mostly) Spares Children – The New York Times (10 articles per month are free)
• ‘No Way Out’: In China, Coronavirus Takes Toll on Other Patients – The New York Times (10 articles per month are free)
• China’s Battle Against Coronavirus: 7 Takeaways – The New York Times (10 articles per month are free)
• Cruises and the Coronavirus: What Passengers Need to Know – The New York Times (10 articles per month are free)
• Inside China’s All-Out War on the Coronavirus – The New York Times (10 articles per month are free)
• World Bank Group Announces Up to $12 Billion Immediate Support for COVID-19 Country Response – The World Bank (free)
• Nations take steps to slow COVID-19 as $12 billion in funds announced – CIDRAP (free)
• Study reveals sharp increase in COVID-19 in kids in Shenzhen – CIDRAP (free)
• Italy is shutting down schools nationwide to help curb its growing coronavirus outbreak – Vox (free)
• Should You Cancel Travel Plans Amid COVID-19 Concerns? Here’s What to Consider – TIME (free)
• A Coronavirus Guide for Older Adults (And Their Family Advocates) – TIME (free)
• Health Experts Are Telling Healthy People Not to Wear Face Masks for Coronavirus. So Why Are So Many Doing It? – TIME (free)
• Lead Your Business Through the Coronavirus Crisis – Harvard Business Review (free)
• China coronavirus infections spike in central city of Wuhan – Reuters (free)
• Coronavirus death toll jumps to 107 in Italy, all schools shut – Reuters (free)
• Here’s Who Should Be Avoiding Crowds Right Now – The Atlantic (free)
• How Computer Modeling Of COVID-19’s Spread Could Help Fight The Virus – NPR (free)

 

4 March 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives.

 

World Health Organization COVID-19 Situation Report:

• WHO: Latest COVID-19 Situation Report – 03 March 2020 (free PDF)
• See also: WHO Director-General’s opening remarks at the media briefing on COVID-19 – 3 March 2020 (free) AND Shortage of personal protective equipment endangering health workers worldwide – World Health Organization (free) AND Updated WHO recommendations for international traffic in relation to COVID-19 outbreak (free) AND WHO Homepage on the Coronavirus disease (COVID-19) outbreak (free resources)
• Advice for the public: When to Use Mask – World Health Organization (free)

Guidelines & Reports:

• Guidelines for pregnant women with suspected SARS-CoV-2 infection – The Lancet Infectious Diseases (free)
• See also: Proposed detailed management algorithm for health-care providers (free PDF))

Latest Articles:

• Supplement: 2019 Novel Coronavirus Disease (COVID-19) Collection – Chinese Medical Journal (free PDF)
• Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore – JAMA (free)
• Response to COVID-19 in Taiwan: Big Data Analytics, New Technology, and Proactive Testing – JAMA (free)
• Priorities for the US Health Community Responding to COVID-19 – JAMA (free)
• Relation Between Chest CT Findings and Clinical Conditions of Coronavirus Disease (COVID-19) Pneumonia: A Multicenter Study – American Journal of Roentgenology (free) AND Commentary: Chinese researchers detail chest CT findings in coronavirus disease (COVID-19) pneumonia – American Roentgen Ray Society (free)
• The Clinical and Chest CT Features Associated with Severe and Critical COVID-19 Pneumonia – Investigative Radiology (free PDF)
• COVID-19 and the anti-lessons of history – The Lancet (free)
• Has China faced only a herald wave of SARS-CoV-2? – The Lancet (free PDF)
• Tom Jefferson: Covid 19—many questions, no clear answers – The BMJ (free)
• Community Transmission of Severe Acute Respiratory Syndrome Coronavirus 2, Shenzhen, China, 2020 – CDC Emerging Infectious Diseases (free)
• The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak – Journal of Autoimmunity (free)
• Corona Virus International Public Health Emergencies: Implications for Radiology Management – Academic Radiology (free)
• Comparison of different samples for 2019 novel coronavirus detection by nucleic acid amplification tests – International Journal of Infectious Diseases (free)
• Coronavirus disease (COVID-19) and neonate: What neonatologist need to know – Journal of Medical Virology (free PDF)
• Therapeutic strategies in an outbreak scenario to treat the novel coronavirus originating in Wuhan, China – F1000Research (free)
• The third coronavirus epidemic in the third millennium: what’s next? – CMJ (free PDF)
• Laboratory abnormalities in patients with COVID-2019 infection – Clinical Chemistry and Laboratory Medicine (CCLM) (free)
• Asymptomatic novel coronavirus pneumonia patient outside Wuhan: The value of CT images in the course of the disease – Clinical Imaging (free)
• Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China – Intensive Care Medicine (free)
• COVID-19: a novel coronavirus and a novel challenge for critical care – Intensive Care Medicine (free)
• Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target – Intensive Care Medicine (free)
• Imaging changes in severe COVID-19 pneumonia – Intensive Care Medicine (free)
• The pandemic of social media panic travels faster than the COVID-19 outbreak – Journal of Travel Medicine (free PDF)
• A case of 2019 Novel Coronavirus in a pregnant woman with preterm delivery – Clinical Infectious Diseases (free PDF)
• Is the Africa prepared for tackling the COVID-19 (SARS-CoV-2) epidemic? – lessons from past outbreaks, ongoing pan-African public health efforts, and implications for the future – International Journal of Infectious Diseases (free PDF)
• Anti-HCV, nucleotide inhibitors, repurposing against COVID-19 – Life Sciences (free PDF)

Preprints:

• Machine learning-based CT radiomics model for predicting hospital stay in patients with pneumonia associated with SARS-CoV-2 infection: A multicenter study – medRxiv (free PDF)
• Epidemiological and clinical features of COVID-19 patients with and without pneumonia in Beijing, China – medRxiv (free PDF)
• Closed environments facilitate secondary transmission of coronavirus disease 2019 (COVID-19) – medRxiv (free PDF)
• Forecasting the Cumulative Number of COVID-19 Deaths in China: Can More Lives Be Saved? – medRxiv (free PDF)
• Effects of weather-related social distancing on city-scale transmission of respiratory viruses – medRxiv (free PDF)
• Precautions are Needed for COVID-19 Patients with Coinfection of Common Respiratory Pathogens – medRxiv (free PDF)
• Estimation of local novel coronavirus (COVID-19) cases in Wuhan, China from off-site reported cases and population flow data from different sources – medRxiv (free PDF)
• Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019 – medRxiv (free PDF)
• The level of plasma C-reactive protein is closely related to the liver injury in patients with COVID-19 – medRxiv (free PDF)
• Clinical significance of IgM and IgG test for diagnosis of highly suspected COVID-19 infection – medRxiv (free PDF)
• Rapid Detection of SARS-CoV-2 Using Reverse transcription RT-LAMP method – medRxiv (free PDF)
• An epidemiological forecast model and software assessing interventions on COVID-19 epidemic in China – medRxiv (free PDF)
• Highly ACE2 Expression in Pancreas May Cause Pancreas Damage After SARS-CoV-2 Infection – medRxiv (free PDF)
• Detectable serum SARS-CoV-2 viral load (RNAaemia) is closely associated with drastically elevated interleukin 6 (IL-6) level in critically ill COVID-19 patients – medRxiv (free PDF)
• Vicarious traumatization in the general public, members, and non-members of medical teams aiding in COVID-19 control – medRxiv (free PDF)
• The spatiotemporal estimation of the dynamic risk and the international transmission of 2019 Novel Coronavirus (COVID-19) outbreak: A global perspective – medRxiv (free PDF)
• A simple model to assess Wuhan lock-down effect and region efforts during COVID-19 epidemic in China Mainland – medRxiv (free PDF)

Selected News & Perspectives:

• I’m an emergency doctor. I expect to get coronavirus – CNN (free)
• COVID-19 Death Rate Higher Than Previously Reported; World Faces 40% Shortage in Health Worker Protective Gear – Health Policy Watch (free)
• Infectious Disease Doctor: What Does (And Doesn’t) Scare Me About The Coronavirus – CommonHealth (free)
• Who is getting sick, and how sick? A breakdown of coronavirus risk by demographic factors – STAT (free)
• WHO: Coronavirus is different from influenza, and that means it can be contained – STAT (free)
• The Coronavirus Outbreak Could Finally Make Telemedicine Mainstream in the U.S. – TIME (free)
• What You Can Do Right Now About the Coronavirus – The Atlantic (free)
• WHO warns of COVID-19-related protective equipment shortage – CIDRAP (free)
• COVID 19: Worsening PPE shortages threaten responses to outbreaks, WHO warns – Science Speaks: Global ID News (free)
• COVID-19: Invest now, or pay later – Science Speaks: Global ID News (free)
• Containing the Epidemic: Should Schools Close for Coronavirus? – Center for Global Development (free)
• The difference between quarantine, isolation, and social distancing, explained – Vox (free)
• What are the symptoms of the new coronavirus? – Vox (free)
• Factbox: Latest on the spread of coronavirus around the world – Reuters (free)
• China reports dwindling new cases, pivots to control risk from overseas – Reuters (free)
• WHO warns of global shortage of medical equipment to fight coronavirus – Reuters (free)
• What Pregnant Women Should Know About Coronavirus – The New York Times (10 articles per month are free)
• Why The Death Rate From Coronavirus Is Plunging In China – NPR (free)
• Coronavirus: World in ‘uncharted territory’ – BBC (free)

 

 

3 March 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives.

 

World Health Organization COVID-19 Situation Report:

• WHO: Latest COVID-19 Situation Report – 02 March 2020 (free PDF)
• See also: WHO Director-General’s opening remarks at the media briefing on COVID-19 – 2 March 2020 (free) AND WHO Homepage on the Coronavirus disease (COVID-19) outbreak (free resources)
• Advice for the public: When to Use Mask – World Health Organization (free)

Online Courses:

• Infection Prevention and Control (IPC) for Novel Coronavirus (COVID-19) – World Health Organization (free)
• COVID-19: Tackling the Novel Coronavirus – London School of Hygiene & Tropical Medicine / FutureLearn (free)

Videos:

• Former CDC Director: ‘This is the calm before the storm’ – CNN Video (free)
• Review of the Current Evidence on #COVID19 in Intensive Care -European Society of Intensive Care Medicine (free)
• COVID-19: Recorded Webcast with Johns Hopkins Experts (free)

Guidelines & Reports:

• Fifth Update: Rapid risk assessment: Outbreak of novel coronavirus disease 2019 (COVID-19): increased transmission globally – fifth update – European Centre for Disease Prevention and Control (free PDF) (via @onisillos)

Latest Articles:

• China’s aggressive measures have slowed the coronavirus. They may not work in other countries – Science (free)
• Guide to Understanding the 2019 Novel Coronavirus – Mayo Clinic Proceedings (free)
• Potential Rapid Diagnostics, Vaccine and Therapeutics for 2019 Novel Coronavirus (2019-nCoV): A Systematic Review – Journal of Clinical Medicine (free)
• Estimated effectiveness of symptom and risk screening to prevent the spread of COVID-19 – eLife (free PDF)
• Managing Emerging Infectious Diseases: Should Travel Be the Fifth Vital Sign? – Annals of Internal Medicine (free)
• World Health Organization declares Global Emergency: A review of the 2019 Novel Coronavirus (COVID-19) – International Journal of Surgery (free)
• Mass masking in the COVID-19 epidemic: people need guidance – The Lancet (free PDF)
• A Case Series of children with 2019 novel coronavirus infection: clinical and epidemiological features – Clinical Infectious Diseases (free PDF)
• A Well Infant with Coronavirus Disease 2019 (COVID-19) with High Viral Load – Clinical Infectious Diseases (free PDF)
• Clinical features and short-term outcomes of 18 patients with corona virus disease 2019 in intensive care unit – Intensive Care Medicine (free)
• Simulating and Forecasting the Cumulative Confirmed Cases of SARS-CoV-2 in China by Boltzmann Function-based Regression Analyses – Journal of Infection (free)
• Characteristics of COVID-19 infection in Beijing – Journal of Infection (free)
• Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19):A multi-center study in Wenzhou city, Zhejiang, China – Journal of Infection (free)
• The COVID-19 outbreak and implications for the Tokyo 2020 Summer Olympic Games – Travel Medicine and Infectious Diseases (free)
• COVID-19: Zoonotic aspects – Travel Medicine and Infectious Diseases (free)
• Critical care crisis and some recommendations during the COVID-19 epidemic in China – Intensive Care Medicine (free)
• The novel coronavirus (SARS-CoV-2) infections in China: prevention, control and challenges – Intensive Care Medicine (free)
• Imaging changes of severe COVID-19 pneumonia in advanced stage – Imaging in Intensive Care Medicine (free)
• Management strategies of neonatal jaundice during the coronavirus disease 2019 outbreak – World Journal of Pediatrics (free)
• A mathematical model for simulating the phase-based transmissibility of a novel coronavirus – Infectious Diseases of Poverty (free)
• Wuhan novel coronavirus (COVID-19): why global control is challenging? – Public Health (free)

Preprints:

• Prediction of survival for severe Covid-19 patients with three clinical features: development of a machine learning-based prognostic model with clinical data in Wuhan – medRxiv (free PDF)
• Transmission characteristics of the COVID-19 outbreak in China: a study driven by data – medRxiv (free PDF)
• Evaluation of Enzyme-Linked Immunoassay and Colloidal Gold- Immunochromatographic Assay Kit for Detection of Novel Coronavirus (SARS-Cov-2) Causing an Outbreak of Pneumonia (COVID-19) – medRxiv (free PDF)

Selected News & Perspectives:

• China’s cases of Covid-19 are finally declining. A WHO expert explains why. – Vox (free)
• Research in the time of coronavirus: keep it ethical – STAT (free)
• A detailed guide to the coronavirus drugs and vaccines in development – STAT (free)
• Mainland China reports lowest number of new coronavirus cases since January – Reuters (free)
• South Korea, Iran, Italy and Japan are greatest virus concern: WHO – Reuters (free)
• Latest on the spread of coronavirus around the world – Reuters (free)
• Coronavirus Update: Containment Is Possible, WHO Says – NPR (free)
• What Does It Mean If You Are Asked To ‘Self-Quarantine’ For The Coronavirus? – Forbes (free)
• Stop Touching Your Face! – The New York Times (10 articles per month are free)
• Surfaces? Sneezes? Sex? How the Coronavirus Can and Cannot Spread – The New York Times (10 articles per month are free)
• Epidemics expert Jonathan Quick: ‘The worst-case scenario for coronavirus is likely – The Guardian (free)

 

---

Tue April 07 – 10 Stories of The Day!

7 Apr, 2020 | 04:41h | UTC

 

1 – COVID‐19: Interim Guidance on Management Pending Empirical Evidence. From an American Thoracic Society‐led International Task Force

Commentary: ATS publishes new guidance on COVID-19 management – American Thoracic Society

 

2 – Management of Infants Born to Mothers with COVID-19 – American Academy of Pediatrics

News Release: AAP issues guidance on infants born to mothers with suspected or confirmed COVID-19 – American Academy of Pediatrics

FAQs: Management of Infants Born to Mothers with Suspected or Confirmed COVID-19 – American Academy of Pediatrics

Commentary: Policy statement outlines recommendations on management of infants born to mothers with COVID-19 – 2 Minute Medicine

 

3 –  Consensus guidelines for managing the airway in children with COVID-19 – Intensive Care Society

 

4 – Editorial: Cardiopulmonary Resuscitation after Hospital Admission with Covid-19 – The BMJ

“This pandemic has changed the risk-benefit balance for CPR: from “there is no harm in trying” to “there is little benefit to the patient, and potentially significant harm to staff.””

 

5 – Effectiveness of Surgical and Cotton Masks in Blocking SARS–CoV-2: A Controlled Comparison in 4 Patients – Annals of Internal Medicine

Commentary: Neither surgical nor cotton masks effectively filter SARS COV-2 – American College of Physicians

 

6 – Opinions on Lifting Coronavirus Pandemic Lockdowns

• How Will We Know When It’s Time to Reopen the Nation? – The New York Times
• Lockdown Can’t Last Forever. Here’s How to Lift It. – The New York Times
• When Can We Lift the Coronavirus Pandemic Restrictions? Not Before Taking These Steps – Scientific American

 

7 – Medical Masks vs N95 Respirators for Preventing COVID‐19 in Health Care Workers: A Systematic Review and Meta‐Analysis of Randomized Trials – Influenza

Commentary: Surgical masks likely good for most COVID-19 treatment – McMaster University

 

8 – Observational Studies: Countries with Universal BCG Vaccination Policy May Have Reduced Mortality from COVID-19

[Preprint] Differential COVID-19-attributable mortality and BCG vaccine use in countries – medRxiv

[Preprint] Association of BCG vaccination policy with prevalence and mortality of COVID-19 – medRxiv

See also: [Preprint] Observational Study: Countries with Universal BCG Vaccination Policy May Have Reduced Morbidity and Mortality for COVID-19 (study and commentaries)

 

9 – Coronavirus Disease 2019 in Children — United States, February 12–April 2, 2020 – Centers for Disease Control and Prevention

Commentaries: U.S. Children With COVID-19 Less Likely To Be Hospitalized Than Adults – NPR AND Why Children Seem to Be Less Affected By the Coronavirus – TIME

 

10 – Coronavirus Disease (COVID-19) Updates / 07 April 2020 Edition

07 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 

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AAP Guideline: Management of Infants Born to Mothers with COVID-19

7 Apr, 2020 | 04:37h | UTC

Management of Infants Born to Mothers with COVID-19 – American Academy of Pediatrics

News Release: AAP issues guidance on infants born to mothers with suspected or confirmed COVID-19 – American Academy of Pediatrics

FAQs: Management of Infants Born to Mothers with Suspected or Confirmed COVID-19 – American Academy of Pediatrics

Commentary: Policy statement outlines recommendations on management of infants born to mothers with COVID-19 – 2 Minute Medicine

 

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COVID‐19: ATS Interim Guidance on Management Pending Empirical Evidence

7 Apr, 2020 | 04:39h | UTC

COVID‐19: Interim Guidance on Management Pending Empirical Evidence. From an American Thoracic Society‐led International Task Force

Commentary: ATS publishes new guidance on COVID-19 management – American Thoracic Society

 

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Guidelines for Managing the Airway in Children with COVID-19

7 Apr, 2020 | 04:28h | UTC

Consensus guidelines for managing the airway in children with COVID-19 – Intensive Care Society

 

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Study: Effectiveness of Surgical and Cotton Masks in Blocking SARS–CoV-2

7 Apr, 2020 | 04:24h | UTC

Effectiveness of Surgical and Cotton Masks in Blocking SARS–CoV-2: A Controlled Comparison in 4 Patients – Annals of Internal Medicine

Commentary: Neither surgical nor cotton masks effectively filter SARS COV-2 – American College of Physicians

 

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Editorial: Is CPR Justified for Hospital Patients with Covid-19?

7 Apr, 2020 | 04:26h | UTC

Editorial: Cardiopulmonary Resuscitation after Hospital Admission with Covid-19 – The BMJ

“This pandemic has changed the risk-benefit balance for CPR: from “there is no harm in trying” to “there is little benefit to the patient, and potentially significant harm to staff.””

 

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Meta-Analysis: Medical Masks vs. N95 Respirators for Preventing COVID‐19 in Health Care Workers

7 Apr, 2020 | 04:22h | UTC

Medical Masks vs N95 Respirators for Preventing COVID‐19 in Health Care Workers: A Systematic Review and Meta‐Analysis of Randomized Trials – Influenza

Commentary: Surgical masks likely good for most COVID-19 treatment – McMaster University

 

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Observational Studies: Countries with Universal BCG Vaccination Policy May Have Reduced Mortality from COVID-19

7 Apr, 2020 | 04:20h | UTC

[Preprint] Differential COVID-19-attributable mortality and BCG vaccine use in countries – medRxiv

[Preprint] Association of BCG vaccination policy with prevalence and mortality of COVID-19 – medRxiv

See also: [Preprint] Observational Study: Countries with Universal BCG Vaccination Policy May Have Reduced Morbidity and Mortality for COVID-19 (study and commentaries)

 

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CDC Study: Coronavirus Disease 2019 in Children

7 Apr, 2020 | 04:18h | UTC

Coronavirus Disease 2019 in Children — United States, February 12–April 2, 2020 – Centers for Disease Control and Prevention

Commentaries: U.S. Children With COVID-19 Less Likely To Be Hospitalized Than Adults – NPR AND Why Children Seem to Be Less Affected By the Coronavirus – TIME

 

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Opinions on Lifting Coronavirus Pandemic Lockdowns

7 Apr, 2020 | 04:23h | UTC

• How Will We Know When It’s Time to Reopen the Nation? – The New York Times
• Lockdown Can’t Last Forever. Here’s How to Lift It. – The New York Times
• When Can We Lift the Coronavirus Pandemic Restrictions? Not Before Taking These Steps – Scientific American
• Related Report: National coronavirus response: A road map to reopening – American Enterprise Institute

 

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Study: Convalescent Plasma Therapy in Severe COVID-19 Patients

7 Apr, 2020 | 04:14h | UTC

Effectiveness of convalescent plasma therapy in severe COVID-19 patients – Proceedings of the National Academy of Sciences

Related Studies: Treatment with convalescent plasma for critically ill patients with SARS-CoV-2 infection – CHEST AND Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma – JAMA

 

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Global Interim Guidance on COVID‐19 During Pregnancy and Puerperium

7 Apr, 2020 | 04:13h | UTC

Global interim guidance on coronavirus disease 2019 (COVID‐19) during pregnancy and puerperium from FIGO and allied partners: Information for healthcare professionals – International Journal of Gynecology & Obstetrics

 

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COVID-19: More Opinions on Hydroxychloroquine

7 Apr, 2020 | 04:17h | UTC

Hydroxychloroquine Update For April 6 – Science Translational Medicine

The Debacle of Hydroxychloroquine and Azithromycin for COVID19 – Dr. John M.

Summary: wait for proper studies before prescribing.

 

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Richard Lehman’s Covid-19 Reviews—6 April 2020

7 Apr, 2020 | 04:16h | UTC

Richard Lehman’s covid-19 reviews, 6 April 2020 – The BMJ Opinion

In this weekly round-up, Richard Lehman looks at a personal selection of articles of relevance to clinicians dealing with covid-19.

 

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Study: Saline vs. Lactated Ringer’s Solution in Surgical Patients

7 Apr, 2020 | 04:11h | UTC

Saline versus Lactated Ringer’s Solution: The Saline or Lactated Ringer’s (SOLAR) Trial – Anesthesiology

 

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Position Statement: Occupational Health Hazards of the Catheterization Laboratory

7 Apr, 2020 | 04:10h | UTC

SCAI Multi-Society Position Statement on Occupational Health Hazards of the Catheterization Laboratory: Shifting the Paradigm for Healthcare Workers’ Protection – Journal of the American College of Cardiology

Commentary: ACC, SCAI Publish Position Statement on Cath Lab Occupational Health Hazards – American College of Cardiology

 

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Opinion – A New Normal With COVID-19: The Next Steps We Must Take

7 Apr, 2020 | 04:12h | UTC

A New Normal With COVID-19: The Next Steps We Must Take – Think Global Health

 

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ASCO Guideline: Management of Hereditary Breast Cancer

7 Apr, 2020 | 04:09h | UTC

Management of Hereditary Breast Cancer: American Society of Clinical Oncology, American Society for Radiation Oncology, and Society of Surgical Oncology Guideline – Journal of Clinical Oncology

 

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