Daily Archives: September 20, 2019 | LinksMedicus Free Medical News & Perspectives

Fri September 20 – 10 Stories of The Day!

20 Sep, 2019 | 08:48h | UTC

1 – Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction – New England Journal of Medicine (link to abstract – $ for full-text)

Related 2019 ESC Congress News Release, Before Publication: Randomized Trial: SGLT2 inhibitors Seems Beneficial for Heart Failure Even in Nondiabetics (free commentaries)

Commentaries: SGLT2 Inhibitor Dapagliflozin Lowers Risk for Worsening Heart Failure – NEJM Journal Watch (free) AND New research shows dapagliflozin used to treat diabetes can also treat heart failure, in patients with and without diabetes (the DAPA-HF Study) – Diabetologia (free)

2 – VA/DoD Clinical Practice Guideline: Diagnosis and Treatment of Low Back Pain – Journal of General Internal Medicine (free)

Source: Low back pain: joint guidelines from US Departments of Veterans Affairs, Defense – Univadis (free registration required)

3 – Association of Early Palliative Care Use With Survival and Place of Death Among Patients With Advanced Lung Cancer Receiving Care in the Veterans Health Administration – JAMA Oncology (free for a limited period)

Editorial: Prolonged Survival With Palliative Care—It Is Possible, but Is It Necessary? (free)

Commentaries: Early Palliative Care Associated with Increased Survival in Lung Cancer Patients – MedicalResearch.com (free) AND Early palliative care for advanced lung cancer increases survival – Veterans Affairs Research Communications (free)

Related Systematic Review: Early palliative care for adults with advanced cancer – Cochrane Library (free summary and original article)

4 – Association of Treatment With Metformin vs Sulfonylurea With Major Adverse Cardiovascular Events Among Patients With Diabetes and Reduced Kidney Function – JAMA (free for a limited period)

Commentaries: Metformin Superior for Lowering CV Risk in Diabetics Who Progress to CKD – Renal & Urology News (free) AND Metformin Monotherapy Benefits Heart Even in Early CKD – MedPage Today (free registration required)

5 – Effect of Linagliptin vs Glimepiride on Major Adverse Cardiovascular Outcomes in Patients With Type 2 Diabetes: The CAROLINA Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Sulfonylureas and Cardiovascular Safety: The Final Verdict? – JAMA (free for a limited period)

Commentary: CAROLINA: No Added Heart Risk With Sulfonylureas – MedPage Today (free registration required)

6 – Preoxygenation before intubation in adult patients with acute hypoxemic respiratory failure: a network meta-analysis of randomized trials – Critical Care (free) (via Park M, MD)

7 – Metabolic support in the critically ill: a consensus of 19 – Critical Care (free) (via Park M, MD)

8 – Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Meta-Analysis of TAVR vs. SAVR in Low-Risk Patients – American College of Cardiology (free) AND TAVR Survival Surpasses SAVR in Low-Risk Patients: Meta-analysis – Medscape (free registration required)

“The one clear unknown that everyone points to is valve durability” (form Medscape)

“longer follow-up regarding valve degeneration will be needed to confirm TAVR as the preferred treatment for low-risk patients with severe AS.” (from American College of Cardiology)

9 – Cochrane Special Collection: Diagnosing Dementia – Cochrane Library (free articles)

Commentary: Dementia diagnosis: a decade of evidence – Evidently Cochrane (free)

10 – News Release: AAN Recommends People 65+ be Screened Yearly for Memory Problems – American Academy of Neurology (free)

Original Recommendations: Quality improvement in neurology: Mild cognitive impairment quality measurement set – American Academy of Neurology (free PDF)

USPSTF Disagrees: USPSTF Draft Statement: Insufficient Evidence to Recommend Screening for Cognitive Impairment in Older Adults (free)

Guideline: Diagnosis and Treatment of Low Back Pain

20 Sep, 2019 | 08:25h | UTC

VA/DoD Clinical Practice Guideline: Diagnosis and Treatment of Low Back Pain – Journal of General Internal Medicine (free)

Source: Low back pain: joint guidelines from US Departments of Veterans Affairs, Defense – Univadis (free registration required)

[Abstract Only] Randomized Trial: SGLT2 Inhibitor Improves Outcomes in Patients with Heart Failure Even in the Absence of Diabetes

20 Sep, 2019 | 08:27h | UTC

Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction – New England Journal of Medicine (link to abstract – $ for full-text)

Related 2019 ESC Congress News Release, Before Publication: Randomized Trial: SGLT2 inhibitors Seems Beneficial for Heart Failure Even in Nondiabetics (free commentaries)

Commentaries: SGLT2 Inhibitor Dapagliflozin Lowers Risk for Worsening Heart Failure – NEJM Journal Watch (free) AND New research shows dapagliflozin used to treat diabetes can also treat heart failure, in patients with and without diabetes (the DAPA-HF Study) – Diabetologia (free)

Randomized Trial: No Difference in Major Cardiovascular Outcomes in Patients with Type 2 Diabetes Treated with DPP-4 Inhibitor vs. Sulfonylurea

20 Sep, 2019 | 08:15h | UTC

Effect of Linagliptin vs Glimepiride on Major Adverse Cardiovascular Outcomes in Patients With Type 2 Diabetes: The CAROLINA Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Sulfonylureas and Cardiovascular Safety: The Final Verdict? – JAMA (free for a limited period)

Commentary: CAROLINA: No Added Heart Risk With Sulfonylureas – MedPage Today (free registration required)

Cohort Study: Early Palliative Care Linked to Increased Survival and Reduced Risk of Death in an Acute Care Setting Among Patients with Advanced Lung Cancer

20 Sep, 2019 | 08:21h | UTC

Association of Early Palliative Care Use With Survival and Place of Death Among Patients With Advanced Lung Cancer Receiving Care in the Veterans Health Administration – JAMA Oncology (free for a limited period)

Editorial: Prolonged Survival With Palliative Care—It Is Possible, but Is It Necessary? (free)

Commentaries: Early Palliative Care Associated with Increased Survival in Lung Cancer Patients – MedicalResearch.com (free) AND Early palliative care for advanced lung cancer increases survival – Veterans Affairs Research Communications (free)

Related Systematic Review: Early palliative care for adults with advanced cancer – Cochrane Library (free summary and original article)

Metabolic Support in the Critically Ill: A Consensus of 19

20 Sep, 2019 | 08:12h | UTC

Metabolic support in the critically ill: a consensus of 19 – Critical Care (free) (via Park M, MD)

Meta-analysis: Preoxygenation Before Intubation in Adult Patients with Acute Hypoxemic Respiratory Failure

20 Sep, 2019 | 08:14h | UTC

Preoxygenation before intubation in adult patients with acute hypoxemic respiratory failure: a network meta-analysis of randomized trials – Critical Care (free) (via Park M, MD)

Cohort Study: Metformin Linked to Reduced Risk of Cardiovascular Events Compared to Sulfonylurea Among Patients with Diabetes and Reduced Kidney Function

20 Sep, 2019 | 08:19h | UTC

Association of Treatment With Metformin vs Sulfonylurea With Major Adverse Cardiovascular Events Among Patients With Diabetes and Reduced Kidney Function – JAMA (free for a limited period)

Commentaries: Metformin Superior for Lowering CV Risk in Diabetics Who Progress to CKD – Renal & Urology News (free) AND Metformin Monotherapy Benefits Heart Even in Early CKD – MedPage Today (free registration required)

Related Commentary on Twitter

Monotherapy treatment with #metformin, compared with a #sulfonylurea, was associated with a lower risk of MACE among patients with diabetes and reduced kidney function https://t.co/Z1EZAjOOET

— JAMA (@JAMA_current) September 19, 2019

Meta-Analysis: Transcatheter vs. Surgical Aortic Valve Replacement in Low-Risk Patients

20 Sep, 2019 | 08:07h | UTC

Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Meta-Analysis of TAVR vs. SAVR in Low-Risk Patients – American College of Cardiology (free) AND TAVR Survival Surpasses SAVR in Low-Risk Patients: Meta-analysis – Medscape (free registration required)

“The one clear unknown that everyone points to is valve durability” (form Medscape)

“longer follow-up regarding valve degeneration will be needed to confirm TAVR as the preferred treatment for low-risk patients with severe AS.” (from American College of Cardiology)

Cochrane Special Collection: Diagnosing Dementia

20 Sep, 2019 | 08:06h | UTC

Cochrane Special Collection: Diagnosing Dementia – Cochrane Library (free articles)

Commentary: Dementia diagnosis: a decade of evidence – Evidently Cochrane (free)

Study: Half of Trials Supporting New Cancer Drug Approvals in Europe Were Judged to be at High Risk of Bias

20 Sep, 2019 | 07:46h | UTC

Design characteristics, risk of bias, and reporting of randomised controlled trials supporting approvals of cancer drugs by European Medicines Agency, 2014-16: cross sectional analysis – The BMJ (free)

Editorial: Flawed evidence underpins approval of new cancer drugs (free)

Commentaries: Gauging the validity of cancer drug trials: a call for collaboration – The BMJ Opinion (free) AND Questions raised over quality of trials supporting new cancer drugs approvals – OnMedica (free) AND Evidence underpinning approval of new cancer drugs raises questions – The BMJ (free)

“Around half of trials that supported new cancer drug approvals in Europe between 2014 and 2016 were judged to be at high risk of bias, which indicates that treatment effects might have been exaggerated, concludes a new study.” (from The BMJ news release)