Urology
[Abstract Only] Randomized Trial: Adjuvant Radiotherapy Following Radical Prostatectomy vs. Radical Prostatectomy Alone in Prostate Cancer Patients with Positive Margins or Extracapsular Extension
10 Sep, 2019 | 00:56h | UTCRandomised Trial of Adjuvant Radiotherapy Following Radical Prostatectomy Versus Radical Prostatectomy Alone in Prostate Cancer Patients with Positive Margins or Extracapsular Extension – European Urology (link to abstract – $ for full-text)
Commentaries: Adjuvant Radiotherapy After Radical Prostatectomy vs Radical Prostatectomy Alone in Patients With Positive Margins or Extracapsular Extension – The ASCO Post (free) AND Adjuvant radiotherapy may be beneficial in treating locally advanced prostate cancer – University of Helsinki (free)
Source: EvidenceAlerts
Systematic Review: Hypofractionation (Fewer, Larger Doses of Daily Radiation) for Clinically Localized Prostate Cancer Results in Similar Oncologic Outcomes
8 Sep, 2019 | 23:00h | UTCHypofractionation for clinically localized prostate cancer – Cochrane Library (free)
Position Statement: Safe Use of Immune Checkpoint Inhibitors in the Multidisciplinary Management of Urological Cancer
27 Aug, 2019 | 00:25h | UTCRelated: Immune Checkpoint Inhibitor Toxicities (free guidelines and reviews on the subject)
Recent Advances in Surgical Management of Urinary Incontinence
27 Aug, 2019 | 00:27h | UTCRecent advances in surgical management of urinary incontinence – F1000Research (free)
[Abstract Only] Study: High Animal Protein Intake Linked to Increased Risk of Kidney Stones
27 Aug, 2019 | 00:26h | UTCPlant and Animal Protein Intakes and Risk of Incident Kidney Stones: Results from the Shanghai Men’s and Women’s Health Studies – Journal of Urology (link to abstract – $ for full-text)
Commentary: Kidney Stones Linked to High Animal Protein Intake – Renal & Urology News (free)
Related: NICE Guideline – Renal and Ureteric Stones: Assessment and Management (free guidelines on the subject) AND Fluid Intake and Dietary Factors and the Risk of Incident Kidney Stones in UK Biobank: A Population-based Prospective Cohort Study – European Urology Focus (free)
Postoperative Management in Patients with Pheochromocytoma and Paraganglioma
27 Aug, 2019 | 00:13h | UTCPostoperative Management in Patients with Pheochromocytoma and Paraganglioma – Cancers (free)
Related Reviews: Current perioperative management of pheochromocytomas – Indian Journal of Urology (free) AND Surgical and Pharmacological Management of Functioning Pheochromocytoma and Paraganglioma – Paraganglioma: A Multidisciplinary Approach (free)
Brachytherapy: An Overview for Clinicians
25 Aug, 2019 | 21:09h | UTCBrachytherapy: An overview for clinicians – CA: A Cancer Journal for Clinicians (free)
Consensus: Oligometastatic Prostate Cancer
18 Aug, 2019 | 21:42h | UTCRelated Guideline: NICE Guideline: Diagnosis and Management of Prostate Cancer (free)
Review: The Use of MRI and PET Imaging Studies for Prostate Cancer Management
18 Aug, 2019 | 21:11h | UTC
Study: Androgen-deprivation Therapies May Increase the Risk of QT Prolongation and Arrhythmias
13 Aug, 2019 | 01:26h | UTCAndrogenic Effects on Ventricular Repolarization: A Translational Study From the International Pharmacovigilance Database to iPSC-Cardiomyocytes – Circulation (free PDF for a limited period)
Commentaries: Androgen-Deprivation Therapy May Increase Risk for QT Prolongation and Torsades de Pointes – The ASCO Post (free) AND ADT Linked to Arrhythmias, QT Prolongation – MedPage Today (free registration required)
Multispecialty Consensus: Imaging in Suspected Renal Colic
9 Aug, 2019 | 08:14h | UTC
Randomized Trial: Five Days of Treatment Not Better than Three Days for Uncomplicated Lower Urinary Tract Infection
9 Aug, 2019 | 07:50h | UTC
Related Commentary on Twitter
Three versus five days of pivmecillinam for #community acquired uncomplicated lower urinary tract infection: a randomised, double-blind, placebo-controlled superiority trial @EClinicalMed @uni_copenhagen #clinicaltrials
Have a read at: https://t.co/RiOIS1686B pic.twitter.com/VUyf5jhwmh
— eClinicalMedicine – The Lancet Discovery Science (@eClinicalMed) August 1, 2019
Meta-Analysis: MRI plus Targeted Biopsy vs. Systematic Biopsy Alone for the Diagnosis of Prostate Cancer
8 Aug, 2019 | 08:13h | UTCCommentaries: The Evolving Paradigm of Prostate Cancer Screening – JAMA Network Open (free) AND MRIs Improve Targeting of Biopsies for Prostate Cancer Diagnosis – MedicalResearch.com (free)
Related Cochrane Review: MRI Pathway vs. Systematic Biopsy for Detecting Prostate Cancer (free)
“Prebiopsy magnetic resonance imaging combined with targeted biopsy is associated with improved detection of clinically significant prostate cancer and reduced numbers of biopsy cores per procedure, while potentially avoiding unnecessary biopsies.”
Simulation Study: Uniform CT Imaging for Patients with Hematuria May Result in Increased Costs and Harms of Secondary Cancers
30 Jul, 2019 | 01:37h | UTCComparison of the Harms, Advantages, and Costs Associated With Alternative Guidelines for the Evaluation of Hematuria – JAMA Internal Medicine (free for a limited period)
Commentaries: Hematuria Practice Guidelines That Explicitly Consider Harms and Costs – JAMA Internal Medicine (free for a limited period) AND Evaluating Hematuria: Uniform Use of CT Seen as Risky and Expensive – NEJM Journal Watch (free)
Related Commentary on Twitter (Thread – Click for More)
Excited to have our work examining tradeoffs of alternative approaches to hematuria evaluation out in @JAMAInternalMed today. Sharing here origin story, highlights from the paper and related thoughts (THREAD)
1/nhttps://t.co/f47L2BZOW7— Matt Nielsen, MD (@m_e_nielsen) July 29, 2019
Female Urethroplasty: A Practical Guide Emphasizing Diagnosis and Surgical Treatment of Female Urethral Stricture Disease
27 Jul, 2019 | 19:57h | UTC
Penile Lesions: Patient Presentation, Differential Diagnosis, and Management
27 Jul, 2019 | 15:19h | UTCRelated Reviews: Penile warts: an update on their evaluation and management – Drugs in Context (free) AND Noninfectious Penile Lesions – American Family Physician (free)
Study: Short MRI Protocols Have High Diagnostic Performance for Prostate Cancer Detection
23 Jul, 2019 | 01:18h | UTCCommentary: Fast MRI Protocol Accurately Identifies Prostate Cancer at Lower Cost – Medscape/Reuters (free)
[Abstract Only] Review: The Global Prevalence of Erectile Dysfunction
23 Jul, 2019 | 01:16h | UTCThe global prevalence of erectile dysfunction: a review – BJU International (link to abstract – $ for full-text)
Commentaries: How common is erectile dysfunction? – Medical News Today (free) AND Erectile Dysfunction Presents Large Global Health Burden – Renal & Urology News (free)
[Abstract Only] Observational Study Points to Increased Cardiovascular and Cerebrovascular Risk with Testosterone Replacement Therapy (TRT) in Aging Men
19 Jul, 2019 | 09:37h | UTCCardiovascular and Cerebrovascular Safety of Testosterone Replacement Therapy Among Aging Men with Low Testosterone Levels: A Cohort Study – American Journal of Medicine (link to abstract – $ for full-text)
Commentary: Testosterone replacement therapy (TRT) can increase men’s risk of stroke and heart attack – Elsevier (free)
Interventions to Treat Erectile Dysfunction and Premature Ejaculation: An Overview of Systematic Reviews
12 Jul, 2019 | 07:54h | UTCRelated Guidelines: Erectile Dysfunction: AUA Guideline (free) AND An Update of the International Society of Sexual Medicine’s Guidelines for the Diagnosis and Treatment of Premature Ejaculation – Sexual Medicine (free)
Androgen Deprivation Therapy Linked to Increased Risk of Dementia in Men with Prostate Cancer
10 Jul, 2019 | 09:30h | UTCCommentaries: Hormone therapy for prostate cancer may raise risk of Alzheimer’s, Dementia – Penn Medicine (free) AND Prostate cancer treatment linked to heightened Alzheimer’s risk – UPI (free) AND Men’s dementia risk higher after androgen deprivation therapy – OnMedica (free) AND Risk of dementia rises with prostate cancer hormone-blocking therapy – Reuters (free)
[Abstract Only] Randomized Trial: First-Line Therapies for Metastatic Prostate Cancer Compared
30 Jun, 2019 | 17:16h | UTCEnzalutamide with Standard First-Line Therapy in Metastatic Prostate Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: ENZAMET Trial Shows Enzalutamide Improves Overall Survival in Hormone-Sensitive Metastatic Prostate Cancer – The ASCO Post (free)
[Abstract Only] Randomized Trial: Ultra-hypofractionated vs. Conventionally Fractionated Radiotherapy for Prostate Cancer
30 Jun, 2019 | 17:18h | UTCUltra-hypofractionated versus conventionally fractionated radiotherapy for prostate cancer: 5-year outcomes of the HYPO-RT-PC randomised, non-inferiority, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Related Commentary on Twitter
NEW Research—Ultra-hypofractionated versus conventionally fractionated radiotherapy for #prostatecancer: 5-year outcomes of the HYPO-RT-PC randomised, non-inferiority, phase 3 trial https://t.co/7weB2Qz3wc pic.twitter.com/mSUvbQHMdw
— The Lancet (@TheLancet) June 20, 2019
[Abstract Only] Meta-Analysis: Natural History of Adrenal Incidentalomas With and Without Mild Autonomous Cortisol Excess
25 Jun, 2019 | 06:33h | UTCNatural History of Adrenal Incidentalomas With and Without Mild Autonomous Cortisol Excess: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Incidentally discovered adrenal tumors rarely grow or affect hormonal function, review finds – ACP Internist (free) AND Healthcare guidelines should be updated for patients with certain adrenal tumors – University of Birmingham (free)
Related Guideline: Management of adrenal incidentalomas: European Society of Endocrinology Clinical Practice Guideline in collaboration with the European Network for the Study of Adrenal Tumors – European Journal of Endocrinology (free)
Study: Association of Coworker Reports About Unprofessional Behavior by Surgeons With Surgical Complications in Their Patients
21 Jun, 2019 | 08:50h | UTCAssociation of Coworker Reports About Unprofessional Behavior by Surgeons With Surgical Complications in Their Patients – JAMA Surgery (free for a limited period)
Commentaries: When Surgeons Are Abrasive To Co-Workers, Patients’ Health May Suffer – NPR (free) AND Unprofessional Behavior by Surgeons Linked to Surgical Complications in Their Patients – MedicalResearch.com (free) AND After surgery, how patients fare may depend on how their doctor behaves, study says – CNN (free)