TOP 10 Medical News Stories
Mon, November 19 – 10 Stories of The Day!
19 Nov, 2018 | 00:45h | UTC
Editorial: Tackling potentially inappropriate prescribing (free)
Commentary: Half of older patients exposed to potentially inappropriate prescribing – MedicalXpress (free)
2 – Twenty Year Trends and Sex Differences in Young Adults Hospitalized with Acute Myocardial Infarction: The ARIC Community Surveillance Study – Circulation (free for a limited period)
Commentaries: Heart attacks are becoming more common in younger people, especially women – AHA News (free) AND Greater Need for Cooperative Care in Women’s Heart Health, Two Studies Suggest – TCTMD (free)
4 – Nonoperative Management of Uncomplicated Appendicitis Among Privately Insured Patients – JAMA Surgery (free for a limited period)
Editorial: Treating the Patient With Appendicitis, Not Just the Appendicitis (free)
Related Randomized Trial: Antibiotic Therapy Alone Seems Reasonable for Uncomplicated Appendicitis (link to abstract, commentaries and resources on the subject)
Commentary: Is Social Media Making You Depressed and Lonely? – MedicalResearch.com (free)
Commentary: CHEST Guidelines for Clinical Diagnosis of Pertussis-Associated Cough – Pulmonology Advisor (free)
8 – Omega‐3 fatty acid addition during pregnancy – Cochrane Library (free)
Summary: Omega-3 fatty acid addition during pregnancy – Cochrane Library (free)
Commentaries: Omega-3 in pregnancy reduces the risk of premature birth: new evidence – Evidently Cochrane (free) AND Omega-3 supplements in pregnancy reduce the risk of premature birth – The Conversation (free)
9 – Dietary fat: From foe to friend? – Science (free for a limited period)
Commentary: Dietary fat is good? Dietary fat is bad? Coming to consensus – Harvard T.H. Chan School of Public Health (free)
10 – Human Resting Energy Expenditure Varies with Circadian Phase – Current Biology (free for a limited period)
Commentaries: How many calories do you burn? It depends on time of day – Cell Press (free) AND Study: Calories burned depend on time of day – UPI (free) AND What time of day do we burn the most calories? – Medical News Today (free) AND Here’s When Your Body Burns the Most Calories, According to a New Study – TIME (free) AND Eat Carbs in the Morning, Fat at Night? – MedicalResearch.com (free)
Fri, November 16 – 10 Stories of The Day!
16 Nov, 2018 | 00:03h | UTC
3 – Perspective: Addressing Health-Related Misinformation on Social Media – JAMA (free for a limited period)
Commentary: Choosing Wisely: 5 Antibiotic Strategies to Avoid in Children – NEJM Journal Watch (free)
See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada
Commentaries: New diabetes drug may increase the risk of serious adverse events – Karolinska Institutet (free) AND SGLT2 Inhibitors Tied to Increased Risk for Amputation, Diabetic Ketoacidosis – NEJM Journal Watch (free) AND SGLT2 Inhibitor Amputation Risk Seen in Real-World Diabetes Study – Medscape (free registration required)
6 – Review: A time to fast – Science (free for a limited period) (via @EricTopol)
7 – Review: Interruption and Reversal of Direct Oral Anticoagulants in Preprocedural and Acute Settings – Journal of the American Board of Family Medicine (free)
Source: Medscape
8 – Acute mesenteric ischaemia: a pictorial review – Insights into Imaging (free)
Summary: Ways to help pregnant women avoid preterm birth – Cochrane Library (free)
Related: Post-Contrast Acute Kidney Injury (free reviews) AND Does contrast cause kidney injury? The evidence (free) AND Meta-Analysis: Acute Kidney Injury After Computed Tomography (link to abstract and commentaries)
Thu, November 15 – 10 Stories of The Day!
15 Nov, 2018 | 01:41h | UTC
“Prednisone treatment during the first 4 weeks after the initiation of ART for HIV infection resulted in a lower incidence of tuberculosis-associated immune reconstitution inflammatory syndrome than placebo, without evidence of an increased risk of severe infections or cancers.”
Commentaries: Expert reaction to study looking at low carbohydrate diets and weight maintenance – Science Media Centre (free) AND How a Low-Carb Diet Might Help You Maintain a Healthy Weight – The New York Times (10 articles per month are free) AND Low carb diets can help maintain weight loss by increasing number of calories burned – The BMJ (free)
3 – Increasing Safe Outpatient Management of Emergency Department Patients With Pulmonary Embolism: A Controlled Pragmatic Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Electronic Decision Support Facilitates Home Discharge of Some PE Patients From ER – MedicalResearch.com (free) AND EMR-Integrated Tool Lets More PE Patients Be Discharged from the ED – NEJM Journal Watch (free)
4 – Perspective: Benjamin Mazer: Are medical errors a huge problem that’s simple to fix? – The BMJ Opinion (free)
6 – Review: Neuroinfections caused by fungi – Infection (free)
7 – Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild cognitive impairment – Cochrane Library (free)
“The evidence on vitamin and mineral supplements as treatments for mild cognitive Impairment is very limited. “
8 – One Month of Cannabis Abstinence in Adolescents and Young Adults Is Associated With Improved Memory – Journal of Clinical Psychiatry (link to abstract – $ for full-text)
Commentaries: When Adolescents Give Up Pot, Their Cognition Quickly Improves – NPR (free) AND Stopping Cannabis Tied to Memory Improvements – NEJM Journal Watch (free)
9 – Long-term Survival following Multivessel Revascularization in Patients with Diabetes (FREEDOM Follow-On Study) – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Long-term FREEDOM: At Nearly 8 years, CABG Maintains Mortality Benefit Over PCI – TCTMD (free) AND FREEDOM Follow-On Study Findings Further Support CABG Over PCI in DM Patients With CAD – American College of Cardiology (free) AND AHA: CABG Still Better for Multivessel Disease in Diabetes – MedPage Today (free registration required)
10 – Antipsychotic drug use and pneumonia: Systematic review and meta-analysis – Journal of Psychopharmacology (link to abstract – $ for full-text)
Commentary: Antipsychotics May Increase Risk of Pneumonia, Meta-Analysis Suggests – Psychiatric News Alert (free)
“Although antipsychotic use was associated with a higher risk of pneumonia, the researchers stopped short of claiming causality, citing a lack of data from randomized, controlled trials and a failure of observational studies to control for relevant confounders like tobacco use and weight.” (from Psychiatric News Alert)
Wed, November 14 – 10 Stories of The Day!
14 Nov, 2018 | 00:01h | UTC
Editorials: Screening for Unhealthy Alcohol Use (free) AND Unhealthy Alcohol Use in Primary Care—The Elephant in the Examination Room (free)
Author Interview: USPSTF Recommendation: Screening and Interventions for Unhealthy Alcohol Use (free audio)
JAMA Patient Page: Screening and Counseling to Reduce Unhealthy Alcohol Use (free)
2 – 2018 IDSA Clinical Practice Guideline for the Management of Outpatient Parenteral Antimicrobial Therapy – Clinical Infectious Diseases (free) (via @ABsteward)
Commentary: Updated Guidelines Advise on Outpatient Parenteral Antimicrobial Therapy – Pharmacy Times (free) AND ID specialist input improves outcomes for outpatient parenteral antimicrobial therapy – Infectious Diseases Society of America (free)
Video Summary: Effect of a Pharmacist-Led Intervention on Inappropriate Prescriptions in Older Adults (free)
4 – Effect of Exercise Intervention on Functional Decline in Very Elderly Patients During Acute Hospitalization: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)
Commentaries: A Novel Exercise Intervention and Functional Status in Very Elderly Patients During Acute Hospitalization – JAMA Internal Medicine (free for a limited period) AND Exercise intervention benefits elderly in hospital – OnMedica (free)
Author Interview: Effect of Exercise Intervention on Functional Decline in Very Elderly Patients (free audio)
Videos: Morning Exercise Session (free) AND Evening Exercise Session (free) AND Balance and Gait Retraining Exercises (free)
5 – Top 8 Healthcare Predictions for 2019 – Forbes (free)
Source: Hospital Medicine Virtual Journal Club
8 – Review: Advances in optimizing the prescription of antibiotics in outpatient settings – The BMJ (free for a limited period)
9 – Clinical Report: Sport-Related Concussion in Children and Adolescents – Pediatrics (free)
Commentaries: Concussion management embraces earlier light exercise, earlier return to school – AAP News Release (free) AND Pediatrics Group Updates Guidance on Sports-Related Concussion – NEJM Journal Watch (free)
Commentaries: Public health burden of antimicrobial resistance in Europe – The Lancet Infectious Diseases (free) AND 33,000 people die every year due to infections with antibiotic-resistant bacteria – European Centre for Disease Prevention and Control (ECDC) (free) AND European study: 33,000 deaths a year from resistant infections – CIDRAP (free)
Tue, November 13 – 10 Stories of The Day!
13 Nov, 2018 | 00:01h | UTC
1 – The Physical Activity Guidelines for Americans – JAMA (free)
Editorial: New Physical Activity Guidelines: A Call to Activity for Clinicians and Patients (free)
Video Summary: Physical Activity Guidelines for Americans, 2nd Edition (free)
Commentaries: New Physical Activity Guidelines Urge Americans: Move More, Sit Less – NPR (free) AND HHS Releases Physical Activity Guidelines for Americans, 2nd edition – U.S. Department of Health & Human Services (free)
Commentaries: Stopping medication for heart failure with improved ejection fraction – The Lancet (free) AND Remission, Not Cure: No Weaning Off Meds for Dilated Cardiomyopathy Patients, Says TRED-HF – TCTMD (free) AND Drug Withdrawal Inadvisable in ‘Recovered’ Dilated Cardiomyopathy – Medscape (free registration required)
Commentaries: Endoscopic Vein-Graft Harvest for CABG Associated With Similar MACE, Less Pain vs Open Procedure: REGROUP – TCTMD (free) AND AHA: Endoscopic Vein-Graft Harvesting Redeems Itself in CABG – MedPage Today (free)
4 – Perspective: Getting Rid of Stupid Stuff – New England Journal of Medicine (free)
5 – Alex Nowbar’s research reviews, 12 November 2018 – The BMJ Opinion (free)
Alex Nowbar reviews the latest research from the top medical journals.
6 – Last Month in Oncology with Dr. Bishal Gyawali – The Health Care Blog (free)
Commentary: WHO uncovers big national variations in antibiotics consumption – Reuters (free)
9 – SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials – The Lancet (link to abstract – $ for full-text)
Commentary: SGLT2 Inhibitors and CV and Renal Outcomes in Type 2 Diabetes – American College of Cardiology (free)
10 – Risk of Malignant Ovarian Cancer Based on Ultrasonography Findings in a Large Unselected Population – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: Most simple ovarian cysts require no treatment, surveillance – UPI (free) AND Less surveillance needed for simple ovarian cysts – University of California, San Francisco (free)
“New study finds that simple cysts should be considered normal and ignored” (from The University of California)
Mon, November 12 – 10 Stories of The Day!
12 Nov, 2018 | 00:01h | UTC
#AHA2018 – Highlights from the AHA Scientific Sessions 2018
1 – Global Burden of Disease Study 2017 – The Lancet (8 free articles)
See also: Infographics with GBD 2017 Study Highlights – Institute for Health Metrics and Evaluation (all free) AND Updated GBD Compare Visualization Tool – Institute for Health Metrics and Evaluation (free resource)
“All eight Global Burden of Disease 2017 papers providing 38 billion estimates of 359 diseases & injuries & 84 risk factors in 195 countries & territories” (via @TheLancet see Tweet)
2 – #AHA2018 – 2018 AHA/ACC Guideline on the Management of Blood Cholesterol – Circulation – A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines (free PDF)
Summary: 2018 ACC/AHA Multisociety Guideline on the Management of Blood Cholesterol – American College of Cardiology (free)
See also: Cholesterol Guideline Hub (free resources)
3 – #AHA2018 – Use of Risk Assessment Tools to Guide Decision-Making in the Primary Prevention of Atherosclerotic Cardiovascular Disease – A Special Report From the American Heart Association and American College of Cardiology (free PDF)
Summary: Use of Risk Assessment Tools to Guide Decision-Making in ASCVD Prevention – American College of Cardiology (free)
4 – #AHA2018 – Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease – New England Journal of Medicine (free)
Editorial: VITAL Signs for Dietary Supplementation to Prevent Cancer and Heart Disease (free)
Commentaries: Vitamin D And Fish Oil Supplements Mostly Disappoint In Long-Awaited Research Results – NPR (free) AND Fish Oil And Vitamin D Pills No Guard Against Cancer Or Serious Heart Trouble – Kaiser Health News (free)
5 – #AHA2018 – Marine n−3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer – New England Journal of Medicine (free)
Commentaries: Vitamin D, omega-3 supplements do not prevent cancer or heart disease, study says – CNN (free) AND Vitamin D and Fish Oils Are Ineffective for Preventing Cancer and Heart Disease – The New York Times (10 articles per month are free)
Related Systematic Review: Omega-3 fatty Acids for the Prevention of Cardiovascular Disease (free review and commentaries)
6 – #AHA2018 – Amarin’s Fish-Oil-Derived Drug Shows Great Promise — With Big Caveats – Forbes (free) (via @cardiobrief)
Original Article: Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia – New England Journal of Medicine (free)
“what seriously bothered five of the six cardiologists I spoke to was that the mineral oil had not behaved as a placebo at all.”
7 – Effective healthcare cost-containment policies: a systematic review – Health Policy (free)
8 – Perioperative alcohol cessation intervention for postoperative complications – Cochrane Library (free)
Summary: Effects of perioperative alcohol cessation interventions on postoperative complications following surgery – Cochrane Library (free)
“Intensive alcohol cessation interventions offered for four to eight weeks to participants undergoing all types of surgical procedures to achieve complete alcohol cessation before surgery probably reduced the number of postoperative complications.”
See Original Article: ESC/EACTS Guidelines on Myocardial Revascularization (free)
Fri, November 9 – 10 Stories of The Day!
9 Nov, 2018 | 01:07h | UTC
1 – Guideline: Management of physical health conditions in adults with severe mental disorders – World Health Organization (free PDF)
News Release: WHO guidelines: Management of physical health conditions in adults with severe mental disorders (free)
WHO Video: Improving the physical health of people with severe mental disorders (free)
2 – A Trial of a Triple-Drug Treatment for Lymphatic Filariasis – New England Journal of Medicine (free)
Editorial: Advancing toward the Elimination of Lymphatic Filariasis (free)
Commentary: Triple-Drug Therapy Superior to Two Drugs for Treating Lymphatic Filariasis – NEJM Journal Watch (free)
3 – Single-Dose Zoliflodacin (ETX0914) for Treatment of Urogenital Gonorrhea – New England Journal of Medicine (link to abstract – $ for full-text)
Related Perspective: Neisseria gonorrhoeae — Rising Infection Rates, Dwindling Treatment Options – New England Journal of Medicine (free)
Commentaries: Novel antibiotic shows promise in treatment of uncomplicated gonorrhea – NIH News Release (free) AND Experimental treatment appears effective against gonorrhea in small study – STAT (free) AND Single Dose of New Oral Antibiotic Cures Most Gonorrhea – Medscape (free registration required)
Commentaries: Among heart attack survivors, drug reduces chances of second heart attack or stroke – University of Colorado Anschutz Medical Campus (free) AND Alirocumab Linked to Lower Risk for Recurrent Ischemic CV Events – NEJM Journal Watch (free)
“An estimated 49 patients would need to be treated for 4 years to prevent one CV event.” (from NEJM Journal Watch)
6 – Head To Head: Could artificial intelligence make doctors obsolete? – The BMJ (free)
Commentaries: Could machines using artificial intelligence make doctors obsolete? – The BMJ (free) AND Stop hyping artificial intelligence—patients will always need human doctors – The BMJ (free)
7 – A Deep Learning Model to Predict a Diagnosis of Alzheimer Disease by Using 18F-FDG PET of the Brain – Radiology (free for a limited period)
Commentaries: Artificial intelligence predicts Alzheimer’s years before diagnosis – Radiology Society of North America (free) AND Expert reaction to study looking at AI technology, brain imaging and Alzheimer’s disease detection – Science Media Centre (free) AND AI May Detect Alzheimer’s Years Before Diagnosis – Medscape (free registration required)
8 – Guideline Synopsis: Incidental Pulmonary Nodules Detected on CT Images – JAMA (free for a limited period)
Commentary: Triple Therapy for COPD Tied to Fewer Exacerbations, More Pneumonia – NEJM Journal Watch (free)
Commentaries: Reduced screen time for young highly recommended for well-being – San Diego State University (free) AND Children and Screens: a Little Can Do a Lot of Damage – Medscape (free registration required)
Thu, November 8 – 10 Stories of The Day!
8 Nov, 2018 | 00:01h | UTC
See also: Executive Summary (free) AND Summary form ACC (free) AND Bradycardia Guideline Hub (free resources)
2 – Basic Emergency Care: approach to the acutely ill and injured – World Health Organization (free PDF)
3 – Podcast: Battle of the Heart Societies: Who Is Right–the US or Europe–Regarding How to Manage Hypertension? – JAMA (free)
Related: Impact of the Discordance Between Blood Pressure Guidelines (free perspective and commentaries)
4 – In win for open access, two major funders won’t cover publishing in hybrid journals – Science (free)
See also: Wellcome and Gates join bold European open-access plan – Nature (free) AND Wellcome is updating its open access policy (free) AND Big funders back plan for instant free access to journals, but researchers say it is risky for science – Science|Business (free)
Related: cOAlition S: Making Open Access a Reality by 2020 (free Statement and commentaries)
5 – Perspective: Why Doctors Hate Their Computers – The New Yorker (free)
“Digitization promises to make medical care easier and more efficient. But are screens coming between doctors and patients?”
6 – Review: State-of-the-Art Diagnosis and Treatment of Hypertension in Pregnancy – Mayo Clinic Proceedings (free)
7 – Review: Lower extremity arterial disease in patients with diabetes: a contemporary narrative review – Cardiovascular Diabetology (free)
Commentary: How Instant Soup, Noodle Burns Send Over 9500 Kids To ERs Each Year – Forbes (free)
Commentary: Link between vaccines and allergies dismissed – Karolinska Institutet (free)
Commentaries: Should there be a tax on red meat? – BBC (free) AND Taxing red meat would save many lives, research shows – The Guardian (free)
Related: To improve global health, tax the things that are killing us – Financial Times (free policies, articles and commentaries) AND Policy lessons from health taxes (free research and commentaries) AND Fiscal policies for diet and the prevention of noncommunicable diseases – World Health Organization (free) AND The Lancet taskforce on NCDs and economics (free series and commentaries)
Wed, November 7 – 10 Stories of The Day!
7 Nov, 2018 | 00:01h | UTC
News Release: New National Guidelines Seek to Improve Access to Palliative Care for People Living with Serious Illness (free)
Commentaries: Palliative care guidelines updated with increased focus on collaboration, communication – ACP Internist (free) AND New Palliative Care Guidelines Demand ‘Seismic Shift’ in Care – Medscape (free registration required)
Related: Summary of the international clinical guidelines for the management of hospital-acquired and ventilator-acquired pneumonia (free) AND International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia (free) AND Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society (free)
3 – Reduced Salt Intake for Heart Failure: A Systematic Review – JAMA Internal Medicine (free for a limited period)
Commentaries: Sodium Restriction in Heart Failure: Too Much Uncertainty—Do the Trials – JAMA Internal Medicine (free for a limited period) AND Review Questions Wisdom of Limiting Salt Intake in Heart Failure – NEJM Journal Watch (free) AND Review: Low-Sodium Diet for HF on Shaky Ground – MedPage Today (free registration required)
4 – Perspective: A Profusion of Diagnoses. That’s Good and Bad – The New York Times (10 articles per month are free)
“…we may also be medicalizing much of normal human behavior — labeling the healthy as diseased, and exposing them to undue risk of stigma, testing and treatment.”
Editorial: Long‐Term Survival Following Off‐Pump Coronary Surgery: Does Surgeon Experience Make a Difference? (free)
6 – Review: Lifestyle Modifications for Preventing and Treating Heart Failure – Journal of the American College of Cardiology (free for a limited period)
7 – Review: Causes and prevention of postoperative myocardial injury – European Journal of Preventive Cardiology (free)
8 – Review: Update on Perioperative Acute Kidney Injury – Anesthesia & Analgesia (free)
Commentaries: Repeated Vaccination May Protect Children From Influenza Infection – JAMA Network Open (free) AND What Getting The Flu Vaccine Every Year Does To Your Immunity – Forbes (free) AND Study: Kids’ flu vaccine protection not reduced by prior vaccination – CIDRAP (free)
10 – Age at last screening and remaining lifetime risk of cervical cancer in older, unvaccinated, HPV-negative women: a modelling study – The Lancet Oncology (link to abstract – $ for full-text)
Commentaries: Study finds there may be little benefit in screening women aged 55 with a negative HPV DNA test – The Lancet (free) AND New test could mean cervical cancer screening could stop sooner – OnMedica (free) AND At What Age Can We Stop Screening for Cervical Cancer? – NEJM Journal Watch (free)
Tue, November 6 – 10 Stories of The Day!
6 Nov, 2018 | 00:01h | UTC
1 – 2018 American Heart Association Focused Update on Advanced Cardiovascular Life Support Use of Antiarrhythmic Drugs During and Immediately After Cardiac Arrest: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care (free PDF) (via @gonzaeperez)
3 – A patient-level pooled analysis of treatment-shortening regimens for drug-susceptible pulmonary tuberculosis – Nature Medicine (link to abstract – $ for full-text)
Commentary: Pulmonary TB can be cured with shorter treatment, study finds – University of California – San Francisco (free)
4 – Policy Statement: Effective Discipline to Raise Healthy Children – American Academy of Pediatrics (free)
Commentaries: AAP policy opposes corporal punishment, draws on recent evidence – AAP News (free) AND Discipline vs. punishment: What works best for children? – AAP News (free) AND Pediatricians strengthen stance against spanking kids – CNN (free) AND Spanking Is Ineffective and Harmful to Children, Pediatricians’ Group Says – The New York Times (10 articles per month are free)
5 – Ann Robinson’s weekly research reviews, 5 November 2018 – The BMJ Opinion (free)
Ann Robinson reviews the latest research from the top medical journals.
6 – Podcast: #123 Sleep Apnea Pearls and Pitfalls – The Curbsiders Internal Medicine Podcast (free audio and summary)
7 – Guideline Summary: Updated clinical practice guidelines on pregnancy care – Medical Journal of Australia (free for 7 days)
See full guidelines: Pregnancy Care Guidelines and related documents – Australian Government Department of Health (free)
Related: 800,000 People Kill Themselves Every Year. What Can We do? (free Guidelines and commentary) AND Recommended Standard Care for People with Suicide Risk (free Guideline and commentary) AND Preventing Teen Suicide: What Does the Evidence Shows (free Guideline and commentary) AND AAP Clinical Report: Suicide and Suicide Attempts in Adolescents (free)
10 – Pedestrian Fatalities Associated With Halloween in the United States – JAMA Pediatrics (free for a limited period)
Commentaries: Pedestrian fatalities increase on Halloween, particularly among children – University of British Columbia (free) AND High risk of child pedestrian deaths at Halloween – OnMedica (free) AND Really Scary! Pediatric Pedestrian Fatalities 10x Higher on Halloween – MedicalResearch.com (free)
Mon, November 5 – 10 Stories of The Day!
5 Nov, 2018 | 00:01h | UTC
Commentaries: Lower threshold for platelet transfusions appears safer – HematologyTimes (free)
Commentary: Disagreements in Blood Pressure Guidelines Lead to Physician, Patient Confusion – Clinical Advisor (free) AND Competing hypertension guidelines: what’s a clinician to do? – Univadis (free registration required)
3 – Deprescribing: the fightback against polypharmacy has begun – The Pharmaceutical Journal (1 free article per month) (via @Deprescribing)
Related: Reducing Inappropriate Medication Use & Polypharmacy (several articles and commentaries on the subject) AND Deprescribing recommendations: An essential consideration for clinical guideline developers – Research in Social and Administrative Pharmacy (free)
4 – Case Report: Fatal Measles Virus Infection After Rituximab-Containing Chemotherapy in a Previously Vaccinated Patient – Open Forum Infectious Diseases (free)
Commentary: Fatal measles case highlights importance of herd immunity in protecting the vulnerable – Infectious Diseases Society of America (free)
5 – Things We Do For No Reason: Acute Treatment of Hypertensive Urgency – Journal of Hospital Medicine (free PDF)
6 – Perspective: Establishing the Effectiveness of Procedural Interventions: The Limited Role of Randomized Trials – JAMA (free for a limited period)
7 – Perspective: Accreditation, Quality, and Making Hospital Care Better – JAMA Forum (free)
Related: Questioning One of Healthcare’s Sacred Cows – Op-Med (free)
See Original Study: Hospital Accreditation not Associated with Better Outcomes in Observational Study (free study and commentaries)
Full Report: Stroke Prevention in Patients With Atrial Fibrillation: A Systematic Review Update (free PDF)
10 – Effect of Digital Cognitive Behavioral Therapy for Insomnia on Health, Psychological Well-being, and Sleep-Related Quality of Life: A Randomized Clinical Trial – JAMA Psychiatry (link to abstract – $ for full-text)
Commentaries: E-therapy may help ease insomnia – Reuters (free) AND Some Apps May Help Curb Insomnia, Others Just Put You To Sleep – NPR (free) AND Insomnia symptoms, overall health improve with online insomnia program – Northwestern University (free)
Fri, November 2 – 10 Stories of The Day!
2 Nov, 2018 | 01:12h | UTC
1 – Guidelines for the safe practice of total intravenous anaesthesia (TIVA) – Anaesthesia (free)
2 – Pediatric Readiness in the Emergency Department – Pediatrics (free)
News Release: Groups update joint guidance on pediatric emergency care (free)
Commentary: Popular drug combination for treatment resistant depression is not more effective than a single antidepressant in primary care – University of Bristol (free)
4 – Report: Cell Phone Radio Frequency Radiation – National Toxicology Program (free)
Commentaries: High exposure to radio frequency radiation associated with cancer in male rats – NIH News Releases (free) AND Expert reaction to study on mobile phones and rats – Science Media Centre (free) AND Study of Cellphone Risks Finds ‘Some Evidence’ of Link to Cancer, at Least in Male Rats – The New York Times (10 articles per month are free)
5 – Perspective: Current and Future Landscape of Nutritional Epidemiologic Research – JAMA (free for a limited period)
6 – Perspective: The Emperor’s New Clothes: a Critical Appraisal of Evidence-based Medicine – International Journal of Medical Sciences (free)
8 – Myocarditis in Adults: ED Presentations, Evaluation, and Management – emDocs (free)
Related: Effects of Sodium and Potassium Intake on Chronic Disease Outcomes and Risks (free report and summary) AND Urinary Sodium Excretion, Blood Pressure, Cardiovascular Disease, and Mortality (link to abstract and commentaries) AND Salt intake and Cardiovascular Disease (free report and commentary)
Wed, October 31 – 10 Stories of The Day!
31 Oct, 2018 | 01:28h | UTC
1 – Association of Short Interpregnancy Interval With Pregnancy Outcomes According to Maternal Age – JAMA Internal Medicine (free for a limited period)
Commentaries: Balancing the Risks and Desires for Pregnancy in Older Mothers: Increasing Morbidity, Declining Fertility – JAMA Internal Medicine (free for a limited period) AND Women ‘should leave at least a year between pregnancies’ – NHS Choices (free) AND Waiting a year between pregnancies lowers health risks, study says – CNN (free) AND Study: Do Even Older Moms Have To Wait 18 Months Between Pregnancies? – CommonHealth (free)
“It seems unlikely that cannabinoids are highly effective medicines for chronic noncancer pain conditions.”
3 – Prevalence of Financial Conflicts of Interest Among Authors of Clinical Guidelines Related to High-Revenue Medications – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: More Than Half of Physician Guideline Authors for Expensive Medications Have Undeclared Conflicts of Interest – MedicalResearch.com (free) AND Many Clinical Guideline Authors Have Undeclared Payments – Medical Health News (free)
4 – Unpublished medical research ‘a threat to public health’ – BBC (free)
5 – Perspective: Surgical Value — Beyond Bundled Payments – NEJM Catalyst (free)
7 – Deep Learning for MR Angiography: Automated Detection of Cerebral Aneurysms – Radiology (free) (@EricTopol)
Editorial: Take turmeric with a grain of salt (free)
Commentary: Oral curcumin shows no benefit in reducing inflammation following vascular surgery – Canadian Medical Association Journal (free)
9 – Book: The Safe Food Imperative: Accelerating Progress in Low- and Middle-Income Countries – The World Bank (free PDF)
Commentary: DOACs in AF: Observational and Randomized Studies Don’t Always Agree – Medscape (free registration required)
Thu, November 1 – 10 Stories of The Day!
1 Nov, 2018 | 00:01h | UTC
1 – Antimicrobial prescribing guidelines – National Institute for Health and Care Excellence (free resources)
Just Published Guidelines: Urinary tract infection (lower): antimicrobial prescribing (free) AND Urinary tract infection (recurrent): antimicrobial prescribing (free) AND Pyelonephritis (acute): antimicrobial prescribing (free) AND Prostatitis (acute): antimicrobial prescribing (free)
See also: Summary of antimicrobial prescribing guidance – managing common infections – National Institute for Health and Care Excellence (free PDF)
Related Study: Survival after Minimally Invasive Radical Hysterectomy for Early-Stage Cervical Cancer – New England Journal of Medicine (free)
Editorial: Surgery in Cervical Cancer – New England Journal of Medicine (free)
Commentaries: Studies Warn Against Minimally Invasive Surgery for Cervical Cancer – The New York Times (10 articles per month are free) AND More deaths seen for less invasive cervical cancer surgery – STAT (free) AND For Cervical Cancer Patients, Less Invasive Surgery Is Worse For Survival – NPR (free)
Commentaries: The association between BMI and mortality: implications for obesity prevention – The Lancet Diabetes & Endocrinology (free) AND BMI of 21-25kg/m2 linked to lowest risk of dying from cancer and heart disease – London School of Hygiene & Tropical Medicine (free) AND Being too fat or too thin ‘can cost four years of life’ – BBC (free)
Commentaries: Expert reaction to study looking at plant based or vegan diets and type 2 diabetes – Science Media Centre (free) AND Vegan diet linked to better diabetes control and wellbeing – OnMedica (free)
5 – Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD) – Cochrane Library (free)
Summary: Preventative antibiotic therapy for people with COPD – Cochrane Library (free)
“Use of continuous and intermittent prophylactic antibiotics results in a clinically significant benefit in reducing exacerbations in COPD patients.”
6 – Revised Australian national guidelines for colorectal cancer screening: family history – Medical Journal of Australia (free for 7 days)
7 – Targeted neurotechnology restores walking in humans with spinal cord injury – Nature (free)
Editorial: Paralysed people walk again after spinal-cord stimulation (free)
Commentaries: Spinal implant helps three paralysed men walk again – BBC (free) AND Once Paralyzed, Three Men Take Steps Again With Spinal Implant – The New York Times (10 articles per month are free)
8 – Review: Management of Cancer-Therapy-Induced LV Dysfunction: Can the Guidelines Help? – American College of Cardiology (free) (via @md_arianemacedo)
Related: Cardio-Onco-Hematology in Clinical Practice (series of reviews and guidelines on the subject)
9 – Payment Designed for People: Introducing the Primary Care Outcomes Model – NEJM Catalyst (free)
Related Study: Early Antibiotic Exposure and Weight Outcomes in Young Children – Pediatrics (link to abstract – $ for full-text)
Commentaries: Expert reaction to antibiotic and antacid use in early childhood and risk of obesity – Science Media Centre (free) AND Antibiotic Exposure in Early Life Tied to Slightly Higher Obesity Risk – NEJM Journal Watch (free) AND Antibiotics, H2RAs and PPIs linked to child obesity – OnMedica (free) AND Two studies tie early antibiotic exposure to increased obesity risk – CIDRAP (free)
Mon, October 29 – 10 Stories of The Day!
29 Oct, 2018 | 00:01h | UTC
1 – Guideline: Myeloma: diagnosis and management – National Institute for Health and Care Excellence (free)
“Proactive administration of high-dose iv iron did not adversely affect mortality or CV events, but enabled reduced erythropoiesis-stimulating agent dosing and transfusion rates.” (via @NatRevNeph see Tweet)
News Release: WHO launches new guideline on health policy and system support to optimize community health worker programmes (free)
Related: Health policy and system support to optimise community health worker programmes: an abridged WHO guideline – The Lancet Global Health (free)
4 – Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of hospital stay and postoperative complications – Cochrane Library (free)
This review suggests that early enteral feeding is associated with a shorter length of hospital stay. For all other outcomes (postoperative complications, mortality, adverse events, and QoL) the findings are inconclusive.
5 – Perspective: Overdiagnosis of Penicillin Allergy Leads to Costly, Inappropriate Treatment – JAMA (free for a limited period)
Related: NICE: Double Check Patients with ‘Penicillin Allergy’ to Avoid Increased MRSA Risk (free) AND Antibiotic Use After Removal of Penicillin Allergy Label (link to abstract and commentaries) AND Allergy Testing in Children With Low-Risk Penicillin Allergy Symptoms (link to abstract and commentaries)
7 – Physician burnout costs up to $17B a year, task force says – HealthcareDive (free)
Related Position Paper: The Business Case for Humanity in Healthcare – National Taskforce for Humanity in Healthcare (free PDF)
Related: Systematic Review: Prevalence of Burnout Among Physicians (link to abstract and commentaries) AND Implementing Optimal Team-Based Care to Reduce Clinician Burnout (free review and commentaries) AND Association Between Physician Burnout and Patient Safety, Professionalism, and Patient Satisfaction (link to abstract and commentaries) AND Physician Burnout Can Lead to Major Medical Errors (link to abstract and commentaries) AND The Burnout Crisis in American Medicine (free perspectives on the subject)
8 – The fight against non-communicable disease in emerging economies – Nature (free)
“Health-care providers in low- and middle-income countries are shifting their focus away from infections, and towards the bigger problems of diabetes and cardiovascular disease.”
9 – Review: Optimizing medication management for patients with cirrhosis: Evidence‐based strategies and their outcomes – Liver International (free) (via @Abraham_RMI)
10 – Albumin administrations can prolong survival for some people with liver disease – NIHR Signal (free)
Original Article: Long-term albumin administration in decompensated cirrhosis (ANSWER): an open-label randomised trial – The Lancet (link to abstract – $ for full-text)
Tue, October 30 – 10 Stories of The Day!
30 Oct, 2018 | 01:15h | UTC
1 – Report: Air pollution and child health: prescribing clean air – World Health Organization (free)
Commentaries: WHO says air pollution kills 600,000 children every year – Reuters (free) AND 90% of world’s children are breathing toxic air, WHO study finds – The Guardian (free)
Related: How air pollution is destroying our health – World Health Organization (free) AND Air pollution is the ‘new tobacco’, warns WHO head – The Guardian (free)
Commentaries: Effectiveness and Safety of Bariatric Procedures for Weight Loss – Annals of Internal Medicine (free) AND Gastric bypass surgery associated with greater weight loss in adults – Kaiser Permanente (free)
3 – Modernized Classification of Cardiac Antiarrhythmic Drugs – Circulation (free)
4 – Drug-Induced Interstitial Lung Disease: A Systematic Review – Journal of Clinical Medicine (free)
Commentary: Drugs’ side effects in lungs ‘more widespread than thought’ – The University of Manchester (free)
5 – Alex Nowbar’s research reviews, 29 October 2018 – The BMJ Opinion (free)
Alex Nowbar reviews the latest research from the top medical journals.
6 – Podcast: #122 Headaches Advanced Class: Migraines, medication overuse, and more! – Curbsiders Internal Medicine Podcast (free audio and summary)
Related: A huge database of scientific retractions is live. That’s great for science. – VOX (free)
8 – Benefits and Harms of Antihypertensive Treatment in Low-Risk Patients With Mild Hypertension – JAMA Internal Medicine (free for a limited period)
Commentaries: Treatment for moderately high blood pressure may be best saved for those at high risk – University of Cambridge (free) AND Study Questions Whether Treating Mild Hypertension Benefits Patients – NEJM Journal Watch (free)
Commentary: A healthy lifestyle cuts stroke risk, irrespective of genetic risk – University of Cambridge (free)
Mon, October 22 – 10 Stories of The Day!
22 Oct, 2018 | 00:46h | UTC
1 – Effect of Theophylline as Adjunct to Inhaled Corticosteroids on Exacerbations in Patients With COPD: A Randomized Clinical Trial – JAMA (free for a limited period)
Commentaries: TWICS results suggest no role for low-dose theophylline as add-on therapy in COPD – Medwire News (free) AND Low-Dose Theophylline Not Effective at Reducing COPD Exacerbations, Study Finds – AJMC (free)
Commentaries: Joint Commission accreditation doesn’t lead to better outcomes, study shows – Modern Healthcare (free) AND Doubt cast on value of hospital accreditation in Harvard study – Healthcare Dive (free)
Invited Commentary: Steroid injection or wrist splint for first-time carpal tunnel syndrome? (free)
“A single corticosteroid injection shows superior clinical effectiveness at 6 weeks compared with night-resting splints.”
News Release: New report asks why doctors find it so hard to talk to patients about dying (free)
Commentaries: Doctors must talk ‘honestly’ to patients about dying – OnMedica (free) AND Doctors ‘need to start early conversation with patients about dying’ – BBC (free)
Related Article: Screen media use and ADHD-related behaviors: Four decades of research – Proceedings of the National Academy of Sciences (free)
7 – Review: Eosinophilic Esophagitis: Review and Update – Frontiers in Medicine (free)
9 – Prokinetics for functional dyspepsia – Cochrane Library (free)
Summary: Medications which promote stomach movement to relieve upper abdominal discomfort that does not have a specific cause – Cochrane Library (free)
“We are unable to say whether prokinetics are effective for the treatment of functional dyspepsia.”
Commentaries: Expansive New Study Says Not Exercising Is Worse for Your Health Than Smoking – TIME (free) AND Researchers show better cardiorespiratory fitness leads to longer life – MedicalXpress (free)
Fri, October 26 – 10 Stories of The Day!
26 Oct, 2018 | 00:04h | UTC
1 – Oxygen therapy for acutely ill medical patients: a clinical practice guideline – The BMJ (free)
News Release: New guidance recommends minimal oxygen use for most people in hospital – The BMJ (free)
Related: Multimorbidity: A Priority for Global Health Research (free report and commentaries) AND Meta-Analysis: Effectiveness of Interventions for Managing Multiple High-Burden Chronic Diseases in Older Adults (free study and commentaries) Designing a High-Performing Health Care System for Patients with Complex Needs (several perspectives on the subject)
4 – Perspective: The troubling epidemic of unnecessary C-sections around the world, explained – VOX (free)
Related WHO Recommendations: Non-Clinical Interventions to Reduce Unnecessary Cesarean Sections (free guideline and commentaries)
Related The Lancet Series: Optimising Cesarean Section Use (free articles)
Related Cochrane Review: Non‐Clinical Interventions for Reducing Unnecessary Caesarean Section (free review and summary)
“The C-section rate has doubled in less than a generation, from 12 percent of all births in 2000 to 21 percent in 2015.”
5 – The skeptic: What precision medicine revolution? – MIT Technology Review (free)
Related: What Precisely Is Precision Oncology—and Will It Work? – The ASCO Post (free)
6 – Review: Similarities and differences between biliary sludge and microlithiasis: Their clinical and pathophysiological significances – Liver Research (free)
7 – Review: Pacemaker‐mediated arrhythmias – Journal of Arrythmia (free)
8 – Low-dose imipramine for refractory functional dyspepsia: a randomised, double-blind, placebo-controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)
Commentary: Refractory functional dyspepsia: low-dose imipramine safe, effective – Univadis (free registration required)
Editorial: Angiotensin converting enzyme inhibitors and lung cancer (free)
Commentaries: Blood pressure drug linked to possible small increased risk of lung cancer – NHS Choices (free) AND Expert reaction to study looking at blood pressure drugs and lung cancer risk – Science Media Centre (free)
“Using the adjuvant recombinant subunit vaccine might prevent more cases of herpes zoster than using the live attenuated vaccine, but the adjuvant recombinant subunit vaccine also carries a greater risk of adverse events at injection sites.”
Thu, October 25 – 10 Stories of The Day!
25 Oct, 2018 | 00:01h | UTC
1 – Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU – New England Journal of Medicine (free for a limited period)
Editorial: Proton-Pump Inhibitor Prophylaxis in the ICU — Benefits Worth the Risks? (free for a limited period)
“Proton pump inhibitors are minimally effective to reduce GI bleeding among the critically ill folks at high risk for stress ulcers. Takeaways: no role for routine PPI for any patients on the WARDS, and shouldn’t be considered ‘routine’ in the ICU” (via @AnilMakam see Tweet)
2 – Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients with Severe Traumatic Brain Injury: The POLAR Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Hypothermia After Traumatic Brain Injury (free)
Commentary: Hypothermia for Severe TBI Called into Question – NEJM Journal Watch (free)
3 – Effect of a Low vs Intermediate Tidal Volume Strategy on Ventilator-Free Days in Intensive Care Unit Patients Without ARDS: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Lessons From ARDS for Non-ARDS Research: Remembrance of Trials Past (free)
“Among patients in the ICU receiving invasive ventilation, a strategy with low tidal volume was not more effective than a strategy using intermediate tidal volume.”
Commentaries: Your risk of a heart attack could increase as it gets colder, study says – CNN (free) AND Cold, cloudy weather ‘could increase your risk of having heart attack’ – The Guardian (free)
Editorial: The Ongoing Saga of Optimal Blood Pressure Level in Patients With Diabetes Mellitus and Coronary Artery Disease (free)
“A U‐shaped relationship between cardiovascular outcomes and BPs was observed.”
Editorial: New Curveball for Hypertension Guidelines? Blood Pressure Targets in Peripheral Artery Disease (free)
“we found a higher rate of lower extremity PAD events with higher and lower SBP and pulse pressure and with lower DBP.”
Commentaries: Score predicts 90-day readmission risk after myocardial infarction – ACP Hospitalist (free) AND Novel risk predictor identifies likelihood of readmission after AMI – Cardiovascular Business (free)
8 – Review: Pulmonary Embolism: Contemporary Medical Management and Future Perspectives – Annals of Vascular Disease (free PDF)
Related Guideline: Surgical Management of Lower Urinary Tract Symptoms attributed to BPH (free guideline and commentary)
Original Article: Self-monitoring blood glucose improves glycemic control in type 2 diabetes without intensive treatment: A systematic review and meta-analysis – Diabetes Research and Clinical Practice (link to abstract – $ for full-text)
Wed, October 24 – 10 Stories of The Day!
24 Oct, 2018 | 00:01h | UTC
1 – ACTIVE: A technical package for increasing physical activity – World Health Organization (free PDF)
News Release: WHO launches ACTIVE: a toolkit for countries to increase physical activity and reduce noncommunicable diseases (free)
Editorials: Challenges and Opportunities for Studying Routine Screening for Abuse (free) AND Addressing Intimate Partner Violence and Abuse of Older or Vulnerable Adults in the Health Care Setting—Beyond Screening (free)
4 – Perspective: Superfoods Are a Marketing Ploy – The Atlantic (free) (via @edyong209 and @onisillos)
5 – Perspective: The Problem With Probiotics – The New York Times (free)
Related: Probiotic Safety—No Guarantees (free perspective)
“There are potential harms as well as benefits, and a lot of wishful thinking and imprecision in the marketing of products containing them.”
6 – Perspective: The Price of Knowledge: Industry-Sponsored Studies in the Era of Evidence-Based Medicine – TCTMD (free)
“How to reduce emergency doctor misinterpretation of wrist X-rays for fracture by nearly 50%? Deep learning AI, of course” (via @EricTopol see Tweet)
8 – Association of Frequency of Organic Food Consumption With Cancer Risk: Findings From the NutriNet-Santé Prospective Cohort Study – JAMA Internal Medicine (free for a limited period)
Commentaries: Organic Foods for Cancer Prevention—Worth the Investment? – JAMA Internal Medicine (free for a limited period) AND Organic food and cancer – Science Media Centre (free) AND Organic foods tied to slightly lower cancer risk – Reuters (free)
9 – Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer – New England Journal of Medicine (free for a limited period)
Commentaries: Not So Fast With Immune Therapy For Breast Cancer – Forbes (free) AND Immunotherapy drugs show some promise against breast cancer – STAT (free)
“…the benefit for most women was small, raising questions about whether the treatment is worth its high cost and side effects.” (from STAT)
10 – Diagnosis of Pulmonary Embolism During Pregnancy: A Multicenter Prospective Management Outcome Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Algorithm Rules Out Pulmonary Embolism in Pregnancy – NEJM Journal Watch (free) AND Algorithm Validated for Pulmonary Embolism Diagnosis in Pregnancy – MedPage Today (free registration required)
Tue, October 23 – 10 Stories of The Day!
23 Oct, 2018 | 00:01h | UTC
#LIVE2018 – Highlights from the European Society of Intensive Care Medicine Congress (via Critical Care Reviews)
1 – #LIVE2018 – Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness – New England Journal of Medicine (free for a limited period)
Editorial: Dopamine Antagonists in ICU Delirium (free for a limited period)
Commentaries: Common use of antipsychotics shown ineffective for delirium in intensive care patients – NIH News Releases (free) AND Antipsychotic Drugs Don’t Ease ICU Delirium Or Dementia – NPR (free) AND Antipsychotics ineffective for treating ICU delirium – Vanderbilt University Medical Center (free)
Related Research: Effect of Haloperidol on Survival Among Critically Ill Adults With a High Risk of Delirium (free)
2 – #LIVE2018 – Energy-Dense versus Routine Enteral Nutrition in the Critically Ill – New England Journal of Medicine (free for a limited period)
Energy-dense formulation for enteral delivery of nutrition was not associated with better outcomes.
3 – #LIVE2018 – Decontamination Strategies and Bloodstream Infections With Antibiotic-Resistant Microorganisms in Ventilated Patients: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Decontamination of Oral or Digestive Tract for Patients in the Intensive Care Unit (free for a limited period)
“Among patients receiving mechanical ventilation in ICUs with moderate to high ABX resistance prevalence, use of chlorhexidine mouthwash, selective oropharyngeal decontamination, or selective digestive tract decontamination was not associated with reductions in ICU-acquired bloodstream infections caused by MDRGNB vs standard care” (via @JAMA_current see Tweet with visual abstract)
4 – #LIVE2018 – Effect of Protocolized Weaning With Early Extubation to Noninvasive Ventilation vs Invasive Weaning on Time to Liberation From Mechanical Ventilation Among Patients With Respiratory Failure: The Breathe Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Weaning From Mechanical VentilationWhat Should Be Done When a Patient’s Spontaneous Breathing Trial Fails? (free for a limited period)
“Among patients requiring mechanical ventilation in whom a spontaneous breathing trial had failed, early extubation to noninvasive ventilation did not shorten time to liberation from any ventilation.”
5 – The Artificial Intelligence Clinician learns optimal treatment strategies for sepsis in intensive care – Nature Medicine (free link via Critical Care Reviews)
Commentaries: AI doctor could boost chance of survival for sepsis patients – Imperial College London (free) AND Artificial intelligence system could improve survival for sepsis patients – NHS National Institute for Health Research (free)
6 – Videos: Order Wisely®: Appropriate use of tests & treatments – High Value Practice Academic Alliance (free) (via @KariTikkinen)
Comprehensive educational program that reviews appropriate use of imaging exams, lab tests, medications, transfusions and procedures to promote high-value practice.
7 – Podcast: #121 HIV Care for the Internist – Curbsiders Internal Medicine Podcast (free audio and summary)
8 – Alex Nowbar’s research reviews—22 October 2018 – The BMJ Opinion (free)
Alex Nowbar reviews the latest research from the top medical journals.
9 – Want To Keep Your Brain Sharp? Take Care Of Your Eyes And Ears – NPR (free)
Related Articles: Longitudinal Relationship Between Hearing Aid Use and Cognitive Function in Older Americans – Journal of the American Geriatrics Society (free) AND Cataract surgery and age-related cognitive decline: A 13-year follow-up of the English Longitudinal Study of Ageing – NPR (free)
Commentaries: Radiotherapy for newly diagnosed oligometastatic prostate cancer – The Lancet (free) AND ESMO 2018: Local radiotherapy improves survival in metastatic prostate cancer with low disease burden – eCancer News (free) AND Radiotherapy offers hopes in advanced prostate cancer – OnMedica (free) AND Cancer trial shows treating the prostate with radiotherapy improves survival – University of Birmingham (free)
Thu, October 18 – 10 Stories of The Day!
18 Oct, 2018 | 00:01h | UTC
Commentaries: Major strides in forecasting future health – The Lancet (free) AND Why Life Expectancy in 2040 Could Be Lower Than It Is Today – LiveScience (free) AND How healthy will we be in 2040? – Institute for Health Metrics and Evaluation (free)
2 – Acute Flaccid Myelitis Investigation Page – Centers for Disease Control and Prevention (free)
Commentaries: CDC, partners probe 127 polio-like cases in 22 states – CIDRAP (free) AND CDC Investigates Cases Of Rare Neurological ‘Mystery Illness’ In Kids – NPR (free) AND Acute Flaccid Myelitis Cases Confirmed in 22 States Physician’s First Watch (free) AND CDC expresses concern over mysterious surge in polio-like paralysis cases – STAT (free)
Related: Cardiovascular Toxicity in Cancer Survivors (free review and guidelines) AND Burden of cardiovascular risk factors and cardiovascular disease in childhood cancer survivors (link to abstract and commentaries) AND The cumulative burden of surviving childhood cancer (link to abstract and commentaries) AND Endocrine Late Effects in Survivors of Cancer in Adolescence and Young Adulthood (free study and commentaries) AND Endocrine Disorders in Survivors of Childhood Cancer (free guideline and commentaries)
4 – Australia is responding to the complex challenge of overdiagnosis – The Medical Journal of Australia (free for 7 days)
Commentaries: Overdiagnosis: a deep cultural problem – MJA InSight (free) AND Overdiagnosis is harming patients and action is required, says chief medical officer – The Sidney Morning Herald (free)
Related: Overdiagnosis: causes and consequences in primary health care – Canadian Family Physician (free) AND Overdiagnosis across medical disciplines: a scoping review – The BMJ Open (free) AND Too much medical care: bad for you, bad for health care systems – STAT News (free) AND Overdiagnosis: what it is and what it isn’t – BMJ Evidence Based Medicine (free) AND Screening: How overdiagnosis and other harms can undermine the benefits – Health News Review (free) AND Position Paper on Overdiagnosis and Action to be Taken – Wonca (free PDF)
5 – Podcast: #119 Nutrition Pearls, Heart Health, Bacon – Curbsiders Internal Medicine Podcast (free audio and summary)
6 – Sarcopenia: revised European consensus on definition and diagnosis – Age and Ageing (free)
8 – Progestogen for preventing miscarriage in women with recurrent miscarriage of unclear etiology – Cochrane Library (free for a limited period)
Summary: Progestogen for preventing miscarriage – Cochrane Library (free)
Commentaries: Study Finds Deep Learning Can Distinguish Recalled-Benign Mammogram Images From Malignant and Negative Cases – The ASCO Post (free) AND AI distinguishes false-positive mammograms from malignant, negative mammograms – Radiology Business (free) AND Deep learning can distinguish recalled-benign mammograms from malignant and negative images – eCancer News (free)
10 – Hospital Readmission Following Takotsubo Syndrome – European Heart Journal – Quality of Care and Clinical Outcomes (link to abstract – $ for full-text)
Commentaries: Takotsubo Syndrome Linked to Heart Failure Admissions and Mortality Risk in Nationwide Study – TCTMD (free) AND Avoiding Broken-Heart Syndrome Readmissions – MedPage Today (free registration required)
Related: International Registry: Long-Term Prognosis of Patients With Takotsubo Syndrome (link to abstract and commentaries) International Expert Consensus Document on Takotsubo Syndrome (free guideline) AND Review: Takotsubo Syndrome (free reviews)
Fri, October 19 – 10 Stories of The Day!
19 Oct, 2018 | 00:01h | UTC
1 – Pre-eclampsia and risk of dementia later in life: nationwide cohort study – The BMJ (free)
Editorial: Pre-eclampsia and the brain (free)
Commentaries: Pre-eclampsia linked to raised risk of vascular dementia – OnMedica (free) AND Pre-eclampsia linked to an increased risk of dementia later in life – The BMJ (free)
2 – Perspective: To Prevent Cardiovascular Disease, Pay Attention to Pregnancy Complications – JAMA (free for a limited period)
Related: Hypertensive Disorders of Pregnancy and Maternal Cardiovascular Disease (link to abstract and commentaries)
3 – Enhanced Recovery in Surgical Intensive Care: A Review – Frontiers in Medicine (free)
4 – Review: Newer technologies for detection of atrial fibrillation – The BMJ (free for a limited period)
5 – Effect of Cricoid Pressure Compared With a Sham Procedure in the Rapid Sequence Induction of Anesthesia: The IRIS Randomized Clinical Trial – JAMA Surgery (free for a limited period)
Commentaries: Is 30 Newtons of Prevention Worth a Pound of a Cure?—Cricoid Pressure – JAMA Surgery (free for a limited period) AND The Case of the Inferior Superiority – EMNerd (free)
Commentary: Long-term safety of silicone breast implants still unclear – Reuters (free)
7 – See It, Want It, Buy It, Eat It – Cancer Research UK (free PDF)
Commentaries: Time spent by children online linked to requests for junk food – University of Liverpool (free) AND Does TV and internet advertising feed children’s junk food habits? – NHS Choices (free)
8 – Deep learning algorithms for detection of critical findings in head CT scans: a retrospective study – The Lancet (link to abstract – $ for full-text)
Commentary: AI: Deep Learning Algorithms Can Detect Critical Head CT Findings – MedicalResearch.com (free)
9 – Antidepressant withdrawal: reviewing the paper behind the headlines – The Mental Elf (free) (via @AllenFrancesMD)
Original Systematic Review: Antidepressant Withdrawal Effects (free article and commentaries)
“Last week a new review said: – Over half of people taking antidepressants experience withdrawal symptoms – These symptoms are severe in over half of cases. The press had a field day! Our blog today by @J_F_Hayes and @sameerjauhar offers a different view” (via @Mental_Elf see Tweet)
10 – Association of Aspirin With Prevention of Venous Thromboembolism in Patients After Total Knee Arthroplasty Compared With Other Anticoagulants: A Noninferiority Analysis – JAMA Surgery (link to abstract – $ for full-text)
Commentaries: More Research Supports Use of Aspirin Alone to Prevent VTE After Knee Replacement Surgery – TCTMD (free) AND Aspirin Noninferior to Other Anticoagulants in Knee Arthroplasty – Journal Watch (free)
Related Randomized Trial: Aspirin Starting Five Days After Hip or Knee Arthroplasty for VTE Prophylaxis (link to abstract, video summary and commentary)
Wed, October 17 – 10 Stories of The Day!
17 Oct, 2018 | 00:01h | UTC
1 – Association Between Bariatric Surgery and Macrovascular Disease Outcomes in Patients With Type 2 Diabetes and Severe Obesity – JAMA (link to abstract – $ for full-text)
Video Summary: How Does Bariatric Surgery Compare With Medical Care for Reducing Cardiovascular Disease in Patients With Type 2 Diabetes? (free)
Commentary: Obesity surgery may lower heart attack danger in diabetics – Associated Press (free)
2 – Perspective: The New Age of Patient Autonomy: Implications for the Patient-Physician Relationship – JAMA (free for a limited period) (via @EricTopol)
3 – Perspective: What should we stop doing in the ICU? – ICU Management & Practice (free)
4 – Perspective: I hate guidelines (but they can improve and you can help) – First10Em (free) (via @srrezaie)
5 – Review: Treatments targeting inotropy – European Heart Journal (free)
6 – Review: Disseminated Intravascular Coagulation: An Update on Pathogenesis, Diagnosis, and Therapeutic Strategies – Clinical and Applied Thrombosis/Hemostasis (free)
Source: Critical Care Reviews Newsletter
7 – Researcher Requests for Inappropriate Analysis and Reporting: A U.S. Survey of Consulting Biostatisticians – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary: When scientists want their data fudged and why you should care – CBC (free)
8 – Heart disease used to be an ailment of the rich. But it’s now striking the world’s poor. – VOX (free)
“In 2016, an estimated 1 million people died of HIV/AIDS, 445,000 people died of malaria, and 1.7 million died of tuberculosis. Nearly 18 million died of heart disease. And more than three-quarters of those deaths occurred in the developing world.”
9 – Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems – Cochrane Library (free for a limited period)
Summary: Calcium supplementation during pregnancy for preventing blood pressure disorders and related problems – Cochrane Library (free)
10 – Early clindamycin for bacterial vaginosis in pregnancy (PREMEVA): a multicentre, double-blind, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Commentary: Study: Antibiotics for bacterial vaginosis don’t cut preterm birth risk – CIDRAP (free)
Tue, October 16 – 10 Stories of The Day!
16 Oct, 2018 | 00:01h | UTC
Commentary: Global study finds youngest in class more likely to be diagnosed with ADHD – University of Adelaide (free)
“Youngest kids in class much more likely get ADHD diagnosis than oldest. Bad News: Simple immaturity now turned into mental illness & treated with meds” (via @AllenFrancesMD see Tweet)
2 – Many Analysts, One Data Set: Making Transparent How Variations in Analytic Choices Affect Results – Advances in Methods and Practices in Psychological Science (free) (via @f_g_zampieri)
“This is one of most important studies published this century. 29 teams used same data set to address same research question; estimated effect sizes ranged from 0.89 to 2.93 in odds-ratio units. Dramatic implications for observational research.” (via @hmkyale see Tweet)
3 – WHO Statement: Ebola virus disease – Democratic Republic of the Congo – World Health Organization (free)
Related: DR Congo: managing Ebola virus in war – The Lancet (free) AND Ebola experts from CDC were pulled from outbreak zone amid security concern – STAT (free) AND Ebola showed up in a war zone. It’s not going well – VOX (free) AND Experts Said A War Zone Ebola Outbreak Would Be A Nightmare. It’s Been Even Worse – HuffPost (free) AND DRC Ebola cases top 200 as security problems fuel the spike – CIDRAP (free)
Related: Innovation for Pandemics (free perspectives and video on the subject)
5 – Ann Robinson’s research reviews, 15 October 2018 – The BMJ Opinion (free)
Ann Robinson reviews the latest research from the top medical journals.
6 – Demystifying serotonin syndrome (or serotonin toxicity) – Canadian Family Physician (free)
8 – Oliguria in critically ill patients: a narrative review – Journal of Nephrology (free)
Source: Critical Care Reviews Newsletter
9 – β-Blocker Use in Pregnancy and the Risk for Congenital Malformations: An International Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Beta-Blocker Use in First Trimester Seems Safe – Physician’s First Watch (free) AND Beta-blocker Use in Pregnancy Doesn’t Up Birth Defect Risk, Study Suggests – TCTMD (free)
10 – Identity inference of genomic data using long-range familial searches – Science (free for a limited period)
Commentaries: Most White Americans’ DNA Can Be Identified Through Genealogy Databases – The New York Times (10 articles per month are free) AND How an Unlikely Family History Website Transformed Cold Case Investigations – The New York Times (10 articles per month are free) AND ‘We are increasingly exposed’: New studies show how easy it is to identify people using genetic databases – STAT (free) AND Supercharged crime-scene DNA analysis sparks privacy concerns – Nature (free)