TOP 10 Medical News Stories

10 – Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life – Cochrane Library (free)

Summary: Vitamin and mineral supplementation for preventing cognitive deterioration in cognitively healthy people in mid and late life – Cochrane Library (free)

Commentary: Preventing dementia: do vitamin and mineral supplements have a role? – Evidently Cochrane (free)

Tue, January 8 – 10 Stories of The Day!

8 Jan, 2019 | 00:01h | UTC

1 – Special Issue: Patient Optimization Before Surgery – Anaesthesia (free supplement)

Editorial: Patient optimisation before surgery: a clear and present challenge in peri‐operative care

– Risk prediction models for major surgery: composing a new tune

– Shared decision‐making in peri‐operative medicine: a narrative review

– Multi‐modal prehabilitation: addressing the why, when, what, how, who and where next?

– Pre‐operative nutrition and the elective surgical patient: why, how and what?

– Pre‐operative respiratory optimisation: an expert review

– Optimisation of pre‐operative anaemia in patients before elective major surgery – why, who, when and how?

– Pre‐operative optimisation of the surgical patient with diagnosed and undiagnosed diabetes: a practical review

– Pre‐operative cardiac optimisation: a directed review

– Peri‐operative optimisation of elderly and frail patients: a narrative review

– Peri‐operative care pathways: re‐engineering care to achieve the ‘triple aim’

– Pre‐optimisation of patients undergoing emergency laparotomy: a review of best practice

2 – Sustainability of Blood Pressure Reduction in Black Barbershops – Circulation (free)

Commentaries: One year later, barbershop intervention continues to lower blood pressure – American Heart Association (free) AND Barbershop Intervention for High BP Has Lasting Effects – TCTMD (free) AND How barbershops could help lower blood pressure – CNN (free)

Related Studies: Cluster-Randomized Trial of Blood-Pressure Reduction in Black Barbershops (free study and commentaries) AND Community-Based Interventions to Improve Cardiovascular Risk in High-Risk Patients (free study and commentaries)

3 – Association of the Hospital Readmissions Reduction Program With Mortality Among Medicare Beneficiaries Hospitalized for Heart Failure, Acute Myocardial Infarction, and Pneumonia – JAMA (link to abstract – $ for full-text)

Commentaries: Did This Health Care Policy Do Harm? – The New York Times (10 articles per month are free) AND Study Finds Implementation of the Hospital Readmissions Reduction Program Associated With Increase in Patient-Level Mortality – Beth Israel Deaconess Medical Center (free) AND Penalties For Hospital Readmissions May Boost Deaths, Study Finds – CommonHealth (free)

4 – How does exercise treatment compare with antihypertensive medications? A network meta-analysis of 391 randomised controlled trials assessing exercise and medication effects on systolic blood pressure – British Journal of Sports Medicine (link to abstract – $ for full-text)

Commentaries: Exercise ‘as good as medicine’ for controlling high blood pressure – NHS Choices (free) AND Exercise may be as good at lowering blood pressure as drugs – OnMedica (free)

5 – FDA warns about increased risk of ruptures or tears in the aorta blood vessel with fluoroquinolone antibiotics in certain patients – U.S. Food & Drug Administration (free)

Commentary: FDA: Fluoroquinolones may cause aortic rupture in some – CIDRAP (free)

Related: Meta-analysis: Fluoroquinolones and the Risk of Aortopathy (free) AND Fluoroquinolone use and risk of aortic aneurysm and dissection (free study and commentaries) AND Committee Recommends New Restrictions on the use of Fluoroquinolones (free report and commentaries) AND FDA Safety Alert: Warnings for Fluoroquinolones on Risks of Mental Health and Low Blood Sugar Adverse Reactions (free report and commentaries) AND When antibiotics turn toxic (free commentary)

6 – Clinical Update: Perioperative Glucose Control in Patients with Diabetes Undergoing Elective Surgery – JAMA (free for a limited period)

7 – Ann Robinson’s research reviews, 7 January 2019 – The BMJ (free)

Ann Robinson reviews the latest research from the top medical journals.

8 – ACC/AATS/AHA/ASE/ASNC/HRS/SCAI/SCCT/SCMR/STS 2019 Appropriate Use Criteria for Multimodality Imaging in the Assessment of Cardiac Structure and Function in Nonvalvular Heart Disease – Journal of the American College of Cardiology (free)

Commentary: New AUC: Multimodality Imaging in Assessing Cardiac Structure and Function in Structural Heart Disease – American College of Cardiology (free)

9 – Long-term Risk of Colorectal Cancer and Related Deaths After a Colonoscopy With Normal Findings – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: 10 years after negative colonoscopy, study shows lower risk of colorectal cancer and death – Kaiser Permanente (free) AND Study: Risk of cancer, death less likely 10 years after cancer-free colonoscopy – UPI (free) AND Negative colonoscopy: data support 10-year rescreening interval – Univadis (free registration required)

10 – Global, Regional, and Country-Specific Lifetime Risks of Stroke, 1990 and 2016 – New England Journal of Medicine (free)

Commentaries: New study reveals ‘startling’ risk of stroke – Institute for Health Metrics and Evaluation (free) AND 1 in 4 globally will have a stroke at age 25 or older, according to new study – CNN (free)

Mon, January 7 – 10 Stories of The Day!

7 Jan, 2019 | 00:01h | UTC

1 – WHO recommendations: Uterotonics for the prevention of postpartum haemorrhage – World Health Organization (free PDF)

News Release: WHO updates guidance to help healthcare workers prevent postpartum haemorrhage (free)

Related Meta-Analysis: Uterotonic agents for preventing postpartum haemorrhage: a network meta‐analysis – Cochrane Library (free) AND Summary: Which drug is best for reducing excessive blood loss after birth? (free)

2 – ADA 2019 Standards of Medical Care in Diabetes (free supplement)

News Release: Patient-centered Care is the Focus and Priority of the 2019 Standards of Medical Care in Diabetes, Published Today by the American Diabetes Association (free)

Summary of Revisions: Standards of Medical Care in Diabetes—2019 (free)

3 – Rapid Recommendations: Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke: a clinical practice guideline – The BMJ (free)

Commentary: Guidelines Recommend Dual Antiplatelet Therapy Immediately After TIA or Minor Stroke NEJM Journal Watch (free)

4 – Clinical Practice Guidelines by the Infectious Diseases Society of America: 2018 Update on Diagnosis, Treatment, Chemoprophylaxis, and Institutional Outbreak Management of Seasonal Influenza – Clinical Infectious Diseases (free)

News Release: Flu is Serious for Pregnant Women and Others at High Risk: Testing and Treatment are Key, Say IDSA Guidelines (free)

5 – Association of Long-term Exercise Training With Risk of Falls, Fractures, Hospitalizations, and Mortality in Older Adults: A Systematic Review and Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentary: Meta-analysis: long-term exercise cuts fall, injury risk in elders – Univadis (free registration required)

6 – Association between intake of non-sugar sweeteners and health outcomes: systematic review and meta-analyses of randomised and non-randomised controlled trials and observational studies – The BMJ (free)

Editorial: Non-sugar sweeteners and health (free)

Commentaries: No evidence of sugar substitutes’ health benefits, finds study – The Guardian (free) AND Evidence Lacking for Benefits from Artificial Sweeteners – NEJM Journal Watch (free)

7 – International variation in radiation dose for computed tomography examinations: prospective cohort study – The BMJ (free)

8 – The use of diuretics in heart failure with congestion — a position statement from the Heart Failure Association of the European Society of Cardiology – European Journal of Heart Failure (free)

9 – 2018 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary – Circulation (free)

10 – Canadian Cardiovascular Society/Canadian Heart Rhythm Society Joint Position Statement on the Cardiovascular Screening of Competitive Athletes – Canadian Journal of Cardiology (free)

Related Position Statement: Recommendations for Participation in Competitive Sports of Athletes with Arterial Hypertension (free)

Related Research: Sudden Cardiac Arrest during Participation in Competitive Sports (link to abstract and commentaries)

Fri, December 14 – 10 Stories of The Day!

14 Dec, 2018 | 00:06h | UTC

1 – Guideline: Antenatal care for uncomplicated pregnancies – National Institute for Health and Care Excellence (free)

2 – 2019 Global Strategy for Prevention, Diagnosis and Management of COPD – GOLD Reports 2019 (free PDF)

3 – Radical Prostatectomy or Watchful Waiting in Prostate Cancer — 29-Year Follow-up – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Long-term study shows most prostate cancer patients don’t need aggressive treatment – STAT (free) AND Radical surgery for some prostate cancers adds three years to life – Reuters (free)

4 – Neurodevelopment in Infants Exposed to Zika Virus In Utero – New England Journal of Medicine (free)

Commentaries: Developmental delays persist as Brazil’s Zika babies grow up – STAT (free) AND Study: 15 percent of infants exposed to Zika develop abnormalities – UPI (free)

5 – Seven versus fourteen Days of Antibiotic Therapy for uncomplicated Gram-negative Bacteremia: a Non-inferiority Randomized Controlled Trial – Clinical Infectious Diseases (free abstract)

Commentary: Study supports shorter antibiotic treatment for bacteremia – CIDRAP (free)

6 – Molecular analysis of bacterial contamination on stethoscopes in an intensive care unit – Infection Control & Hospital Epidemiology (free)

Commentaries: DNA study shows stethoscopes loaded with bacteria, including staphylococcus – Society for Healthcare Epidemiology of America (free) AND ICU Stethoscopes Teeming With Bacteria – MedPage Today (free)

7 – Report: Survive and Thrive: Transforming care for every small and sick newborn – UNICEF and the World Health Organization (free PDF)

News Release: Nearly 30 million sick and premature newborns in dire need of treatment every year (free)

8 – Driving with Dementia or Mild Cognitive Impairment: Consensus Guidelines for Clinicians – Royal College of Psychiatrists (free PDF)

Commentary: When should dementia patients stop driving? A new guidance for clinicians – Newcastle University (free)

9 – Guideline: Clinically-assisted nutrition and hydration – British Medical Association (free guideline and other resources)

Commentary: Decisions about clinically-assisted nutrition and hydration: guiding doctors, helping patients – The BMJ Opinion (free)

“just because we can keep someone alive indefinitely, should we?”

10 – Christmas, national holidays, sport events, and time factors as triggers of acute myocardial infarction: SWEDEHEART observational study 1998-2013 – The BMJ (free)

Commentaries: Higher risk of heart attack on Christmas Eve – The BMJ, via EurekAlert (free) AND Christmas Is a Peak Time for Heart Attacks – The New York Times (10 articles per month are free)

Thu, December 13 – 10 Stories of The Day!

13 Dec, 2018 | 01:33h | UTC

1 – European Society for Vascular Surgery (ESVS) 2019 Clinical Practice Guidelines on the Management of Abdominal Aorto-iliac Artery Aneurysms (free)

2 – Clinical Practice Guideline: Obesity Surgery and the Treatment of Metabolic Diseases – Deutsches Ärzteblatt international (free)

3 – Statin Safety and Associated Adverse Events: A Scientific Statement From the American Heart Association – Arteriosclerosis, Thrombosis, and Vascular Biology (free PDF)

News Release: Statins have low risk of side effects (free)

4 – Assessment of Self-monitoring of Blood Glucose in Individuals With Type 2 Diabetes Not Using Insulin – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Millions of low-risk people with diabetes may be testing their blood sugar too often – University of Michigan (free) AND Many diabetics needlessly test blood sugar at home – Reuters (free)

5 – Death and readmissions after hospital discharge during the December holiday period: cohort study – The BMJ (free)

Commentary: Hospital discharge during December holidays tied to more readmissions, deaths – Reuters (free)

6 – Incretin based drugs and risk of cholangiocarcinoma among patients with type 2 diabetes: population based cohort study – The BMJ (free)

Commentary: Do incretin-based drugs cause cholangiocarcinoma? – Univadis (free registration required)

7 – Geriatrics update 2018: Challenges in mental health, mobility, and postdischarge care – Cleveland Clinic Journal of Medicine (free)

8 – Coronary Artery Calcium and Long-Term Risk of Death, Myocardial Infarction, and Stroke: The Walter Reed Cohort Study – JACC: Cardiovascular Imaging (link to abstract – $ for full-text)

Commentary: Calcium Score and Long-Term ASCVD Outcomes – American College of Cardiology (free)

9 – Medication administration errors and mortality: Incidents reported in England and Wales between 2007 ̶ 2016 – Research in Social and Administrative Pharmacy (free)

Commentary: New study sheds light on medication administration errors leading to death — omission is a common cause – University of Eastern Finland (free)

10 – Systematic review of high-cost patients’ characteristics and healthcare utilization – BMJ Open (free)

Wed, December 12 – 10 Stories of The Day!

12 Dec, 2018 | 00:46h | UTC

1 – The 2018 Altmetric Top 100 Articles (free)

“In the past year, Altmetric has tracked over 25 million mentions of 2.8 million research outputs. This page highlights the top 100 most-mentioned scholarly articles published in the past year – those which have truly captured the public imagination.”

2 – Guideline: Infection prevention in the operating room anesthesia work area – Infection Control & Hospital Epidemiology (free)

Commentary: New guidance focuses on reducing infections in anesthesiology – Healio (free registration required)

3 – Liberal versus conservative fluid therapy in adults and children with sepsis or septic shock – Cochrane Library (free)

Summary: Different fluid therapy strategies for sepsis and septic shock – Cochrane Library (free)

4 – Viewpoint: Questions for Artificial Intelligence in Health Care – JAMA (free for a limited period)

Related: Humanizing Artificial Intelligence – JAMA (free for a limited period)

5 – Overdiagnosis and industry influence: how cow’s milk protein allergy is extending the reach of infant formula manufacturers – The BMJ (free)

Commentaries: Disentangling ourselves from “Big Formula” – The BMJ (free) AND Infant formula companies are behind the guidelines on milk allergy, and their sales are soaring – The Conversation (free)

6 – Special Issue: Comorbidities, Deprescribing, and the Healthcare of Older People – Public Policy & Aging Report (free articles)

Commentary: Deprescribing can be valuable tool in managing polypharmacy, experts say – The Gerontological Society of America (free)

Related: Deprescribing: the fightback against polypharmacy has begun – The Pharmaceutical Journal (free) AND Reducing Inappropriate Medication Use & Polypharmacy (several articles and commentaries on the subject)

7 – Position of the Academy of Nutrition and Dietetics: Micronutrient Supplementation – Journal of the Academy of Nutrition and Dietetics (free)

Commentary: Dietary Supplements Don’t Prevent Chronic Disease – Medscape (free registration required)

“The routine and indiscriminate use of micronutrient supplements for the prevention of chronic disease is not recommended”

8 – Stool test is useful before GPs refer for possible inflammatory bowel disease – NIHR Signal (free)

Original Article: Faecal calprotectin effectively excludes inflammatory bowel disease in 789 symptomatic young adults with/without alarm symptoms: a prospective UK primary care cohort study – Alimentary Pharmacology and Therapeutics (free)

9 – COP24 special report: health and climate change – World Health Organization (free PDF)

Commentaries: Health benefits far outweigh the costs of meeting climate change goals – World Health Organization (free) AND Save millions of lives by tackling climate change, says WHO – World Health Organization (free) AND Tackling climate change could save millions of lives, report says – CNN (free)

10 – Global status report on road safety 2018 – World Health Organization (free)

Commentaries: Road injuries leading cause of death for the young, despite safety gains: UN report – UN News (free) AND Measurement is not enough for global road safety: implementation is key – The Lancet Public Health (free)

Tue, December 11 – 10 Stories of The Day!

11 Dec, 2018 | 00:01h | UTC

1 – Manual: Preventing surgical site infections: implementation approaches for evidence-based recommendations – World Health Organization (free PDF) (via @onisillos)

2 – Recommendations on screening for breast cancer in women aged 40–74 years who are not at increased risk for breast cancer – Canadian Medical Association Journal (free)

Summary: Breast Cancer Update (2018) – Canadian Task Force on Preventive Health Care (free)

News Release: Breast cancer screening: New emphasis on shared decision-making between women and their doctors (free)

See Also: Infographics for Shared Decision-Making (free)

3 – The Association of Coloproctology of Great Britain and Ireland consensus guidelines in surgery for inflammatory bowel disease – Colorectal Disease (free)

4 – Clinical Impact of the Polypill for Cardiovascular Prevention in Latin America: A Consensus Statement of the Inter-American Society of Cardiology – Global Heart (free) (via @gonzaeperez)

5 – Comparative effectiveness and safety of interventions for acute diarrhea and gastroenteritis in children: A systematic review and network meta-analysis – PLOS One (free)

6 – Review: Management Options for Irritable Bowel Syndrome – Mayo Clinic Proceedings (free)

7 – What These Medical Journals Don’t Reveal: Top Doctors’ Ties to Industry – The New York Times (10 articles per month are free)

8 – Cochrane Special Collections: Diagnosing skin cancer (free articles)

News Release: Cochrane Library Special Collection: Diagnosing skin cancer (free)

9 – Patient safety after implementation of a coproduced family centered communication programme: multicenter before and after intervention study – The BMJ (free)

Commentaries: Ensure that the family’s voice is heard first and last, and in their own words – The BMJ Opinion (free) AND Improving patient safety? Ask the patient – The BMJ Opinion (free) AND A new way to curb harmful medical errors: talk more to patients and families – STAT (free)

10 – Ultrarestrictive Opioid Prescription Protocol for Pain Management After Gynecologic and Abdominal Surgery – JAMA Network Open (free)

Commentaries: Striving for Evidence-Based Postoperative Opioid Prescribing While Optimizing Perioperative Pain Management—Shifting to Conservative Prescribing – JAMA Network Open (free) AND Opioid Prescriptions Can Be Drastically Reduced After Surgery with No Increase in Pain, Study Shows – Roswell Park (free)

Mon, December 10 – 10 Stories of The Day!

10 Dec, 2018 | 00:01h | UTC

1 – Guideline: Chronic obstructive pulmonary disease (acute exacerbation): antimicrobial prescribing – National Institute for Health and Care Excellence (free)

Commentary: GPs should consider restricting antibiotics for COPD – OnMedica (free)

2 – Guideline: Chronic obstructive pulmonary disease in over 16s: diagnosis and management – National Institute for Health and Care Excellence (free)

3 – Guideline: Post-traumatic stress disorder – National Institute for Health and Care Excellence (free)

4 – Essential points from Evidence-based Clinical Practice Guidelines for Chronic Kidney Disease 2018 – Japanese Society of Nephrology (free)

5 – Quantifying the benefits and harms of various preventive health activities – Australian Journal of General Practice (free) (via @PaulGlasziou)

6 – Dr. Lisa Schwartz, Critic of Medical Excess, Is Dead at 55 – The New York Times (10 articles per month are free)

7 – Critical review of the evidence underlying management of glucocorticoid-induced hyperglycaemia – European Journal of Endocrinology (free)

8 – Prevalence of and Factors Associated With Patient Nondisclosure of Medically Relevant Information to Clinicians – JAMA Network Open (free)

Commentaries: Threats to the Validity of the Clinical Interview: Can Anything Be Done? – JAMA Network Open (free) AND Patients often withhold relevant information from doctors – Reuters (free) AND Most Patients Have Held Back the Truth From Doctors, JAMA Results Show – AJMC (free) AND Why patients lie to their doctors – University of Utah Health (free) AND Majority of Patients Withhold Important Information From Their Health Care Providers – MedicalResearch.com (free)

9 – The UCL–Lancet Commission on Migration and Health: the health of a world on the move (free articles – registration required)

Commentaries: Harmful myths about migration and health used to justify policies of exclusion are unfounded – London School of Hygiene & Tropical Medicine (free) AND Report: Facts About Migrants Don’t Always Match What The Headlines Say – NPR (free) AND Myths about migrants spreading disease ‘inform hostile policies’ – The Guardian (free)

10 – Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial – The Lancet (free)

Commentaries: Fluoxetine and recovery after stroke – The Lancet (free) AND Fluoxetine (Prozac) Did Not Reduce Risk of Depression After Stroke, But Did Raise Risk of Fractures – MedicalResearch.com (free) AND Common antidepressant does not aid stroke recovery, study finds – University of Edinburgh (free)

Fri, December 7 – 10 Stories of The Day!

7 Dec, 2018 | 00:10h | UTC

1 – 2018 ACC Expert Consensus Decision Pathway on Tobacco Cessation Treatment – Journal of the American College of Cardiology (free)

Summary: 2018 ACC Decision Pathway on Tobacco Cessation Treatment – American College of Cardiology (free)

2 – Anesthesia interventions that alter perioperative mortality: a scoping review – Systematic Review (free)

3 – Apixaban to Prevent Venous Thromboembolism in Patients with Cancer – New England Journal of Medicine (free)

Commentary: NOACs Significantly Curb Risk of VTE in Cancer Patients – TCTMD (free)

4 – 2018 recommendations for the management of community acquired pneumonia – Jornal Brasileiro de Pneumologia (free PDF)

5 – Review: Assessment and initial management of acute undifferentiated fever in tropical and subtropical regions – The BMJ (free for a limited period)

6 – Review: Diaphragmatic dysfunction – Pulmonology (free)

7 – Review: Examination of the Patient with Dizziness or Imbalance – Medical Clinics of North America (free)

8 – Perspective: Risk-Reducing Mastectomy in BRCA1 and BRCA2 Mutation Carriers: A Complex Discussion – JAMA (free for a limited period)

9 – China backs bold plan to tear down journal paywalls – Nature (free)

Related: Europe’s Bold Open-Access Plan Detailed (free report and commentaries)

10 – Epigenetically reprogrammed methylation landscape drives the DNA self-assembly and serves as a universal cancer biomarker – Nature Communications (free)

Commentaries: One test to diagnose them all: researchers exploit cancers’ unique DNA signature – The Conversation (free) AND Nano-signature discovery could revolutionise cancer diagnosis – University of Queensland (free) AND ‘Universal fingerprint’ in cancer DNA points to potential blood test. But it’s not ready for patients – Cancer Research UK (free) AND Holy grail cancer test? Hold on. Here’s what you need to know – HealthNewsReview (free)

Thu, December 6 – 10 Stories of The Day!

6 Dec, 2018 | 00:01h | UTC

1 – Systematic Review: What are the most common conditions in primary care? – Canadian Family Physician (free)

2 – Perspective: Whole-Fat or Nonfat Dairy? The Debate Continues – JAMA (free for a limited period)

3 – Livebirth after uterus transplantation from a deceased donor in a recipient with uterine infertility – The Lancet (link to abstract – $ for full-text)

Commentaries: For the first time, a baby is born via a uterus transplant from a deceased donor – STAT (free) AND Mother gives birth with uterus from deceased donor – OnMedica (free) AND Expert reaction to first baby born by uterus transplant from a deceased donor – Science Media Centre (free) AND First baby born after deceased womb transplant – BBC (free)

4 – 2018 Korean Guideline of Atrial Fibrillation Management – Korean Circulatory Journal (free)

5 – Nurse staffing, nursing assistants and hospital mortality: retrospective longitudinal cohort study – BMJ Quality & Safety (free)

Commentaries: Lack of nurses linked to increased risk of patient death – OnMedica (free) AND Low Nurse Staffing Increases Risk for Inpatient Death – Medscape (free registration required)

6 – Caring for the critically ill patients over 80: a narrative review – Annals of Intensive Care (free)

7 – Cardiac Screening of Young Athletes: a Practical Approach to Sudden Cardiac Death Prevention – Current Treatment Options in Cardiovascular Medicine (free)

8 – Podcast: Delirium: Prevention, Diagnosis, and Treatment – JAMA (free)

9 – Association of estimated sleep duration and naps with mortality and cardiovascular events: a study of 116 632 people from 21 countries – European Heart Journal (free)

News Release: Too much or too little sleep linked to increased risk of cardiovascular disease and death – European Society of Cardiology (free)

Editorial: Sleep and cardiovascular risk: how much is too much of a good thing? (free)

10 – Association of Primary Care Consultation Patterns With Early Signs and Symptoms of Psychosis – JAMA Network Open (free)

Commentaries: Identifying Risk of Psychosis in a Primary Care Setting – JAMA Network Open (free) AND Spotting patients at risk for psychosis: 12 high-risk symptoms – Univadis (free registration required)

Wed, December 5 – 10 Stories of The Day!

5 Dec, 2018 | 00:01h | UTC

1 – Finding the Balance Between Benefits and Harms When Using Statins for Primary Prevention of Cardiovascular Disease: A Modeling Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Statins may be significantly overprescribed for primary prevention, computer model suggests – ACP Internist (free) AND Benefits of Statins Only Exceed Harms at Higher 10-Year Risk Thresholds, Study Suggests – TCTMD (free) AND Higher Risk Thresholds May Be Needed for Starting Statins for Primary CVD Prevention, Study Suggests – NEJM Journal Watch (free) AND Statins are being overprescribed, study suggests – OnMedica (free)

2 – The Ethics of Heritable Genome Editing: New Considerations in a Controversial Area – JAMA (free for a limited period)

3 – Fasting-Evoked En Route Hypoglycemia in Diabetes (FEEHD): An Overlooked Form of Hypoglycemia in Clinical Practice – International Journal of Endocrinology (free)

Commentary: Fasting for lab tests isn’t good for patients with diabetes – Michigan State University (free)

4 – Last Month in Oncology with Dr. Bishal Gyawali: November 2018 – eCancer News (free)

5 – Review: Confounders of severe asthma: diagnoses to consider when asthma symptoms persist despite optimal therapy – World Allergy Organization Journal (free)

6 – Perspective: Potential Risks and Benefits of Mental Health Screening of Physicians – JAMA (free for a limited period)

7 – Perspective: Why the world is becoming more allergic to food – BBC (free)

8 – Clinical validation of a risk scale for serious outcomes among patients with chronic obstructive pulmonary disease managed in the emergency department – Canadian Medical Association Journal (free)

News Release: Tool identifies which patients with COPD are at risk of death, serious complications (free)

Commentary: Tool quickly identifies risk for deadly COPD complications – UPI (free)

9 – Predictors of dementia misclassification when using brief cognitive assessments – Neurology (free PDF)

Commentary: Study Finds Biases in Widely Used Dementia Identification Tests – University of Exeter (free) AND Primary Care Tests Flunk for Classifying Dementia – MedPage Today (free registration required) AND Brief Cognitive Exams Commonly Misdiagnose Dementia – NEJM Journal Watch (free)

10 – Body-weight fluctuation and incident diabetes mellitus, cardiovascular disease, and mortality: a 16-year prospective cohort study – The Journal of Clinical Endocrinology & Metabolism (link to abstract – $ for full-text)

Commentaries: Weight cycling is associated with a higher risk of death – The Endocrine Society (free) AND Study: Yo-yo diets can increase death risk – UPI (free)

Tue, December 4 – 10 Stories of The Day!

4 Dec, 2018 | 00:10h | UTC

1 – Why the HIV epidemic is not over – World Health Organization (free)

2 – Clinical Report: Selecting Appropriate Toys for Young Children in the Digital Era – American Academy of Pediatrics (free)

News Release: Best toys for children’s development? Hint: They are not electronic or costly – AAP News (free)

Commentaries: AAP Offer Toy Tips for Parents and Clinicians in the Digital Age – NEJM Journal Watch (free) AND Empty boxes top high-tech toys on doctor-recommended list – Associated Press (free)

3 – Perspective: Why Hospitals Should Let You Sleep – The New York Times (10 articles per month are free)

“Frequent disruptions are more than just annoying for patients. They can also cause harm.”

4 – Podcast: #128 Aspirin Overhyped and Overused – The Curbsiders Internal Medicine Podcast (free)

5 – Editorial: Focus on randomised clinical trials – Intensive Care Medicine (free PDF) (via @CritCareReviews)

“Their results add to what appears to be a constant theme in critical care, ‘less is more’ based on RCT results”

6 – Alex Nowbar’s weekly research reviews, 3 December 2018 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

7 – Interpreting the Athlete’s ECG: Current State and Future Perspectives – Current Treatment Options in Cardiovascular Medicine (free)

8 – Economic and Quality-of-Life Outcomes of Natriuretic Peptide–Guided Therapy for Heart Failure – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Natriuretic peptide-guided therapy falls flat in improving HFrEF outcomes – Cardiovascular Business (free) AND Quality-of-Life Outcomes With Natriuretic Peptide-Guided Therapy for Heart Failure – Cardiology Advisor (free)

9 – Clinical practice guidelines for older people with multimorbidity and life-limiting illness: what are the implications for deprescribing? – Therapeutic Advances in Drug Safety (free)

10 – Impact of patient and public involvement on enrolment and retention in clinical trials: systematic review and meta-analysis – The BMJ (free)

Commentaries: Joanna Crocker: Time to embrace patient involvement in clinical trials? – The BMJ Opinion (free) AND “Researchers don’t know what they’re missing”—the impact of patient involvement in research – The BMJ Opinion (free) AND Impact of PPI in clinical trials – University of Oxford (free)

Mon, December 3 – 10 Stories of The Day!

3 Dec, 2018 | 00:01h | UTC

1 – Hydroxyurea for Children with Sickle Cell Anemia in Sub-Saharan Africa – New England Journal of Medicine (free)

Commentaries: Studies Show Improved Sickle Cell Disease Outcomes Worldwide – American Society of Hematology (free) AND ASH 2018: Large Single-Arm Trial of Hydroxyurea for Sickle Cell Anemia in Sub-Saharan Africa – The ASCO Post (free) AND Sickle cell anemia treatment safely lowers disease burden in African children – Cincinnati Children’s Hospital Medical Center (free) AND ‘From Nothing to Gangbusters’: A Treatment for Sickle-Cell Disease Proves Effective in Africa – New England Journal of Medicine (10 articles per month are free)

2 – 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis – Arthritis Care & Research (free)

3 – 2018 Global Nutrition Report (free)

Commentaries: 2018 Global Nutrition Report reveals malnutrition is unacceptably high and affects every country in the world, but there is also an unprecedented opportunity to end it – UNICEF (free) AND ‘Diabolical’ diets: four in 10 children consume sugary drinks daily – The Guardian (free) AND ‘No country is untouched’: Global Nutrition Report highlights compounding malnutrition – Devex (free)

4 – Global Atlas of Cardiovascular Disease 2000-2016: The Path to Prevention and Control – Global Heart (free)

5 – Medical Screening Tests You Do and Don’t Need – Consumer Reports (free) (via @EricTopol)

“Some may be life-saving, but others can waste time and money—and pose risks”

6 – Current opinions for the management of asthma associated with ear, nose and throat comorbidities – European Respiratory Review (free)

7 – Viewpoint: The Challenges of Improving Treatments for Depression – JAMA (free)

8 – Outdoor Artificial Nighttime Light and Use of Hypnotic Medications in Older Adults: A Population-Based Cohort Study – Journal of Clinical Sleep Medicine (free)

Commentary: Light pollution may cause insomnia in older adults – American Academy of Sleep Medicine (free)

9 – Unscrambling the relations of egg and meat consumption with type 2 diabetes risk – American Journal of Clinical Nutrition (free)

Commentary: LLU School of Public Health study finds meat, not eggs, is linked to type 2 diabetes – Loma Linda University School of Public Health (free)

10 – Associations of Smoke‐Free Policies in Restaurants, Bars, and Workplaces With Blood Pressure Changes in the CARDIA Study – Journal of the American Heart Association (free)

News Release: Smoke-free policies associated with lower blood pressure – American Heart Association (free)

Editorial: Necessity of Preventing Cardiovascular Disease by Smoke‐Free Policies (free)

Commentaries: Smoking bans tied to lower blood pressure in non-smokers – Reuters (free) AND Smoking bans in restaurants, workplaces linked to lower SBP – Cardiovascular Business (free)

Thu, November 29 – 10 Stories of The Day!

29 Nov, 2018 | 00:29h | UTC

1 – ASH Clinical Practice Guidelines on Venous Thromboembolism – American Society of Hematology (free)

News Release: New clinical practice guidelines for venous thromboembolism (free)

2 – Principles for Patient and Family Partnership in Care: An American College of Physicians Position Paper – Annals of Internal Medicine (free)

News Release: American College of Physicians releases principles to guide patient partnership in health care (free)

3 – A guideline for the diagnosis and management of polycythaemia vera. A British Society for Haematology Guideline (free)

4 – Attention Deficit–Hyperactivity Disorder and Month of School Enrollment – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: When starting school, younger children are more likely to be diagnosed with ADHD – Harvard Medical School (free) AND Youngest Children In A Class Are Most Likely To Get ADHD Diagnosis – NPR (free) AND Younger school entry could set stage for ADHD diagnosis – Associated Press (free)

Related: Systematic Review: Youngest in Class More Likely to be Diagnosed with ADHD (free study and commentaries)

5 – Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome – New England Journal of Medicine (link to abstract – $ for full-text)

Video Summary: Alirocumab and CV Events after Acute Coronary Syndrome (free)

6 – Prolonged thromboprophylaxis with low molecular weight heparin for abdominal or pelvic surgery – Cochrane Library (free)

Summary: Do blood thinner injections given after abdominal surgery further reduce blood clots if continued after discharge from the hospital? – Cochrane Library (free)

7 – Plan S: From Principles to Implementation. cOAlition S Releases Implementation Guidance on Plan S (free)

Commentary: Funders flesh out details of Europe’s bold open-access plan (free)

Related: In Win for Open Access, Two Major Funders Won’t Cover Publishing in Hybrid Journals (free commentaries) AND cOAlition S: Making Open Access a Reality by 2020 (free Statement and commentaries)

8 – Is our constant use of digital technologies affecting our brain health? We asked 11 experts – VOX (free)

9 – WHO Housing and health guidelines – World Health Organization (free)

10 – Global, regional, and national estimates of pneumonia morbidity and mortality in children younger than 5 years between 2000 and 2015: a systematic analysis – The Lancet Global Health (free)

Invited Commentary: Global childhood pneumonia: the good news, the bad news, and the way ahead (free)

Fri, November 30 – 10 Stories of The Day!

30 Nov, 2018 | 00:26h | UTC

1 – The 2018 report of the Lancet Countdown on health and climate change: shaping the health of nations for centuries to come – The Lancet (free registration required)

Editorial: Humanising health and climate change (free)

Commentaries: Global warming will increase heat-related death and disease – study – Reuters (free) AND Climate change and air pollution damaging health and causing millions of premature deaths – International Institute for Applied Systems Analysis (free) AND 5 ways climate change is bad for your health – Imperial College London (free)

Related: Projections of Temperature-Related Excess Mortality Under Climate Change Scenarios (free study and commentaries) AND Quantifying Excess Deaths Related to Heatwaves Under Climate Change Scenarios (free study and commentaries)

2 – Inpatient and Outpatient Infection as a Trigger of Cardiovascular Disease: The ARIC Study – Journal of the American Heart Association (free)

Editorial: Spark That Lights the Fire: Infection Triggers Cardiovascular Event (free)

Commentary: Infections may be a ‘trigger’ for heart attack, stroke – American Heart Association News (free)

3 – Fluoroquinolones and the risk of aortopathy: A systematic review and meta-analysis – International Journal of Cardiology (free)

“…current fluoroquinolone use was significantly associated with increased risk of aortic aneurysm and dissection.”

4 – Progress Toward Regional Measles Elimination — Worldwide, 2000–2017 – Centers for Disease Control and Prevention (free)

Commentaries: Measles cases spike globally due to gaps in vaccination coverage – World Health Organization (free) AND Report: Measles spike triggered by vaccination gaps – CIDRAP (free) AND Measles cases surged globally in 2017 due to gaps in vaccine coverage, health agencies say – CNN (free)

5 – Cesarean delivery rate and staffing levels of the maternity unit – PLOS One (free)

Commentary: Staffing more doctors and midwives tied to lower C-section rates – Reuters (free)

6 – We’re Living Longer … But A Medical Journal Sees Many Causes For Alarm – NPR (free)

Related Editorial: GBD 2017: a fragile world – The Lancet (free)

7 – Disease Outbreak News: Ebola virus disease – Democratic Republic of the Congo – World Health Organization (free)

Commentaries: DRC’s 426-case Ebola outbreak now 2nd largest ever – CIDRAP (free) AND Ebola and War in the Democratic Republic of Congo: Avoiding Failure and Thinking Ahead – JAMA (free) AND Ramping Up the Response to Ebola – New England Journal of Medicine (free) AND Ebola outbreak in east Congo now world’s second biggest – Reuters (free)

8 – Potentially serious incidental findings on brain and body magnetic resonance imaging of apparently asymptomatic adults: systematic review and meta-analysis – The BMJ (free)

Commentary: Many incidental findings spotted on MRIs, few turn out to be cancer – Reuters (free)

9 – Low-dose imipramine for refractory functional dyspepsia: a randomised, double-blind, placebo-controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)

Commentary: Low-Dose Imipramine Alternative Treatment for Refractory Functional Dyspepsia – Clinical Advisor (free)

10 – Cardiovascular toxicities associated with immune checkpoint inhibitors: an observational, retrospective, pharmacovigilance study – The Lancet Oncology (link to abstract – $ for full-text)

Commentary: Cardiovascular Toxicities Associated With Immune Checkpoint Inhibitor Treatment – The ASCO Post (free)

Wed, November 28 – 10 Stories of The Day!

28 Nov, 2018 | 00:01h | UTC

1 – Global, regional, and national burden of Alzheimer’s disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 – The Lancet Neurology (free)

Invited Commentary: Statistics on the burden of dementia: need for stronger data – The Lancet (free)

“In 2016, globally, 43·8 million individuals lived with dementia, increased from 20.2 million in 1990; dementia was the fifth leading cause of death globally (2·4 million) and more women than men had dementia” (via @TheLancet see Tweet with infographic)

2 – Sex differences in faecal occult blood test screening for colorectal cancer – British Journal of Surgery (free)

Commentaries: Screening for colorectal cancer spares male patients from intense treatments – University of Helsinki (free) AND FOBT Colorectal Cancer Screening Only Effective in Men – Medscape (free registration required)

3 – Comparative risk of harm associated with trazodone or atypical antipsychotic use in older adults with dementia: a retrospective cohort study – Canadian Medical Association Journal (free)

Commentaries: Study finds alternative to antipsychotic medication for seniors also has drawbacks – The Globe and Mail (free) AND Trazadone linked to more falls, major fractures in dementia patients – UPI (free) AND Trazadone associated with similar risk of falls and major fractures as antipsychotics in seniors with dementia – Canadian Medical Association Journal (free) AND Aggression in Dementia: Alternatives to Antipsychotics Also Have Side Effects – MedicalResearch.com (free)

4 – Review: Therapy and Management of Pneumocystis jirovecii – Infection – Journal of Fungi (free)

This article belongs to the Special Issue Treatments for Fungal Infections (free reviews)

5 – Arterial thrombosis in unusual sites: A practical review – European Journal of Haematology (free)

6 – Survey Snapshot: What Would Accelerate the Adoption of Value-Based Care? – NEJM Catalyst (free)

7 – Ten simple rules for collaboratively writing a multi-authored paper – PLOS Computational Biology (free) (via @Abraham_RMI)

8 – Assessment of Pregabalin Postapproval Trials and the Suggestion of Efficacy for New Indications: A Systematic Review – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentary: Some research may be encouraging ineffective prescriptions, says new study – McGill University (free)

“Our point is not to condemn these individual trials. Instead, we are saying that—when you zoom out and look at what’s happening at the level of the forest—the trees begin to look less healthy.” (from McGill University)

9 – Viewpoint: A Global Public Health Victory for Tobacco Plain-Packaging Laws in Australia – JAMA Internal Medicine (free)

10 – Long-Term Protection After Fractional-Dose Yellow Fever Vaccination: Follow-up Study of a Randomized, Controlled, Noninferiority Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentary: Study affirms fractional dosing with yellow fever vaccine – CIDRAP (free)

Related: Fractional-Dose Yellow Fever Vaccination (free research and perspective)

Tue, November 27 – 10 Stories of The Day!

27 Nov, 2018 | 01:18h | UTC

1 – Guideline: Urinary tract infection (catheter-associated): antimicrobial prescribing – National Institute for Health and Care Excellence (free)

Related: NICE Antimicrobial Prescribing Guidelines (free guidelines and resources)

2 – SEOM clinical practice guideline: management and prevention of febrile neutropenia in adults with solid tumors (2018) – Clinical and Translational Oncology (free)

Related: Guideline: Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy (free guidelines on the subject)

3 – Genome-edited baby claim provokes international outcry – Nature (free)

4 – Implant Files – The International Consortium of Investigative Journalists (free articles)

News Releases: Medical Devices Harm Patients Worldwide As Governments Fail On Safety (free) AND ICIJ publishes new investigation: the Implant Files (free) AND About The Implant Files Investigation (free)

Commentaries: How lobbying blocked European safety checks for dangerous medical implants – The BMJ (free) AND Revealed: faulty medical implants harm patients around world – The Guardian (free) AND Medical device rules need ‘drastic change’ to protect patients – BBC (free)

5 – Clinical Practice Guideline: Maintenance Intravenous Fluids in Children – Pediatrics (free)

News Release: Evidence-based guideline recommends isotonic solutions for children who need intravenous fluids – AAP News (free)

6 – Podcast: #127 STIs: Syphilis, Gonorrhea and Chlamydia – The Curbsiders Internal Medicine Podcast (free)

7 – Ann Robinson’s research reviews, 26 November 2018 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

8 – Guideline Synopsis: Diagnosis and Management of Nonalcoholic Liver Disease – JAMA (free for a limited period)

9 – Acute Liver Failure: Evidence-Based Evaluation and Management – emDocs (free)

10 – 2018 ACC Expert Consensus Decision Pathway on Novel Therapies for Cardiovascular Risk Reduction in Patients With Type 2 Diabetes and Atherosclerotic Cardiovascular Disease – Journal of the American College of Cardiology (free)

Mon, November 26 – 10 Stories of The Day!

26 Nov, 2018 | 00:01h | UTC

1 – AAPT Diagnostic Criteria for Fibromyalgia – the Journal of Pain (free)

2 – Green‐top Guideline: Care of Women with Obesity in Pregnancy – Royal College of Obstetricians and Gynaecologists (free)

3 – Opioid-Prescribing Guidelines for Common Surgical Procedures: An Expert Panel Consensus – Journal of the American College of Surgeons (free)

Commentary: Johns Hopkins Experts Create Opioid Prescribing Guidelines For 20 Common Surgical Procedures – Johns Hopkins Newsroom (free)

4 – Coronary Physiology Beyond Coronary Flow Reserve in Microvascular Angina: JACC State-of-the-Art Review – Journal of the American College of Cardiology (free)

5 – Anxiety, Depression and Post Traumatic Stress Disorder after critical illness: a UK-wide prospective cohort study – Critical Care (free)

Commentaries: Over half of former ICU patients in the UK report symptoms of psychological disorders – BioMed Central (free) AND ICU stay can lead to depression – Reuters (free)

6 – Dietary Patterns and Breast Cancer Risk: A Systematic Review – Anticancer Research (free)

7 – A systematic review of the next‐day effects of heavy alcohol consumption on cognitive performance – Addiction (free)

8 – Effect of testing for cancer on cancer‐ or venous thromboembolism (VTE)‐related mortality and morbidity in people with unprovoked VTE – Cochrane Library (free)

Summary: Effect of testing for cancer (on cancer and blood clot-related death and illness) in people with unprovoked blood clots in the legs and lungs – Cochrane Library (free)

9 – Cannabinoids for Chronic Pain – Therapeutics Initiative (free)

“At the present time we lack good evidence that any cannabis-derived product works for chronic pain”

10 – Diagnosis and Management of Primary Biliary Cholangitis – The American Journal of Gastroenterology (free)

Fri, November 23 – 10 Stories of The Day!

23 Nov, 2018 | 00:26h | UTC

1 – Multicenter Trial of a Combination Probiotic for Children with Gastroenteritis – New England Journal of Medicine (link to abstract – $ for full-text)

Related Study: Lactobacillus rhamnosus GG versus Placebo for Acute Gastroenteritis in Children – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Two studies find probiotic therapy ineffective against stomach flu, diarrhea – Reuters (free) AND Probiotics no help to young kids with stomach virus – Washington University in St. Louis (free) AND Probiotics Found To Be Ineffective For Easing Symptoms Of Kids’ Stomach Bugs – NPR (free)

2 – Global, regional, and national burden of tuberculosis, 1990–2016: results from the Global Burden of Diseases, Injuries, and Risk Factors 2016 Study – The Lancet Infectious Diseases (free)

Invited Commentary: Global burden of tuberculosis: where we are and what to do – The Lancet Infectious Diseases (free)

Related: Global Tuberculosis Report 2018 – World Health Organization (free report and commentaries)

3 – Rotating night shift work and adherence to unhealthy lifestyle in predicting risk of type 2 diabetes: results from two large US cohorts of female nurses – The BMJ (free)

Commentaries: Night shifts worsen diabetes risk for unhealthy women – OnMedica (free) AND Night shifts and unhealthy lifestyle linked to particularly high risk of type 2 diabetes – MedicalXpress (free) AND Unhealthy nurses working irregular night shifts at high diabetes risk – Nursing Times (free)

4 – Food sources of fructose-containing sugars and glycaemic control: systematic review and meta-analysis of controlled intervention studies – The BMJ (free)

Commentary: Sugary Drinks Are More Harmful To Diabetics Than Sweetened Foods, According To Large-Scale Research Review – IFLScience (free)

5 – Recommendations on the Use of Ultrasound Guidance for Adult Thoracentesis: A Position Statement of the Society of Hospital Medicine – Journal of Hospital Medicine (free)

6 – Evaluation of the clinical outcomes of telehealth for managing diabetes: A PRISMA-compliant meta-analysis – Medicine (free)

7 – Effect of diet protein restriction on progression of chronic kidney disease: A systematic review and meta-analysis – PLOS One (free)

8 – Selective serotonin reuptake inhibitor use during early pregnancy and congenital malformations: a systematic review and meta-analysis of cohort studies of more than 9 million births – BMC Medicine (free)

9 – Associations Between Breast Cancer Survivorship and Adverse Mental Health Outcomes: A Systematic Review – JNCI: Journal of the National Cancer Institute (free)

Commentary: Adverse Mental Health Outcomes in Breast Cancer Survivors – The ASCO Post (free)

“There is compelling evidence of an increased risk of anxiety, depression and suicide, and neurocognitive and sexual dysfunctions in breast cancer survivors compared with women with no prior cancer.”

10 – Depression, antidepressants, and the risk of non-valvular atrial fibrillation: A nationwide Danish matched cohort study – European Journal of Preventive Cardiology (free)

Commentary: Depressed people have an increased risk of atrial fibrillation – European Society of Cardiology (free) AND Study: Depressed patients see up to 7-fold higher risk for AFib – Cardiovascular Business (free)

Wed, November 21 – 10 Stories of The Day!

21 Nov, 2018 | 00:01h | UTC

1 – Draft Recommendation Statement: Prevention of Human Immunodeficiency Virus (HIV) Infection: Pre-Exposure Prophylaxis – U.S. Preventive Services Task Force (free)

Commentaries: Panel recommends everyone at high risk of getting HIV be offered a prevention pill – STAT (free) AND U.S. officials recommend use of PrEP pills to stop spread of HIV – UPI (free)

Related Clinical Guidelines: HIV Pre-exposure Prophylaxis (free articles)

2 – Critical appraisal and systematic review of guidelines for perioperative diabetes management: 2011–2017 – Endocrine (free)

Source: Hospital Medicine Virtual Journal Club

3 – Intermediate Diabetes Outcomes in Patients Managed by Physicians, Nurse Practitioners, or Physician Assistants: A Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Diabetes outcomes similar when primary care provided by NPs, PAs, or physicians, study finds – ACP Internist Weekly (free) AND Diabetics Cared for by NPs, PAs Do as Well as Those in Physicians’ Care – NEJM Journal Watch (free)

4 – Preoperative fasting in children: review of existing guidelines and recent developments – British Journal of Anaesthesia (free)

5 – Replication failures in psychology not due to differences in study populations – Nature (free)

Related: Evaluating the Replicability of Social Science Experiments (link to abstract and commentaries) AND Essay: The Experiments Are Fascinating. But Nobody Can Repeat Them – The New York Times (10 articles per month are free)

6 – Overall Survival with Palbociclib and Fulvestrant in Advanced Breast Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Drug improves survival in metastatic breast cancer – Northwestern University (free)

7 – Report: 2018 Access to Medicine Index – Access to Medicine Foundation (free PDF)

Commentaries: Big pharma leaves big gaps: drugmakers urged to do more for poor – Reuters (free) AND Big pharma ‘failing to develop urgent drugs for poorest countries’ – The Guardian (free)

8 – Ezetimibe for the prevention of cardiovascular disease and all‐cause mortality events – Cochrane Library (free)

Summary: Ezetimibe for the prevention of heart disease and death – Cochrane Library (free)

In individuals with established atherosclerotic cardiovascular disease, Ezetimibe has modest beneficial effects, primarily driven by a reduction in non‐fatal MI and non‐fatal stroke, but with little or no effect on clinical fatal endpoints.

9 – Updated European Consensus Statement on diagnosis and treatment of adult ADHD – European Psychiatry (free)

10 – Improving the quality of life of care home residents with dementia: Cost-effectiveness of an optimized intervention for residents with clinically significant agitation in dementia – Alzheimer’s & Dementia (link to abstract – $ for full-text)

Commentaries: Care homes with dementia ‘carer champions’ reduce agitation and antipsychotics – carehome.co.uk (free) AND Improving dementia care and treatment saves thousands of pounds in care homes – University of Exeter (free)

Thu, November 22 – 10 Stories of The Day!

22 Nov, 2018 | 00:01h | UTC

1 – Guideline: Management of Neonates Born at ≤34 6/7 Weeks’ Gestation With Suspected or Proven Early-Onset Bacterial Sepsis – Pediatrics (free)

News Release: New sepsis guidance addresses epidemiology, microbiology, recommended empiric treatment – AAP News (free)

2 – Guideline: Dysmenorrhea and Endometriosis in the Adolescent – American College of Obstetricians and Gynecologists (free)

Commentary: OB/GYN Group Issues Guidance on Dysmenorrhea, Endometriosis in Adolescents – NEJM Journal Watch (free)

3 – Viewpoint: Protecting the Value of Medical Science in the Age of Social Media and “Fake News” – JAMA (free)

4 – Burnout syndrome among medical residents: A systematic review and meta-analysis – PLOS One (free)

5 – Things We Do For No Reason: Routine Chest Radiographs after Uncomplicated Thoracentesis – Journal of Hospital Medicine (free PDF)

6 – Deep learning for chest radiograph diagnosis: A retrospective comparison of the CheXNeXt algorithm to practicing radiologists – PLOS Medicine (free) (via @EricTopol)

Commentaries: AI matched, outperformed radiologists in screening X-rays for certain diseases – Stanford Medicine (free)

7 – Predicting the risk of emergency admission with machine learning: Development and validation using linked electronic health records – PLOS Medicine (free)

Commentary: Machine learning can help healthcare workers predict whether patients may require emergency hospital admission, new study finds – University of Oxford (free)

8 – Why A New Study Says Scientists Should Use Twitter – Forbes (free) (via @onisillos)

Related: Scientists on Twitter: Preaching to the choir or singing from the rooftops? (link to study and perspectives on the subject)

9 – A review of antibiotic prophylaxis for traveler’s diarrhea: past to present – Tropical Diseases, Travel Medicine and Vaccines (free)

10 – Association of Concussion With the Risk of Suicide: A Systematic Review and Meta-Analysis – JAMA Surgery (link to abstract – $ for full-text)

Commentaries: Concussions tied to doubled risk of suicide – Reuters (free) AND Suicide Risk Doubles After Concussion – Medscape (free registration required)

Tue, November 20 – 10 Stories of The Day!

20 Nov, 2018 | 01:38h | UTC

1 – World malaria report 2018 – World Health Organization (free PDF)

News Release: WHO and partners launch new country-led response to put stalled malaria control efforts back on track (free)

Commentaries: WHO reports malaria setbacks; groups launch response plan – CIDRAP (free) AND Malaria on the rise in more than 13 countries, experts warn – CNN (free) AND The Fight Against Malaria Has Reached a Standstill – The New York Times (10 articles per month are free) AND Faltering malaria fight should refocus on high-risk countries, says WHO – Reuters (free)

2 – Risk of sexual transmission of human immunodeficiency virus with antiretroviral therapy, suppressed viral load and condom use: a systematic review – Canadian Medical Association Journal (free)

News Release: Negligible risk of transmitting HIV during sex when viral load is suppressed (free)

Related: UNAIDS Explainer: UNDETECTABLE = UNTRANSMITTABLE (free report and commentaries)

3 – Workplace bullying and workplace violence as risk factors for cardiovascular disease: a multi-cohort study – European Heart Journal (free)

Editorial: Victimization in the workplace: a new target for cardiovascular prevention? (free)

Commentaries: Bullying and violence at work increases the risk of cardiovascular disease – European Society of Cardiology (free) AND Workplace bullying and violence tied to higher risk of heart problems – Reuters (free)

4 – Zackary Berger’s weekly research reviews, 19 November – The BMJ Opinion (free)

5 – Abraar Karan: Has the physical exam had its day? – The BMJ Opinion (free)

“Seeing patients in clinic today, I know that putting my stethoscope on them has a therapeutic effect, even if as their doctor, I am quite certain their heart and lungs are normal. However, this doesn’t mean the physical exam should not evolve.” (via @AbraarKaran see Tweet)

6 – Prevalence of Falls and Fall‐Related Outcomes in Older Adults with Self‐Reported Vision Impairment – Journal of the American Geriatrics Society (free)

Commentaries: Study: Impaired vision raises risk of falls in older adults – UPI (free) AND Having poor vision can raise risk for falls among older adults – American Geriatrics Society (free)

7 – AR101 Oral Immunotherapy for Peanut Allergy – New England Journal of Medicine (free)

Editorial: Oral Desensitization to Peanuts (free)

Commentaries: Oral Immunotherapy Desensitizes Youth with Peanut Allergy – NEJM Journal Watch (free) AND Peanut allergy treatment ‘in sight’ – BBC (free) AND Peanut allergy treatment is effective but not always easy to tolerate, new review shows – STAT (free)

8 – Policy Statement: The Role of Pediatricians in Global Health – Pediatrics (free)

News Release: Defining pediatricians’ role in global health: 10 recommendations (free)

9 – Development and Validation of a Deep Learning-Based Automatic Detection Algorithm for Active Pulmonary Tuberculosis on Chest Radiographs – Clinical Infectious Diseases (free PDF)

Commentary: Algorithm outperforms radiologists in detecting active pulmonary TB – Healio (free registration required)

10 – Development and Validation of a Deep Learning Algorithm for Improving Gleason Scoring of Prostate Cancer – Cornell University Library (free PDF)

Commentary: Google deep-learning system grades prostate cancer with 70% accuracy – AI in Healthcare (free)