Tech & Innovation

CAR T-Cell Therapies Drive Outcomes in Lymphoma, Myeloma

26 Dec, 2017 | 23:13h | UTC

CAR T-Cell Therapies Drive Outcomes in Lymphoma, Myeloma: Treatments Hold Promise for People with Hard-to-Treat Blood Cancers – 2017 American Society of Hematology Annual Meeting (free)

Research: Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant

7 Dec, 2017 | 22:06h | UTC

Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Gene Therapy for Factor IX Deficiency (free)

Commentary: One-dose gene therapy produces clotting factor, safely stops bleeding in hemophilia B patients – MedicalXpress (free)

Research: Diagnostic Accuracy of Pediatric Teledermatology Using Parent-Submitted Photographs

3 Dec, 2017 | 20:13h | UTC

Diagnostic Accuracy of Pediatric Teledermatology Using Parent-Submitted Photographs: A Randomized Clinical Trial – JAMA Dermatology (link to abstract – $ for full-text)

Commentaries: Parent-Supplied Photos Allow Pediatric Dermatology Diagnoses without an Office Visit in Most Instances – Children’s Hospital of Philadelphia (free) AND Smartphone pics may be sharp enough for dermatology diagnosis – Reuters (free)

Big data often yields small returns. Here’s how to fix that

3 Dec, 2017 | 20:13h | UTC

Big data often yields small returns. Here’s how to fix that – STAT (free)

ACC Health Policy Statement on Healthcare Transformation in the Era of Digital Health, Big Data, and Precision Health

28 Nov, 2017 | 19:38h | UTC

2017 Roadmap for Innovation—ACC Health Policy Statement on Healthcare Transformation in the Era of Digital Health, Big Data, and Precision Health – Journal of The American College of Cardiology (free)

News Release: ACC’s Innovation Roadmap Provides Framework for Future of Care Delivery (free)

Summary with key points to remember: ACC Statement on Transforming Cardiovascular Care Through Innovation (free)

Research: AVATAR therapy for auditory verbal hallucinations in people with psychosis

28 Nov, 2017 | 19:29h | UTC

AVATAR therapy for auditory verbal hallucinations in people with psychosis: a single-blind, randomised controlled trial – The Lancet Psychiatry (free)

Commentaries: Understanding AVATAR therapy: who, or what, is changing? – The Lancet Psychiatry (free) AND Avatars can help schizophrenia patients control threatening voices – Reuters (free) Avatar therapy ‘reduces power of schizophrenia voices’ – BBC (free)

How might artificial intelligence improve healthcare?

26 Nov, 2017 | 00:11h | UTC

Richard Smith: How might artificial intelligence improve healthcare? – The BMJ Opinion (free)

Research: Detecting hip fractures with radiologist-level performance using deep neural networks

25 Nov, 2017 | 22:43h | UTC

Detecting hip fractures with radiologist-level performance using deep neural networks – Cornell University Library (free)

Research: Radiologist-Level Pneumonia Detection on Chest X-Rays with Deep Learning

20 Nov, 2017 | 17:56h | UTC

CheXNet: Radiologist-Level Pneumonia Detection on Chest X-Rays with Deep Learning – Stanford ML Group (free)

“We develop an algorithm that can detect pneumonia from chest X-rays at a level exceeding practicing radiologists”

Research: Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct

20 Nov, 2017 | 14:10h | UTC

Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct – New England Journal of Medicine (free)

Editorial: A New DAWN for Imaging-Based Selection in the Treatment of Acute Stroke (free)

Commentaries: Landmark study may impact standard stroke treatment guidelines – MedicalXpress (free) AND Thrombectomy Works While Infarct Core is Small – MedPage Today (free registration required)

“DAWN data: Consider a “tissue window” rather than a “time window”” (from MedPage Today)

Research: Regeneration of the entire human epidermis using transgenic stem cells

11 Nov, 2017 | 19:19h | UTC

Regeneration of the entire human epidermis using transgenic stem cells – Nature (link to abstract – $ for full-text)

Commentaries: A Dying Boy Gets a New, Gene-Corrected Skin – The Atlantic (free) Gene Therapy Creates Replacement Skin to Save a Dying Boy – The New York Times (free) AND ‘Extraordinary’ tale: Stem cells heal a young boy’s lethal skin disease – STAT (free) AND Scientists grow replacement skin for boy suffering devastating genetic disorder – The Guardian (free) Boy with rare disease gets brand new skin with gene therapy – Associated Press (free)

The Growing Value of Digital Health: Evidence and Impact on Human Health and the Healthcare System

11 Nov, 2017 | 17:07h | UTC

The Growing Value of Digital Health: Evidence and Impact on Human Health and the Healthcare System – IQVIA Institute (free)

Commentary: Study Names Top Apps for Patients to Manage Illnesses – Medscape (free registration required)

“An impressive, in-depth report on digital health, shows how the field is taking hold” (RT @EricTopol see Tweet)

Is gene editing ethical?

23 Oct, 2017 | 20:45h | UTC

Is gene editing ethical? – Medical News Today (free)

Research: Antibiotic susceptibility testing in less than 30 min using direct single-cell imaging

17 Oct, 2017 | 19:02h | UTC

Antibiotic susceptibility testing in less than 30 min using direct single-cell imaging – Proceedings of the National Academy of Sciences (free)

Commentary: Rapid Test for Antibiotic Susceptibility – JAMA (free)

Perspectives: Lost in Thought: The Limits of the Human Mind and the Future of Medicine

1 Oct, 2017 | 16:10h | UTC

Lost in Thought: The Limits of the Human Mind and the Future of Medicine – New England Journal of Medicine (free)

Research: Evaluation of telephone first approach to demand management in English general practice

1 Oct, 2017 | 16:08h | UTC

Evaluation of telephone first approach to demand management in English general practice: observational study – The BMJ (free)

Editorial: Telephone first consultations in primary care (free)

Commentaries: Phone-first GP consults ‘no panacea for reducing workload’ – OnMedica (free) AND No evidence to support claims that telephone consultations reduce GP workload or hospital referrals – University of Cambridge (free)

Related study: Direct-To-Consumer Telehealth May Increase Access To Care But Does Not Decrease Spending – Health Affairs (link to abstract – $ for full-text) AND Commentaries: Telehealth Doctor Visits May Be Handy, But Aren’t Cheaper Overall – NPR (free) AND Are Virtual Doctor Visits Really Cost-Effective? Not So Much, Study Says – Health News Florida (free)

Research: Association of Multiorgan Computed Tomographic Phenomap With Adverse Cardiovascular Health Outcomes

1 Oct, 2017 | 15:23h | UTC

Association of Multiorgan Computed Tomographic Phenomap With Adverse Cardiovascular Health Outcomes: The Framingham Heart Study – JAMA Cardiology (link to abstract – $ for full-text)

“Machine learning identifies an “unfavorable” multi-organ phenotype associated with adverse health outcome”. (RT @JAMACardio see Tweet)

The Promise and Challenge of Liquid Biopsies

19 Sep, 2017 | 22:26h | UTC

Medical News & Perspectives: Going With the Flow: The Promise and Challenge of Liquid Biopsies – JAMA (free)

Study: Safety of Medical Abortion Provided Through Telemedicine

18 Sep, 2017 | 16:33h | UTC

Safety of Medical Abortion Provided Through Telemedicine Compared With in Person – Obstetrics & Gynecology (free PDF)

Commentaries: Abortion via telemedicine as safe as seeing doctor in person – Reuters (free) AND Abortion Via Telemedicine Is Totally Safe, Study Says – HuffPost (free) AND Medical Abortion Via Telemedicine Found Safe – MedPage Today (free registration required)

See more on the impact of artificial intelligence in healthcare in our June 14^th issue (see #2) in our April 28^th issue (see #1) and in our April 10^th issue (see #8).

Study: Identifying incipient dementia individuals using machine learning and amyloid imaging

4 Sep, 2017 | 15:26h | UTC

Identifying incipient dementia individuals using machine learning and amyloid imaging – Neurobiology of Aging (free)

Commentaries: A.I., Big Data Project Predicts Dementia 2 Years Before Symptoms Onset, Researchers Show – Alzheimer’s News Today (free) AND Artificial intelligence predicts dementia before onset of symptoms – Science Daily (free)

See also related article and commentaries on Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons

Study: Software-guided versus nurse-directed blood glucose control in critically ill patients

1 Sep, 2017 | 18:47h | UTC

Software-guided versus nurse-directed blood glucose control in critically ill patients: the LOGIC-2 multicenter randomized controlled clinical trial – Critical Care (free)

Source: Hospital Medicine Virtual Journal Club

Study: Is Parkinson’s Care Via Telemedicine as Effective as Going to the Clinic?

26 Aug, 2017 | 20:24h | UTC

National randomized controlled trial of virtual house calls for Parkinson disease – Neurology (link to abstract – $ for full-text)

Press release: Is Parkinson’s Care Via Telemedicine as Effective as Going to the Clinic? – American Academy of Neurology (free)

Commentaries: How Telemedicine Helps Those With Parkinson’s – Huffington Post (free) AND Telemedicine Equals Office Visits in Parkinson’s – MedPage Today (free registration required)