Rheumatology

A nationwide cohort study in South Korea, including 1.8 million pregnancies, investigated the association between the use of nonsteroidal anti-inflammatory drugs (NSAIDs) during early pregnancy and neonatal and maternal adverse outcomes.

The study revealed that pregnant women exposed to NSAIDs during early pregnancy were at increased risk of oligohydramnios and had a slightly higher likelihood of having an infant with major congenital malformations and low birth weight. These risks remained elevated when comparing NSAIDs against acetaminophen or past users.

The study suggests that clinicians should weigh the need to prescribe NSAIDs in early pregnancy against the modest but possible risk of neonatal and maternal outcomes and consider prescribing nonselective NSAIDs for <10 days, with continued careful monitoring for any safety signals.

Article: Neonatal and maternal adverse outcomes and exposure to nonsteroidal anti-inflammatory drugs during early pregnancy in South Korea: A nationwide cohort study – PLOS Medicine

RCT | Baricitinib vs. placebo for systemic lupus erythematosus

3 Mar, 2023 | 13:39h | UTC

Baricitinib for systemic lupus erythematosus: a double-blind, randomised, placebo-controlled, phase 3 trial (SLE-BRAVE-I) – The Lancet (link to abstract – $ for full-text)

Commentary: Benefit of baricitinib for treatment of patients with moderately to severely active SLE is unclear – Monash University

Commentary on Twitter

NEW in @TheLancet—Two phase 3 trials of #baricitinib for systemic #lupus erythematosus #SLE-BRAVE-I > https://t.co/wX0w7w4Glm

SLE-BRAVE-II > https://t.co/56sd0DmjN9

Linked Comment by Laura Durcan (@Rheum2improve) & Grainne Murphy > https://t.co/RBJYEcSNle pic.twitter.com/XW6sXQnSn9

— The Lancet Rheumatology (@TheLancetRheum) February 27, 2023

Cohort Study | Risk factors for serious infections in ANCA-associated vasculitis

2 Mar, 2023 | 12:52h | UTC

Risk factors for serious infections in ANCA-associated vasculitis – Annals of the Rheumatic Diseases

Commentary from the author on Twitter

Just published in @ARD_BMJ (https://t.co/mZVZ7HZaLC) – risk of severe infections in #AAV. The prophylactic use of low-dose TMP/SMX may reduce this risk. A work I am really proud of. Many thanks to all my co-authors, especially to my friend @AKronbichler for his endless support!

— Balazs Odler (@odlerb) January 26, 2023

Chronic low back pain: a narrative review of recent international guidelines for diagnosis and conservative treatment

27 Feb, 2023 | 12:46h | UTC

Chronic Low Back Pain: A Narrative Review of Recent International Guidelines for Diagnosis and Conservative Treatment – Journal of Clinical Medicine

M-A | Pregnancy outcomes in Takayasu arteritis patients

24 Feb, 2023 | 13:40h | UTC

Summary: The systematic review and meta-analysis examined the data from 27 studies with 825 pregnancies and found that pregnant women with Takayasu arteritis (TA) are at higher risk for adverse pregnancy outcomes; 37% developed hypertension, 14% developed pre-eclampsia, and the occurrence of miscarriage was 16%. High disease activity during pregnancy, renal artery involvement, and history of hypertension were identified as risk factors, while maternal age or prolonged disease duration did not pose a risk. The most common treatments were corticosteroids, anti-hypertensive agents, low-dose aspirin, and azathioprine. The study was limited by the heterogeneity of the included studies and the lack of large-scale prospective case-control studies, indicating the need for further research.

Article: Pregnancy outcomes in Takayasu arteritis patients: a systematic review and meta-analysis – Scientific Reports

Guideline | Exercise-based knee and anterior cruciate ligament injury prevention

15 Feb, 2023 | 16:02h | UTC

Exercise-Based Knee and Anterior Cruciate Ligament Injury Prevention – Journal of Orthopaedic & Sports Physical Therapy

Takayasu Arteritis | JACC Focus Seminar

14 Feb, 2023 | 10:39h | UTC

Takayasu Arteritis: JACC Focus Seminar 3/4 – Journal of the American College of Cardiology

2022 American College of Rheumatology/EULAR classification criteria for Takayasu arteritis – Annals of the Rheumatic Diseases

2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Giant Cell Arteritis and Takayasu Arteritis – Arthritis & Rheumatology

Retrospective Study | Outcomes of percutaneous intervention in patients with Takayasu arteritis

14 Feb, 2023 | 10:38h | UTC

Outcomes of Percutaneous Intervention in Patients With Takayasu Arteritis – Journal of the American College of Cardiology

Commentary: Percutaneous Intervention in Patients With Takayasu Arteritis – Journal of the American College of Cardiology

2022 American College of Rheumatology/EULAR classification criteria for Takayasu arteritis – Annals of the Rheumatic Diseases

2021 American College of Rheumatology/Vasculitis Foundation Guideline for the Management of Giant Cell Arteritis and Takayasu Arteritis – Arthritis & Rheumatology

Position Paper | Diagnosis, prevention and treatment of common shoulder injuries in sport

10 Feb, 2023 | 14:01h | UTC

Diagnosis, prevention and treatment of common shoulder injuries in sport: grading the evidence – a statement paper commissioned by the Danish Society of Sports Physical Therapy (DSSF) – British Journal of Sports Medicine

Commentary on Twitter

Common shoulder injuries 💪 – grading the evidence on: 📊

🔍 Diagnosis – included 19 clinical tests
✋ Prevention – injury prevention programmes
🏋️‍♂️ Treatment – stretching, ice packs, strengthening, compression

Statement paper commissioned by DSSF

➡️ https://t.co/CN7usTd3HR pic.twitter.com/xavDN5MICY

— British Journal of Sports Medicine (BJSM) (@BJSM_BMJ) January 16, 2023

RCT | Efficacy and safety of bimekizumab in axial spondyloarthritis

10 Feb, 2023 | 13:42h | UTC

Efficacy and safety of bimekizumab in axial spondyloarthritis: results of two parallel phase 3 randomised controlled trials – Annals of the Rheumatic Diseases

Bimekizumab in patients with active psoriatic arthritis and previous inadequate response or intolerance to tumour necrosis factor-α inhibitors: a randomised, double-blind, placebo-controlled, phase 3 trial (BE COMPLETE) – The Lancet

Bimekizumab in patients with psoriatic arthritis, naive to biologic treatment: a randomised, double-blind, placebo-controlled, phase 3 trial (BE OPTIMAL) – The Lancet

Bimekizumab versus Secukinumab in Plaque Psoriasis – New England Journal of Medicine

Bimekizumab versus Adalimumab in Plaque Psoriasis – New England Journal of Medicine

Summary: Calcium and vitamin D for improving bone health in healthy premenopausal women – Cochrane Library

Cohort Study | Autoimmune diseases and new-onset atrial fibrillation

3 Feb, 2023 | 13:52h | UTC

Autoimmune diseases and new-onset atrial fibrillation: a UK Biobank study – EP Europace

Review | Perioperative evaluation and management of patients on glucocorticoids

2 Feb, 2023 | 14:35h | UTC

Perioperative Evaluation and Management of Patients on Glucocorticoids – Journal of the Endocrine Society

M-A | Comparative efficacy of exercise therapy and oral NSAIDs and paracetamol for knee or hip osteoarthritis

1 Feb, 2023 | 13:28h | UTC

Comparative efficacy of exercise therapy and oral non-steroidal anti-inflammatory drugs and paracetamol for knee or hip osteoarthritis: a network meta-analysis of randomised controlled trials – British Journal of Sports Medicine

Commentary on Twitter

Network meta-analysis of 152 RCTs (17431 pts) comparing efficacy of exercise therapy, NSAIDs, Tylenol for knee or hip osteoarthritis: Found all 3 equivalent at 4 wk, 8 wk and 24 wks. https://t.co/rKck2AacL4 pic.twitter.com/YEAMh9UxTs

— Dr. John Cush (@RheumNow) January 10, 2023

Recommendations for the management of incidental musculoskeletal findings on MRI and CT

31 Jan, 2023 | 14:08h | UTC

Recommendations for the Management of Incidental Musculoskeletal Findings on MRI and CT – Canadian Association of Radiologists Journal

Estimated prevalence and clinical manifestations of UBA1 variants associated with VEXAS syndrome in a clinical population

30 Jan, 2023 | 00:51h | UTC

Estimated Prevalence and Clinical Manifestations of UBA1 Variants Associated With VEXAS Syndrome in a Clinical Population – JAMA (free for a limited period)

Commentaries:

Study provides an estimate of people in the United States with VEXAS syndrome – News Medical

VEXAS Syndrome More Prevalent Than Previous Estimates, Certain Types Of Rheumatologic Conditions – HCP Live

Prevalence of VEXAS Syndrome Identified in U.S. Health System – HealthDay

Recently identified inflammatory disease VEXAS syndrome may be more common than thought, study suggests – CNN

M-A | Metabolic adverse events associated with systemic corticosteroid therapy

24 Jan, 2023 | 14:10h | UTC

Metabolic adverse events associated with systemic corticosteroid therapy—a systematic review and meta-analysis – BMJ Open

Health and economic outcomes associated with musculoskeletal disorders attributable to high BMI in 192 countries

23 Jan, 2023 | 13:16h | UTC

Health and Economic Outcomes Associated With Musculoskeletal Disorders Attributable to High Body Mass Index in 192 Countries and Territories in 2019 – JAMA Network Open

SR | Splinting for carpal tunnel syndrome

M-A | Maternal and infant outcomes of pregnancy associated with anti-SSA/RO antibodies

RCT | Intra-articular 10 mg triamcinolone acetonide non-inferior to 40 mg for knee osteoarthritis pain relief

Review | MRI image features with an evident relation to low back pain

Review | Treatment of systemic sclerosis

Cohort Study | Early pregnancy exposure to NSAIDs is associated with slightly higher risks of neonatal and maternal adverse outcomes