Rheumatology
RCT: Therapeutic drug monitoring during infliximab induction does not improve disease remission in patients with chronic immune-mediated inflammatory diseases
7 May, 2021 | 08:27h | UTCEffect of Therapeutic Drug Monitoring vs Standard Therapy During Infliximab Induction on Disease Remission in Patients With Chronic Immune-Mediated Inflammatory Diseases: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Treatment Strategies for Patients With Immune-Mediated Inflammatory Diseases – JAMA (free for a limited period)
Commentary: Mixed Results with Refined Treatment Strategies for Rheumatic Diseases – Physician’s Weekly
Commentary on Twitter
Study findings do not support routine use of proactive therapeutic drug monitoring during infliximab induction for improving immune-mediated inflammatory disease remission rates https://t.co/sDslkVm3u9
— JAMA (@JAMA_current) May 5, 2021
RCT: Among patients with rheumatoid arthritis in remission, tapering conventional DMARDs using half-dose resulted in disease flares in 25% of patients compared with 6% of patients in the stable-dose group.
7 May, 2021 | 08:26h | UTCEffect of Half-Dose vs Stable-Dose Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Disease Flares in Patients With Rheumatoid Arthritis in Remission: The ARCTIC REWIND Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Treatment Strategies for Patients With Immune-Mediated Inflammatory Diseases – JAMA (free for a limited period)
Commentary: Mixed Results with Refined Treatment Strategies for Rheumatic Diseases – Physician’s Weekly
New studies in patients with moderate-to-severe psoriasis show greater skin clearance with Bimekizumab, a monoclonal IgG1 antibody that selectively inhibits both interleukin-17A and interleukin-17F
25 Apr, 2021 | 21:08h | UTCStudy 1: Bimekizumab versus Secukinumab in Plaque Psoriasis – New England Journal of Medicine
Study 2: Bimekizumab versus Adalimumab in Plaque Psoriasis – New England Journal of Medicine
Related studies: Bimekizumab efficacy and safety in moderate to severe plaque psoriasis (BE READY): a multicentre, double-blind, placebo-controlled, randomised withdrawal phase trial – The Lancet AND Bimekizumab versus ustekinumab for the treatment of moderate to severe plaque psoriasis (BE VIVID): efficacy and safety from a 52-week, multicentre, double-blind, active comparator and placebo controlled phase 3 trial – The Lancet
Long-Term Cardiovascular Outcomes in Systemic Lupus Erythematosus
23 Apr, 2021 | 08:08h | UTCCardiovascular Outcomes in Systemic Lupus Erythematosus – American College of Cardiology
Original study: Long-Term Cardiovascular Outcomes in Systemic Lupus Erythematosus – Journal of the American College of Cardiology (link to abstract – $ for full-text)
USPSTF Statement: Insufficient evidence to recommend Vitamin D deficiency screening
14 Apr, 2021 | 01:47h | UTCVitamin D Deficiency in Adults: Screening – U.S. Preventive Services Task Force
Evidence Report: Screening for Vitamin D Deficiency in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force
Editorial: The USPSTF 2021 Recommendations on Screening for Asymptomatic Vitamin D Deficiency in Adults: The Challenge for Clinicians Continues – JAMA AND Why USPSTF Still Finds Insufficient Evidence to Support Screening for Vitamin D Deficiency – JAMA Network Open
JAMA Patient Page: Screening for Vitamin D Deficiency in Adults
NICE Guideline: Assessment and Management of Chronic Pain in Over 16s
8 Apr, 2021 | 08:54h | UTC
RCT: Upadacitinib vs. Adalimumab for Psoriatic Arthritis
5 Apr, 2021 | 00:57h | UTCTrial of Upadacitinib and Adalimumab for Psoriatic Arthritis – New England Journal of Medicine (link to abstract – $ for full-text)
RCT: Surgical microdiscectomy versus transforaminal epidural steroid injection in patients with sciatica secondary to herniated lumbar disc
25 Mar, 2021 | 08:12h | UTC
Commentary on Twitter
NEW RESEARCH—Surgical microdiscectomy and
transforaminal epidural steroid injection are similarly effective at reducing #pain and disability from #sciatica secondary to herniated lumbar disc https://t.co/xXOr1aOX8K #LancetRheumatology #OpenAccess pic.twitter.com/2CHh1YD2gm— The Lancet Rheumatology (@TheLancetRheum) March 19, 2021
Systematic review: Interventions for cutaneous disease in systemic lupus erythematosus
17 Mar, 2021 | 02:30h | UTCInterventions for cutaneous disease in systemic lupus erythematosus – Cochrane Library
RCT: Little benefit from osteopathic manipulative treatment on activity limitations in patients with nonspecific subacute and chronic low back pain
16 Mar, 2021 | 01:39h | UTCEffect of Osteopathic Manipulative Treatment vs Sham Treatment on Activity Limitations in Patients With Nonspecific Subacute and Chronic Low Back Pain: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)
Visual abstract: Effect of Osteopathic Manipulative Treatment vs Sham Treatment on Activity Limitations in Patients With Nonspecific Subacute and Chronic Low Back Pain
RCT: Efficacy of a combination of conservative therapies vs. an education comparator on clinical outcomes in thumb base osteoarthritis
14 Mar, 2021 | 20:13h | UTCEfficacy of a Combination of Conservative Therapies vs an Education Comparator on Clinical Outcomes in Thumb Base Osteoarthritis: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)
Commentary: Mix of treatments could be way to restore hand function in thumb-base osteoarthritis – University of Sydney
Commentary on Twitter
In people with thumb base #osteoarthritis, a combination of conservative treatments provided small beneficial effects on hand function at 6 weeks, but not pain, compared to an education control. Effects on hand function and pain were greater at 12 weeks https://t.co/lxaIubgTKT
— JAMA Internal Medicine (@JAMAInternalMed) March 9, 2021
Cardiovascular disease risk in immune-mediated inflammatory diseases: recommendations for clinical practice
7 Mar, 2021 | 19:20h | UTC
RCT: Rituximab vs. tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis
7 Mar, 2021 | 19:06h | UTCCommentary: Precision medicine in rheumatology: are we getting closer? – The Lancet
Commentary on Twitter
For patients with rheumatoid #arthritis and low or absent B-cell lineage expression signature in synovial tissue, tocilizumab is more effective than rituximab, suggests the first biopsy-driven trial. Read the results in full: https://t.co/XjzOqeBwdc pic.twitter.com/hODUwDy8BP
— The Lancet (@TheLancet) January 26, 2021
Guideline: Epidural interventions in the management of chronic spinal pain
5 Mar, 2021 | 08:09h | UTC
Systematic Review: Belimumab for systemic lupus erythematosus
2 Mar, 2021 | 01:11h | UTCBelimumab for systemic lupus erythematosus – Cochrane Library
Joint Statement: Hydroxychloroquine use with respect to retinal toxicity
28 Feb, 2021 | 20:41h | UTCCommentary: Societies Agree on Eye Safety for HCQ – MedPage Today (free registration required) AND ACR, medical societies reach consensus on hydroxychloroquine retinopathy – Healio (free registration required)
Commentary on Twitter
? Joint statement on #Hydroxychloroquine use with respect to retinal toxicity ? by several #rheumatology and #opthtalmology societies. #ocular #toxicity relates to #HCQ dosage and duration of use and is seen in 4.3% to 13.8% of patients ?#Lupus #SLEhttps://t.co/ocFSCmgVsN
— Laurent ARNAUD (@Lupusreference) February 18, 2021
RCT: Effect of telephone cognitive behavioral therapy for insomnia in older adults with osteoarthritis pain
25 Feb, 2021 | 08:29h | UTCCommentary: Effective treatment for insomnia delivered in a few short phone calls – University of Washington
Musculoskeletal involvement of COVID-19: review of imaging
24 Feb, 2021 | 02:43h | UTCMusculoskeletal involvement of COVID-19: review of imaging – Skeletal Radiology
Commentaries: Radiological images confirm ‘COVID-19 can cause the body to attack itself’ – Northwestern University AND Imaging highlights COVID-19’s MSK manifestations – AuntMinnie
RCT: Avacopan for the treatment of ANCA-associated vasculitis
18 Feb, 2021 | 02:50h | UTCAvacopan for the Treatment of ANCA-Associated Vasculitis – New England Journal of Medicine (link to abstract – $ for full-text)
RCT: Among patients with knee osteoarthritis, high-intensity strength training was not associated with better outcomes compared with low-intensity strength training or an attention control
17 Feb, 2021 | 01:24h | UTCCommentary: No Benefit from High-Intensity Strength Training for Knee Osteoarthritis – NEJM Journal Watch
Commentary on Twitter
Hot from press: JAMA paper puts question mark on the effectiveness of both low- and high-intensity exercise for knee OA pain. Attention controls had similar improvement. Contextual effects and RTM phenomenon in OA may be powerful! https://t.co/EBrXZcvyXH@OARSInews @JAMA_current pic.twitter.com/880InW1Lag
— Martin Englund (@dr_englund) February 16, 2021
Effect of High-Intensity Strength Training on Knee Pain and Knee Joint Compressive Forces Among Adults With Knee OsteoarthritisThe START Randomized Clinical Trial
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— Physio Meets Science (@PhysioMeScience) February 16, 2021
Cohort study: Risk factors associated with transition from acute to chronic low back pain
17 Feb, 2021 | 01:21h | UTC
Commentary on Twitter
Risk Factors Associated With Transition From Acute to Chronic Low Back Pain in US Patients Seeking Primary Care
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— Physio Meets Science (@PhysioMeScience) February 16, 2021
Review: Diagnosis and treatment of hip and knee osteoarthritis
16 Feb, 2021 | 02:05h | UTCDiagnosis and Treatment of Hip and Knee Osteoarthritis: A Review – JAMA (free or a limited period)
Effectiveness of telerehabilitation in physical therapy: A rapid overview
16 Feb, 2021 | 01:53h | UTCEffectiveness of telerehabilitation in physical therapy: A rapid overview – Physical Therapy
FDA Drug Safety Communication: Initial safety trial results find Tofacitinib, used for arthritis and ulcerative colitis, may increase the risk of serious heart-related problems and cancer
9 Feb, 2021 | 01:00h | UTCCommentary: Arthritis, Colitis Drug Tied to Heart-Related Problems and Cancer – NEJM Journal Watch
Randomized trial: Effect of diacerein vs. celecoxib on symptoms in knee osteoarthritis
29 Jan, 2021 | 01:30h | UTCCommentary: Noninferiority of diacerein to celecoxib demonstrated for knee OA pain – Medwire News