Rheumatology
2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis.
10 Jun, 2021 | 09:37h | UTCCommentary: The 2021 Treatment Guidelines for Rheumatoid Arthritis – Rheumatology Network
M-A: Effectiveness of telerehabilitation in physical therapist practice.
10 Jun, 2021 | 09:29h | UTC
ANCA-Associated Vasculitis: An Update.
4 Jun, 2021 | 10:23h | UTCANCA-Associated Vasculitis: An Update – Journal of Clinical Medicine
RCT: Among patients with ANCA-associated vasculitis without severe glomerulonephritis or alveolar hemorrhage treated with Rituximab, a reduced-dose glucocorticoids regimen (prednisolone 0.5 mg/kg/d) was noninferior to a high-dose glucocorticoid regimen (prednisolone 1 mg/kg/d) for the induction of disease remission.
4 Jun, 2021 | 10:25h | UTC
Podcast | Osteoporosis in Primary Care.
1 Jun, 2021 | 08:06h | UTC#277 Bone Up on Osteoporosis in Primary Care with Dr. Carolyn Crandall – The Curbsiders
EULAR recommendations for intra-articular therapies.
28 May, 2021 | 08:16h | UTCEULAR recommendations for intra-articular therapies – Annals of Rheumatic Diseases
Methotrexate reduces immune response to mRNA COVID-19 vaccine in patients with immune-mediated inflammatory disease.
26 May, 2021 | 08:38h | UTCCommentary: Methotrexate users have a reduced immune response to mRNA COVID-19 vaccine – BMJ
Large cohort study confirms the renal toxicities of anti-inflammatories, suggesting Ibuprofen may be the safest option among them.
19 May, 2021 | 08:28h | UTCComparative Risks of Nonsteroidal Anti-Inflammatory Drugs on CKD – Clinical Journal of the American Society of Nephrology (link to abstract – $ for full-text)
Commentary: Study: Ibuprofen Found Safest NSAID for the Kidney – MPR
Commentary on Twitter
Comparative Risks of Nonsteroidal Anti-Inflammatory Drugs on CKD
Read this new @CJASN study and listen to the accompanying podcast:https://t.co/GL1ITzh4O4 pic.twitter.com/lZGeFqfrDZ
— American Society of Nephrology (@ASNKidney) April 29, 2021
2021 EULAR recommendations for the implementation of self-management strategies in patients with inflammatory arthritis
13 May, 2021 | 05:49h | UTCCommentary: EULAR issues recommendations on self-management strategies for inflammatory arthritis – MedwireNews
Editorial | “Peeling off musculoskeletal labels: sticks and stones may break my bones, but diagnostic labels can hamstring me forever”
11 May, 2021 | 08:59h | UTC
Commentary on Twitter
Grateful to share our new @BJSM_BMJ editorial @KarimKhan_IMHA @DrLouiseTulloh
Peeling off musculoskeletal labels: sticks and stones may break my bones, but diagnostic labels can hamstring me forever
📄🔓 https://t.co/5LAEUNK6d2#PreventingOverdiagnosis #TooMuchMedicine pic.twitter.com/ZD0CyxmGHp
— Daniel Friedman (@ddfriedman) May 6, 2021
RCT: Efficacy and safety of voclosporin for lupus nephritis – voclosporin + MMF + low dose corticosteroids achieved complete renal response at week 52 more often than MMF + low dose corticosteroids alone (41% vs. 23%).
10 May, 2021 | 00:48h | UTCEfficacy and safety of voclosporin versus placebo for lupus nephritis (AURORA 1): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)
RCT: Therapeutic drug monitoring during infliximab induction does not improve disease remission in patients with chronic immune-mediated inflammatory diseases
7 May, 2021 | 08:27h | UTCEffect of Therapeutic Drug Monitoring vs Standard Therapy During Infliximab Induction on Disease Remission in Patients With Chronic Immune-Mediated Inflammatory Diseases: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Treatment Strategies for Patients With Immune-Mediated Inflammatory Diseases – JAMA (free for a limited period)
Commentary: Mixed Results with Refined Treatment Strategies for Rheumatic Diseases – Physician’s Weekly
Commentary on Twitter
Study findings do not support routine use of proactive therapeutic drug monitoring during infliximab induction for improving immune-mediated inflammatory disease remission rates https://t.co/sDslkVm3u9
— JAMA (@JAMA_current) May 5, 2021
RCT: Among patients with rheumatoid arthritis in remission, tapering conventional DMARDs using half-dose resulted in disease flares in 25% of patients compared with 6% of patients in the stable-dose group.
7 May, 2021 | 08:26h | UTCEffect of Half-Dose vs Stable-Dose Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Disease Flares in Patients With Rheumatoid Arthritis in Remission: The ARCTIC REWIND Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Treatment Strategies for Patients With Immune-Mediated Inflammatory Diseases – JAMA (free for a limited period)
Commentary: Mixed Results with Refined Treatment Strategies for Rheumatic Diseases – Physician’s Weekly
New studies in patients with moderate-to-severe psoriasis show greater skin clearance with Bimekizumab, a monoclonal IgG1 antibody that selectively inhibits both interleukin-17A and interleukin-17F
25 Apr, 2021 | 21:08h | UTCStudy 1: Bimekizumab versus Secukinumab in Plaque Psoriasis – New England Journal of Medicine
Study 2: Bimekizumab versus Adalimumab in Plaque Psoriasis – New England Journal of Medicine
Related studies: Bimekizumab efficacy and safety in moderate to severe plaque psoriasis (BE READY): a multicentre, double-blind, placebo-controlled, randomised withdrawal phase trial – The Lancet AND Bimekizumab versus ustekinumab for the treatment of moderate to severe plaque psoriasis (BE VIVID): efficacy and safety from a 52-week, multicentre, double-blind, active comparator and placebo controlled phase 3 trial – The Lancet
Long-Term Cardiovascular Outcomes in Systemic Lupus Erythematosus
23 Apr, 2021 | 08:08h | UTCCardiovascular Outcomes in Systemic Lupus Erythematosus – American College of Cardiology
Original study: Long-Term Cardiovascular Outcomes in Systemic Lupus Erythematosus – Journal of the American College of Cardiology (link to abstract – $ for full-text)
USPSTF Statement: Insufficient evidence to recommend Vitamin D deficiency screening
14 Apr, 2021 | 01:47h | UTCVitamin D Deficiency in Adults: Screening – U.S. Preventive Services Task Force
Evidence Report: Screening for Vitamin D Deficiency in Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force
Editorial: The USPSTF 2021 Recommendations on Screening for Asymptomatic Vitamin D Deficiency in Adults: The Challenge for Clinicians Continues – JAMA AND Why USPSTF Still Finds Insufficient Evidence to Support Screening for Vitamin D Deficiency – JAMA Network Open
JAMA Patient Page: Screening for Vitamin D Deficiency in Adults
NICE Guideline: Assessment and Management of Chronic Pain in Over 16s
8 Apr, 2021 | 08:54h | UTC
RCT: Upadacitinib vs. Adalimumab for Psoriatic Arthritis
5 Apr, 2021 | 00:57h | UTCTrial of Upadacitinib and Adalimumab for Psoriatic Arthritis – New England Journal of Medicine (link to abstract – $ for full-text)
RCT: Surgical microdiscectomy versus transforaminal epidural steroid injection in patients with sciatica secondary to herniated lumbar disc
25 Mar, 2021 | 08:12h | UTC
Commentary on Twitter
NEW RESEARCH—Surgical microdiscectomy and
transforaminal epidural steroid injection are similarly effective at reducing #pain and disability from #sciatica secondary to herniated lumbar disc https://t.co/xXOr1aOX8K #LancetRheumatology #OpenAccess pic.twitter.com/2CHh1YD2gm— The Lancet Rheumatology (@TheLancetRheum) March 19, 2021
Systematic review: Interventions for cutaneous disease in systemic lupus erythematosus
17 Mar, 2021 | 02:30h | UTCInterventions for cutaneous disease in systemic lupus erythematosus – Cochrane Library
RCT: Little benefit from osteopathic manipulative treatment on activity limitations in patients with nonspecific subacute and chronic low back pain
16 Mar, 2021 | 01:39h | UTCEffect of Osteopathic Manipulative Treatment vs Sham Treatment on Activity Limitations in Patients With Nonspecific Subacute and Chronic Low Back Pain: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)
Visual abstract: Effect of Osteopathic Manipulative Treatment vs Sham Treatment on Activity Limitations in Patients With Nonspecific Subacute and Chronic Low Back Pain
RCT: Efficacy of a combination of conservative therapies vs. an education comparator on clinical outcomes in thumb base osteoarthritis
14 Mar, 2021 | 20:13h | UTCEfficacy of a Combination of Conservative Therapies vs an Education Comparator on Clinical Outcomes in Thumb Base Osteoarthritis: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)
Commentary: Mix of treatments could be way to restore hand function in thumb-base osteoarthritis – University of Sydney
Commentary on Twitter
In people with thumb base #osteoarthritis, a combination of conservative treatments provided small beneficial effects on hand function at 6 weeks, but not pain, compared to an education control. Effects on hand function and pain were greater at 12 weeks https://t.co/lxaIubgTKT
— JAMA Internal Medicine (@JAMAInternalMed) March 9, 2021
Cardiovascular disease risk in immune-mediated inflammatory diseases: recommendations for clinical practice
7 Mar, 2021 | 19:20h | UTC
RCT: Rituximab vs. tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis
7 Mar, 2021 | 19:06h | UTCCommentary: Precision medicine in rheumatology: are we getting closer? – The Lancet
Commentary on Twitter
For patients with rheumatoid #arthritis and low or absent B-cell lineage expression signature in synovial tissue, tocilizumab is more effective than rituximab, suggests the first biopsy-driven trial. Read the results in full: https://t.co/XjzOqeBwdc pic.twitter.com/hODUwDy8BP
— The Lancet (@TheLancet) January 26, 2021
Guideline: Epidural interventions in the management of chronic spinal pain
5 Mar, 2021 | 08:09h | UTC