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Systematic Reviews & Meta-analysis

Meta-Analysis: Dual vs. Triple Antithrombotic Therapy in Patients with Atrial Fibrillation following PCI

23 Apr, 2018 | 16:47h | UTC

Safety and efficacy of dual vs. triple antithrombotic therapy in patients with atrial fibrillation following percutaneous coronary intervention: a systematic review and meta-analysis of randomized clinical trials – European Heart Journal (free)

Compared with triple antithrombotic therapy, dual antithrombotic therapy shows a reduction in TIMI major or minor bleeding by 47% with comparable outcomes of major adverse cardiac events.

 


Meta-Analysis: Cognitive Outcomes of Children Born Extremely or Very Preterm

23 Apr, 2018 | 16:36h | UTC

Cognitive Outcomes of Children Born Extremely or Very Preterm Since the 1990s and Associated Risk Factors: A Meta-analysis and Meta-regression – JAMA Pediatrics (link to abstract – $ for full-text)

Commentaries: Preemies and underweight babies more likely to have low IQs – Reuters (free) AND Despite Advancing Neonatal Health, Preterm Babies Still Risk Cognitive Impairment – MedicalResearch.com (free)

 


Meta-Analysis: Sleep Duration and Incidence of Obesity in Infants, Children, and Adolescents

23 Apr, 2018 | 16:34h | UTC

Sleep duration and incidence of obesity in infants, children, and adolescents: a systematic review and meta-analysis of prospective studies – Sleep (link to abstract – $ for full-text)

Commentary: Lack of Sleep leads to Obesity in Children and Adolescents – University of Warwick (free)

 


Perspective: Time to Challenge the Spurious Hierarchy of Systematic Over Narrative Reviews?

20 Apr, 2018 | 01:36h | UTC

Time to challenge the spurious hierarchy of systematic over narrative reviews? – European Journal of Clinical Investigation (free) (via @kennylinafp and @Abraham_RMI)

 


Systematic Review: Transradial vs Transfemoral Approach for Coronary Angiography

20 Apr, 2018 | 01:33h | UTC

Transradial versus transfemoral approach for diagnostic coronary angiography and percutaneous coronary intervention in people with coronary artery disease – Cochrane Library (link to abstract – $ for full-text)

Summary: Radial artery versus femoral artery approach for performing coronary catheter procedures in people with coronary artery disease – Cochrane Library (free)

“Transradial approach for diagnostic coronary angiography or PCI (or both) in CAD may reduce short-term net adverse clinical events, cardiac death, all-cause mortality, bleeding, and access site complications”.

 


Meta-analysis: “Artificial Pancreas” Treatment for Outpatients with Type 1 Diabetes

20 Apr, 2018 | 01:35h | UTC

Artificial pancreas treatment for outpatients with type 1 diabetes: systematic review and meta-analysis – The BMJ (free)

Editorial: Closed loop systems in type 1 diabetes (free for a limited period)

 


Systematic Review: Exercise Interventions and Patient Beliefs for People with Hip, Knee or Hip and Knee Osteoarthritis

18 Apr, 2018 | 01:09h | UTC

Exercise interventions and patient beliefs for people with hip, knee or hip and knee osteoarthritis: a mixed methods review – Cochrane Library (free)

 


Meta-Analysis: Lung Ultrasound vs Chest Radiograph in Critically Ill Patients With Respiratory Symptoms

17 Apr, 2018 | 20:04h | UTC

Diagnostic Accuracy of Chest Radiograph, and When Concomitantly Studied Lung Ultrasound, in Critically Ill Patients With Respiratory Symptoms: A Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text)

Commentary: Lung ultrasound accuracy beats X-ray in critically ill patients with respiratory symptoms – Univadis (free registration required)

 


Meta-Analysis: Association Between Newer Antidiabetic Drug Classes and Mortality

18 Apr, 2018 | 00:56h | UTC

Association Between Use of Sodium-Glucose Cotransporter 2 Inhibitors, Glucagon-like Peptide 1 Agonists, and Dipeptidyl Peptidase 4 Inhibitors With All-Cause Mortality in Patients With Type 2 Diabetes – JAMA (free)

Multimedia (2 minute video): Association Between Newer Antidiabetic Drug Classes and Mortality in Patients With Type 2 Diabetes (free)

Commentary: Diabetes drug may not reduce risk of death – Imperial College London (free)

 


Systematic Review: Use of Smartphones for Early Detection of Melanoma

17 Apr, 2018 | 20:02h | UTC

Use of Smartphones for Early Detection of Melanoma: Systematic Review – Journal of Medical Internet Research (free)

Commentary: Teledermatology improves course of melanoma care from 80 to 10 days – Clinical Innovation + Technology (free)

 


Systematic Review: Indicators of Intensive Care Unit Capacity Strain

15 Apr, 2018 | 23:42h | UTC

Indicators of intensive care unit capacity strain: a systematic review – Critical Care (free)

 


Meta-analysis: Risk Thresholds for Alcohol Consumption

14 Apr, 2018 | 19:51h | UTC

Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies – The Lancet (free)

Editorial: Thresholds for safer alcohol use might need lowering (free)

Commentaries: Drinking a pint of beer may lower your life expectancy by the same amount as smoking a cigarette – new research – The Conversation (free) AND Expert reaction to study looking at drinking alcohol, life expectancy and alcohol limits – Science Media Centre (free) AND More than six weekly glasses of wine could curb life expectancy by up to five years – OnMedica (free) AND Consuming more than five drinks a week could shorten your life – University of Cambridge, via ScienceDaily (free) AND How much alcohol is too much? A new study says it’s found the number – PBS News Hour (free)

 


Systematic Review: Non-invasive Brain Stimulation Techniques for Chronic Pain

14 Apr, 2018 | 19:42h | UTC

Non-invasive brain stimulation techniques for chronic pain – Cochrane Library (free)

“There is a lack of high-quality evidence to support or refute the effectiveness of non-invasive brain stimulation techniques for chronic pain”

 


Meta-analysis: antibiotics for the treatment of skin and soft tissue abscesses

13 Apr, 2018 | 01:41h | UTC

Systemic Antibiotics for the Treatment of Skin and Soft Tissue Abscesses: A Systematic Review and Meta-Analysis – Annals of Emergency Medicine (free)

Commentary: Meta-Analysis Favors Antibiotics After Drainage of Skin Abscesses – NEJM Journal Watch (free)

See related guideline with infographic: Antibiotics after incision and drainage for uncomplicated skin abscesses: a clinical practice guideline – The BMJ (free) AND Meta-Analysis: Antibiotics for uncomplicated skin abscesses: systematic review and network meta-analysis – BMJ Open (free)

 


Systematic review: antidepressants versus placebo for panic disorder in adults

13 Apr, 2018 | 01:17h | UTC

Antidepressants versus placebo for panic disorder in adults – Cochrane Library (link to abstract – $ for full-text)

Summary: Antidepressants for panic disorder in adults – Cochrane Library (free)

Commentary: Antidepressants are moderately effective in panic disorder – Univadis (free registration required)

 


Systematic review: exercise improves intermittent claudication leg pain on walking

13 Apr, 2018 | 00:54h | UTC

Exercise improves intermittent claudication leg pain on walking – NIHR Signal (free)

Original article: Exercise for intermittent claudication – Cochrane Library (free)

 


Meta-analysis: weight loss as a predictor of cancer in primary care

12 Apr, 2018 | 02:49h | UTC

Weight loss as a predictor of cancer in primary care: a systematic review and meta-analysis – British Journal of General Practice (free)

Commentaries: Weight loss is an important predictor of cancer – University of Oxford (free)

 


Systematic review: honey for acute cough in children

12 Apr, 2018 | 02:33h | UTC

Honey for acute cough in children – Cochrane Library (link to abstract – $ for full-text)

Summary: Honey for acute cough in children – Cochrane Library (free)

“Honey probably relieves cough symptoms to a greater extent than no treatment, diphenhydramine, and placebo, but may make little or no difference compared to dextromethorphan.”

 


Consolidated principles for screening based on a systematic review and consensus process

12 Apr, 2018 | 01:55h | UTC

Consolidated principles for screening based on a systematic review and consensus process – Canadian Medical Association Journal (free)

 


Systematic review: alpha-blockers as medical expulsive therapy for ureteral stones

12 Apr, 2018 | 01:56h | UTC

Alpha-blockers as medical expulsive therapy for ureteral stones – Cochrane Library (link to abstract – $ for full-text)

Summary: Alpha-blockers for ureteral stones in adult patients with symptoms of stone disease – Cochrane Library (free)

 


Systematic review: percutaneous vertebroplasty for osteoporotic vertebral compression fracture

12 Apr, 2018 | 01:07h | UTC

Percutaneous vertebroplasty for osteoporotic vertebral compression fracture – Cochrane Library (link to abstract – $ for full-text)

Summary: Featured Review: Vertebroplasty for treating spinal fractures due to osteoporosis – Cochrane Library (free)

High quality evidence shows that vertebroplasty does not provide more clinically important benefits than placebo but may cause people harm”.

 


Meta-analysis: safety of early discharge after primary angioplasty in low-risk patients with STEMI

6 Apr, 2018 | 01:13h | UTC

Safety of early discharge after primary angioplasty in low-risk patients with ST-segment elevation myocardial infarction: A meta-analysis of randomised controlled trials – European Journal of Preventive Cardiology (link to abstract – $ for full-text)

“The findings of this meta-analysis suggested that the early discharge strategy after successful primary angioplasty is safe among selected low-risk STEMI patients. A shorter hospital stay could benefit both the patients and the healthcare systems”.

 


Meta-analysis: reducing falls in older adults recently discharged from hospital

5 Apr, 2018 | 18:49h | UTC

Reducing falls in older adults recently discharged from hospital: a systematic review and meta-analysis – Age and Ageing (link to abstract – $ for full-text)

Commentary: Fall prevention gets harder when elderly leave hospital – Reuters (free)

 

 


Systematic review: ivermectin and permethrin for treating scabies

5 Apr, 2018 | 18:41h | UTC

Ivermectin and permethrin for treating scabies – Cochrane Library (free)

Summary: Ivermectin and permethrin for treating scabies – Cochrane Library (free)

 


Systematic review: inhaled anti-pseudomonal antibiotics in cystic fibrosis

5 Apr, 2018 | 18:42h | UTC

Inhaled anti-pseudomonal antibiotics for long-term therapy in cystic fibrosis – Cochrane Library (link to abstract – $ for full-text)

Summary: Inhaling antibiotics to treat lung infection in people with cystic fibrosis – Cochrane Library (free)

 


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