Systematic Reviews & Meta-analysis
Meta-Analysis: Vitamin D to Prevent Exacerbations of COPD
17 Jan, 2019 | 00:08h | UTCVitamin D to prevent exacerbations of COPD: systematic review and meta-analysis of individual participant data from randomised controlled trials – Thorax (link to abstract – $ for full-text)
Commentary: Treat vitamin D deficiency to prevent attacks of chronic obstructive pulmonary disease – The Conversation (free)
Meta-analysis: Vitamin D to prevent exacerbations of COPD
15 Jan, 2019 | 00:15h | UTCVitamin D to prevent exacerbations of COPD: systematic review and meta-analysis of individual participant data from randomised controlled trials – Thorax (link to abstract – $ for full-text)
Commentaries: Vitamin D supplementation reduced COPD exacerbations in deficient patients: meta-analysis – PulmCCM (free) AND Treat vitamin D deficiency to prevent attacks of chronic obstructive pulmonary disease – The Conversation (free)
Systematic Review: Antiamoebic Drugs for Treating Amoebic Colitis
15 Jan, 2019 | 00:16h | UTCAntiamoebic drugs for treating amoebic colitis – Cochrane Library (free)
Summary: Antiamoebic drugs for treating amoebic colitis – Cochrane Library (free)
Thyroid Hormone Treatment Does Not Help Adults with Mildly Abnormal Thyroid Tests
13 Jan, 2019 | 23:18h | UTCThyroid hormone treatment does not help adults with mildly abnormal thyroid tests – NIHR Signal (free)
Original Study: Meta-Analysis: Treating Subclinical Hypothyroidism is Not Associated with Quality of Life and Thyroid-Related Symptoms (link to abstract and commentaries)
Disease Management Interventions for Heart Failure
13 Jan, 2019 | 20:57h | UTCDisease management interventions for heart failure – Cochrane Library (free)
Summary: Disease management programmes for heart failure – Cochrane Library (free)
Systematic Review: Pyronaridine‐artesunate for Treating Uncomplicated Plasmodium Falciparum Malaria
13 Jan, 2019 | 18:21h | UTCPyronaridine‐artesunate for treating uncomplicated Plasmodium falciparum malaria – Cochrane Library (free)
Summary: Pyronaridine-artesunate for treating uncomplicated Plasmodium falciparum (P falciparum) malaria – Cochrane Library (free)
Commentary: Pyronaridine-artesunate for treating uncomplicated Plasmodium falciparum malaria – Liverpool School of Tropical Medicine (free)
Systematic Review: Novel Mitral valve Technologies—Transcatheter Mitral Valve Implantation
13 Jan, 2019 | 17:02h | UTC
Association Between Sunlight Exposure and Risk of Age-related Macular Degeneration
13 Jan, 2019 | 16:47h | UTC
Systematic Review: Treatment of Localized Extranodal NK/T Cell Lymphoma, Nasal Type
13 Jan, 2019 | 16:56h | UTC
Comparative Effectiveness of the Core Components of Cardiac Rehabilitation on Mortality and Morbidity
13 Jan, 2019 | 16:45h | UTC
Association Between Sunlight Exposure and Risk of Age-related Macular Degeneration
13 Jan, 2019 | 16:51h | UTC
Meta-Analysis: Massive Open Online Courses vs. Traditional Courses in Medicine Education
13 Jan, 2019 | 16:40h | UTC
Meta-Analysis: Opioids for Chronic Noncancer Pain
10 Jan, 2019 | 21:44h | UTCOpioids for Chronic Noncancer Pain: A Systematic Review and Meta-analysis – JAMA (link to abstract – $ for full-text)
Video Summary: How Effective are Opioids for Chronic Noncancer Pain? (free)
Commentaries: Opioids unlikely to provide clinically meaningful reduction in chronic non-cancer pain – 2 Minute Medicine (free) AND Opioids offer little chronic pain benefit and wane over time, study says – CNN (free)
Related: Opioid vs Nonopioid Medications in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain (free study, guideline and commentaries)
Meta-Analysis: Catheter Ablation of Atrial Fibrillation in Patients With Heart Failure
10 Jan, 2019 | 21:26h | UTCCatheter Ablation of Atrial Fibrillation in Patients With Heart Failure: A Meta-analysis of Randomized Controlled Trials – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Catheter ablation better than drug therapy for a-fib, heart failure – UPI (free) AND Catheter Ablation Boosts Outcomes in Patients With A-fib and Heart Failure: Meta-analysis – TCTMD (free)
Meta-Analysis: Pharmacological Treatments and Pain Control in Patients with Knee Osteoarthritis
10 Jan, 2019 | 19:50h | UTCAssociation of Pharmacological Treatments With Long-term Pain Control in Patients With Knee Osteoarthritis: A Systematic Review and Meta-analysis – JAMA (link to abstract – $ for full-text)
Commentaries: Medications may not heal long-term knee pain, study says – UPI (free) AND Knee osteoarthritis: 31 medications provide only uncertain pain control in large meta-analysis – Univadis (free registration required)
Systematic Review: Short-acting Insulins vs. Regular Insulin for Type 2 Diabetes
9 Jan, 2019 | 22:54h | UTCShort‐acting insulin analogues versus regular human insulin for adult, non‐pregnant persons with type 2 diabetes mellitus – Cochrane Library (free)
Summary: Short-acting insulin analogues versus regular human insulin for type 2 diabetes mellitus – Cochrane Library (free)
“The current evidence from clinical trials suggests neither clear benefits nor clear harms from the use of short‐acting insulin analogues over regular human insulin.”
Comparative Safety and Effectiveness of Treatments for Alzheimer’s Disease
9 Jan, 2019 | 22:10h | UTC
Systematic Review: Vitamin and Mineral Supplementation for Maintaining Cognitive Function Mid and Late Life
8 Jan, 2019 | 20:12h | UTCVitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life – Cochrane Library (free)
Summary: Vitamin and mineral supplementation for preventing cognitive deterioration in cognitively healthy people in mid and late life – Cochrane Library (free)
Commentary: Preventing dementia: do vitamin and mineral supplements have a role? – Evidently Cochrane (free)
Related Commentary on Twitter
New @CochraneDCIG Review finds 'no good evidence to suggest that middle‐aged or older people can preserve cognitive function or prevent dementia by taking vitamin or mineral supplements' https://t.co/8cyuiG8mtw 28 studies, 83,000 participants. #CochraneEvidence pic.twitter.com/N1VK0C6BuR
— The Cochrane Library (@CochraneLibrary) December 23, 2018
Meta-Analysis: Operative Treatment vs. Nonoperative Treatment of Achilles Tendon Ruptures
8 Jan, 2019 | 20:48h | UTCCommentaries: Surgeons should know when not to operate – The BMJ Opinion (free) AND Surgery or Not for Achilles Rupture? Meta-Analysis Finds Mixed Bag – NEJM Journal Watch (free)
Systematic Review: Routine Preoperative Medical Testing for Cataract Surgery
8 Jan, 2019 | 13:40h | UTCRoutine preoperative medical testing for cataract surgery – Cochrane Library (free)
Summary: Routine preoperative medical testing for cataract surgery – Cochrane Library (free)
Related Perspective: A Preoperative Medical History and Physical Should Not Be a Requirement for All Cataract Patients – Journal of General Internal Medicine (free)
Related Research: Preoperative Medical Testing in Medicare Patients Undergoing Cataract Surgery – New England Journal of Medicine (free)
“This review has shown that routine preoperative testing does not increase the safety of cataract surgery.”
Systematic Review: Point‐of‐care Ultrasonography for Diagnosing Thoracoabdominal Injuries in Patients with Blunt Trauma
8 Jan, 2019 | 11:18h | UTCPoint‐of‐care ultrasonography for diagnosing thoracoabdominal injuries in patients with blunt trauma – Cochrane Library (free)
Summary: How accurate is bedside ultrasound for the diagnosis of injuries to the abdomen or chest in patients with blunt injuries? – Cochrane Library (free)
Meta-Analysis: Efficacy and Safety of Agents in IgA Nephropathy
8 Jan, 2019 | 10:50h | UTC
Meta-Analysis: Proton Pump Inhibitors and Risk of Hip Fracture
7 Jan, 2019 | 19:35h | UTCProton pump inhibitors and risk of hip fracture: a meta-analysis of observational studies – Osteoporosis International (link to abstract – $ for full-text)
Commentary: PPIs up risk for hip fracture in large meta-analysis – Univadis (free registration required)
Related Commentary on Twitter
Metanalysis of 24 PPI studies, 319,568 hip fracture pts, suggests PPIs associated with a greater risk of hip fracture (RR 1.20, 95% CI 1.14–1.28, p < 0.0001) and may be greater with higher dose (RR 1.30, 95% CI 1.20–1.40, p < 0.0001). https://t.co/nbiEIPRaXg
— Dr. John Cush (@RheumNow) December 17, 2018
Meta‐analysis: Prognostic Accuracy of the HEART Score for Prediction of Major Adverse Cardiac Events in Patients Presenting With Chest Pain
4 Jan, 2019 | 20:50h | UTC
Systematic Review: Phosphodiesterase Inhibitors for Lower Urinary Tract Symptoms Consistent with Benign Prostatic Hyperplasia
4 Jan, 2019 | 20:48h | UTCPhosphodiesterase inhibitors for lower urinary tract symptoms consistent with benign prostatic hyperplasia – Cochrane Library (free)
Summary: Phosphodiesterase inhibitors for treatment of urinary problems in men with benign prostatic hyperplasia – Cochrane Library (free)