Systematic Reviews & Meta-analysis
M-A | Identifying the optimal therapeutics for patients with hormone receptor-positive, HER2-positive advanced breast cancer
9 May, 2023 | 14:24h | UTC
M-A | Lower vs higher fluid volumes in sepsis: no significant impact on mortality or serious adverse events
8 May, 2023 | 13:16h | UTC
SR | What Is the efficacy of intra-articular injections in the treatment of ankle osteoarthritis
8 May, 2023 | 12:48h | UTC
M-A | Effectiveness of handwashing with soap for preventing acute respiratory infections in low-income and middle-income countries
5 May, 2023 | 15:28h | UTCNews Release: Handwashing during ‘normal times’ can reduce burden of respiratory disease – London School of Hygiene & Tropical Medicine
Commentary from the author: New meta-analysis – handwashing promotion reduces respiratory infections by 17%
Commentary from the author on Twitter
Our new meta-analysis in @TheLancet : promoting handwashing with soap reduces respiratory infections by 17%.
Paper
? https://t.co/83RnQFbZoiBlogpost
? https://t.co/YZi91FGpo2Handwashing is not just for pandemics.
Endemic pneumonia kills 2.5m every year. pic.twitter.com/ulOUljLZUO— Ian Ross (@IanRossUK) April 28, 2023
SR | Perampanel add‐on for drug‐resistant focal epilepsy
4 May, 2023 | 13:49h | UTCPerampanel add‐on for drug‐resistant focal epilepsy – Cochrane Library
Summary: Perampanel add-on for drug-resistant focal epilepsy – Cochrane Library
Treating long-lasting low back pain without surgery: the latest evidence
4 May, 2023 | 13:40h | UTCTreating long-lasting low back pain without surgery: the latest evidence – Evidently Cochrane
SR | In people with prediabetes, Vitamin D may have a small benefit in decreasing the risk of diabetes
4 May, 2023 | 13:28h | UTCVitamin D and Risk for Type 2 Diabetes in People With Prediabetes: A Systematic Review and Meta-analysis of Individual Participant Data From 3 Randomized Clinical Trials – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries:
How Helpful Is Vitamin D in Prediabetes? – ConscienHealth
M-A | Efficacy of osteoporosis interventions on fracture prevention in postmenopausal women
3 May, 2023 | 15:37h | UTC
M-A | Direct oral anticoagulants versus warfarin across the spectrum of kidney function in patients with AF
3 May, 2023 | 15:32h | UTCDirect Oral Anticoagulants Versus Warfarin Across the Spectrum of Kidney Function: Patient-Level Network Meta-Analyses From COMBINE AF – Circulation (free for a limited period)
Commentary on Twitter
Direct Oral Anticoagulants versus Warfarin Across the Spectrum of Kidney Function: Patient-Level Network Meta-Analyses from COMBINE AF @jlharrington_md #AHAJournals https://t.co/6Rzlt09m9W pic.twitter.com/2oknvnken8
— Circulation (@CircAHA) April 18, 2023
SR | Fecal transplantation for treatment of inflammatory bowel disease
2 May, 2023 | 13:39h | UTCFecal transplantation for treatment of inflammatory bowel disease – Cochrane Library
M-A | Immune checkpoint inhibitors vs. chemotherapy in the 2nd-line treatment of advanced esophageal squamous cell carcinoma
28 Apr, 2023 | 12:56h | UTC
A systematic review on clinical guidelines of home health care in heart failure patients
28 Apr, 2023 | 12:41h | UTC
M-A | Corticosteroids in community-acquired bacterial pneumonia
26 Apr, 2023 | 14:29h | UTCCorticosteroids in Community-Acquired Bacterial Pneumonia: a Systematic Review, Pairwise and Dose-Response Meta-Analysis – Journal of General Internal Medicine (if the link is paywalled, try this one)
Related:
RCT | Hydrocortisone reduces mortality in severe community-acquired pneumonia
ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia
M-A | Non-opioid analgesics for the prevention of chronic postsurgical pain
26 Apr, 2023 | 14:17h | UTC
Post-tuberculosis lung impairment: systematic review and meta-analysis of spirometry data from 14 621 people
26 Apr, 2023 | 14:11h | UTC
M-A | Prevalence of atypical pathogens in patients with severe pneumonia
26 Apr, 2023 | 14:02h | UTC
M-A | Efficacy of erector spinae plane block for postoperative analgesia lumbar surgery
26 Apr, 2023 | 13:53h | UTC
SR | Cranberries can prevent recurrent urinary tract infections in selected patients
25 Apr, 2023 | 14:41h | UTCCranberries for preventing urinary tract infections – Cochrane Library
Summary: Cranberries for preventing urinary tract infections – Cochrane Library
Commentaries:
Cranberry juice can prevent recurrent UTIs, but only for some people – The Conversation
Review confirms that cranberry products help prevent urinary tract infections – News Medical
M-A | Surgical versus non-surgical treatment for sciatica
25 Apr, 2023 | 14:39h | UTCEditorial: Early surgery for sciatica – The BMJ
News Release: Surgery for sciatica reduces leg pain and disability, but benefits are short-lived – University of Oxford
Commentary on Twitter
Very low to low certainty evidence suggests that discectomy was superior to non-surgical treatment or epidural steroid injections in reducing leg pain and disability in people with sciatica with a surgical indication, but the benefits reduced over timehttps://t.co/kHL2HBNscF
— The BMJ (@bmj_latest) April 19, 2023
SR | Angiogenesis inhibitors for the treatment of epithelial ovarian cancer
25 Apr, 2023 | 14:22h | UTCAngiogenesis inhibitors for the treatment of epithelial ovarian cancer – Cochrane Library
Evidence Analysis | Blood pressure targets – how low can you get?
24 Apr, 2023 | 13:47h | UTCBlood pressure targets – how low can you get? – Evidently Cochrane
Original Article: SR | Blood pressure targets for the treatment of people with hypertension and cardiovascular disease.
Commentary on Twitter
Blood pressure targets – how low can you get? https://t.co/ERLm6Mihl8 In this @CochraneUK blog, GP @rtwalton123 looks at the latest guidance & @CochraneLibrary evidence on what #BloodPressure targets to aim for, balancing the benefits of treatment against risk of side effects. pic.twitter.com/8EQH0JLzzc
— The Cochrane Library (@CochraneLibrary) April 19, 2023
M-A | 5-alpha-reductase inhibitors are not associated with increased risk of mortality from prostate cancer
24 Apr, 2023 | 13:30h | UTCAssociation Between 5α-Reductase Inhibitors and Prostate Cancer Mortality: A Systematic Review and Meta-analysis – JAMA Oncology (free for a limited period)
Commentary on Twitter
Systematic review & meta-analysis drawing on 2 decades of epidemiologic literature and including data from over 3 million patients shows no significant association between use of 5-alpha reductase inhibitor use and mortality from prostate cancer. https://t.co/3l9jT1l2P9 #PCSM
— JAMA Oncology (@JAMAOnc) April 21, 2023
SR | Etiology, diagnosis, and modern management of chronic pancreatitis
24 Apr, 2023 | 13:29h | UTCEtiology, Diagnosis, and Modern Management of Chronic Pancreatitis: A Systematic Review – JAMA Surgery (free for a limited period)
M-A | Electroconvulsive therapy may be superior to ketamine for patients with major depressive episode
21 Apr, 2023 | 13:03h | UTCKetamine vs Electroconvulsive Therapy for Major Depressive Episode: A Systematic Review and Meta-analysis – JAMA Psychiatry (link to abstract – $ for full-text)
Commentaries:
Electroconvulsive Therapy Bests Ketamine in Treating Major Depressive Episodes – HCP Live
M-A | Adverse events related to tirzepatide (a dual GIP/GLP-1 receptor agonist)
21 Apr, 2023 | 12:59h | UTCAdverse Events Related to Tirzepatide – Journal of the Endocrine Society
Related:
Tirzepatide Once Weekly for the Treatment of Obesity – New England Journal of Medicine
Tirzepatide cardiovascular event risk assessment: a pre-specified meta-analysis – Nature Medicine
Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes: The SURPASS-5 Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)