Systematic Reviews & Meta-analysis
M-A: Triple vs. dual inhaler therapy in patients with moderate to severe asthma – fewer severe asthma exacerbations, but without significant differences in quality of life or mortality.
1 Jun, 2021 | 08:12h | UTCTriple vs Dual Inhaler Therapy and Asthma Outcomes in Moderate to Severe Asthma: A Systematic Review and Meta-analysis – JAMA (free for a limited period)
Commentary on Twitter
Among patients with moderate to severe asthma, triple therapy compared with dual therapy was significantly associated with fewer severe asthma exacerbations and modest improvements in asthma control but no significant difference in quality of life https://t.co/icKsWu0Md9 #ATS2021
— JAMA (@JAMA_current) May 19, 2021
M-A: Prokinetics may improve tolerance to gastric feeding to some extent in critically ill adults.
26 May, 2021 | 08:16h | UTC
M-A: A biofeedback‐guided program or pelvic floor muscle electric stimulation can improve early recovery of urinary continence after radical prostatectomy.
26 May, 2021 | 08:13h | UTC
Living systematic review: The evidence is insufficient to determine the benefits and harms of vitamin D supplementation as a treatment of COVID‐19.
25 May, 2021 | 08:55h | UTCSummary: Is vitamin D an effective and safe treatment for COVID-19? – Cochrane Library
Meta-analysis: New generation antidepressants for depression in children and adolescents – “most newer antidepressants may reduce depression symptoms in a small and unimportant way compared with placebo”.
25 May, 2021 | 08:40h | UTC
Systematic Review: Oral dextrose gel reduces the risk of neonatal hypoglycemia in at‐risk infants and probably reduces the risk of major neurological disability at two years.
25 May, 2021 | 08:38h | UTCOral dextrose gel to prevent hypoglycaemia in at‐risk neonates – Cochrane Library
Summary: Oral dextrose gel for prevention of low blood glucose levels in newborn babies – Cochrane Library
Pessaries for pelvic organ prolapse – looking at the Cochrane evidence.
24 May, 2021 | 08:17h | UTCPessaries for pelvic organ prolapse – looking at the Cochrane evidence – Evidently Cochrane
Original Review: Pessaries (mechanical devices) for managing pelvic organ prolapse in women – Cochrane Library
M-A: Comparison of treatments for cocaine use disorder among adults – Only contingency management programs were significantly associated with an increased likelihood of reductions in cocaine use among adults.
21 May, 2021 | 08:28h | UTC
M-A: Among patients undergoing total knee arthroplasty, glucocorticoid supplementation in periarticular infiltration analgesia is effective and does not increase complications or side effects.
21 May, 2021 | 08:22h | UTC
M-A: In patients with anaphylaxis, the use of multiple epinephrine doses is necessary in 7.7% of cases.
21 May, 2021 | 08:19h | UTCCommentary: How Often Does Anaphylaxis Require Redosing of Epinephrine? – Journal Feed
M-A: Psychologic treatment of depression compared with pharmacotherapy and combined treatment in primary care – Psychotherapy has comparable effects to those of pharmacotherapy, and combined treatment might be better than either psychotherapy or pharmacotherapy alone.
20 May, 2021 | 08:34h | UTC
Commentary on Twitter
https://twitter.com/pimcuijpers/status/1391999860505825286
Systematic review: Prognostic factors for pain chronicity in low back pain – “Higher pain intensity, higher body weight, carrying heavy loads at work, difficult working positions, and depression were the most frequently observed risk factors for chronic low back pain”
20 May, 2021 | 08:32h | UTCPrognostic factors for pain chronicity in low back pain: a systematic review – Pain Reports
Systematic review: Paying for performance to improve the delivery of health interventions in low‐ and middle‐income countries.
19 May, 2021 | 08:19h | UTCSummary: Paying for performance to improve the delivery of health interventions in LMICs
Systematic Review: Surfactant therapy via thin catheter in preterm infants with or at risk of respiratory distress syndrome is associated with reduced risk of death or bronchopulmonary dysplasia, less intubation in the first 72 hours, and reduced incidence of major complications and in‐hospital mortality.
19 May, 2021 | 08:20h | UTC
Commentary on Twitter
https://twitter.com/CochraneUK/status/1393463418913443843
M-A: Screening test (Hospital Anxiety and Depression Scale – HADS-D) can identify hospitalized patients with depression.
18 May, 2021 | 07:23h | UTCKnowledge translation tool: Using the HADS-D to Screen for Depression
Commentary on Twitter (thread – click for more)
Our @DepressdP IPDMA on HADS-D accuracy, led by Dr. Yin Wu, was published today in @bmj_latest! We pooled data from 101 studies and found that a cutoff of >=7 maximized combined sensitivity and specificity. Read more here: https://t.co/iMmsjoeW7f
— Brooke Levis (@blevis_epi) May 10, 2021
Systematic review: Treatment of gastro-esophageal reflux disease to help manage asthma in adults and children may result in reduced use of rescue medications, but the benefits on the number of exacerbations and hospital utilization remain uncertain.
18 May, 2021 | 07:27h | UTC
2 recent meta-analysis highlight the benefits of short term (30 days) dual antiplatelet therapy with aspirin + clopidogrel in patients within 24 hours of high-risk transient ischemic attack or mild-moderate ischemic stroke.
17 May, 2021 | 08:16h | UTCMeta-analysis 1: Dual Antiplatelet Therapy Versus Aspirin in Patients With Stroke or Transient Ischemic Attack: Meta-Analysis of Randomized Controlled Trials – Stroke
Meta-analysis 2: Efficacy and Safety of Using Dual Versus Monotherapy Antiplatelet Agents in Secondary Stroke Prevention: Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials – Circulation (link to abstract – $ for full-text)
Commentary: Dual vs. Monotherapy Antiplatelet Agents in Secondary Stroke Prevention – American College of Cardiology
Related Guideline: Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke – The BMJ
Systematic review: Combination fixed‐dose beta-agonist and steroid inhaler as required is clinically effective in adults and adolescents with mild asthma.
14 May, 2021 | 08:23h | UTC
Systematic review: Treatments for unruptured intracranial aneurysms – There is currently insufficient good-quality evidence to support either conservative treatment or interventional treatments (microsurgical clipping or endovascular coiling)
13 May, 2021 | 05:51h | UTCTreatments for unruptured intracranial aneurysms – Cochrane Library
Summary: Treatments for unruptured intracranial aneurysms – Cochrane Library
A global database of COVID-19 vaccinations
11 May, 2021 | 09:28h | UTCA global database of COVID-19 vaccinations – Nature Human Behaviour
See website: Statistics and Research: Coronavirus (COVID-19) Vaccinations – Our World in Data
Commentaries on Twitter
Since the beginning of the COVID vaccinations we brought together the global data.
It's the most cited resource that @OurWorldInData has ever produced. Thousands of citations every week.
Just now our vaccination dataset has been published in Nature!https://t.co/COmCMNSbw2
— Max Roser (@MaxCRoser) May 10, 2021
A stunner.
One of my favorite graphics from the pandemic: the story of the unprecedented #SARSCoV2 vaccines
Published today @NatureHumBehav @OurWorldInData https://t.co/raPq8H3DSq@redouad @MaxCRoser @_HannahRitchie @EOrtizOspina @lucasrodesg @lucasrodesg @JoeHasell @appel_cam pic.twitter.com/x1LYobAOkM— Eric Topol (@EricTopol) May 10, 2021
M-A: Metabolic–bariatric surgery is associated with increased long-term survival in adults with obesity, the effects being more pronounced for people with pre-existing diabetes
11 May, 2021 | 09:11h | UTCAssociation of metabolic–bariatric surgery with long-term survival in adults with and without diabetes: a one-stage meta-analysis of matched cohort and prospective controlled studies with 174 772 participants – The Lancet (link to abstract – $ for full-text)
Systematic review: Use of compression stockings by airline passengers can reduce symptomless deep vein thrombosis and leg edema
11 May, 2021 | 09:04h | UTCCompression stockings for preventing deep vein thrombosis in airline passengers – Cochrane Library
USPSTF Draft Statement: Insufficient evidence to recommend multivitamin supplements for the prevention of CVD or cancer. The statement also recommends against the use of beta-carotene (increases risk of CVD mortality and lung cancer) or vitamin E (clear evidence of no benefit)
5 May, 2021 | 08:30h | UTCDraft Evidence Review: Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and Cancer
[Preprint] Frequency of neurological manifestations in COVID-19: a systematic review and meta-analysis of 350 studies – up to one-third of COVID-19 patients analyzed in this review, 89% of whom were hospitalized, experienced at least one neurological manifestation
4 May, 2021 | 08:44h | UTCCommentary: Study finds one-third of COVID-19 patients experience neurological symptoms – News Medical
Systematic review: Interventions for increasing solid organ donor registration
28 Apr, 2021 | 08:11h | UTCInterventions for increasing solid organ donor registration – Cochrane Library
Summary: Interventions for increasing solid organ donor registration – Cochrane Library