Systematic Reviews & Meta-analysis
M-A: Simultaneous use of hypertonic saline and IV furosemide for fluid overload – “Benefits of the HSS+Fx over Fx were observed across all examined outcomes in acute decompensated heart failure patients with fluid overload”.
1 Jul, 2021 | 09:41h | UTCSimultaneous Use of Hypertonic Saline and IV Furosemide for Fluid Overload: A Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text)
Systematic Review: Cilostazol for intermittent claudication – “Cilostazol has been shown to improve walking distance in people with intermittent claudication. However, participants taking cilostazol had higher odds of experiencing headache”.
1 Jul, 2021 | 09:42h | UTCCilostazol for intermittent claudication – Cochrane Library
Summary: Cilostazol for peripheral arterial disease – Cochrane Library
M-A: The utility of the rapid shallow breathing index in predicting successful extubation – “As a stand-alone test, the RSBI has moderate sensitivity and poor specificity for predicting extubation success”.
30 Jun, 2021 | 10:07h | UTCThe Utility of the Rapid Shallow Breathing Index in Predicting Successful Extubation: A Systematic Review and Meta-analysis – CHEST (link to abstract – $ for full-text)
Systematic review: the evidence behind robot-assisted abdominopelvic surgery – “there is currently no clear advantage with existing robotic platforms, which are costly and increase operative duration”.
29 Jun, 2021 | 09:55h | UTCThe Evidence Behind Robot-Assisted Abdominopelvic Surgery: A Systematic Review – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary: Robotic Platforms Not Superior for Abdominopelvic Surgery – HealthDay
Systematic review: low‐dose oral misoprostol probably has many benefits over other methods for labor induction.
24 Jun, 2021 | 09:44h | UTCLow‐dose oral misoprostol for induction of labour – Cochrane Library
Another meta-analysis supports aspirin withdrawal one to three months after percutaneous coronary intervention and continuation with P2Y12 inhibitor monotherapy.
18 Jun, 2021 | 08:22h | UTC
M-A: Acute treatments for episodic migraine in adults.
18 Jun, 2021 | 08:18h | UTCAcute Treatments for Episodic Migraine in Adults: A Systematic Review and Meta-analysis – JAMA (free for a limited period)
Editorial: Acute Treatment for Migraine: Contemporary Treatments and Future Directions (free for a limited period)
Commentary on Twitter (thread – click for more)
Science marches breathlessly forward – or, at least tries to expand its indication.
Anti–calcitonin gene-related peptide antibody infusion, again, vs. placebo.
— Ryan Radecki, MD MS (@emlitofnote) June 17, 2021
M-A: Extracorporeal membrane oxygenation for COVID-19.
16 Jun, 2021 | 08:22h | UTC
M-A: Ibuprofen and other NSAIDs superior to codeine for managing outpatient postoperative pain.
15 Jun, 2021 | 08:55h | UTCOriginal Article: Managing postoperative pain in adult outpatients: a systematic review and meta-analysis comparing codeine with NSAIDs – Canadian Medical Association Journal
Parental education and inequalities in child mortality: a global systematic review and meta-analysis.
15 Jun, 2021 | 08:52h | UTCCommentaries: Children of well-educated people have higher survival rates – Norwegian University of Science and Technology AND Parental education’s role in child survival – The Lancet
Commentary on Twitter (thread – click for more)
NEW study suggests lower parental education is a risk factor for child mortality, even after controlling for other markers of family socioeconomic status.
Thus, universal quality education could help ⬇️ neonatal & child mortality (#SDG target 3.2). Read https://t.co/1saJ9KwUyC. pic.twitter.com/5pctnQft4M
— The Lancet (@TheLancet) June 12, 2021
M-A: Among patients with kidney failure treated with dialysis, mineralocorticoid receptor antagonists reduce cardiovascular and all-cause mortality without increasing the risk of hyperkalemia.
15 Jun, 2021 | 08:53h | UTCEfficacy and Safety of Mineralocorticoid Receptor Antagonists in Kidney Failure Patients Treated with Dialysis: A Systematic Review and Meta-Analysis – Clinical Journal of the American Society of Nephrology (link to abstract – $ for full-text)
Commentary on Twitter
Patients with kidney failure have a high risk of cardiovascular diseases. This meta-analysis suggests that mineralocorticoid receptor antagonists might improve clinical outcomes of patients with kidney failure without a major increase in hyperkalemia risk https://t.co/o3aO3KK2S6 pic.twitter.com/5xuCgs6FbQ
— CJASN (@CJASN) June 14, 2021
M-A: Effect of ultrashort-acting betablockers on mortality in patients with sepsis with persistent tachycardia.
14 Jun, 2021 | 08:33h | UTC
M-A: No difference in major postoperative complications or mortality with perioperative liberal vs. restrictive fluid strategies in major abdominal elective surgery.
14 Jun, 2021 | 08:30h | UTC
M-A: Safety of thoracentesis and tube thoracostomy in patients with uncorrected coagulopathy.
11 Jun, 2021 | 08:15h | UTCCommentary: Is Thoracentesis Safe in Coagulopathic Patients? – JournalFeed
M-A: Effectiveness of telerehabilitation in physical therapist practice.
10 Jun, 2021 | 09:29h | UTC
Systematic review: Frequency, signs and symptoms, and criteria adopted for long COVID-19.
9 Jun, 2021 | 08:22h | UTC
M-A: Hospital-at-home interventions for patients with chronic disease who present to the emergency department – similar mortality risk, lower risk for readmission, lower depression and anxiety scores, and a lower risk for long-term care admission vs. in-hospital stay.
9 Jun, 2021 | 08:20h | UTCInvited commentary: Hospitalization at Home for Patients With Acute Exacerbation of Chronic Disease—Further Evidence to Inform Practice – JAMA Network Open
Related: Pandemic Boosts an Old Idea—Bringing Acute Care to the Patient AND Randomized trial: Admission Avoidance Hospital at Home + Geriatric Assessment led to similar outcomes compared to hospital admission for older persons AND Most COVID-19 patients receiving home-based hospital care did not require escalation to traditional hospital setting – Approximately 1 in 5 were admitted within 14 days. Higher oxygen saturation was associated with decreased odds of transfer, whereas higher comorbidity burden was associated with increased risk.
2 new meta-analysis detail neurologic and psychiatric conditions in COVID-19.
6 Jun, 2021 | 23:54h | UTCNeurologic, psychiatric conditions common in COVID-19 – CIDRAP
Moving from bytes to bedside: a systematic review on the use of artificial intelligence in the intensive care unit.
6 Jun, 2021 | 23:42h | UTC
Commentary on Twitter
Overview of current maturity of using #ArtificialIntelligence in #ICU, research methodologies, risk of bias: SR including 494 studies. To date, vast majority of published ICU #AI models remain in prototyping/development environment, not tested at bedside. https://t.co/kTpSy2Is7J https://t.co/oU11J3XYjA pic.twitter.com/tKIwQYqgRH
— Intensive Care Medicine (@yourICM) June 5, 2021
M-A: The benefit of dysphagia screening in adult patients with stroke.
6 Jun, 2021 | 23:43h | UTC
M-A: In hypoxemic non-hypercapnic patients, early extubation followed by noninvasive ventilation can reduce the total number of days of invasive mechanical ventilation (mean difference, − 2.04 days), without effects in ICU mortality.
4 Jun, 2021 | 10:27h | UTC
M-A: Parenting interventions to promote early child development in the first three years of life.
3 Jun, 2021 | 10:37h | UTC
M-A: After an acute coronary syndrome treated with coronary stenting, dual antiplatelet therapy (DAPT) for 1 to 3 months followed by P2Y12 inhibitor monotherapy is associated with improved outcomes compared with traditional DAPT for 12 months.
2 Jun, 2021 | 08:26h | UTCMeta-Analysis of Duration of Dual Antiplatelet Therapy in Acute Coronary Syndrome Treated With Coronary Stenting – American Journal of Medicine (link to abstract – $ for full-text)
Systematic review: Driving performance under treatment of most frequently prescribed drugs for mental disorders – 31% of schizophrenic or schizoaffective patients under antipsychotics, and 18% of unipolar and bipolar patients under antidepressants showed severe impairment in skills relevant for driving.
2 Jun, 2021 | 08:24h | UTC
M-A: Delivery room interventions for hypothermia in preterm neonates – “use of a plastic bag or wrap with a plastic cap or with heated humidified gas was associated with lower risk of major brain injury and mortality”.
1 Jun, 2021 | 08:10h | UTCDelivery Room Interventions for Hypothermia in Preterm Neonates: A Systematic Review and Network Meta-analysis – JAMA Pediatrics (link to abstract – $ for full-text)