Randomized Trials | Page 56 of 58 | Links Medicus Content Curation & Alerts in Medicine

Propofol vs. Volatile Anesthetics: RCT finds no difference in postoperative pulmonary complications after lung resection surgery

9 Mar, 2021 | 02:17h | UTC

Comparative Effect of Propofol and Volatile Anesthetics on Postoperative Pulmonary Complications After Lung Resection Surgery: A Randomized Clinical Trial – Anesthesia & Analgesia (link to abstract – $ for full-text)

RCT: Primary tumor resection plus chemotherapy vs. chemotherapy alone for colorectal cancer patients with asymptomatic, synchronous unresectable metastases

7 Mar, 2021 | 19:23h | UTC

Primary Tumor Resection Plus Chemotherapy Versus Chemotherapy Alone for Colorectal Cancer Patients With Asymptomatic, Synchronous Unresectable Metastases (JCOG1007; iPACS): A Randomized Clinical Trial – Journal of Clinical Oncology

Original study: No Survival Benefit to Primary Resection Before Chemo in Metastatic Colorectal Cancer – Medscape / Reuters

Primary tumor resection followed by chemotherapy in patients with metastatic colorectal cancer doesn't improve survival over chemotherapy alone https://t.co/iOYqjaABzi @JCOG_official #crcsm #JCO pic.twitter.com/RCj2OHEehH

— Journal of Clinical Oncology (@JCO_ASCO) March 5, 2021

RCT: Half-dose vs. full-dose Edoxaban in 14,014 patients with Atrial Fibrillation

7 Mar, 2021 | 19:13h | UTC

Randomized, Double-Blind Comparison of Half-Dose Versus Full-Dose Edoxaban in 14,014 Patients With Atrial Fibrillation – Journal of the American College of Cardiology

Commentary: Lower Dose of Edoxaban Supported in ENGAGE-AF-TIMI 48 Analysis – TCTMD

Study: Cancer patients benefit from using automated device to manage their symptoms

7 Mar, 2021 | 19:21h | UTC

Cancer patients benefit from using automated device to manage their symptoms – News Medical / University of Leeds

Original study: Phase III Randomized Controlled Trial of eRAPID: eHealth Intervention During Chemotherapy – Journal of Clinical Oncology

Editorial: Benefits of Digital Symptom Monitoring With Patient-Reported Outcomes During Adjuvant Cancer Treatment – Journal of Clinical Oncology

Conversion of Propranolol to Carvedilol in patients with cirrhosis and ascites: Small randomized, open label study suggests improvement in outcomes

7 Mar, 2021 | 19:08h | UTC

Conversion of Propranolol to Carvedilol Improves Renal Perfusion and Outcome in Patients With Cirrhosis and Ascites – Clinical Gastroenterology (link to abstract – $ for full-text)

RCT: Biologic mesh implantation is associated with serious abdominal wall complications in patients undergoing emergency abdominal surgery

7 Mar, 2021 | 19:07h | UTC

Biologic mesh implantation is associated with serious abdominal wall complications in patients undergoing emergency abdominal surgery: A randomized-controlled clinical trial – Trauma & Acute Care Surgery (link to abstract – $ for full-text)

RCT: Rituximab vs. tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis

7 Mar, 2021 | 19:06h | UTC

Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial – The Lancet

Commentary: Precision medicine in rheumatology: are we getting closer? – The Lancet

Commentary on Twitter

For patients with rheumatoid #arthritis and low or absent B-cell lineage expression signature in synovial tissue, tocilizumab is more effective than rituximab, suggests the first biopsy-driven trial. Read the results in full: https://t.co/XjzOqeBwdc pic.twitter.com/hODUwDy8BP

— The Lancet (@TheLancet) January 26, 2021

Randomized, crossover trial: A comparison of two hybrid closed-loop systems in adolescents and young adults with type 1 diabetes

7 Mar, 2021 | 19:03h | UTC

A comparison of two hybrid closed-loop systems in adolescents and young adults with type 1 diabetes (FLAIR): a multicentre, randomised, crossover trial – The Lancet (link to abstract – $ for full-text)

Commentary on Twitter

In a crossover trial of adolescents and young adults with type 1 #diabetes, daytime hyperglycaemia was reduced without increasing hypoglycaemia using the advanced hybrid closed-loop system compared with the 670G system. Read the study: https://t.co/WtU9O3uGkb pic.twitter.com/bf8HV6scKQ

— The Lancet (@TheLancet) January 18, 2021

RCT: Evaluation of oral dextrose gel for prevention of neonatal hypoglycemia

7 Mar, 2021 | 19:01h | UTC

Evaluation of oral dextrose gel for prevention of neonatal hypoglycemia (hPOD): A multicenter, double-blind randomized controlled trial – PLOS Medicine

RCT: Safety of combined division vs. separate division of the splenic vein in patients undergoing distal pancreatectomy

5 Mar, 2021 | 08:25h | UTC

Safety of Combined Division vs Separate Division of the Splenic Vein in Patients Undergoing Distal Pancreatectomy: A Noninferiority Randomized Clinical Trial – JAMA Surgery

Commentaries: An Evidence-Based Beneficial Shortcut for Distal Pancreatic Resection – JAMA Surgery AND Surgical Shortcut Noninferior to Standard Technique for Pancreatic Resection – Physician’s Weekly

Commentary on Twitter

https://twitter.com/JAMASurgery/status/1367157880261144577

RCT: No benefit from oral corticosteroids following endoscopic sinus surgery for chronic rhinosinusitis without nasal polyposis

5 Mar, 2021 | 08:22h | UTC

Oral Corticosteroids Following Endoscopic Sinus Surgery for Chronic Rhinosinusitis Without Nasal Polyposis: A Randomized Clinical Trial – JAMA Otolaryngology Head Neck Surgery

Commentary on Twitter

Should you use oral steroids after sinus surgery for chronic rhinosinusitis w/o polyps? Steroids may have no benefit (and some risk!) as found in this double-blinded placebo-controlled randomized trial conducted by @StanfordMed https://t.co/mgtF3FYiVs

— JAMA Otolaryngology – Head & Neck Surgery (@JAMAOto) March 4, 2021

RCT: Mixed findings with Terlipressin plus Albumin for the treatment of Type 1 hepatorenal syndrome

4 Mar, 2021 | 08:35h | UTC

Terlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome – New England Journal of Medicine (link to abstract – $ for full-text)

RCT: Albumin provides no benefit to hospitalized patients with decompensated cirrhosis

4 Mar, 2021 | 08:37h | UTC

A Randomized Trial of Albumin Infusions in Hospitalized Patients with Cirrhosis – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Albumin provides no benefit to hospitalized patients with advanced liver disease – University College London

RCT: High dose once a week Semaglutide (2.4 mg) in adults with overweight or obesity, and type 2 diabetes

4 Mar, 2021 | 08:31h | UTC

Semaglutide 2·4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial – The Lancet

Commentary: Drug found effective for weight loss in patients with obesity and diabetes, international study show – UT Southwestern Medical Center

RCT: Nivolumab plus Cabozantinib vs. Sunitinib for Advanced Renal-Cell Carcinoma

4 Mar, 2021 | 08:33h | UTC

Nivolumab plus Cabozantinib versus Sunitinib for Advanced Renal-Cell Carcinoma – New England Journal of Medicine (link to abstract – $ for full-text)

RCT: Irrigating acetic acid solution during colonoscopy for the detection of sessile serrated neoplasia

4 Mar, 2021 | 08:16h | UTC

Irrigating Acetic Acid Solution During Colonoscopy for the Detection of Sessile Serrated Neoplasia: A Randomized Controlled Trial – Digestive Diseases and Sciences

RCT: Laparoscopic anterior resection with or without transanal tube for rectal cancer patients

4 Mar, 2021 | 08:02h | UTC

Laparoscopic anterior resection with or without transanal tube for rectal cancer patients – A multicenter randomized controlled trial – The American Journal of Surgery (link to abstract – $ for full-text)

Using Bayesian Methods to Augment the Interpretation of Critical Care Trials. An Overview of Theory and Example Reanalysis of the Alveolar Recruitment for Acute Respiratory Distress Syndrome Trial

3 Mar, 2021 | 08:36h | UTC

Using Bayesian Methods to Augment the Interpretation of Critical Care Trials. An Overview of Theory and Example Reanalysis of the Alveolar Recruitment for Acute Respiratory Distress Syndrome Trial – American Journal of Respiratory and Critical Care Medicine

Commentary on Twitter

I love this paper on Bayes.

Aren’t trials just like medical tests: they update our prior knowledge or beliefs?

If you can discuss a trial using its p-wave or confidence intervals, why not its posterior probabilities given *justified* priors.

(Yes, I am enthralled!) https://t.co/w1ym9jgQD5

— John Mandrola, MD (@drjohnm) March 1, 2021

RCT: High flow oxygen does not change the risk of mortality in patients with a suspected acute coronary syndrome

3 Mar, 2021 | 08:37h | UTC

High flow oxygen and risk of mortality in patients with a suspected acute coronary syndrome: pragmatic, cluster randomised, crossover trial – The BMJ

Commentary on Twitter

Supplementary high flow oxygen given for ischaemic symptoms to patients with suspected acute coronary syndrome was not associated with a change in 30 day mortality, finds new #BMJResearch https://t.co/CDhfFyVL88

— The BMJ (@bmj_latest) March 2, 2021

RCT: Effect of Blinatumomab vs. Chemotherapy in children with high-risk first-relapse B-Cell Acute Lymphoblastic Leukemia

3 Mar, 2021 | 08:19h | UTC

Effect of Blinatumomab vs Chemotherapy on Event-Free Survival Among Children With High-risk First-Relapse B-Cell Acute Lymphoblastic Leukemia: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Blinatumomab for Treatment of Children With High-risk Relapsed B-Cell Acute Lymphoblastic Leukemia – JAMA (free for a limited period)

RCT: Omega-3 supplements do not reduce cardiovascular events in elderly patients after myocardial infarction

3 Mar, 2021 | 08:13h | UTC

Effects of n-3 Fatty Acid Supplements in Elderly Patients After Myocardial Infarction: A Randomized, Controlled Trial – Circulation (link to abstract – $ for full-text)

Commentary: Omega-3 fatty acids did not reduce risk of cardiac events in elderly heart attack survivors – News Medical

Commentary on Twitter

OMEMI: In RCT of elderly patients with a recent acute myocardial infarction, n-3 fatty acid supplementation did not reduce clinical events. Read more: https://t.co/nGs5DGGtmT #AHAJournals @Oslounivsykehus @UniOslo @pmyhre @AAKalstad pic.twitter.com/I3Gr89ztyj

— Circulation (@CircAHA) February 11, 2021

Five-year outcomes from randomized, phase III trials: Nivolumab vs. Docetaxel in previously treated non–small-cell lung cancer

3 Mar, 2021 | 08:10h | UTC

Five-Year Outcomes From the Randomized, Phase III Trials CheckMate 017 and 057: Nivolumab Versus Docetaxel in Previously Treated Non–Small-Cell Lung Cancer – Journal of Clinical Oncology

Commentary on Twitter

At 5 years of follow up in CheckMate 017 and 057 trials, nivolumab continues to demonstrate a survival benefit vs docetaxel in patients with previously-treated advanced NSCLC https://t.co/oswZhdAPTW #JCO #lcsm #immunoonc pic.twitter.com/4FZJlfig99

— Journal of Clinical Oncology (@JCO_ASCO) February 9, 2021

RCT: Extended vs. limited pelvic lymph node dissection during radical prostatectomy for intermediate- and high-risk prostate cancer

3 Mar, 2021 | 08:05h | UTC

Extended Versus Limited Pelvic Lymph Node Dissection During Radical Prostatectomy for Intermediate- and High-risk Prostate Cancer: Early Oncological Outcomes from a Randomized Phase 3 Trial – European Urology (link to abstract – $ for full-text)

Commentary: Extended pelvic lymph node dissection during RP does not appear beneficial – Urology Times

Commentary on Twitter

Extended Versus Limited Pelvic Lymph Node Dissection During Radical Prostatectomy for Intermediate- and High-risk Prostate Cancer: Early Oncological Outcomes from a Randomized Phase 3 Trial#VisualAbstract https://t.co/7fAFlKmfTf @jeanlestingi @qdtrinh @RafaelFCoelho2 pic.twitter.com/es53WpXBFR

— European Urology (@EUplatinum) December 10, 2020