Psychiatry
RCT | Pregnant individuals benefit from brief interpersonal psychotherapy for depression
21 Apr, 2023 | 13:05h | UTCCommentary: Interpersonal Psychotherapy Reduces Depression Symptoms of Pregnant Women – HCP Live
Commentary on Twitter
A randomized clinical trial of prenatal interpersonal psychotherapy showed rapid decreases in depression. Depression in the intervention group dropped from 37% before intervention to 6% after (vs. 26% in control group). https://t.co/rJADZZkfER
— JAMA Psychiatry (@JAMAPsych) April 19, 2023
M-A | Electroconvulsive therapy may be superior to ketamine for patients with major depressive episode
21 Apr, 2023 | 13:03h | UTCKetamine vs Electroconvulsive Therapy for Major Depressive Episode: A Systematic Review and Meta-analysis – JAMA Psychiatry (link to abstract – $ for full-text)
Commentaries:
Electroconvulsive Therapy Bests Ketamine in Treating Major Depressive Episodes – HCP Live
Guideline | Management of psychiatric disorders in patients with hepatic and gastrointestinal diseases
19 Apr, 2023 | 13:07h | UTC
Comprehensive clinical practice guidelines for the management of psychiatric emergencies
18 Apr, 2023 | 13:34h | UTCClinical Practice Guidelines for Management of Suicidal Behaviour
Clinical Practice Guidelines for Assessment and Management of Aggressive and Assaultive Behaviour
Clinical Practice Guidelines on Breaking Bad News
Clinical Practice Guidelines for the Use of Electroconvulsive Therapy
Clinical Practice Guidelines for the Use of Transcranial Direct Current Stimulation in Psychiatry
The earlier the better: an RCT of treatment timing effects for toddlers on the autism spectrum
17 Apr, 2023 | 12:52h | UTC
SR | Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD)
17 Apr, 2023 | 12:39h | UTC
Brief Review | Hoarding disorder: evidence and best practice in primary care
11 Apr, 2023 | 14:28h | UTCHoarding disorder: evidence and best practice in primary care – British Journal of General Practice
SR | Epidemiology of injecting drug use, related harms & exposure to behavioral and environmental risks
11 Apr, 2023 | 14:26h | UTCInvited Commentary: Surveillance of injecting drug use as a global health imperative – The Lancet Global Health
News Release: Evidence of injecting drug use found in 190 countries: global review – UNSW Sydney
Related Article: Global coverage of interventions to prevent and manage drug-related harms among people who inject drugs: a systematic review – The Lancet Global Health
SR | Global coverage of interventions to prevent and manage drug-related harms among people who inject drugs
11 Apr, 2023 | 14:24h | UTCInvited Commentary: Harm reduction interventions for people who inject drugs – The Lancet Global Health
News Release: Evidence of injecting drug use found in 190 countries: global review – UNSW Sydney
Commentary on Twitter (thread – click for more)
Online first: Global coverage of interventions to prevent and manage drug-related harms among people who inject drugs: a systematic review https://t.co/2xvrQryyLN (1/4)
— The Lancet Global Health (@LancetGH) April 3, 2023
Consensus Paper | An approach to deprescribe antidepressants for depression in older adults
6 Apr, 2023 | 13:25h | UTCRelated:
Discontinuing antidepressants: Pearls and pitfalls.
A method for tapering antipsychotic treatment that may minimize the risk of relapse
Systematic Review: Managing Antidepressant Discontinuation
Randomized controlled trial: preventive cognitive therapy for prevention of depressive recurrence
RCT | Assessing low-dose ketamine’s antidepressant & antisuicidal effects in patients with treatment-resistant depression
5 Apr, 2023 | 13:44h | UTC
Commentary on Twitter
RCT: ketamine infusion (0.5 mg/kg) is a safe and effective treatment for patients with TRD and prominent suicidal ideation vs. midazolam. Response was noted when the current depressive episode lasted for <24 months and the number of failed AD is ≤4 https://t.co/QKNy8bUKBK pic.twitter.com/GyfQp0pmpO
— P𝘧OL (@psychopharmacol) April 4, 2023
SR | Efficacy and tolerance of second-generation antipsychotics in anorexia nervosa
5 Apr, 2023 | 12:48h | UTC
RCT | Mindfulness therapy proves more effective and affordable than cognitive behavioral therapy for depression
4 Apr, 2023 | 14:04h | UTCSummary: The LIGHTMind Randomized Clinical Trial studied 410 adults with mild to moderate depression, comparing the clinical effectiveness and cost-effectiveness of practitioner-supported mindfulness-based cognitive therapy self-help (MBCT-SH) to practitioner-supported cognitive behavioral therapy self-help (CBT-SH). The trial provided participants with either an MBCT-SH or CBT-SH workbook and six support sessions with a trained practitioner. Depressive symptom severity was measured using the Patient Health Questionnaire (PHQ-9) score at 16 weeks after randomization.
Results showed that MBCT-SH led to significantly greater reductions in depressive symptoms and was more cost-effective than CBT-SH. The between-group difference was 1.5 PHQ-9 points, and MBCT-SH cost health services £526 ($631) less per participant over a 42-week follow-up period. A substantial portion of this cost difference was due to additional face-to-face individual psychological therapy accessed by CBT-SH participants outside of the study intervention.
The trial concluded that offering practitioner-supported MBCT-SH for mild to moderate depression could improve outcomes and save money compared to CBT-SH. To translate these findings into practice, proper training and supervision for practitioners delivering MBCT-SH are necessary. Future research should focus on corroborating and extending these findings, exploring factors contributing to MBCT-SH’s relative effectiveness, and examining potential barriers and facilitators for successful implementation in routine clinical practice.
Commentary:
Mindfulness better than CBT for treating depression, study finds – The Guardian
Practitioner-Supported Mindfulness-Based Cognitive Therapy Aids Depression – HealthDay
Commentary on Twitter
Practitioner-supported mindfulness-based cognitive therapy self-help for mild-moderate depression is clinically- and cost-effective compared to currently recommended practitioner-support CBT self-help. https://t.co/H23AfwiO7X pic.twitter.com/xTHzYG4oqg
— JAMA Psychiatry (@JAMAPsych) March 22, 2023
M-A | No significant health benefits found for low-volume alcohol intake
4 Apr, 2023 | 13:48h | UTCSummary: This systematic review and meta-analysis aimed to investigate the association between alcohol use and all-cause mortality, taking into account potential sources of bias. The study analyzed data from 107 cohort studies published between January 1980 and July 2021, which included 4,838,825 participants and 425,564 deaths.
The study found no significant reductions in all-cause mortality risk for drinkers who consumed less than 25 grams of ethanol per day compared to lifetime nondrinkers. However, there was a significantly increased risk of all-cause mortality among female drinkers who drank 25 or more grams per day and male drinkers who drank 45 or more grams per day.
The analysis highlighted the importance of controlling for former drinker bias and misclassification errors and found sex differences in the risk of all-cause mortality.
In conclusion, the updated meta-analysis found no significantly reduced risk of all-cause mortality associated with low-volume alcohol consumption after adjusting for potential confounding factors. The study recommends that future longitudinal studies in this field should attempt to minimize lifetime selection biases by not including former and occasional drinkers in the reference group and by using younger cohorts at baseline.
Commentary: Drinking Alcohol Brings No Health Benefits, Study Finds – HealthDay
Related:
Prioritising action on alcohol for health and development – The BMJ
RCT | Memantine outperforms placebo for hair-pulling and skin-picking behaviors
4 Apr, 2023 | 13:40h | UTCDouble-Blind Placebo-Controlled Study of Memantine in Trichotillomania and Skin-Picking Disorder – American Journal of Psychiatry (link to abstract – $ for full-text)
News release: New research points to drug option for hair-pulling, skin-picking disorders – University of Chicago
Commentary: Memantine May Reduce Symptoms of Hair-Pulling, Skin-Picking Disorder – Psychiatric News Alert
Cohort Study | Preoperative depression has minimal impact on 5-year bariatric surgery outcomes
4 Apr, 2023 | 13:23h | UTC
Applying AI to MRI | A promising approach for detecting severe mental illness risk
4 Apr, 2023 | 13:25h | UTC
ICU Delirium | Bayesian analysis suggests high probabilities of benefits and low probabilities of harm with the use of haloperidol
3 Apr, 2023 | 13:43h | UTCHaloperidol vs. placebo for the treatment of delirium in ICU patients: a pre-planned, secondary Bayesian analysis of the AID–ICU trial – Intensive Care Medicine (free for a limited period)
Original article: RCT | Haloperidol for the treatment of delirium in ICU patients did not significantly improve outcomes.
Commentary on Twitter
Haloperidol vs placebo in acutely admitted, adult #ICU pts with #delirium? With IV haloperidol 2.5 mg × 3 daily & as needed doses up to max 20 mg daily:
➡️ high probabilities of benefits
➡️ low probabilities of harm for primary & most secondary outcomes
🖇️ https://t.co/iNRVVozlRJ pic.twitter.com/NJbhvxxdYx— Intensive Care Medicine (@yourICM) March 27, 2023
Perspective | Teen girls are faring worse than boys on nearly all mental health measures—here’s why
3 Apr, 2023 | 13:33h | UTCTeen Girls Are Faring Worse Than Boys on Nearly All Mental Health Measures—Here’s Why – JAMA (free for a limited period)
Commentary on Twitter
The latest @CDCgov Youth Risk Behavior Survey, administered in 2021, shows that mental health has worsened for all adolescents, but especially for girls. Nearly a third of teen girls said they seriously considered suicide. https://t.co/gVHoLYtI5b #MedicalNews
— JAMA (@JAMA_current) March 28, 2023
Study shows clinical instability and severity are predictors for psychiatric hospitalization
31 Mar, 2023 | 13:42h | UTCCommentaries:
New study reveals clinical instability predicts psychiatric hospitalization – MedicalXpress
Instability, Clinical Severity Predict Hospitalization Risk for Psychiatric Illness – HCP Live
M-A | Exploring the efficacy of psychotherapies for depression
31 Mar, 2023 | 13:19h | UTC
ICU Burnout Crisis | Meta-analysis reveals over 40% prevalence in medical professionals
30 Mar, 2023 | 14:30h | UTCHigh-level burnout in physicians and nurses working in adult ICUs: a systematic review and meta-analysis – Intensive Care Medicine (if the link is paywalled, try this one)
Related:
AAP Clinical Report | Physician health and wellness.
M-A | Physicians suffering burnout are twice as likely to be involved in patient safety incidents.
Systematic Review | Predictors of burnout among healthcare providers.
Physician Well-being 2.0: Where Are We and Where Are We Going? – Mayo Clinic Proceedings
Assessment of Risk Factors for Suicide Among US Health Care Professionals
Beyond Burnout: Docs Decry ‘Moral Injury’ From Financial Pressures of Health Care
Hospital administration response to physician stress and burnout – Journal of Hospital Practice
Opinion: It’s Time to Talk About Physician Burnout and Moral Injury
Systematic Review: Effect of Organization-Directed Workplace Interventions on Physician Burnout
The 3 Causes Of Physician Burnout (And Why There’s No Simple Solution) – Forbes
Physician Burnout: A Global Crisis
The Burnout Crisis in American Medicine – The Atlantic
Physician burnout costs up to $17B a year, task force says – HealthcareDive
Systematic Review: Prevalence of Burnout Among Physicians
Association Between Physician Burnout and Patient Safety, Professionalism, and Patient Satisfaction
Commentary on Twitter
High-level burnout in adult ICUs physicians & nurses, SR/MA
➡️ prevalence > 40% in all #ICU HCWs, 41% physicians/44% nurses
➡️ #COVID19? ⬆️ burnout only in nurses
Preventive/therapeutic measures to improve well-being crucial as a consensual definitio.
🖇️ https://t.co/kUcZ7P9iqz pic.twitter.com/owqC1W5yLu— Intensive Care Medicine (@yourICM) March 28, 2023
Review | Insomnia diagnosis and treatment across the lifespan
30 Mar, 2023 | 13:36h | UTCInsomnia diagnosis and treatment across the lifespan – Journal of Family Practice
Alcohol minimum unit pricing in Scotland led to substantial decrease in alcohol-attributable deaths and hospitalizations
29 Mar, 2023 | 13:28h | UTCNews Release: Minimum unit pricing for alcohol associated with a 13% decrease in deaths from alcohol consumption in Scotland – Lancet
Commentaries:
Minimum pricing averts alcohol deaths, study claims – BBC
Scotland’s minimum pricing linked to 13% drop in alcohol-related deaths, study finds – The Guardian
Commentary on Twitter (thread – click for more)
Minimum unit pricing for #alcohol was introduced in Scotland in 2018 (50p per unit) with the aim of reducing alcohol consumption in the heaviest drinkers.
A new study analyses the impact of the policy on alcohol-specific hospitalisations and deaths. https://t.co/ehoHjbc8lw
— The Lancet (@TheLancet) March 21, 2023
Cohort Study | Associations between betablockers and psychiatric and behavioral outcomes
29 Mar, 2023 | 12:57h | UTCNews Release: Use of β-blockers linked with reductions in violence – News Medical/PLOS
Commentaries:
Beta blockers: how these common heart medications may reduce the risk of violence – The Conversation
Expert reaction to study looking at beta-blockers and lower rates of violence – Science Media Centre