Pharmacology/Pharmaceutical Industry
Opinion | Covid-19 vaccine passports and vaccine hesitancy: freedom or control?
31 Mar, 2021 | 03:29h | UTCCovid-19 vaccine passports and vaccine hesitancy: freedom or control? – The BMJ Opinion
“Recent debates around “vaccine passports,” or formal/mandatory certification of vaccination, point towards a potential widening societal divide between those who are vaccinated and those who are not.”
All the Covid-19 vaccines prevent death and severe disease, and that’s what matters, experts say
31 Mar, 2021 | 03:28h | UTC
M-A: Evaluating Progestogens for Preventing Preterm Birth
30 Mar, 2021 | 03:02h | UTCEvaluating Progestogens for Preventing Preterm birth International Collaborative (EPPPIC): meta-analysis of individual participant data from randomised controlled trials – The Lancet (link to abstract – $ for full-text)
RCT: A multi-modal analgesic strategy after trauma can reduce opioid exposure and achieve adequate acute pain control
30 Mar, 2021 | 02:57h | UTC
Commentary on Twitter
A generic multimodal pain regimen reduced opioids and discharge from the hospital with an opioid prescription while achieving similar pain control.https://t.co/7JURYCfbxa#VisualAbstract #SoMe4Surgery@johnaharvin @UTHealthACS @UTHealthSurg#AuthorVideo: https://t.co/F5YY06FiEe pic.twitter.com/XmdgNYkpfR
— Journal of the American College of Surgeons (JACS) (@acsJACS) March 16, 2021
Analysis of conflicts of interest among authors and researchers of European clinical guidelines in cardiovascular medicine
30 Mar, 2021 | 02:53h | UTC
Commentary on Twitter (thread – click for more)
We've just published in @Clin_Med our analysis of financial conflicts of interest (CoIs) amongst the authors of 5 ESC Guidelines. What we found was quite surprising. We would love to know what you all think!https://t.co/U371ROXGAv
Let's start with a poll 👇🏽
— Benoy Shah MD (@dr_benoy_n_shah) March 28, 2021
‘Real world’ study by CDC shows Pfizer and Moderna vaccines were 90% effective
30 Mar, 2021 | 03:27h | UTC‘Real world’ study by CDC shows Pfizer and Moderna vaccines were 90% effective – STAT
Commentary on Twitter (thread – Click for more)
https://twitter.com/hildabast/status/1376648088878608386
Antimicrobial resistance in ICUs: an update in the light of the COVID-19 pandemic
30 Mar, 2021 | 03:21h | UTC
Study: mRNA vaccine is associated with decreased SARS-CoV-2 viral load in individuals with breakthrough infection, suggesting a role in suppressing onward transmission
30 Mar, 2021 | 03:25h | UTC
Commentaries on Twitter
https://twitter.com/nresearchnews/status/1376667763914240000
(Thread – Click for more)
New @NatureMedicine: The concern about asymptomatic transmission addressed in nearly 5,000 people after 1st dose of mRNA vaccine (~2 -5 wks). Viral load markedly reduced (high Ct). Supports vaccine effect for blocking or strongly reducing chance of spreadhttps://t.co/mmJmZPZfHK pic.twitter.com/0TTf4cFZed
— Eric Topol (@EricTopol) March 29, 2021
Cochrane Library Editorial: Contested effects and chaotic policies: the 2020 story of (hydroxy) chloroquine for treating COVID‐19
28 Mar, 2021 | 22:55h | UTCCommentary and Infographic: Is chloroquine or hydroxychloroquine useful in treating people with COVID-19, or in preventing infection in people who have been exposed to the virus? – Cochrane Library
Original review: Chloroquine or hydroxychloroquine for prevention and treatment of COVID‐19 – Cochrane Library
Commentary on Twitter
New #VisualAbstract for the @Cochrane_IDG systematic review on #Chloroquine or #hydroxychloroquine for prevention and treatment of #COVID19 https://t.co/U7TnMzQTil Many thanks to @tylerdau & @cg_coleman from @EmoryMedicine pic.twitter.com/tlFKKa31E8
— The Cochrane Library (@CochraneLibrary) March 25, 2021
Long term outcomes of participants in the PARAMEDIC2 randomized trial of adrenaline in out-of-hospital cardiac arrest – although survival was improved, adrenalin was not associated with favorable neurologic outcomes
28 Mar, 2021 | 22:21h | UTCCommentary: PARAMEDIC2 – Epinephrine vs Placebo OHCA 6-12 Months – Journal Feed
Original study: Randomized Trial: Epinephrine in Out-of-Hospital Cardiac Arrest (study and commentaries) AND Opinion: Epinephrine Harms/Helps in Out of Hospital Cardiac Arrest
NICE Guideline Update: Cannabis-based medicinal products
28 Mar, 2021 | 22:24h | UTCCannabis-based medicinal products – National Institute for Health and Care Excellence
Quadrivalent influenza nanoparticle vaccines induce broad protection against a wide variety of seasonal and pandemic influenza strains in animal models
28 Mar, 2021 | 22:01h | UTCQuadrivalent influenza nanoparticle vaccines induce broad protection – Nature
Commentary: Nanoparticle flu vaccine blocks seasonal and pandemic strains – University of Washington School of Medicine
Interleukin‐6 blocking agents for treating COVID‐19: a living systematic review
28 Mar, 2021 | 22:40h | UTCInterleukin‐6 blocking agents for treating COVID‐19: a living systematic review – Cochrane Library
Commentary on Twitter
https://twitter.com/CochraneUK/status/1375456773486874628
Evolution of the randomized clinical trial in the era of precision oncology
26 Mar, 2021 | 08:35h | UTCEvolution of the Randomized Clinical Trial in the Era of Precision Oncology – JAMA Oncology
Commentary on Twitter
Food for thoughts: randomized clinical trials in the era of precision oncology
➡️PFS, not OS predominant endpoint
➡️Modest median survival gains
➡️Almost all industry funded
➡️Substantial increase in use of professional medical writers#radonchttps://t.co/k92MEs1eWR— Matthias Guckenberger (@Mat_Guc) March 25, 2021
FDA approval standards for anticancer agents — lessons from two recent approvals in breast cancer
26 Mar, 2021 | 08:30h | UTC
Commentary on Twitter
Our paper published today in @NatRevClinOncol discussing the dropping of bar for approval of cancer drugs. These two examples highlight why we all should seriously be concerned about this low bar. https://t.co/T27QI00dj2 pic.twitter.com/26Df3fJsoD
— Bishal Gyawali, MD, PhD, FASCO (@oncology_bg) March 25, 2021
RCT: Abrocitinib vs. Placebo or Dupilumab for Atopic Dermatitis
26 Mar, 2021 | 08:27h | UTCAbrocitinib versus Placebo or Dupilumab for Atopic Dermatitis – New England Journal of Medicine
M-A: Fracture risk is lower in patients anticoagulated with NOACs compared to patients treated with warfarin
26 Mar, 2021 | 08:26h | UTCCommentary: NOACs associated with a 16% lower risk of bone fractures than warfarin – Cardiovascular Business
RCT: Fixed (40 mg twice daily) or variable (0.5 mg/kg twice daily) dosing of prophylactic enoxaparin after surgical procedures
26 Mar, 2021 | 08:23h | UTCOptimal Dosing of Prophylactic Enoxaparin after Surgical Procedures: Results of the Double-Blind, Randomized, Controlled FIxed or Variable Enoxaparin (FIVE) Trial – Plastic and Reconstructive Surgery (link to abstract – $ for full-text)
Pushing back against U.S. health officials, AstraZeneca says new analysis confirms efficacy of its Covid-19 vaccine
26 Mar, 2021 | 09:01h | UTCNews release: AZD1222 US Phase III primary analysis confirms safety and efficacy – AstraZeneca
See also: Latest results put Oxford–AstraZeneca COVID vaccine back on track – Nature AND AstraZeneca’s absurd and unprecedented dispute with regulators, explained – Vox AND Expert reaction to press release from AstraZeneca announcing primary data on safety and efficacy from the US trial of the Oxford-AstraZeneca COVID-19 vaccine – Science Media Centre AND AstraZeneca says COVID-19 vaccine 76% effective in new analysis, to seek U.S. approval – Reuters AND AstraZeneca’s new data showing Covid vaccine slightly less effective than suggested doesn’t worry experts – The Guardian AND Latest AstraZeneca Report Supports Effectiveness Of COVID Vaccine – NPR
Variant-proof vaccines — invest now for the next pandemic
26 Mar, 2021 | 08:48h | UTCVariant-proof vaccines — invest now for the next pandemic – Nature
Covid: The London bus trip that saved maybe a million lives (about the creation of the RECOVERY Trial)
26 Mar, 2021 | 08:53h | UTCCovid: The London bus trip that saved maybe a million lives – BBC
Related: Covid-19: The Inside Story of the RECOVERY Trial
Commentary on Twitter
Very cool story by @JamesTGallagher about a convo on a London bus that led to the creation of the RECOVERY trial, which has been a shining (& too rare) example of how to do critical research in a pandemic. Bravo @PeterHorby & @MartinLandray h/t @hildabast https://t.co/BRSJLSFXdc
— Helen Branswell 🇨🇦 (@HelenBranswell) March 25, 2021
[Press release – not published yet] Trial of multi drug-resistant TB treatment ends enrolment early after independent board indicates new regimen is superior
25 Mar, 2021 | 08:10h | UTC
Commentary on Twitter
Promising news improving treatment #MDR #TB https://t.co/Lxjb7LBofy Translating findings to available drugs & diagnostics back it up will be key pic.twitter.com/YGp8d9ixww
— Michael Marks (@dr_michaelmarks) March 24, 2021
RCT: Effect of Intrawound Vancomycin Powder in Operatively Treated High-risk Tibia Fractures
25 Mar, 2021 | 08:04h | UTCEffect of Intrawound Vancomycin Powder in Operatively Treated High-risk Tibia Fractures: A Randomized Clinical Trial – JAMA Surgery (free for a limited period)
Viewpoint | Precision Dosing: A Clinical and Public Health Imperative
25 Mar, 2021 | 07:40h | UTCPrecision Dosing: A Clinical and Public Health Imperative – JAMA
Author interview: Precision Dosing—A Clinical and Public Health Imperative
Covid-19: What do we know about Sputnik V and other Russian vaccines?
25 Mar, 2021 | 08:27h | UTCCovid-19: What do we know about Sputnik V and other Russian vaccines? – The BMJ
Related: Russia’s Sputnik V COVID-19 vaccine candidate appears safe and is 91.6% effective (study and commentaries)