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Pharmacology/Pharmaceutical Industry

Perspective | “‘Too good to be true’: Doubts swirl around trial that saw 77% reduction in COVID-19 mortality”.

9 Jul, 2021 | 10:13h | UTC

‘Too good to be true’: Doubts swirl around trial that saw 77% reduction in COVID-19 mortality – Science (a few articles per month are free)

 

M-A: Comparative efficacy and safety of vancomycin, linezolid, tedizolid, and daptomycin in treating patients with suspected or proven complicated skin and soft tissue infections.

9 Jul, 2021 | 09:57h | UTC

Comparative Efficacy and Safety of Vancomycin, Linezolid, Tedizolid, and Daptomycin in Treating Patients with Suspected or Proven Complicated Skin and Soft Tissue Infections: An Updated Network Meta-Analysis – Infectious Diseases and Therapy

 

Commentary on Twitter

 

M-A: Little benefit from muscle relaxants for adults with non-specific low back pain.

9 Jul, 2021 | 10:02h | UTC

Efficacy, acceptability, and safety of muscle relaxants for adults with non-specific low back pain: systematic review and meta-analysis – The BMJ

Commentary: New analysis finds muscle relaxant drugs to be largely ineffective for low back pain – News Medical

Related studies: M-A: Effectiveness of treatments for acute and subacute mechanical non-specific low back pain AND RCT: Little benefit from osteopathic manipulative treatment on activity limitations in patients with nonspecific subacute and chronic low back pain AND M-A: Little benefit from antidepressants for low back pain AND Meta-analysis: Little benefit from antidepressants for the treatment of back pain and osteoarthritis AND ACP/AAFP Guideline: Nonpharmacologic and pharmacologic management of acute pain from non–low back, musculoskeletal injuries in adults

 

Commentaries on Twitter

 

Prospective national cohort in Chile showed CoronaVac effectiveness was 65.9% for symptomatic Covid-19, 87.5% for hospitalization, 90.3% for ICU admission, and 86.3% for death.

8 Jul, 2021 | 09:22h | UTC

Effectiveness of an Inactivated SARS-CoV-2 Vaccine in Chile – New England Journal of Medicine

Related: Phase 1/2 RCT: CoronaVac is well tolerated and safe and induces strong humoral responses in children and adolescents aged 3–17 years. AND WHO approval of Chinese CoronaVac COVID vaccine will be crucial to curbing pandemic. AND Brazilian town experiment shows mass vaccination can wipe out COVID-19.

 

Commentary on Twitter

https://twitter.com/hildabast/status/1412890823948079105

 

Mounting evidence suggests Sputnik COVID vaccine is safe and effective.

8 Jul, 2021 | 09:14h | UTC

Mounting evidence suggests Sputnik COVID vaccine is safe and effective – Nature

Related: Russia Pushes Ahead with Open License Approach to Sputnik V – Despite WHO Concerns Over Manufacturing Practices – Health Policy Watch

 

Antibiotic resistance during and beyond COVID-19.

8 Jul, 2021 | 09:09h | UTC

Antibiotic resistance during and beyond COVID-19 – JAC-Antimicrobial Resistance

 

Perspective | Should People With Immune Problems Get Third Vaccine Doses?

8 Jul, 2021 | 09:07h | UTC

Should People With Immune Problems Get Third Vaccine Doses? – The New York Times (a few articles per month are free)

Related: [Preprint] 3rd AstraZeneca shot gives strong immunity. AND Case series: Safety and immunogenicity of a third dose of SARS-CoV-2 vaccine in solid organ transplant recipients.

 

Study Commentary: Decreased Antibiotic Use for Acute Otitis Media and Acute Sinusitis Following Implementation of Childhood PCV13 Immunization.

8 Jul, 2021 | 08:54h | UTC

Decreased Antibiotic Use for Acute Otitis Media and Acute Sinusitis Following Implementation of Childhood PCV13 Immunization – NEJM Journal Watch

Original study: Impact of the 13-valent pneumococcal conjugate vaccine on acute otitis media and acute sinusitis epidemiology in British Columbia, Canada – Journal of Antimicrobial Chemotherapy

 

A narrative review of evidence to guide deprescribing among older adults.

8 Jul, 2021 | 08:51h | UTC

A narrative review of evidence to guide deprescribing among older adults – Journal of General and Family Medicine

Related: Polypharmacy, inappropriate prescribing, and deprescribing in older people: through a sex and gender lens. (several resources on the subject)

 

M-A: Are antimicrobial stewardship interventions effective and safe in long-term care facilities?

8 Jul, 2021 | 08:52h | UTC

Are antimicrobial stewardship interventions effective and safe in long-term care facilities? A systematic review and meta-analysis – Clinical Microbiology and Infection

 

M-A: Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19 – “The 4% absolute risk reduction in mortality from 25% to 21% with IL-6 inhibition added to glucocorticoids may not translate to patients with a lower baseline mortality risk and likely do not justify the additional expense and risk for toxicities for patients hospitalized with modest oxygen requirements and a stable clinical course (from editorial)”.

7 Jul, 2021 | 09:02h | UTC

Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19: A Meta-analysis – JAMA

Editorial: IL-6 Receptor Antagonist Therapy for Patients Hospitalized for COVID-19: Who, When, and How? – JAMA

Commentaries: Interleukin-6 antagonists improve outcomes in hospitalised COVID-19 patients – King’s College London AND WHO advises 2 monoclonal antibodies for severe COVID – CIDRAP

 

Commentary on Twitter (thread – click for more)

https://twitter.com/msh_manu/status/1412473073715056645

 

A living WHO guideline on drugs for covid-19 – interleukin-6 receptor blockers are now recommended for patients with severe or critical covid-19.

7 Jul, 2021 | 09:03h | UTC

A living WHO guideline on drugs for covid-19 – The BMJ

 

Commentary on Twitter

 

WHO recommends life-saving interleukin-6 receptor blockers for COVID-19 and urges producers to join efforts to rapidly increase access – “These are the first drugs found to be effective against COVID-19 since corticosteroids were recommended by WHO in September 2020”.

7 Jul, 2021 | 09:00h | UTC

WHO recommends life-saving interleukin-6 receptor blockers for COVID-19 and urges producers to join efforts to rapidly increase access – World Health Organization

 

Commentary on Twitter (thread – click for more)

 

RCOG Guidance: Coronavirus (COVID-19) Vaccination in Pregnancy.

7 Jul, 2021 | 08:53h | UTC

Coronavirus (COVID-19) Vaccination in Pregnancy – Royal College of Obstetricians & Gynaecologists

See also: Resources and FAQs – Royal College of Obstetricians & Gynaecologists

 

Commentary on Twitter

 

RCT: Cardiovascular and renal outcomes with Efpeglenatide (a GLP-1 receptor agonist) in Type 2 Diabetes.

7 Jul, 2021 | 08:45h | UTC

Cardiovascular and Renal Outcomes with Efpeglenatide in Type 2 Diabetes – New England Journal of Medicine

Commentary: Efpeglenatide Cuts Risk of CV Events and Kidney Disease in High-Risk T2D Patients, Regardless of SGLT2 Status – AJMC

 

RCT: Daratumumab-based treatment for immunoglobulin light-chain amyloidosis.

7 Jul, 2021 | 08:44h | UTC

Daratumumab-Based Treatment for Immunoglobulin Light-Chain Amyloidosis – New England Journal of Medicine

 

RCT: An antibiotic-prescribing feedback to high-volume primary care physicians led to significant reductions in total and prolonged-duration antibiotic prescriptions, as well as drug costs.

7 Jul, 2021 | 08:47h | UTC

Effect of Antibiotic-Prescribing Feedback to High-Volume Primary Care Physicians on Number of Antibiotic Prescriptions: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)

Commentary: Studies highlight impact of clinician feedback on antibiotic prescribing – CIDRAP

 

Commentary on Twitter (thread – click for more)

 

Opinion | Fractionation of COVID-19 vaccine doses could extend limited supplies and reduce mortality.

6 Jul, 2021 | 10:18h | UTC

Fractionation of COVID-19 vaccine doses could extend limited supplies and reduce mortality – Nature Medicine

 

Commentary on Twitter

 

RCT: Ivermectin does not prevent hospitalizations in patients with COVID-19.

6 Jul, 2021 | 10:16h | UTC

Ivermectin to prevent hospitalizations in patients with COVID-19 (IVERCOR-COVID19) a randomized, double-blind, placebo-controlled trial – BMC Infectious Diseases

Commentary: Ivermectin: balance of evidence shows no significant benefit against Covid-19 – MSN News

Related: Ivermectin for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials – “IVM did not reduce all-cause mortality, length of stay or viral clearance in RCTs in COVID-19 patients with mostly mild disease”. AND Ivermectin is the new hydroxychloroquine, take 2 – “Ivermectin shouldn’t be used to treat COVID-19 outside of the context of a well-designed clinical trial”. AND Therapeutics and COVID-19 | WHO guideline update advises Ivermectin should only be used to treat COVID-19 within clinical trials AND RCT: Ivermectin does not improve time to resolution of symptoms among adults with mild COVID-19

 

Choosing Wisely for COVID-19: ten evidence-based recommendations for patients and physicians.

6 Jul, 2021 | 10:21h | UTC

Choosing Wisely for COVID-19: ten evidence-based recommendations for patients and physicians – Nature Medicine

 

Editorial | Do not just sit there, do something … but do no harm: the worrying aspects of COVID-19 experimental interventions.

6 Jul, 2021 | 10:14h | UTC

Do not just sit there, do something … but do no harm: the worrying aspects of COVID-19 experimental interventions – Intensive Care Medicine

 

Commentary on Twitter

 

Guideline | Hydroxychloroquine and Chloroquine Retinopathy: Recommendations on Monitoring.

6 Jul, 2021 | 10:03h | UTC

Executive summary: Hydroxychloroquine and Chloroquine Retinopathy: Recommendations on Monitoring – Royal College of Ophthalmologists

Full Guideline: The Royal College of Ophthalmologists recommendations on monitoring for hydroxychloroquine and chloroquine users in the United Kingdom (2020 revision): executive summary

See also: The Royal College of Ophthalmologists recommendations on monitoring for hydroxychloroquine and chloroquine users in the United Kingdom (2020 revision): executive summary – Eye

 

M-A: The efficacy of systemic glucocorticosteroids for pain in rheumatoid arthritis.

6 Jul, 2021 | 09:54h | UTC

The efficacy of systemic glucocorticosteroids for pain in rheumatoid arthritis: a systematic literature review and meta-analysis – Rheumatology

 

WHO challenges Pfizer and Moderna to openly share their know-how to accelerate COVID vaccine production.

5 Jul, 2021 | 02:36h | UTC

WHO Challenges Pfizer and Moderna to Openly Share Their Know-How to Accelerate COVID Vaccine Production – Health Policy Watch

 

Joint COVAX Statement on the Equal Recognition of Vaccines – COVAX urges all government authorities to recognize as fully vaccinated all people who have received COVID-19 vaccines that have been deemed safe and effective by WHO.

5 Jul, 2021 | 02:39h | UTC

Joint COVAX Statement on the Equal Recognition of Vaccines – World Health Organization

 

Commentary on Twitter (thread – click for more)

 

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