Open access
Open access
Powered by Google Translator Translator

Pharmacology/Pharmaceutical Industry

Report: Fully vaccinated people account for 1.2% of England’s Covid-19 deaths.

14 Sep, 2021 | 10:07h | UTC

Fully vaccinated people account for 1.2% of England’s Covid-19 deaths – The Guardian

Original Report: Deaths involving COVID-19 by vaccination status, England: deaths occurring between 2 January and 2 July 2021 – Office for National Statistics

 

COVID-19 vaccine efficacy does not support boosters for general population, review concludes.

14 Sep, 2021 | 10:08h | UTC

News release: COVID-19 vaccine efficacy does not support boosters for general population, review concludes – The Lancet

Original article: Considerations in boosting COVID-19 vaccine immune responses – The Lancet

Commentaries:

FDA experts among group opposing US booster shot plan – Associated Press

FDA vaccine regulators argue against Covid-19 vaccine boosters in new international review – STAT

Global experts pan wider use of COVID vaccine booster dose – CIDRAP

Expert reaction to viewpoint article on COVID-19 booster vaccines for general populations – Science Media Centre

Boosters Are ‘Not Appropriate’ – Reach Unvaccinated First – Health Policy Watch

Data Doesn’t Support Need for COVID-19 Vaccine Boosters: Experts – HealthDay

In a new review, some F.D.A. scientists and others say boosters aren’t needed for the general population. – The New York Times

 

Covid: Single jab recommended for 12 to 15-year-olds by UK’s top doctors.

14 Sep, 2021 | 10:05h | UTC

Covid: Single jab recommended for 12 to 15-year-olds by UK’s top doctors – BBC

See also: Covid-19: Children aged 12-15 should be offered vaccine, say UK’s chief medical officers – The BMJ

 

M-A: Study shows significant risk of major bleeding during extended oral anticoagulant therapy for first unprovoked venous thromboembolism.

14 Sep, 2021 | 08:55h | UTC

Long-Term Risk for Major Bleeding During Extended Oral Anticoagulant Therapy for First Unprovoked Venous Thromboembolism: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries:

Long-term Anticoagulation After Unprovoked VTE: New Insights – TCTMD

Extended Anticoagulation Tied to Major Bleeding Risk – HealthDay

 

Commentary on Twitter

 

One hundred years of insulin therapy.

14 Sep, 2021 | 08:52h | UTC

One hundred years of insulin therapy – Nature Reviews Endocrinology

 

Commentary on Twitter

 

Antifungal Susceptibility Testing: A Primer for Clinicians.

14 Sep, 2021 | 08:46h | UTC

Antifungal Susceptibility Testing: A Primer for Clinicians – Open Forum Infectious Diseases

 

Commentary on Twitter

 

What’s the evidence for COVID-19 booster shots?

12 Sep, 2021 | 22:05h | UTC

What’s the evidence for COVID-19 booster shots? – Canadian Medical Association Journal

 

Perspective | We’re Asking the Impossible of Vaccines – “Complete protection against infection has long been hailed as the holy grail of vaccination. It might simply be unachievable”.

12 Sep, 2021 | 21:59h | UTC

We’re Asking the Impossible of Vaccines – The Atlantic

 

Commentary on Twitter

 

India’s DNA COVID vaccine is a world first – more are coming.

10 Sep, 2021 | 05:30h | UTC

India’s DNA COVID vaccine is a world first – more are coming – Nature

 

Guideline: Medical cannabis or cannabinoids for chronic pain.

10 Sep, 2021 | 05:22h | UTC

Medical cannabis or cannabinoids for chronic pain: a clinical practice guideline – The BMJ

See also: Medical cannabis or cannabinoids for chronic non-cancer and cancer related pain: a systematic review and meta-analysis of randomised clinical trials – The BMJ

Editorial: Medical cannabis for chronic pain – The BMJ

Related: Cannabis and Cannabinoid Analgesia position statement – “Due to the lack of high-quality clinical evidence, the IASP does not currently endorse general use of cannabis and cannabinoids for pain relief.” (several resources on the subject)

 

Commentary on Twitter

 

Drug-drug interactions with direct oral anticoagulants: practical recommendations for clinicians.

10 Sep, 2021 | 04:59h | UTC

Drug-Drug Interactions with Direct Oral Anticoagulants: Practical Recommendations for Clinicians – The American Journal of Medicine

 

Two observational studies suggest spontaneous abortion is not increased following COVID-19 mRNA vaccination during pregnancy.

9 Sep, 2021 | 10:04h | UTC

Study 1: Spontaneous Abortion Following COVID-19 Vaccination During Pregnancy – JAMA

Study 2: Receipt of mRNA Covid-19 Vaccines and Risk of Spontaneous Abortion – New England Journal of Medicine

 

Commentary on Twitter

 

[Preprint] RCT: Additional heterologous vs. homologous booster vaccination in immunosuppressed patients without SARS-CoV-2 antibody seroconversion after primary mRNA vaccination.

9 Sep, 2021 | 09:55h | UTC

Additional heterologous versus homologous booster vaccination in immunosuppressed patients without SARS-CoV-2 antibody seroconversion after primary mRNA vaccination: a randomized controlled trial – medRxiv

 

Commentary on Twitter (thread – click for more)

https://twitter.com/hildabast/status/1435720202147143680

 

AstraZeneca bosses warn against rush for boosters – “giving the most vulnerable, who may not have built up a full immune response from the first two, a third, top-up dose is “sensible”. But any decision to give a third, booster jab “to large swathes of the population”, to extend their protection from the first two, must be based on clinical data”.

9 Sep, 2021 | 09:59h | UTC

AstraZeneca bosses warn against rush for boosters – BBC

 

Commentary on Twitter (thread – click for more)

 

WHO appeals for countries to postpone COVID-19 vaccine boosters until 2022 to prioritize vaccinating the most at-risk people around the world who are yet to receive their first dose.

9 Sep, 2021 | 10:00h | UTC

WHO Appeals to Postpone COVID-19 Vaccine Boosters Until 2022; Tedros Lashes out at Pharma Association – Health Policy Watch

See also:

WHO chief urges halt to booster shots for rest of the year – Associated Press

WHO extends moratorium on booster COVID vaccine doses – CIDRAP

 

RCT: A Seven-days course of antibiotics for the treatment of bloodstream infections by Enterobacterales was noninferior to a 14-days course.

9 Sep, 2021 | 09:03h | UTC

Seven versus 14-days course of antibiotics for the treatment of bloodstream infections by Enterobacterales. A randomized, controlled trial – Clinical Microbiology and Infection

 

Commentary on Twitter

 

Editorial | Anticholinergic drugs and dementia: time for transparency in the face of uncertainty.

9 Sep, 2021 | 08:57h | UTC

Anticholinergic drugs and dementia: time for transparency in the face of uncertainty – Cochrane Library

Systematic review: Anticholinergic burden (prognostic factor) for prediction of dementia or cognitive decline in older adults with no known cognitive syndrome – Cochrane Library

 

Commentary on Twitter

 

Perspective | Rethinking medication adherence.

9 Sep, 2021 | 08:55h | UTC

Rethinking Medication Adherence – Therapeutics Initiative

 

Cochrane review: evidence is insufficient to draw meaningful conclusions if SARS‐CoV‐2-specific monoclonal antibodies are effective in the treatment of COVID-19.

7 Sep, 2021 | 21:51h | UTC

Summary: Are laboratory-made, COVID-19-specific monoclonal antibodies an effective treatment for COVID-19? – Cochrane Library

Original review: SARS‐CoV‐2‐neutralising monoclonal antibodies for treatment of COVID‐19 – Cochrane Library

 

Chile authorizes Sinovac vaccine for kids of 6 and older.

7 Sep, 2021 | 21:45h | UTC

Chile authorizes Sinovac vaccine for kids of 6 and older – Associated Press

 

Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.

7 Sep, 2021 | 21:48h | UTC

Effectiveness of the BNT162b2 mRNA COVID-19 vaccine in pregnancy – Nature Medicine

 

Commentaries on Twitter

 

AAP flu recommendations allow for coadministration with COVID-19 vaccine.

7 Sep, 2021 | 21:44h | UTC

News release: AAP flu recommendations allow for coadministration with COVID-19 vaccine – American Academy of Pediatrics

Guidance: Recommendations for Prevention and Control of Influenza in Children, 2021–2022 – American Academy of Pediatrics

Technical report: Recommendations for Prevention and Control of Influenza in Children, 2021–2022 – American Academy of Pediatrics

Related: New CDC Guidance says influenza and Covid vaccines can be given together – “COVID-19 vaccines and other vaccines may now be administered without regard to timing”

 

Commentary on Twitter

 

Supplement: Current Issues in Venous Thromboembolism.

7 Sep, 2021 | 21:36h | UTC

Homepage: Current Issues in Venous Thromboembolism – Postgraduate Medicine

Editorial: Current issues in venous thromboembolism

A review of upper extremity deep vein thrombosis

Outpatient treatment of emergency department patients diagnosed with venous thromboembolism

Venous thromboembolism prophylaxis in high-risk orthopedic and cancer surgery

Prophylaxis and treatment of COVID-19 related venous thromboembolism

Challenges in the diagnostic approach of suspected pulmonary embolism in COVID-19 patients

Catheter-directed thrombolysis and mechanical intervention in deep venous thrombosis: what is the status after the ATTRACT trial?

Post-hospital discharge venous thromboembolism prophylaxis in medically ill patients

Radiologic mimics of pulmonary embolism

A comprehensive review of DOACs for cancer associated VTE prophylaxis or treatment

 

Extended intervals and extra doses of the AstraZeneca vaccine are associated with increased immunogenicity.

7 Sep, 2021 | 10:56h | UTC

Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002) – The Lancet

Invited commentary: Longer intervals and extra doses of ChAdOx1 nCoV-19 vaccine

 

Commentaries on Twitter

(thread – click for more)

(thread – click for more)

 

Antibiotics use is linked to increased risk of subsequent colorectal cancer.

7 Sep, 2021 | 21:25h | UTC

Antibiotics Use and Subsequent Risk of Colorectal Cancer: A Swedish Nationwide Population-Based Study – JNCI: Journal of the National Cancer Institute

Commentaries:

Antibiotics linked to increased risk of colon cancer – Umea University

Study links antibiotics use and increased subsequent risk of colorectal cancer – MedicalResearch.com

 

Stay Updated in Your Specialty

Telegram Channels
Free

WhatsApp alerts 10-day free trial

No spam, just news.