Pharmacology/Pharmaceutical Industry | Page 172 of 172 | Links Medicus Content Curation & Alerts in Medicine

The evidence so far suggests that PCSK9 inhibitor use probably leads to little or no difference in mortality and leads to a modest absolute risk reduction (often less than 1%) in cardiovascular events in high-risk patients.

Advil, Motrin and other NSAIDs painkillers should be prescription only, Danish study says

28 Apr, 2017 | 16:37h | UTC

Advil, Motrin and other NSAIDs painkillers should be prescription only, Danish study says – Pittsburgh Post-Gazette (free) (RT @medpagetodaysee Tweet)

Original article: Non-steroidal anti-inflammatory drug use is associated with increased risk of out-of-hospital cardiac arrest: a nationwide case–time–control study – European Heart Journal – Cardiovascular Pharmacotherapy (free)

See more commentaries on this study in our March 17 issue, see #5.

Azithromycin doesn’t seem to increase the risk of ventricular arrhythmia

26 Apr, 2017 | 16:04h | UTC

Cohort study: Use of azithromycin and risk of ventricular arrhythmia – Canadian Medical Association Journal (free)

Source: No Major Azithromycin Arrhythmia Risk in Huge European Cohort – Medscape (free registration required)

Contradicting a previous study (free) and a 2013 safety warning from the US Food and Drug Administration (free), this large cohort did not show an association between azithromycin and ventricular arrhythmia when compared to amoxicillin.

New warnings about the use of codeine and tramadol

24 Apr, 2017 | 15:32h | UTC

FDA Safety Alert: Codeine and Tramadol Medicines: Drug Safety Communication – Restricting Use in Children, Recommending Against Use in Breastfeeding Women (free)

FDA Statement: New warnings about the use of codeine and tramadol in children & nursing mothers (free)

Commentaries on the statement: FDA: Codeine Now Contraindicated for Pain and Cough in Kids – Physician’s First Watch (free) AND Codeine cough syrup should not be given to kids, FDA warns – STAT News (free)

These drugs should not be used at all for children younger than 12 years, and their use should also be limited in some older children.

β-Blocker Exposure in Pregnancy and Risk of Fetal Cardiac Anomalies

20 Apr, 2017 | 14:28h | UTC

β-Blocker Exposure in Pregnancy and Risk of Fetal Cardiac Anomalies – JAMA Internal Medicine (link to abstract – $ for full-text)

See also: No Fetal Heart Risk from Mom’s Beta-Blocker Use – MedPage Today (free registration required)

Associations of Maternal Antidepressant Use and Complications in Offspring

19 Apr, 2017 | 14:12h | UTC

Associations of Maternal Antidepressant Use During the First Trimester of Pregnancy With Preterm Birth, Small for Gestational Age, Autism Spectrum Disorder, and Attention-Deficit/Hyperactivity Disorder in Offspring – JAMA (link to abstract – $ for full-text)

Contradicting a previous study showing increased risk of autism with antidepressant use during pregnancy (free), this large retrospect cohort study of 1 580 629 Swedish offspring did not show an association of antidepressant use during pregnancy and autism or other neurodevelopment problems.

Insulin pump didn’t improve glycemic control compared to training on injections

18 Apr, 2017 | 13:58h | UTC

Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE) – The BMJ (free)

Short term use of oral corticosteroids and related harms

13 Apr, 2017 | 16:07h | UTC

Short term use of oral corticosteroids and related harms among adults in the United States: population based cohort study – The BMJ (free)

Corticosteroids, even if used for short periods of time, seems to be associated with significant morbidity and mortality. In this retrospective cohort with 1.5 million adults, the incidence of acute adverse events (sepsis, venous thromboembolism, fracture) increased by twofold to fivefold above background rates.

How Many Pills Are Too Many?

12 Apr, 2017 | 15:56h | UTC

How Many Pills Are Too Many? – The New York Times (10 articles per month are free)

“Evidence has mounted about the dangers of taking multiple, perhaps unnecessary, medications” (from Tweet)

Seniors are given so many drugs, it’s madness

10 Apr, 2017 | 15:54h | UTC

Seniors are given so many drugs, it’s madness – The Globe and Mail (free) (RT @RasoiniR)

“While most prescribing is well-intentioned, it’s also unco-ordinated; there is a tendency to overmedicate and leave people on drugs for too long”.

Antipsychotics May Boost Respiratory Failure Risk in COPD – MedPage Today

7 Apr, 2017 | 15:50h | UTC

Association Between Antipsychotic Agents and Risk of Acute Respiratory Failure in Patients With Chronic Obstructive Pulmonary Disease – JAMA Psychiatry (Link to abstract – $ required for full-text) (RT @atscommunity)

See also: Antipsychotics Tied to Respiratory Failure in At-Risk Patients – Medscape (free registration required) AND Antipsychotics May Boost Respiratory Failure Risk in COPD – MedPage Today (free registration required)

Inhaled Corticosteroids May Raise Women’s Risk of the Metabolic Syndrome

6 Apr, 2017 | 15:10h | UTC

Inhaled Corticosteroids May Raise Women’s Risk of the Metabolic Syndrome – NewsWise (free)

This study was presented at #ENDO2017 and hasn’t been published yet.

Anti-leukotriene agents in persistent asthma

3 Apr, 2017 | 19:15h | UTC

Addition of anti-leukotriene agents to inhaled corticosteroids for adults and adolescents with persistent asthma – Cochrane Database of Systematic Reviews (link to summary – $ required for full-text)

Source: EvidenceAlerts

In patients with asthma not controlled with daily low-dose inhaled corticosteroids, adding anti-leukotriene agents reduced by half the number of patients with asthma exacerbations requiring an oral corticosteroid and improved lung function and asthma control.

Non–Vitamin K Antagonist Oral Anticoagulants in Patients With Atrial Fibrillation and Valvular Heart Disease

30 Mar, 2017 | 17:27h | UTC

Non–Vitamin K Antagonist Oral Anticoagulants in Patients With Atrial Fibrillation and Valvular Heart Disease – Journal of the American College of Cardiology (free)

Source: SciCombinator

Except for patients with moderate/severe mitral stenosis or mechanical heart valves, who were excluded in most trials, high-dose NOACs was as effective and safe for patients with valvular heart disease as for patients without valvular disorders.