Pharmacology/Pharmaceutical Industry
Present and future of metastatic colorectal cancer treatment
11 Aug, 2017 | 12:48h | UTCReview: Present and future of metastatic colorectal cancer treatment: A review of new candidate targets – World Journal of Gastroenterology (free)
Interventions for emergency contraception
10 Aug, 2017 | 22:29h | UTCInterventions for emergency contraception – Cochrane Library (link to abstract – $ for full-text)
Summary: Methods of emergency contraception (free)
On-demand pre-exposure prophylaxis for HIV
10 Aug, 2017 | 22:31h | UTCEfficacy, safety, and effect on sexual behaviour of on-demand pre-exposure prophylaxis for HIV in men who have sex with men: an observational cohort study – The Lancet HIV (free registration required)
Commentaries: PrEP on demand or every day? – The Lancet HIV (free registration required) AND HIV pre-exposure prophylaxis can be taken as needed – Reuters (free)
“four doses of PrEP around the time of sexual activity cut the risk of HIV by 97 percent” (from Reuters Health)
Antipsychotic drugs for the acute treatment of patients with a first episode of schizophrenia
10 Aug, 2017 | 20:52h | UTCAntipsychotic drugs for the acute treatment of patients with a first episode of schizophrenia: a systematic review with pairwise and network meta-analyses – The Lancet Psychiatry (link to abstract – $ for full-text)
Commentary: First-Episode Psychosis Drug Choice: No Clear Winner – Medscape (free registration required)
What do hypnotics cost hospitals and healthcare?
10 Aug, 2017 | 17:16h | UTCWhat do hypnotics cost hospitals and healthcare? – F1000 Research (free)
Source: Hospital Medicine Virtual Journal Club
“A best estimate is that U.S. costs of hypnotic harms to healthcare systems are on the order of $55 billion, but conceivably might be as low as $10 billion or as high as $100 billion”.
How long should I take antibiotics?
9 Aug, 2017 | 17:04h | UTCRelated: The antibiotic course has had its day – The BMJ (free) AND Keep taking the tablets: three reasons to stay the full antibiotics course – The Conversation (free) (RT @Onisillos) AND Why you really should take your full course of antibiotics – The Conversation (free)
Treatment for Hepatitis C Virus by Community-Based Nonspecialist Providers
9 Aug, 2017 | 17:00h | UTCExpansion of Treatment for Hepatitis C Virus Infection by Task Shifting to Community-Based Nonspecialist Providers: A Nonrandomized Clinical Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Nonspecialists Could Safely Provide Hepatitis C Care – Physician’s First Watch (free) AND HCV treatment by NPs, PCPs appears safe, effective as that provided by subspecialists – ACP Internist (free)
“Expansion of Treatment for HCV Infection by Task Shifting to Community-Based Nonspecialists” (RT @kennylinafp see Tweet)
Gadolinium deposition in the brain: summary of evidence and recommendations
9 Aug, 2017 | 15:37h | UTCGadolinium deposition in the brain: summary of evidence and recommendations – The Lancet Neurology (free registration required)
Commentaries: Gadolinium deposition: practical guidelines in the face of uncertainty – The Lancet Neurology (free registration required) AND MRI Contrast Agents Accumulate in the Brain – Case Western Reserve University, via NewsWise (free)
Too Many Meds?
5 Aug, 2017 | 20:02h | UTCToo Many Meds? America’s Love Affair With Prescription Medication – Consumer Reports (free)
See more on “Deprescribing” in our May 8th issue (see #7), May 9th issue (see #4) and May 15th issue (see #2), and also a related article on Current and future perspectives on the management of polypharmacy
“Yes. Way Too Many Meds. Think De-prescribe”. (RT @EricTopol see Tweet)
Bevacizumab for advanced cervical cancer
3 Aug, 2017 | 21:56h | UTCBevacizumab for advanced cervical cancer: final overall survival and adverse event analysis of a randomised, controlled, open-label, phase 3 trial – The Lancet (link to abstract – $ for full-text)
“Benefit of adding bevacizumab to CT for cervical cancer is sustained: OS curves remain separated with ext. follow-up” and “Unfortunately though bevacizumab is out of reach of many patients living in #LMICs” (RT @oncology_bg see Tweets)
Trial of Tocilizumab in Giant-Cell Arteritis
3 Aug, 2017 | 21:39h | UTCTrial of Tocilizumab in Giant-Cell Arteritis – New England Journal of Medicine (link to abstract – $ for full-text)
Quick Take Video Summary: The GiACTA Trial (free)
Commentaries: Tocilizumab improves remission rates in giant-cell arteritis: The GiACTA trial – 2 Minute Medicine (free) AND Phase 3 trial confirms superiority of tocilizumab to steroids for giant cell arteritis – Massachusetts General Hospital, via EurekAlert (free) AND Tocilizumab With Steroid Taper Superior in GCA – Medscape (free registration required)
Oral fluoroquinolones and risk of secondary pseudotumor cerebri syndrome
3 Aug, 2017 | 20:21h | UTCOral fluoroquinolones and risk of secondary pseudotumor cerebri syndrome – Neurology (link to abstract – $ for full-text)
Commentary: Fluoroquinolones May Up Risk of PTCS, a Rare But Serious Condition – MPR (free) (RT @AmeshAA see Tweet)
Opioid Use in Pregnancy, Neonatal Abstinence Syndrome, and Childhood Outcomes
3 Aug, 2017 | 13:37h | UTC
Medication errors in anesthesia: unacceptable or unavoidable?
3 Aug, 2017 | 13:25h | UTCReview: Medication errors in anesthesia: unacceptable or unavoidable? – Brazilian Journal of Anesthesiology (free)
Better drugs, faster: The potential of AI-powered humans
1 Aug, 2017 | 18:25h | UTCBetter drugs, faster: The potential of AI-powered humans – BBC News (free)
Tenofovir reduces mother-to-child hepatitis B transmission
1 Aug, 2017 | 17:30h | UTCTenofovir reduces mother-to-child hepatitis B transmission – NIHR Signal (free)
Original article: Systematic review with meta-analysis: the efficacy and safety of tenofovir to prevent mother-to-child transmission of hepatitis B virus – Alimentary Pharmacology and Therapeutics (link to abstract – $ for full-text)
Association of Statin Use With Risk of Back Disorder Diagnoses
27 Jul, 2017 | 22:52h | UTCAssociation of Statin Use With Risk of Back Disorder Diagnoses – JAMA Internal Medicine (free)
Commentaries: Statin Use Could Be Associated With Higher Risk of Back Disorders – American Journal of Managed Care (free) AND Are Statins Behind Some Back Problems? – MedPage Today (free registration required)
Observational analysis suggests a possible association, data from randomized trials needed.
Antipsychotics in Acute Schizophrenia
27 Jul, 2017 | 17:34h | UTCSixty Years of Placebo-Controlled Antipsychotic Drug Trials in Acute Schizophrenia: Systematic Review, Bayesian Meta-Analysis, and Meta-Regression of Efficacy Predictors – American Journal of Psychiatry (link to abstract – $ for full-text)
Commentary: Antipsychotic Response Rates Through the Prism of 60 Years – Psychiatric Times (free)
Source: EvidenceAlerts (free resource to find articles of interest)
Twice as many patients improved with antipsychotics as with placebo, confirming the benefits of antipsychotic drugs for the treatment of schizophrenia.
Ivermectin – Old Drug, New Tricks?
27 Jul, 2017 | 16:50h | UTCReview: Ivermectin – Old Drug, New Tricks? – Trends in Parasitology (free)
Inconsistent Guideline Recommendations for Cardiovascular Prevention
25 Jul, 2017 | 00:55h | UTCViewpoint: Inconsistent Guideline Recommendations for Cardiovascular Prevention and the Debate About Zeroing in on and Zeroing LDL-C Levels With PCSK9 Inhibitors – JAMA (free)
Viewpoint: Treatment of Cholesterol in 2017
25 Jul, 2017 | 00:50h | UTCViewpoint: Treatment of Cholesterol in 2017 – JAMA (free)
Recent advances in the treatment of venous thromboembolism in the era of the direct oral anticoagulants
25 Jul, 2017 | 00:39h | UTCReview: Recent advances in the treatment of venous thromboembolism in the era of the direct oral anticoagulants – F1000 Research (free)
Source: Critical Care Reviews Newsletter
High-dose versus standard-dose influenza vaccination on hospitalizations
25 Jul, 2017 | 00:31h | UTCCommentaries: Study: High-dose flu vaccine cuts hospitalizations in nursing home residents – CIDRAP (free) AND High-dose influenza vaccine for nursing home residents reduces hospitalisations – OnMedica (free) AND High Dose Influenza Vaccine Leads to Lower Rate of Hospitalization From Respiratory Illnesses in Nursing Home Residents – University Hospitals Cleveland Medical Center, via NewsWise (free)
Is cyclobenzaprine useful for pain?
25 Jul, 2017 | 00:24h | UTCIs cyclobenzaprine useful for pain? – Therapeutics Initiative (free)
“…cyclobenzaprine is a long-acting sedative, not a muscle relaxant, and questioning whether any potential benefits are worth the side effects”. (from TI Newsletter). “If prescribed, a dose of 5 mg at bedtime should be tried first. Evidence suggests titration based on response and tolerability to a maximum dose of 15 mg/day, for no longer than one week”.
New Long-Acting Injectable HIV Therapies
25 Jul, 2017 | 00:15h | UTCCommentary: Long-Acting Injectable HIV Regimens Show Promise – Physician’s First Watch (free) AND Injections ‘next revolution’ in HIV: study – BBC (free)