Pharmacology/Pharmaceutical Industry
[Abstract Only] Meta-Analysis: Cardiovascular, Mortality, and Kidney Outcomes with GLP-1 Receptor Agonists in Patients with Type 2 Diabetes
18 Sep, 2019 | 01:34h | UTCCardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Commentary: GLP-1 RA Benefits Extend Beyond MACE Reduction – MedPage Today (free registration required)
Source: EvidenceAlerts
Cohort Study: Donepezil Associated with Increased Risk of Rhabdomyolysis
17 Sep, 2019 | 08:07h | UTCCommentaries: Commonly used drug for Alzheimer’s disease doubles risk of hospitalization – Canadian Medical Association Journal (free) Study: Common Alzheimer’s disease drug doubles hospitalization risk – UPI (free) AND Rhabdomyolysis risk with donepezil double that of other AD meds – OnMedica (free)
Ketamine and Depression: A Narrative Review
17 Sep, 2019 | 07:57h | UTCKetamine and depression: a narrative review – Drug Design, Development and Therapy (free)
Related Systematic Review: Ketamine and other glutamate receptor modulators for depression in adults – Cochrane Library (free)
Cohort Study: Associations Between Paracetamol Intake Between 18 and 32 Weeks Gestation and Neurocognitive Outcomes in the Child
17 Sep, 2019 | 07:33h | UTCCommentaries: Taking paracetamol during pregnancy may affect the child’s behaviour in early years – The Conversation (free) AND Expert reaction to study looking at paracetamol in pregnancy and behaviour, memory and IQ in children – Science Media Centre (free) AND Paracetamol in pregnancy linked to behaviour problems in children – OnMedica (free)
Related: Meta-Analysis: Prenatal Exposure to Acetaminophen and Risk for ADHD and Autistic Spectrum Disorder (free)
Review: Association Between Antipsychotic Medication Use and Diabetes
17 Sep, 2019 | 01:01h | UTCAssociation Between Antipsychotic Medication Use and Diabetes – Current Diabetes Reports (free)
Small Randomized Trial Suggests a Benefit from Metformin as Adjunctive Therapy in Patients with Epidermal Growth Factor Receptor–Mutated Lung Adenocarcinoma
16 Sep, 2019 | 00:46h | UTCEffect of Metformin Plus Tyrosine Kinase Inhibitors Compared With Tyrosine Kinase Inhibitors Alone in Patients With Epidermal Growth Factor Receptor–Mutated Lung Adenocarcinoma: A Phase 2 Randomized Clinical Trial – JAMA Oncology (free for a limited period)
Commentary: Metformin Repurposed: Boosts Survival in TKI-Treated Lung Cancer – MedPage Today (free registration required)
ACE inhibitors and ARBs: Managing Potassium and Renal Function
16 Sep, 2019 | 02:14h | UTCEditorial: ACE inhibitor and ARB therapy: Practical recommendations (free)
Observational Study Suggests Antibiotics Can Greatly Impair the Response to Immune Checkpoint Inhibitors in Patients with Cancer
16 Sep, 2019 | 00:48h | UTCAssociation of Prior Antibiotic Treatment With Survival and Response to Immune Checkpoint Inhibitor Therapy in Patients With Cancer – JAMA Oncology (free for a limited period)
Author Interview: Association of Prior Antibiotic Treatment With Survival and Response to Immune Checkpoint Inhibitor Therapy in Patients With Cancer (free audio)
Commentaries: Antibiotics reduce survival rates in cancer patients taking immunotherapy – Imperial College London (free) AND Antibiotics prior to immunotherapy lower survival rate for cancer patients, study says – UPI (free)
Related Commentary on Twitter
https://twitter.com/EricTopol/status/1172514038330212357
[Abstract Only] Study: Few People with Peanut Allergy Tolerate Peanut After Stopping Oral Immunotherapy
15 Sep, 2019 | 23:32h | UTCFew people with peanut allergy tolerate peanut after stopping oral immunotherapy – NIH News Releases (free)
Original Study: Sustained outcomes in oral immunotherapy for peanut allergy (POISED study): a large, randomised, double-blind, placebo-controlled, phase 2 study – The Lancet (link to abstract – $ for full-text)
Related: Meta-Analysis: Oral Immunotherapy for Peanut Allergy INCREASES Allergic and Anaphylactic Reactions (link to abstract and commentaries)
Study: Off-target Toxicity is a Common Mechanism of Action of Cancer Drugs Undergoing Clinical Trials
13 Sep, 2019 | 08:19h | UTCOff-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials – Science Translational Medicine (free for a limited period)
Commentaries: Cancer drugs don’t always work as intended, researchers warn – Cold Spring Harbor Laboratory (free) AND Why Aren’t Cancer Drugs Better? The Targets Might Be Wrong – The New York Times (10 articles per month are free)
[Abstract Only] Randomized Trial: Omega 3 Supplementation Not Effective for Reducing the Incidence of Early Preterm Delivery
12 Sep, 2019 | 08:48h | UTCA Randomized Trial of Prenatal n−3 Fatty Acid Supplementation and Preterm Delivery – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Fish oil study fails to show reduction in premature babies – Reuters (free)
[Abstract Only] Study: Oral Fluoroquinolones and Risk of Mitral and Aortic Regurgitation
11 Sep, 2019 | 08:05h | UTCOral Fluoroquinolones and Risk of Mitral and Aortic Regurgitation – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Fluoroquinolones and Cardiac Valve Regurgitation Risk – American College of Cardiology (free) AND Commonly used antibiotics may lead to heart problems – University of British Columbia (free)
Related: Committee Recommends New Restrictions on the use of Fluoroquinolones (free report and commentaries) AND FDA Safety Alert: Warnings for Fluoroquinolones on Risks of Mental Health and Low Blood Sugar Adverse Reactions (free statement and commentaries) AND FDA Warns About Increased Risk of Aortic Dissection and Ruptures of Aortic Aneurism with Fluoroquinolones (free report and commentaries) AND Fluoroquinolone use and serious arrhythmias: A nationwide case-crossover study – Resuscitation (link to abstract – $ for full-text)
Systematic Review: Once‐daily vs. Multiple‐daily Dosing with Intravenous Aminoglycosides for Cystic Fibrosis
11 Sep, 2019 | 00:05h | UTCOnce‐daily versus multiple‐daily dosing with intravenous aminoglycosides for cystic fibrosis – Cochrane Library (free)
The Serotonin Syndrome: From Molecular Mechanisms to Clinical Practice
11 Sep, 2019 | 00:00h | UTCRelated Reviews: Serotonin syndrome: Preventing, recognizing, and treating it – Cleveland Clinic Journal of Medicine (free) AND Demystifying serotonin syndrome (or serotonin toxicity) – Canadian Family Physician (free)
[Abstract Only] Meta-analysis: SGLT2 Inhibitors Beneficial for the Prevention of Kidney Failure in Patients with Type 2 Diabetes
10 Sep, 2019 | 01:14h | UTCSGLT2 inhibitors for the prevention of kidney failure in patients with type 2 diabetes: a systematic review and meta-analysis – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Commentaries: Meta-analysis supports use of SGLT2 inhibitors to prevent kidney failure – Medicine Matters (free) AND New study confirms protective effect of diabetes drugs against kidney failure – George Institute for Global Health (free)
[Abstract Only] Twins, Triplets Have Higher Risk of Medical Mix-ups in Neonatal ICUs
10 Sep, 2019 | 01:12h | UTCTwins, triplets have higher risk of medical mix-ups in neonatal ICUs – Reuters (free)
Original Article: Risk of Wrong-Patient Orders Among Multiple vs Singleton Births in the Neonatal Intensive Care Units of 2 Integrated Health Care Systems – JAMA Pediatrics (link to abstract – $ for full-text)
[Abstract Only] Randomized Trial: In Adults with Mild to Moderate Asthma, As-Needed Long-acting Beta-agonist Plus an Inhaled Corticosteroid is as Effective as Maintenance Inhaled Corticosteroid Therapy Plus As-needed Short-acting Beta-agonist
5 Sep, 2019 | 08:24h | UTCBudesonide-formoterol reliever therapy versus maintenance budesonide plus terbutaline reliever therapy in adults with mild to moderate asthma (PRACTICAL): a 52-week, open-label, multicentre, superiority, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
ASCO Guideline: Use of Endocrine Therapy for Breast Cancer Risk Reduction
5 Sep, 2019 | 08:15h | UTCRelated: USPSTF Recommendation Statement: Medication Use to Reduce Risk of Breast Cancer (free)
USPSTF Recommendation Statement: Medication Use to Reduce Risk of Breast Cancer
4 Sep, 2019 | 09:11h | UTCRecommendation Summary: Medication Use to Reduce Risk of Breast Cancer (free)
Editorials: Medications to Reduce Breast Cancer Risk: Promise and Limitations (free for a limited period) AND Breast Cancer Chemoprevention—Can We Make a Case for Precision Medicine? (free for a limited period)
Evidence Report and Systematic Review: Medication Use for the Risk Reduction of Primary Breast Cancer in Women – US Preventive Services Task Force (free)
Author Interview: USPSTF Recommendation: Medication Use to Reduce Risk of Breast Cancer (free audio)
Commentaries: Medication can lower some women’s risk of breast cancer – Reuters (free) AND USPSTF: Aromatase Inhibitors Recommended to Help Prevent Breast Cancer – NEJM Journal Watch (free)
Guidelines on the Management of Patients Developing QT Prolongation on Antipsychotic Medication
4 Sep, 2019 | 09:00h | UTC
#ESCCongress – [Not Published Yet] Randomized Trial: SGLT2 inhibitors Seems Beneficial for Heart Failure Even in Nondiabetics
2 Sep, 2019 | 01:09h | UTCCommentaries: Dapagliflozin in Patients With Heart Failure and Reduced Ejection Fraction – DAPA-HF – American College of Cardiology (free) Dapagliflozin reduces death and hospitalisation in patients with heart failure – European Society of Cardiology (free)
Related Commentary on Twitter
DAPA-HF trial at #ESCCongress: significant reduction of events in HFrEF patients by dapagliflozine. Half of the 5744 pts had diabetes, the others did not: same effect in both groups.
SGLT2 inhibitors just better diuretics or the "statins of HF"?@escardio #cardiotwitter pic.twitter.com/nzTv58d0cd— Stephan Achenbach (@Steph_Achenbach) September 1, 2019
Meta-Analysis: Menopausal Hormone Therapy Increases Breast Cancer Risk
30 Aug, 2019 | 08:55h | UTCCommentaries: Menopausal hormones: definitive evidence for breast cancer – The Lancet (free) AND Menopausal hormone therapy and 20-year breast cancer mortality – The Lancet (free) AND Hormone therapy during menopause raises breast cancer risk for years, study finds – STAT (free) AND Expert reaction to study looking at HRT use and risk of breast cancer – Science Media Centre (free)
Study: Sodium Polystyrene Sulphonate is Associated with Increased Risk of GI Adverse Events in Patients with CKD
30 Aug, 2019 | 08:28h | UTCCommentary: Hyperkalemia Drug Again Linked to Adverse GI Events – Renal & Urology News (free)
Related Study: Risk of Hospitalization for Serious Adverse Gastrointestinal Events Associated with Sodium Polystyrene Sulfonate (link to abstract and commentary)
Cohort Study: SGLT2 Inhibitors Associated with Reduced Risk of Heart Failure
30 Aug, 2019 | 08:24h | UTCCommentaries: SGLT2 inhibitors cut heart failure risk for T2D patients – Cardiovascular Business (free) AND Newer diabetes drug drops heart failure risk by 34 percent, study says – UPI (free)
Related observational studies: SGLT2 agents may reduce cardiovascular risk in diabetics (link to abstract and commentaries)
Randomized Trial: Effect of Low-Dose Vasopressin on Need for Transfusions in Patients With Trauma and Hemorrhagic Shock
29 Aug, 2019 | 06:45h | UTCEffect of Low-Dose Supplementation of Arginine Vasopressin on Need for Blood Product Transfusions in Patients With Trauma and Hemorrhagic Shock: A Randomized Clinical Trial – JAMA Surgery (free for a limited period)
Commentaries: Vasopressin as an Early Adjunct to Resuscitation in Hemorrhagic Shock: Crisis AVERTed? – JAMA Surgery (free) AND Giving trauma patients blood pressure stabilizing hormone cuts transfusions by half – University of Pennsylvania School of Medicine (free)
Author Interview: Arginine Vasopressin Supplementation in Early Traumatic Shock (free)
“Additional research is necessary to determine whether including AVP improves morbidity or mortality.”