Pediatrics – Infectious Diseases | Page 13 of 19 | Links Medicus Content Curation & Alerts in Medicine

Kids are losing school days to quarantines. Here’s a way to keep them in classrooms – “Test-to-stay could dramatically reduce close contact quarantines”.

10 Oct, 2021 | 21:52h | UTC

Kids are losing school days to quarantines. Here’s a way to keep them in classrooms – NPR

Heart-inflammation risk from Pfizer COVID vaccine is very low.

10 Oct, 2021 | 21:42h | UTC

Heart-inflammation risk from Pfizer COVID vaccine is very low – Nature

Original studies:

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

[Preprint] COVID-19 in children due to SARS-CoV-2 Delta strain resembles illness due to the Alpha variant, with short duration and similar symptom burden.

10 Oct, 2021 | 21:44h | UTC

Illness characteristics of COVID-19 in children infected with the SARS-CoV-2 Delta variant – medRxiv

Commentary on Twitter

Did you hear “Delta is different”, when it comes to #COVID19 symptom severity in children?

GOOD NEWS 🥳

Turns out there is barely any difference at all between Delta and Alpha in symptom duration, severity, or risk of “long covid”

Myth busted 💥 https://t.co/iPd9AedXaS

— Alasdair Munro (@apsmunro) October 7, 2021

Bioethics | The Trolley Problem and Vaccinating Young People Against COVID-19.

10 Oct, 2021 | 21:50h | UTC

The Trolley Problem and Vaccinating Young People Against COVID-19 – Science-Based Medicine

How the risk of Covid-19 for kids compares to other dangers.

8 Oct, 2021 | 10:26h | UTC

How the risk of Covid-19 for kids compares to other dangers – Vox

WHO approves first ever malaria vaccine for children at risk.

7 Oct, 2021 | 10:40h | UTC

WHO recommends groundbreaking malaria vaccine for children at risk – World Health Organization

Commentaries:

WHO Approves First Ever Malaria Vaccine – Health Policy Watch

A historic day for malaria – reaction to WHO decision on the RTS,S vaccine – London School of Hygiene & Tropical Medicine

In major decision, WHO recommends broad rollout of world’s first malaria vaccine – STAT

Why the WHO approval of the first malaria vaccine is a big deal – Vox

WHO greenlights the world’s first malaria vaccine — but it’s not a perfect shot – NPR

The World Health Organization Just Endorsed The World’s First Malaria Vaccine – TIME

WHO Backs Widespread Use Of First Malaria Vaccine – Forbes

World’s 1st malaria vaccine recommended by WHO – LiveScience

Commentaries on Twitter

I started my career as a #malaria researcher, and I longed for the day that we would have an effective vaccine against this ancient and terrible disease. Today is that day: @WHO is recommending the broad use of the world’s first malaria vaccine. #EndMalaria https://t.co/Oh1O155tYj

— Tedros Adhanom Ghebreyesus (@DrTedros) October 6, 2021

(thread – click for more)

A child dies from #malaria every two minutes.
One death is one too many.

🚨 Today, WHO recommends RTS,S, a groundbreaking malaria vaccine, to reduce child illness & deaths in areas with moderate and high malaria transmission https://t.co/xSk58nTIV1 #VaccinesWork pic.twitter.com/mSECLtRhQs

— World Health Organization (WHO) (@WHO) October 6, 2021

Supplement: Triumphs of Vaccination.

6 Oct, 2021 | 08:55h | UTC

Homepage: Triumphs of Vaccination – The Journal of Infectious Diseases

Triumphs of Immunization

Pertussis (Whooping Cough)

Hib Vaccines: Their Impact on Haemophilus influenzae Type b Disease

The Rotavirus Vaccine Story: From Discovery to the Eventual Control of Rotavirus Disease

Hepatitis B Vaccines

Triumph of Pneumococcal Conjugate Vaccines: Overcoming a Common Foe

Rubella Eradication: Not Yet Accomplished, but Entirely Feasible

Human Papillomavirus Vaccines

Smallpox

Live Attenuated Varicella Vaccine: Prevention of Varicella and of Zoster

Immunization Against Poliomyelitis and the Challenges to Worldwide Poliomyelitis Eradication

Influenza Vaccines: Successes and Continuing Challenges

Measles in the 21st Century: Progress Toward Achieving and Sustaining Elimination

Herpes Zoster Vaccines

Overview of the United States’ Immunization Program

The World of Immunization: Achievements, Challenges, and Strategic Vision for the Next Decade

New analysis shows benefits of offering two doses of COVID-19 vaccine to children aged 12-17 clearly outweigh risks.

3 Oct, 2021 | 22:52h | UTC

News release: New analysis shows benefits of offering two doses of COVID-19 vaccine to children aged 12-17 clearly outweigh risks – The Royal Society of Medicine

Original report: Vaccinating adolescents against SARS-CoV-2 in England: a risk-benefit analysis

Editorial | Clinical ethics: consent for vaccination in children.

3 Oct, 2021 | 22:53h | UTC

Clinical ethics: consent for vaccination in children – Archives of Disease in Childhood

Impact of COVID-19 on Pediatric Immunocompromised Patients.

1 Oct, 2021 | 10:36h | UTC

Impact of COVID-19 on Pediatric Immunocompromised Patients – Pediatric Clinics of North America

Neurological Effects of COVID-19 in Children.

1 Oct, 2021 | 10:40h | UTC

Neurological Effects of COVID-19 in Children – Pediatric Clinics of North America

Opinion | Data from routine Covid testing can help schools stay open this year.

29 Sep, 2021 | 10:14h | UTC

Data from routine Covid testing can help schools stay open this year – STAT

Routine COVID testing doubles detection at 3 public schools.

29 Sep, 2021 | 10:16h | UTC

Routine COVID testing doubles detection at 3 public schools – CIDRAP

Original study: Assessment of a Program for SARS-CoV-2 Screening and Environmental Monitoring in an Urban Public School District – JAMA Network Open

WHO and partners call for urgent action on meningitis – New meningitis strategy aims to save more than 200,000 lives annually.

29 Sep, 2021 | 10:06h | UTC

News release: WHO and partners call for urgent action on meningitis – New meningitis strategy aims to save more than 200,000 lives annually – World Health Organization

See guidance: Defeating meningitis by 2030: a global road map – World Health Organization

Commentaries:

WHO Launches First Global Strategy to Eliminate Bacterial Meningitis by 2030 – Health Policy Watch

LSHTM joins WHO to call for urgent action on meningitis – London School of Hygiene & Tropical Medicine

Commentary on Twitter (thread – click for more)

🆕! First ever global strategy to #DefeatMeningitis – a debilitating disease that kills hundreds of thousands of people each year. 👉https://t.co/wG6CqmOPH1 pic.twitter.com/0q6fkTwRHm

— World Health Organization (WHO) (@WHO) September 28, 2021

Editorial: It’s time to send children back to school.

28 Sep, 2021 | 09:49h | UTC

It’s time to send children back to school – Nature Medicine

CDC Report: Schools without mask requirements were more likely to have Covid-19 outbreaks.

26 Sep, 2021 | 22:10h | UTC

Association Between K–12 School Mask Policies and School-Associated COVID-19 Outbreaks — Maricopa and Pima Counties, Arizona, July–August 2021 – CDC Morbidity and Mortality Weekly Report

Commentary: Schools Without Mask Requirements More Likely to See COVID-19 Outbreaks – U.S. News

Commentary on Twitter

New @CDCMMWR finds schools in two Arizona counties w/o a mask requirement were 3.5 times more likely to have a #COVID19 outbreak than schools requiring masks from the start of the school year. CDC recommends universal masking for all K–12 schools. More: https://t.co/suuuLNItxJ. pic.twitter.com/zYYqXoLH3j

— CDC (@CDCgov) September 24, 2021

RCT confirms antibiotics are not needed for most children with uncomplicated lower respiratory tract infection if pneumonia is not suspected clinically.

24 Sep, 2021 | 09:00h | UTC

Antibiotics for lower respiratory tract infection in children presenting in primary care in England (ARTIC PC): a double-blind, randomised, placebo-controlled trial – The Lancet

Commentary on Twitter

#Antibiotic resistance is a global public health threat.

New trial indicates, unless pneumonia is suspected, clinicians should provide safety-netting advice but not prescribe antibiotics for most children presenting with chest infections. https://t.co/mOwLG5rZd1 #AMR pic.twitter.com/b0c7Z5flQk

— The Lancet (@TheLancet) September 23, 2021

Randomized phase 1/2 trial: Safety and immunogenicity of an inactivated COVID-19 vaccine, BBIBP-CorV, in children and adolescents aged 3–17 years.

23 Sep, 2021 | 10:16h | UTC

Safety and immunogenicity of an inactivated COVID-19 vaccine, BBIBP-CorV, in people younger than 18 years: a randomised, double-blind, controlled, phase 1/2 trial – The Lancet Infectious Diseases

[Press release – not published yet] Pfizer announces COVID-19 vaccine in children 5 to 11 years produced strong neutralizing antibody responses.

21 Sep, 2021 | 09:57h | UTC

Pfizer and BioNTech Announce Positive Topline Results From Pivotal Trial of COVID-19 Vaccine in Children 5 to 11 Years – Pfizer and BioNTech

Commentaries:

Covid-19 vaccine for 5- to 11-year-olds is safe and shows ‘robust’ antibody response, Pfizer says – CNN

Pfizer says COVID-19 vaccine safe, effective in younger children – CIDRAP

Pfizer Covid-19 vaccine generates robust antibody response in children, without serious safety issues, company says – STAT

Expert reaction to press release giving topline results from Pfizer and BioNTech from their phase 2/3 trial looking at safety and antibody responses from their COVID-19 vaccine in children aged 5 to 11 – Science Media Centre

Commentaries on Twitter

I'm so glad to see that Pfizer has data to submit for their vaccine for 5-11 year olds. But any strong assertions about safety, such as for low incidence side-effects like myocarditis, cannot made from a trial of ~1500 children.

— Eric Topol (@EricTopol) September 20, 2021

(thread – click for more)

BREAKING NEWS: Pfizer releases results of 5-11 year old trial for its vaccine. 2-dose 10 microgram regimen (Pfizer uses 30 mcg for 12 and up) administered 21 days apart (sigh, we now know we need longer duration between doses for better effectiveness)https://t.co/43MHnlZgqg

— Monica Gandhi MD, MPH (@MonicaGandhi9) September 20, 2021

(thread – click for more)

https://twitter.com/hildabast/status/1439976038964940803

An Update on Coronavirus Disease 2019 (COVID-19) and Pregnancy.

21 Sep, 2021 | 09:51h | UTC

An Update on Coronavirus Disease 2019 (COVID-19) and Pregnancy – American Journal of Obstetrics and Gynecology

Review: Long COVID symptoms in children rarely persist beyond three months.

19 Sep, 2021 | 23:47h | UTC

News release: Long COVID symptoms in children rarely persist beyond three months – Murdoch Children’s Research Institute

Original study: How Common Is Long COVID in Children and Adolescents? – The Pediatric Infectious Disease Journal

Commentary: Long Covid in children and adolescents is less common than previously feared – The Guardian

Cohort study: long term follow-up showed most patients with post–COVID-19 Multisystem Inflammatory Syndrome in Children had good outcomes with no significant medium- or long-term sequelae.

Long COVID: the physical and mental health of children and non-hospitalized young people after SARS-CoV-2 infection – one in seven children may still have symptoms 15 weeks after infection.

Do kids get long COVID? And how often? A pediatrician looks at the data – Children also get Long Covid, but much less often than adults.

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

Cohort study: Risk factors for long covid in previously hospitalized children.

M-A: More than 50 long-term effects of COVID-19.

Commentary on Twitter (thread – click for more)

#LongCOVID

We reviewed 14 studies of persisting symptoms following #COVID19 in #children & #adolescents

Most had major limitations and should be interpreted with caution.

True risk is likely to be nearer 1 in 100 than often quoted 1 in 7.#medpeds #IDTwitter

(Long) 🧵1/n pic.twitter.com/YL2h516sNX

— Nigel Curtis (@nigeltwitt) September 17, 2021

Perspective | Schools have begun mass testing for COVID-19. But hurdles and uncertainties remain.

16 Sep, 2021 | 10:06h | UTC

Schools have begun mass testing for COVID-19. But hurdles and uncertainties remain – Science

Cluster RCT: Daily contact testing of school-based contacts was non-inferior to self-isolation for control of COVID-19 transmission.

15 Sep, 2021 | 10:01h | UTC

Daily testing for contacts of individuals with SARS-CoV-2 infection and attendance and SARS-CoV-2 transmission in English secondary schools and colleges: an open-label, cluster-randomised trial – The Lancet

Invited commentary: Daily antigen testing to reduce disruption when schools return – The Lancet

Covid: Single jab recommended for 12 to 15-year-olds by UK’s top doctors.

14 Sep, 2021 | 10:05h | UTC

Covid: Single jab recommended for 12 to 15-year-olds by UK’s top doctors – BBC

Cohort study: long term follow-up showed most patients with post–COVID-19 Multisystem Inflammatory Syndrome in Children had good outcomes with no significant medium- or long-term sequelae.

12 Sep, 2021 | 21:54h | UTC

One-Year Outcomes of Critical Care Patients Post–COVID-19 Multisystem Inflammatory Syndrome in Children – JAMA Pediatrics

Commentary: Outcome Good at One Year for Majority of PIMS-TS Patients – HealthDay

Commentary on Twitter

A new study reports that a small number of pediatric patients are at risk for poor long-term outcomes of multisystem inflammatory syndrome in children. https://t.co/rUk4YEGRin pic.twitter.com/CgBi33Mzd5

— JAMA Pediatrics (@JAMAPediatrics) September 2, 2021

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