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Pediatrics (all articles)

Randomized phase 1/2 trial: Safety and immunogenicity of an inactivated COVID-19 vaccine, BBIBP-CorV, in children and adolescents aged 3–17 years.

23 Sep, 2021 | 10:16h | UTC

Safety and immunogenicity of an inactivated COVID-19 vaccine, BBIBP-CorV, in people younger than 18 years: a randomised, double-blind, controlled, phase 1/2 trial – The Lancet Infectious Diseases

Related: Phase 1/2 RCT: CoronaVac is well tolerated and safe and induces strong humoral responses in children and adolescents aged 3–17 years.

 

AHA Scientific Statement: Sleep‐disordered breathing and cardiovascular disease in children and adolescents.

23 Sep, 2021 | 10:02h | UTC

Sleep‐Disordered Breathing and Cardiovascular Disease in Children and Adolescents: A Scientific Statement From the American Heart Association – Journal of the American Heart Association

News release: Obstructive sleep apnea is common in kids and may impact blood pressure, heart health – American Heart Association

 

[Press release – not published yet] Pfizer announces COVID-19 vaccine in children 5 to 11 years produced strong neutralizing antibody responses.

21 Sep, 2021 | 09:57h | UTC

Pfizer and BioNTech Announce Positive Topline Results From Pivotal Trial of COVID-19 Vaccine in Children 5 to 11 Years – Pfizer and BioNTech

Commentaries:

Covid-19 vaccine for 5- to 11-year-olds is safe and shows ‘robust’ antibody response, Pfizer says – CNN

Pfizer says COVID-19 vaccine safe, effective in younger children – CIDRAP

Pfizer Covid-19 vaccine generates robust antibody response in children, without serious safety issues, company says – STAT

Expert reaction to press release giving topline results from Pfizer and BioNTech from their phase 2/3 trial looking at safety and antibody responses from their COVID-19 vaccine in children aged 5 to 11 – Science Media Centre

 

Commentaries on Twitter

(thread – click for more)

(thread – click for more)

https://twitter.com/hildabast/status/1439976038964940803

 

An Update on Coronavirus Disease 2019 (COVID-19) and Pregnancy.

21 Sep, 2021 | 09:51h | UTC

An Update on Coronavirus Disease 2019 (COVID-19) and Pregnancy – American Journal of Obstetrics and Gynecology

 

RCT: Preemptive intervention may improve developmental outcomes in infants showing early signs of autism.

21 Sep, 2021 | 09:01h | UTC

Effect of Preemptive Intervention on Developmental Outcomes Among Infants Showing Early Signs of Autism: A Randomized Clinical Trial of Outcomes to Diagnosis – JAMA Pediatrics (free for a limited period)

Commentaries:

Intervening Before 18 Months May Reduce Odds of Autism Diagnosis in Babies Identified at High Risk – Psychiatric News Alert

Expert reaction to trial looking at the effect of a pre-emptive intervention in children showing early signs of autism on developmental outcomes – Science Media Centre

Autism therapy aimed at infants may reduce likelihood of later diagnosis – The Guardian

 

Commentary on Twitter

 

Review: Long COVID symptoms in children rarely persist beyond three months.

19 Sep, 2021 | 23:47h | UTC

News release: Long COVID symptoms in children rarely persist beyond three months –  Murdoch Children’s Research Institute

Original study: How Common Is Long COVID in Children and Adolescents? – The Pediatric Infectious Disease Journal

Commentary: Long Covid in children and adolescents is less common than previously feared – The Guardian

Related:

Cohort study: long term follow-up showed most patients with post–COVID-19 Multisystem Inflammatory Syndrome in Children had good outcomes with no significant medium- or long-term sequelae.

Long COVID: the physical and mental health of children and non-hospitalized young people after SARS-CoV-2 infection – one in seven children may still have symptoms 15 weeks after infection.

Do kids get long COVID? And how often? A pediatrician looks at the data – Children also get Long Covid, but much less often than adults.

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

Cohort study: Risk factors for long covid in previously hospitalized children.

M-A: More than 50 long-term effects of COVID-19.

 

Commentary on Twitter (thread – click for more)

 

RCT: The addition of telemedicine to improve standard care for medically complex children was associated with improved clinical outcomes and reduced costs.

17 Sep, 2021 | 10:00h | UTC

Telemedicine for Children With Medical Complexity: A Randomized Clinical Trial – Pediatrics

 

Review | Prevention of unintentional injuries in children under five years.

17 Sep, 2021 | 09:58h | UTC

Prevention of unintentional injuries in children under five years – BMC Pediatrics

 

Perspective | Schools have begun mass testing for COVID-19. But hurdles and uncertainties remain.

16 Sep, 2021 | 10:06h | UTC

Schools have begun mass testing for COVID-19. But hurdles and uncertainties remain – Science

Related: Cluster RCT: Daily contact testing of school-based contacts was non-inferior to self-isolation for control of COVID-19 transmission.

 

Cluster RCT: Daily contact testing of school-based contacts was non-inferior to self-isolation for control of COVID-19 transmission.

15 Sep, 2021 | 10:01h | UTC

Daily testing for contacts of individuals with SARS-CoV-2 infection and attendance and SARS-CoV-2 transmission in English secondary schools and colleges: an open-label, cluster-randomised trial – The Lancet

Invited commentary: Daily antigen testing to reduce disruption when schools return – The Lancet

 

Five hundred patients with gut malrotation: thirty years of experience with the introduction of a new surgical procedure.

16 Sep, 2021 | 09:48h | UTC

Five Hundred Patients With Gut Malrotation: Thirty Years of Experience With the Introduction of a New Surgical Procedure – Annals of Surgery

 

Supplement: FIGO Working Group for Preterm Birth – Good Practice Recommendations.

15 Sep, 2021 | 08:56h | UTC

Homepage: FIGO Working Group for Preterm Birth – Good Practice Recommendations – International Journal of Gynecology & Obstetrics

Editorial: FIGO good practice recommendations for reducing preterm birth and improving child outcomes

FIGO good practice recommendations on the importance of registry data for monitoring rates and health systems performance in prevention and management of preterm birth

FIGO good practice recommendations on modifiable causes of iatrogenic preterm birth

FIGO good practice recommendations on reduction of preterm birth in pregnancies conceived by assisted reproductive technologies

FIGO good practice recommendations on progestogens for prevention of preterm delivery

FIGO good practice recommendations on cervical cerclage for prevention of preterm birth

FIGO good practice recommendations on the use of pessary for reducing the frequency and improving outcomes of preterm birth

FIGO good practice recommendations on the use of prenatal corticosteroids to improve outcomes and minimize harm in babies born preterm

FIGO good practice recommendations on magnesium sulfate administration for preterm fetal neuroprotection

FIGO good practice recommendations on delayed umbilical cord clamping

 

Covid: Single jab recommended for 12 to 15-year-olds by UK’s top doctors.

14 Sep, 2021 | 10:05h | UTC

Covid: Single jab recommended for 12 to 15-year-olds by UK’s top doctors – BBC

See also: Covid-19: Children aged 12-15 should be offered vaccine, say UK’s chief medical officers – The BMJ

 

Cohort study: long term follow-up showed most patients with post–COVID-19 Multisystem Inflammatory Syndrome in Children had good outcomes with no significant medium- or long-term sequelae.

12 Sep, 2021 | 21:54h | UTC

One-Year Outcomes of Critical Care Patients Post–COVID-19 Multisystem Inflammatory Syndrome in Children – JAMA Pediatrics

Commentary: Outcome Good at One Year for Majority of PIMS-TS Patients – HealthDay

 

Commentary on Twitter

 

The Delta Covid variant and children: transmission in kids is low and only 2% hospitalized, report finds.

12 Sep, 2021 | 21:56h | UTC

The Delta Covid variant and children: transmission in kids is low and only 2% hospitalised, report finds – The Guardian

Report: COVID-19 Delta variant in schools and early childhood education and care services in NSW, Australia: 16 June to 31 July 2021 – NCIRS

News release: COVID-19 Delta variant in schools and early childhood education and care services in NSW, Australia: 16 June to 31 July 2021

 

Commentary on Twitter (thread – click for more)

 

RCT: Limiting screen time for young adults after concussion results in shorter duration of symptoms.

12 Sep, 2021 | 21:38h | UTC

News release: Limiting screen time for young adults after concussion results in shorter duration of symptoms – University of Massachusetts Medical School

Original study: Effect of Screen Time on Recovery From Concussion: A Randomized Clinical Trial – JAMA Pediatrics (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Chile authorizes Sinovac vaccine for kids of 6 and older.

7 Sep, 2021 | 21:45h | UTC

Chile authorizes Sinovac vaccine for kids of 6 and older – Associated Press

 

Kids and COVID: why young immune systems are still on top.

7 Sep, 2021 | 21:46h | UTC

Kids and COVID: why young immune systems are still on top – Nature

 

Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.

7 Sep, 2021 | 21:48h | UTC

Effectiveness of the BNT162b2 mRNA COVID-19 vaccine in pregnancy – Nature Medicine

 

Commentaries on Twitter

 

AAP flu recommendations allow for coadministration with COVID-19 vaccine.

7 Sep, 2021 | 21:44h | UTC

News release: AAP flu recommendations allow for coadministration with COVID-19 vaccine – American Academy of Pediatrics

Guidance: Recommendations for Prevention and Control of Influenza in Children, 2021–2022 – American Academy of Pediatrics

Technical report: Recommendations for Prevention and Control of Influenza in Children, 2021–2022 – American Academy of Pediatrics

Related: New CDC Guidance says influenza and Covid vaccines can be given together – “COVID-19 vaccines and other vaccines may now be administered without regard to timing”

 

Commentary on Twitter

 

Defining pediatric metabolic (dysfunction)-associated fatty liver disease: an international expert consensus statement.

7 Sep, 2021 | 21:26h | UTC

Defining paediatric metabolic (dysfunction)-associated fatty liver disease: an international expert consensus statement – The Lancet Gastroenterology & Hepatology (free registration required)

 

Commentary on Twitter

 

CDC report: Hospitalization rates for Covid-19 were 10 times higher among unvaccinated than among fully vaccinated adolescents.

7 Sep, 2021 | 10:52h | UTC

Hospitalizations Associated with COVID-19 Among Children and Adolescents — COVID-NET, 14 States, March 1, 2020–August 14, 2021 – CDC Morbidity and Mortality Weekly Report

Commentaries:

More kids hospitalized with Covid-19 in states with lower vaccination rates, CDC report finds – CNN

The hospitalization rate among teens who are unvaccinated is 10 times higher than teens who are vaccinated, new CDC data shows – Insider

Child COVID hospital cases up in low-vaccination states – CIDRAP

 

Commentary on Twitter

 

Podcast: Febrile Infants (based on the new AAP Guideline).

7 Sep, 2021 | 10:31h | UTC

#33: Febrile Infants – When Babies Are Too Hot – The Cribsiders

Original guideline:

AAP Guideline: Evaluation and management of well-appearing febrile infants 8 to 60 days old.

Commentaries:

Landmark Febrile Neonate, Febrile Infant Guideline from the AAP – JournalFeed

Small Talk – Hot Off The Presses: The Latest AAP Guidelines for the Febrile Neonate – emDocs

Related:

M-A: Low prevalence of bacterial meningitis among well-appearing febrile infants aged 29-60 days with positive urinalysis results – “These results suggest that for these infants, the decision to use lumbar puncture should not be guided by urinalysis results alone”.

Things We Do for No Reason: Lumbar Punctures in Low-Risk Febrile Infants with Bronchiolitis

[Abstract Only] Observational Study Suggests Testing for Meningitis May Not be Necessary for Febrile Well-Appearing Young Infants with Positive Urinalysis

Study: Clinical Prediction Rule to Identify Febrile Infants at Low Risk for Serious Bacterial Infections

Cohort Study: Accuracy of Complete Blood Cell Counts to Identify Febrile Infants 60 Days or Younger With Invasive Bacterial Infections

 

AHA Scientific Statement: Genetic testing for heritable cardiovascular diseases in pediatric patients.

6 Sep, 2021 | 10:33h | UTC

Genetic Testing for Heritable Cardiovascular Diseases in Pediatric Patients: A Scientific Statement From the American Heart Association – Circulation: Genomic and Precision Medicine

News release: Genetic testing in children for heart disorders should be family-centered, include counseling – American Heart Association

 

Commentary on Twitter

https://twitter.com/CSHeartResearch/status/1428750055863844866

 

Position paper on the diagnosis and management of pediatric acute liver failure.

6 Sep, 2021 | 10:31h | UTC

North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Position Paper on the Diagnosis and Management of Pediatric Acute Liver Failure – Journal of Pediatric Gastroenterology and Nutrition

 

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