Pediatrics (all articles) | Page 39 of 119 | Links Medicus Content Curation & Alerts in Medicine

RCT: High dose Rifampicin with or without Levofloxacin vs. standard of care for pediatric tuberculous meningitis.

24 Mar, 2022 | 08:12h | UTC

Randomized Clinical Trial of High Dose Rifampicin with or without Levofloxacin versus Standard of Care for Paediatric Tuberculous Meningitis: The TBM-KIDS Trial – Clinical Infectious Diseases

Cohort Study: No association of neonatal hypoglycemia with academic performance in mid-childhood.

23 Mar, 2022 | 10:05h | UTC

Association of Neonatal Hypoglycemia With Academic Performance in Mid-Childhood – JAMA (free for a limited period)

New WHO guidelines on the management of tuberculosis in children and adolescents.

22 Mar, 2022 | 09:52h | UTC

WHO consolidated guidelines on tuberculosis Module 5: Management of tuberculosis in children and adolescents – World Health Organization

Commentary: New Children’s TB Guidelines a ‘Game-Changer’ With Non-Invasive Tests, Shortened Treatments – Health Policy Watch

Study shows whole-genome risk prediction of common diseases in human preimplantation embryos is feasible, leading to ethical concerns.

22 Mar, 2022 | 09:42h | UTC

Whole-genome risk prediction of common diseases in human preimplantation embryos – Nature Medicine

Invited Commentaries:

Polygenic embryo testing: understated ethics, unclear utility – Nature Medicine

The uncertain science of preimplantation and prenatal genetic testing – Nature Medicine

Commentary: As genetic testing of human embryos expand, researchers call for frank assessment of profound ethical implications – The Hastings Center

Commentary on Twitter (thread – click for more)

Preimplantation genetic testing of human embryos is a rapidly advancing field, but scientists and ethicists are calling for caution.
We present 3 articles highlighting new research and expert commentary on this controversial topic.
THREAD 🧵

— Nature Medicine (@NatureMedicine) March 21, 2022

Guidelines on sickle cell disease: secondary stroke prevention in children and adolescents.

22 Mar, 2022 | 08:34h | UTC

Guidelines on sickle cell disease: secondary stroke prevention in children and adolescents. Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular guidelines project: Associação Médica Brasileira – 2022 – Hematology, Transfusion and Cell Therapy

Consensus Paper: Vitamin D and calcium intakes in general pediatric populations.

22 Mar, 2022 | 08:36h | UTC

Vitamin D and calcium intakes in general pediatric populations: A French expert consensus paper – Archives de Pédiatrie

Rapid point-of-care genotyping to avoid aminoglycoside-induced ototoxicity in neonatal intensive care.

22 Mar, 2022 | 08:01h | UTC

Rapid Point-of-Care Genotyping to Avoid Aminoglycoside-Induced Ototoxicity in Neonatal Intensive Care – JAMA Pediatrics

Editorial: Genetic Testing in Newborns Moves From Rare to Routine Application

Commentary on Twitter

The MT-RNR1 m.1555A>G variant predisposes to profound aminoglycoside-induced ototoxicity
The MT-RNR1 POCT was able to genotype the m.1555A>G variant in 26 minutes. #IDTwitter #medtwitter #TwitteRx #MedEd #PIDTwitter https://t.co/BbkpNMiNHN

— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) March 21, 2022

Guideline: Umbilical cord management in preterm and term infants.

21 Mar, 2022 | 08:48h | UTC

Guideline No. 424: Umbilical Cord Management in Preterm and Term Infants – Journal of Obstetrics and Gynaecology Canada

Systematic Review: Strategies for using topical corticosteroids in children and adults with eczema.

21 Mar, 2022 | 08:33h | UTC

Strategies for using topical corticosteroids in children and adults with eczema – Cochrane Library

Summary: What is the best way to use topical corticosteroids to treat people with eczema? – Cochrane Library

Commentary on Twitter

https://twitter.com/CochraneUK/status/1504548242738102273

RCT: Nebulized Poractant Alfa in premature babies with respiratory distress syndrome.

21 Mar, 2022 | 08:25h | UTC

A Randomized, Controlled Trial to Investigate the Efficacy of Nebulized Poractant Alfa in Premature Babies with Respiratory Distress Syndrome – The Journal of Pediatrics

Commentary: Should we give up on nebulised surfactant? – Neonatal Research

Commentary on Twitter

The CURONEB RCT by Dani et al. in @JPediatr stopped early, but showed that nebulised poractant alfa is safe but does not reduce respiratory failure within 72 hours in 28-33 weekers https://t.co/gW57rPTd4f #FOAMneo #EBNEOalerts #neoEBM #neotwitter pic.twitter.com/G5Cii33fRD

— Evidence-Based Neo (@EBNEO) March 8, 2022

AHA Scientific Statement: Advances in managing transition to adulthood for adolescents with congenital heart disease.

18 Mar, 2022 | 08:19h | UTC

Advances in Managing Transition to Adulthood for Adolescents With Congenital Heart Disease: A Practical Approach to Transition Program Design: A Scientific Statement From the American Heart Association – Journal of the American Heart Association

News Release: For youth with a heart defect, shift to adult-focused care is key to health, quality of life – American Heart Association

M-A: Comparative efficacy and safety of pharmacological interventions to prevent Mother-to-Child transmission of hepatitis B virus.

18 Mar, 2022 | 07:37h | UTC

Comparative efficacy and safety of pharmacological interventions to prevent Mother-to-Child transmission of hepatitis B virus: A systematic review and network meta-analysis – American Journal of Obstetrics & Gynecology

Trends in HPV–associated cancers, demographic characteristics, and vaccinations in the US, 2001-2017.

17 Mar, 2022 | 08:16h | UTC

Trends in Human Papillomavirus–Associated Cancers, Demographic Characteristics, and Vaccinations in the US, 2001-2017 – JAMA Network Open

Author Interview: Trends in Human Papillomavirus–Associated Cancers, Demographic Characteristics, and Vaccinations

[Not published yet] Single-dose HPV vaccine highly effective, researchers say – “Results of randomized controlled trial in Kenya bring new energy to eliminate cervical cancer worldwide”.

A national HPV vaccination program in England was associated with an estimated reduction in cervical cancer rates of 87% for those offered the vaccine at age 12–13 years.

Three-year follow-up of 2-dose versus 3-dose HPV vaccine

Nationwide cohort study in Sweden shows HPV vaccination linked to reduced risk of invasive cervical cancer

CDC: 92% of Human Papillomavirus–Attributable Cancers can be Targeted by HPV Vaccination

Meta-Analysis: Population-level Impact of HPV Vaccination Programs

AAP Policy Statement: Vitamin K and the newborn infant.

16 Mar, 2022 | 10:08h | UTC

Vitamin K and the Newborn Infant – Pediatrics

News Release: Vitamin K policy addresses birth dose for term, preterm infants; parental concerns – American Academy of Pediatrics

Commentary: Newborns Should Receive Vitamin K Within Six Hours of Birth – HealthDay

Cohort Study: Patterns of early life weight gain and female onset of puberty.

16 Mar, 2022 | 08:46h | UTC

Patterns of Early Life Weight Gain and Female Onset of Puberty – Journal of the Endocrine Society

Commentary: Early life weight gain predicts pubertal onset in girls – Healio

How to: Clostridioides difficile infection in children.

16 Mar, 2022 | 08:39h | UTC

How to: Clostridioides difficile infection in children – Clinical Microbiology and Infection

Retrospective Cohort: Asthma in children and adolescents is not associated with increased risk of SARS-CoV-2 infection.

15 Mar, 2022 | 08:55h | UTC

Asthma and the Risk of SARS-CoV-2 Infection Among Children and Adolescents – Pediatrics

Commentary: Kids with asthma not at higher risk of COVID-19, study finds – CIDRAP

We expected people with asthma to fare worse during COVID. Turns out they’ve had a break.

M-A: Asthma does not increase the risk of infection, hospitalization, ICU admission, and mortality from COVID-19

Systematic review: No evidence that patients with asthma are at increased risk of COVID-19 diagnosis, hospitalization or death

Asthma in COVID-19 hospitalizations: An overestimated risk factor?

Open Label RCT: Azithromycin for poorly controlled asthma in children.

15 Mar, 2022 | 08:39h | UTC

Azithromycin for Poorly Controlled Asthma in Children: A randomized controlled trial – CHEST (link to abstract – $ for full-text)

Commentary: Adding azithromycin to standard care improves asthma control, exacerbations in children – Healio

Systematic Review: Binocular versus standard occlusion or blurring treatment for unilateral amblyopia in children aged three to eight years.

14 Mar, 2022 | 01:16h | UTC

Binocular versus standard occlusion or blurring treatment for unilateral amblyopia in children aged three to eight years – Cochrane Library

Observational Study: Comparison of intracranial pressure measurements before and after hypertonic saline or mannitol treatment in children with severe traumatic brain injury.

14 Mar, 2022 | 00:51h | UTC

Comparison of Intracranial Pressure Measurements Before and After Hypertonic Saline or Mannitol Treatment in Children With Severe Traumatic Brain Injury – JAMA Network Open

Invited Commentary: ADAPTing to a New Era of Comparative Effectiveness Research in Traumatic Brain Injury—Generating Evidence From Observational Data – JAMA Network Open

Commentary on Twitter

For children with severe TBI, hypertonic saline is recommended in published guidelines. However, mannitol is in wide-spread clinical use. In this comparative effectiveness, hypertonic saline was associated with improved ICP compared to mannitol. https://t.co/7JW224Dbio

— JAMA Network Open (@JAMANetworkOpen) March 10, 2022

SHEA neonatal intensive care unit (NICU) white paper series: Practical approaches for preventing central line-associated bloodstream infections.

11 Mar, 2022 | 09:53h | UTC

SHEA neonatal intensive care unit (NICU) white paper series: Practical approaches for the prevention of central line-associated bloodstream infections – Infection Control and Hospital Epidemiology

News Release: Practical approaches for the prevention of central line-associated bloodstream infections in NICU – Society for Healthcare Epidemiology of America

RCT: In pediatric ICUs, a bundled intervention that emphasized a physiologically focused cardiopulmonary resuscitation training did not improve outcomes in cardiac arrest.

11 Mar, 2022 | 09:37h | UTC

Effect of Physiologic Point-of-Care Cardiopulmonary Resuscitation Training on Survival With Favorable Neurologic Outcome in Cardiac Arrest in Pediatric ICUs: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentary: CPR Intervention Failed to Improve Survival in Kids With Cardiac Arrest — Physiologically focused CPR training did not lead to difference in survival to discharge – MedPage Today (free registration required)

Commentary on Twitter

Among patients in pediatric ICUs, a bundled intervention that emphasized physiologically focused CPR training and structured clinical event debriefing did not significantly improve patient survival to hospital discharge with favorable neurologic outcome. https://t.co/MbmmSM0Xrt

— JAMA (@JAMA_current) March 8, 2022